MX367076B - Composiciones de arni de proteina convertasa subtilisina kexina 9 (pcsk9) y metodos de uso de las mismas. - Google Patents

Composiciones de arni de proteina convertasa subtilisina kexina 9 (pcsk9) y metodos de uso de las mismas.

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Publication number
MX367076B
MX367076B MX2015007035A MX2015007035A MX367076B MX 367076 B MX367076 B MX 367076B MX 2015007035 A MX2015007035 A MX 2015007035A MX 2015007035 A MX2015007035 A MX 2015007035A MX 367076 B MX367076 B MX 367076B
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MX
Mexico
Prior art keywords
methods
pcsk9
irna compositions
rnai agents
pcsk9 irna
Prior art date
Application number
MX2015007035A
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English (en)
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MX2015007035A (es
Inventor
Fitzgerald Kevin
Milstein Stuart
Querbes William
Frank-Kamenetsky Maria
Maier Martin
Kuchimanchi Satyanarayana
Charisse Klaus
Manoharan Muthiah
Borodovsky Anna
G Kallanthottathil Rajeev
Original Assignee
Alnylam Pharmaceuticals Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49841845&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX367076(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of MX2015007035A publication Critical patent/MX2015007035A/es
Publication of MX367076B publication Critical patent/MX367076B/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/06—Antihyperlipidemics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C12N2310/3533—Halogen
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/35—Special therapeutic applications based on a specific dosage / administration regimen

Abstract

La presente invención se refiere a agentes de iARN, por ejemplo, agentes de iARN bicatenario, que se dirigen al gen PCSK9, y a métodos de uso de tales agentes de iARN para inhibir la expresión de PCSK9 y métodos para tratar sujetos que tienen un trastorno de lípidos, tal como una hiperlipidemia.
MX2015007035A 2012-12-05 2013-12-05 Composiciones de arni de proteina convertasa subtilisina kexina 9 (pcsk9) y metodos de uso de las mismas. MX367076B (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261733518P 2012-12-05 2012-12-05
US201361793530P 2013-03-15 2013-03-15
US201361886916P 2013-10-04 2013-10-04
US201361892188P 2013-10-17 2013-10-17
PCT/US2013/073349 WO2014089313A1 (en) 2012-12-05 2013-12-05 PCSK9 iRNA COMPOSITIONS AND METHODS OF USE THEREOF

Publications (2)

Publication Number Publication Date
MX2015007035A MX2015007035A (es) 2015-09-25
MX367076B true MX367076B (es) 2019-08-05

Family

ID=49841845

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015007035A MX367076B (es) 2012-12-05 2013-12-05 Composiciones de arni de proteina convertasa subtilisina kexina 9 (pcsk9) y metodos de uso de las mismas.
MX2019009283A MX2019009283A (es) 2012-12-05 2015-06-03 Composiciones de arni de proteina convertasa subtilisina kexina 9 (pcsk9) y metodos de uso de las mismas.

Family Applications After (1)

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MX2019009283A MX2019009283A (es) 2012-12-05 2015-06-03 Composiciones de arni de proteina convertasa subtilisina kexina 9 (pcsk9) y metodos de uso de las mismas.

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Country Link
US (2) US10125369B2 (es)
EP (3) EP3336187A1 (es)
JP (4) JP6574383B2 (es)
KR (2) KR102096014B1 (es)
CN (2) CN108220295B (es)
AR (1) AR093835A1 (es)
AU (3) AU2013355237C1 (es)
BR (1) BR112015013105B1 (es)
CA (1) CA2892160C (es)
CY (1) CY1120195T1 (es)
DK (1) DK2929031T5 (es)
ES (1) ES2657608T3 (es)
FR (1) FR21C1021I2 (es)
HK (2) HK1213598A1 (es)
HR (1) HRP20180126T2 (es)
HU (2) HUE035887T2 (es)
IL (2) IL238917B (es)
LT (2) LT2929031T (es)
LU (1) LUC00209I2 (es)
MX (2) MX367076B (es)
NL (1) NL301107I2 (es)
NO (1) NO2021024I1 (es)
NZ (1) NZ709013A (es)
PL (1) PL2929031T4 (es)
PT (1) PT2929031T (es)
RS (1) RS56783B9 (es)
SI (1) SI2929031T1 (es)
WO (1) WO2014089313A1 (es)
ZA (1) ZA201503829B (es)

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