DK2929031T5 - Pcsk9-irna-sammensætninger og fremgangsmåder til anvendelse deraf - Google Patents

Pcsk9-irna-sammensætninger og fremgangsmåder til anvendelse deraf Download PDF

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DK2929031T5
DK2929031T5 DK13811327.9T DK13811327T DK2929031T5 DK 2929031 T5 DK2929031 T5 DK 2929031T5 DK 13811327 T DK13811327 T DK 13811327T DK 2929031 T5 DK2929031 T5 DK 2929031T5
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pcsk9
methods
irna compositions
irna
compositions
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DK13811327.9T
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DK2929031T3 (da
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Anna Borodovsky
Rajeev G Kallanthottathil
Kevin Fitzgerald
Maria Frank-Kamenetsky
William Querbes
Martin Maier
Klaus Charisse
Satyanarayana Kuchimanchi
Muthiah Manoharan
Stuart Milstein
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Alnylam Pharmaceuticals Inc
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12Y304/21—Serine endopeptidases (3.4.21)
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/312—Phosphonates
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    • C12N2310/34—Spatial arrangement of the modifications
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C12N2310/3533—Halogen
    • C—CHEMISTRY; METALLURGY
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/35—Special therapeutic applications based on a specific dosage / administration regimen
DK13811327.9T 2012-12-05 2013-12-05 Pcsk9-irna-sammensætninger og fremgangsmåder til anvendelse deraf DK2929031T5 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261733518P 2012-12-05 2012-12-05
US201361793530P 2013-03-15 2013-03-15
US201361886916P 2013-10-04 2013-10-04
US201361892188P 2013-10-17 2013-10-17
PCT/US2013/073349 WO2014089313A1 (en) 2012-12-05 2013-12-05 PCSK9 iRNA COMPOSITIONS AND METHODS OF USE THEREOF

Publications (2)

Publication Number Publication Date
DK2929031T3 DK2929031T3 (da) 2018-01-29
DK2929031T5 true DK2929031T5 (da) 2021-08-23

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US (2) US10125369B2 (da)
EP (3) EP3336187A1 (da)
JP (4) JP6574383B2 (da)
KR (2) KR20200035490A (da)
CN (2) CN108220295B (da)
AR (1) AR093835A1 (da)
AU (3) AU2013355237C1 (da)
BR (1) BR112015013105B1 (da)
CA (1) CA2892160C (da)
CY (1) CY1120195T1 (da)
DK (1) DK2929031T5 (da)
ES (1) ES2657608T3 (da)
FR (1) FR21C1021I2 (da)
HK (2) HK1213598A1 (da)
HR (1) HRP20180126T2 (da)
HU (2) HUE035887T2 (da)
IL (2) IL238917B (da)
LT (2) LT2929031T (da)
LU (1) LUC00209I2 (da)
MX (2) MX367076B (da)
NL (1) NL301107I2 (da)
NO (1) NO2021024I1 (da)
NZ (1) NZ709013A (da)
PL (1) PL2929031T4 (da)
PT (1) PT2929031T (da)
RS (1) RS56783B9 (da)
SI (1) SI2929031T1 (da)
WO (1) WO2014089313A1 (da)
ZA (1) ZA201503829B (da)

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