DK2895621T3 - Fremgangsmåder og sammensætning til diagnosticering, prognose og behandling af neurologiske tilstande - Google Patents

Fremgangsmåder og sammensætning til diagnosticering, prognose og behandling af neurologiske tilstande Download PDF

Info

Publication number
DK2895621T3
DK2895621T3 DK13836501.0T DK13836501T DK2895621T3 DK 2895621 T3 DK2895621 T3 DK 2895621T3 DK 13836501 T DK13836501 T DK 13836501T DK 2895621 T3 DK2895621 T3 DK 2895621T3
Authority
DK
Denmark
Prior art keywords
forecast
diagnosis
treatment
composition
methods
Prior art date
Application number
DK13836501.0T
Other languages
English (en)
Inventor
Eli Hatchwell
Peggy S Eis
Original Assignee
Population Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Population Bio Inc filed Critical Population Bio Inc
Application granted granted Critical
Publication of DK2895621T3 publication Critical patent/DK2895621T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/16—Assays for determining copy number or wherein the copy number is of special importance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2835—Movement disorders, e.g. Parkinson, Huntington, Tourette
DK13836501.0T 2012-09-14 2013-09-13 Fremgangsmåder og sammensætning til diagnosticering, prognose og behandling af neurologiske tilstande DK2895621T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261743919P 2012-09-14 2012-09-14
PCT/US2013/059739 WO2014043519A1 (en) 2012-09-14 2013-09-13 Methods and compositions for diagnosing, prognosing, and treating neurological conditions

Publications (1)

Publication Number Publication Date
DK2895621T3 true DK2895621T3 (da) 2020-11-30

Family

ID=50278721

Family Applications (1)

Application Number Title Priority Date Filing Date
DK13836501.0T DK2895621T3 (da) 2012-09-14 2013-09-13 Fremgangsmåder og sammensætning til diagnosticering, prognose og behandling af neurologiske tilstande

Country Status (4)

Country Link
US (3) US9976180B2 (da)
EP (1) EP2895621B1 (da)
DK (1) DK2895621T3 (da)
WO (1) WO2014043519A1 (da)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10522240B2 (en) 2006-05-03 2019-12-31 Population Bio, Inc. Evaluating genetic disorders
US7702468B2 (en) 2006-05-03 2010-04-20 Population Diagnostics, Inc. Evaluating genetic disorders
US8862410B2 (en) 2010-08-02 2014-10-14 Population Diagnostics, Inc. Compositions and methods for discovery of causative mutations in genetic disorders
WO2013054200A2 (en) 2011-10-10 2013-04-18 The Hospital For Sick Children Methods and compositions for screening and treating developmental disorders
EP2773779B1 (en) * 2011-11-04 2020-10-14 Population Bio, Inc. Methods and compositions for diagnosing, prognosing, and treating neurological conditions
WO2013086041A1 (en) * 2011-12-05 2013-06-13 The Trustees Of Columbia University In The City Of New York Transcriptome wiring analysis in parkinson's disease and uses thereof
WO2013120018A1 (en) 2012-02-09 2013-08-15 Population Diagnostics, Inc. Methods and compositions for screening and treating developmental disorders
US9976180B2 (en) 2012-09-14 2018-05-22 Population Bio, Inc. Methods for detecting a genetic variation in subjects with parkinsonism
US10233495B2 (en) 2012-09-27 2019-03-19 The Hospital For Sick Children Methods and compositions for screening and treating developmental disorders
US9445769B2 (en) * 2013-12-06 2016-09-20 President And Fellows Of Harvard College Method and apparatus for detecting disease regression through network-based gait analysis
US9443063B2 (en) 2013-12-06 2016-09-13 President And Fellows Of Harvard College Method and apparatus for using gait analysis to determine a health quality measure
WO2015200434A1 (en) * 2014-06-24 2015-12-30 Alseres Neurodiagnostics, Inc. Preictive neurodiagnostic methods
GB2558326B (en) * 2014-09-05 2021-01-20 Population Bio Inc Methods and compositions for inhibiting and treating neurological conditions
CN107683446B (zh) 2015-03-13 2020-11-03 苹果公司 用于自动识别眼睛追踪设备的至少一个用户的方法以及眼睛追踪设备
WO2017165817A1 (en) * 2016-03-25 2017-09-28 Bioceryx Inc. Apparatuses and methods for assessing target sequence numbers
US10583286B2 (en) * 2016-08-23 2020-03-10 Boston Scientific Neuromodulation Corporation Methods and devices for neuromodulation of the adrenal gland
WO2018053573A1 (en) * 2016-09-22 2018-03-29 Garvan Institute Of Medical Research Device for presenting sequencing data
US10240205B2 (en) 2017-02-03 2019-03-26 Population Bio, Inc. Methods for assessing risk of developing a viral disease using a genetic test
EP3601603A4 (en) * 2017-03-27 2020-12-30 Caris Science, Inc. OLIGONUCLEOTIDE PROBES AND THEIR USES
WO2018202740A1 (en) * 2017-05-04 2018-11-08 Universitat De Barcelona Method for predicting early onset and severity of levodopa induced dyskinesia (lid) in subjects diagnosed of parkinson disease (pd)
CN106980321B (zh) * 2017-05-18 2019-04-16 中国科学院合肥物质科学研究院 一种六足履式无人地面车辆的上台阶步态规划系统及其方法
EP3668891B1 (en) * 2017-08-16 2023-07-26 Lgv1 S.R.L. Vtft isoform of a bpifb4 protein for use in neuronal deseases and injuries
WO2019070745A1 (en) 2017-10-02 2019-04-11 Blackthorn Therapeutics, Inc. METHODS AND SYSTEMS FOR COMPUTER-GENERATED PREDICTIVE APPLICATION OF NEURO-IMAGING MAPPING DATA AND GENE EXPRESSION
US11767562B2 (en) * 2018-03-08 2023-09-26 St. John's University Circulating serum cell-free DNA biomarkers and methods
JP7379387B2 (ja) 2018-06-05 2023-11-14 エフ． ホフマン－ラ ロシュ アーゲー Ａｔｘｎ２発現を制御するためのオリゴヌクレオチド
CN108913767A (zh) * 2018-07-20 2018-11-30 中南大学湘雅医院 一种帕金森病致病基因、试剂盒及应用
AU2019316556B9 (en) 2018-08-08 2024-01-04 Pml Screening, Llc Methods for assessing the risk of developing progressive multifocal leukoencephalopathy caused by john cunningham virus by genetic testing
US11286485B2 (en) 2019-04-04 2022-03-29 Hoffmann-La Roche Inc. Oligonucleotides for modulating ATXN2 expression
CN112522381A (zh) * 2020-12-07 2021-03-19 苏州赛美科基因科技有限公司 一种同时检测基因突变与拷贝数变化的高通量方法
CN112597935A (zh) * 2020-12-29 2021-04-02 北京影谱科技股份有限公司 一种注意力水平检测方法、装置、计算设备及存储介质
CN112964876A (zh) * 2021-01-29 2021-06-15 泰达国际心血管病医院 前列腺素h2 d-异构酶抗体的新用途及st段抬高型心肌梗死早期筛查诊断试剂盒
CN113032563B (zh) * 2021-03-22 2023-07-14 山西三友和智慧信息技术股份有限公司 一种基于人工遮掩关键词的正则化文本分类微调方法
WO2023164562A1 (en) * 2022-02-25 2023-08-31 The Board Of Regents Of The University Of Texas System Dorsal medulla surface texture as an imaging metric to distinguish between neurological disorders systems and methods
WO2023220700A1 (en) * 2022-05-13 2023-11-16 The Trustees Of Indiana University Metabolic biomarkers for assessing friedreich's ataxia in a subject

Family Cites Families (162)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3625214A (en) 1970-05-18 1971-12-07 Alza Corp Drug-delivery device
US4906474A (en) 1983-03-22 1990-03-06 Massachusetts Institute Of Technology Bioerodible polyanhydrides for controlled drug delivery
US4557508A (en) 1984-04-12 1985-12-10 Cameron Iron Works, Inc. Tubular connector
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4789734A (en) 1985-08-06 1988-12-06 La Jolla Cancer Research Foundation Vitronectin specific cell receptor derived from mammalian mesenchymal tissue
US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
AU610083B2 (en) 1986-08-18 1991-05-16 Clinical Technologies Associates, Inc. Delivery systems for pharmacological agents
US6024983A (en) 1986-10-24 2000-02-15 Southern Research Institute Composition for delivering bioactive agents for immune response and its preparation
US5075109A (en) 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
US5001139A (en) 1987-06-12 1991-03-19 American Cyanamid Company Enchancers for the transdermal flux of nivadipine
US4992445A (en) 1987-06-12 1991-02-12 American Cyanamid Co. Transdermal delivery of pharmaceuticals
US4897268A (en) 1987-08-03 1990-01-30 Southern Research Institute Drug delivery system and method of making the same
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US6054270A (en) 1988-05-03 2000-04-25 Oxford Gene Technology Limited Analying polynucleotide sequences
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
JP3771253B2 (ja) 1988-09-02 2006-04-26 ダイアックス コープ． 新規な結合タンパク質の生成と選択
US5766573A (en) 1988-12-06 1998-06-16 Riker Laboratories, Inc. Medicinal aerosol formulations
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5527681A (en) 1989-06-07 1996-06-18 Affymax Technologies N.V. Immobilized molecular synthesis of systematically substituted compounds
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
ATE174058T1 (de) 1989-11-06 1998-12-15 Cell Genesys Inc Herstellung von proteinen mittels homologer rekombination
US5252743A (en) 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
US5272071A (en) 1989-12-22 1993-12-21 Applied Research Systems Ars Holding N.V. Method for the modification of the expression characteristics of an endogenous gene of a given cell line
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
ES2139598T3 (es) 1990-07-10 2000-02-16 Medical Res Council Procedimientos para la produccion de miembros de parejas de union especifica.
DE69129154T2 (de) 1990-12-03 1998-08-20 Genentech Inc Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
WO1992010092A1 (en) 1990-12-06 1992-06-25 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5190029A (en) 1991-02-14 1993-03-02 Virginia Commonwealth University Formulation for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
EP1820858B1 (en) 1991-03-01 2009-08-12 Dyax Corporation Chimeric protein comprising micro-protein having two or more disulfide bonds and embodiments thereof
AU662148B2 (en) 1991-04-10 1995-08-24 Scripps Research Institute, The Heterodimeric receptor libraries using phagemids
DE4122599C2 (de) 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid zum Screenen von Antikörpern
US5384261A (en) 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
JP3645903B2 (ja) 1992-03-04 2005-05-11 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 比較ゲノムハイブリダイゼーション（ｃｇｈ）
US7534567B2 (en) 1992-03-04 2009-05-19 The Regents Of The University Of California Detection of nucleic acid sequence differences by comparative genomic hybridization
US5541061A (en) 1992-04-29 1996-07-30 Affymax Technologies N.V. Methods for screening factorial chemical libraries
US5376359A (en) 1992-07-07 1994-12-27 Glaxo, Inc. Method of stabilizing aerosol formulations
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US20040197774A1 (en) 1992-11-12 2004-10-07 Michael Wigler Representational approach to DNA analysis
EP0678034B1 (en) 1993-01-11 1999-05-26 Dana Farber Cancer Institute Inducing cytotoxic t lymphocyte responses
US5837832A (en) 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US5858659A (en) 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
EP0730663B1 (en) 1993-10-26 2003-09-24 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US6287850B1 (en) 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
EP0695941B1 (en) 1994-06-08 2002-07-31 Affymetrix, Inc. Method and apparatus for packaging a chip
US6300063B1 (en) 1995-11-29 2001-10-09 Affymetrix, Inc. Polymorphism detection
EP2369007B1 (en) 1996-05-29 2015-07-29 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
EP0937097B1 (en) 1996-11-06 2001-08-16 Sequenom, Inc. Compositions and methods for immobilizing nucleic acids to solid supports
EP0878552A1 (en) 1997-05-13 1998-11-18 Erasmus Universiteit Rotterdam Molecular detection of chromosome aberrations
US6210878B1 (en) 1997-08-08 2001-04-03 The Regents Of The University Of California Array-based detection of genetic alterations associated with disease
ATE537270T1 (de) 1997-10-30 2011-12-15 Cold Spring Harbor Lab Sondenanordnungen und deren verwendungen für verfahren zur dns-unterscheidung
US6207392B1 (en) 1997-11-25 2001-03-27 The Regents Of The University Of California Semiconductor nanocrystal probes for biological applications and process for making and using such probes
US20090304653A1 (en) 1998-01-30 2009-12-10 Evolutionary Genomics, Inc. Methods to identify polynucleotide and polypeptide sequences which may be associated with physiological and medical conditions
US6429027B1 (en) 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
US20030207295A1 (en) 1999-04-20 2003-11-06 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
WO2001016156A1 (en) 1999-08-30 2001-03-08 Human Genome Sciences, Inc. Attractin-like polynucleotides, polypeptides, and antibodies
US6423499B1 (en) 1999-09-10 2002-07-23 The United States Of America, As Represented By The Secretary Of Agriculture PCR primers for detection and identification of plant pathogenic species, subspecies, and strains of acidovorax
US6146834A (en) 1999-09-10 2000-11-14 The United States Of America As Represented By The Secretary Of Agriculture PCR primers for detection of plant pathogenic species and subspecies of acidovorax
US7211390B2 (en) 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7244559B2 (en) 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7030231B1 (en) 1999-09-30 2006-04-18 Catalyst Biosciences, Inc. Membrane type serine protease 1 (MT-SP1) and uses thereof
US6251607B1 (en) 1999-12-09 2001-06-26 National Science Council Of Republic Of China PCR primers for the rapid and specific detection of Salmonella typhimurium
US6892141B1 (en) 2000-03-17 2005-05-10 Hitachi, Ltd. Primer design system
AU2001231091A1 (en) 2000-01-21 2001-07-31 Vincent P. Stanton Jr. Identification of genetic components of drug response
US6828097B1 (en) 2000-05-16 2004-12-07 The Childrens Mercy Hospital Single copy genomic hybridization probes and method of generating same
EP1366192B8 (en) 2000-10-24 2008-10-29 The Board of Trustees of the Leland Stanford Junior University Direct multiplex characterization of genomic dna
US20040018491A1 (en) 2000-10-26 2004-01-29 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
AU785425B2 (en) 2001-03-30 2007-05-17 Genetic Technologies Limited Methods of genomic analysis
GB0113908D0 (en) 2001-06-07 2001-08-01 Univ London Designing degenerate PCR primers
US20030049663A1 (en) 2001-06-27 2003-03-13 Michael Wigler Use of reflections of DNA for genetic analysis
AU2002336421A1 (en) 2001-08-31 2003-04-14 The Government Of The United States Of America, Asrepresented By The Secretary Of The Department Of Measurements of multiple molecules using a cryoarray
US20030082606A1 (en) 2001-09-04 2003-05-01 Lebo Roger V. Optimizing genome-wide mutation analysis of chromosomes and genes
US6977148B2 (en) 2001-10-15 2005-12-20 Qiagen Gmbh Multiple displacement amplification
US20050124022A1 (en) 2001-10-30 2005-06-09 Maithreyan Srinivasan Novel sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US6902921B2 (en) 2001-10-30 2005-06-07 454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US7107155B2 (en) 2001-12-03 2006-09-12 Dnaprint Genomics, Inc. Methods for the identification of genetic features for complex genetics classifiers
US6916621B2 (en) 2002-03-27 2005-07-12 Spectral Genomics, Inc. Methods for array-based comparitive binding assays
US7282330B2 (en) 2002-05-28 2007-10-16 U.S. Genomics, Inc. Methods and apparati using single polymer analysis
WO2004018633A2 (en) 2002-08-20 2004-03-04 The Government Of The United States Of America As Represented By The Secretary, Department Of Healthand Human Services Abca13 nucleic acids and proteins, and uses thereof
US7011949B2 (en) 2002-09-30 2006-03-14 Agilent Technologies, Inc. Methods and compositions for producing labeled probe nucleic acids for use in array based comparative genomic hybridization applications
US7822555B2 (en) 2002-11-11 2010-10-26 Affymetrix, Inc. Methods for identifying DNA copy number changes
US10229244B2 (en) 2002-11-11 2019-03-12 Affymetrix, Inc. Methods for identifying DNA copy number changes using hidden markov model based estimations
CA2505472A1 (en) 2002-11-11 2004-05-27 Affymetrix, Inc. Methods for identifying dna copy number changes
WO2005003375A2 (en) 2003-01-29 2005-01-13 454 Corporation Methods of amplifying and sequencing nucleic acids
US20050021236A1 (en) 2003-02-14 2005-01-27 Oklahoma Medical Research Foundation And Intergenetics, Inc. Statistically identifying an increased risk for disease
JP2006525814A (ja) 2003-05-23 2006-11-16 コールド スプリング ハーバー ラボラトリー ヌクレオチド配列の実質的表示
AU2004253882B2 (en) 2003-06-20 2010-06-10 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
KR100647277B1 (ko) 2003-08-14 2006-11-17 삼성전자주식회사 Ｂ형 간염 검사용 ｐｃｒ 프라이머 세트 및 이를 포함하는 ｂ형 간염 검사 키트
US20070141577A1 (en) 2003-09-11 2007-06-21 Moore Thomas F Method
WO2005042763A2 (en) 2003-10-28 2005-05-12 Bioarray Solutions Ltd. Optimization of gene expression analysis using immobilized capture probes
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
JP2008504803A (ja) 2004-01-09 2008-02-21 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 遺伝子発現の細胞型特異的パターン
US20050233339A1 (en) 2004-04-20 2005-10-20 Barrett Michael T Methods and compositions for determining the relationship between hybridization signal of aCGH probes and target genomic DNA copy number
EP1751306A1 (en) 2004-04-30 2007-02-14 Yale University Methods and compositions for cancer diagnosis
US20080166357A1 (en) 2004-05-11 2008-07-10 Stefan Golz Diagnostics and Therapeutics for Diseases Associated with Dipeptidyl-Peptidase 6 (Dpp6)
US20060024711A1 (en) 2004-07-02 2006-02-02 Helicos Biosciences Corporation Methods for nucleic acid amplification and sequence determination
US20060012793A1 (en) 2004-07-19 2006-01-19 Helicos Biosciences Corporation Apparatus and methods for analyzing samples
US7276720B2 (en) 2004-07-19 2007-10-02 Helicos Biosciences Corporation Apparatus and methods for analyzing samples
US20060024678A1 (en) 2004-07-28 2006-02-02 Helicos Biosciences Corporation Use of single-stranded nucleic acid binding proteins in sequencing
US7595159B2 (en) 2004-11-03 2009-09-29 The Brigham And Women's Hospital, Inc. Prediction of Parkinson's disease using gene expression levels of peripheral blood samples
NO323175B1 (no) 2004-12-23 2007-01-15 Jan O Aasly Framgangsmate for a pavise en mutasjon som forarsaker arvelig parkinsonisme
BRPI0520012A2 (pt) 2005-02-18 2009-04-14 Us Gov Health & Human Serv identificação de marcadores moleculares de diagnóstico para endometriose em linfócitos do sangue
CN100340674C (zh) 2005-04-28 2007-10-03 中国人民解放军总医院 耳聋相关基因突变及其检测方法
WO2006116873A1 (en) 2005-05-05 2006-11-09 Mount Sinai Hospital Diagnosis and treatment of endometriosis
WO2007070640A2 (en) 2005-12-14 2007-06-21 Wigler Michael H Use of roma for characterizing genomic rearrangements
EP3091462B1 (en) 2005-12-14 2020-06-17 Cold Spring Harbor Laboratory Methods for assessing probabilistic measures of clinical outcome using genomic profiling
CA3127202A1 (en) 2006-02-28 2007-09-07 Biogen Ma Inc. Methods of treating inflammatory and autoimmune diseases with natalizumab
JP5491171B2 (ja) 2006-04-12 2014-05-14 メディカル リサーチ カウンシル 方法
US7702468B2 (en) 2006-05-03 2010-04-20 Population Diagnostics, Inc. Evaluating genetic disorders
US10522240B2 (en) 2006-05-03 2019-12-31 Population Bio, Inc. Evaluating genetic disorders
CN101148684A (zh) 2006-09-22 2008-03-26 上海交通大学医学院附属瑞金医院 多发性内分泌腺瘤ii型基因突变检测的新方法
JP2010508354A (ja) 2006-10-31 2010-03-18 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 広汎性発達障害の処置
US20080131887A1 (en) 2006-11-30 2008-06-05 Stephan Dietrich A Genetic Analysis Systems and Methods
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
EP2639578B1 (en) 2006-12-14 2016-09-14 Life Technologies Corporation Apparatus for measuring analytes using large scale fet arrays
US11287425B2 (en) 2009-04-22 2022-03-29 Juneau Biosciences, Llc Genetic markers associated with endometriosis and use thereof
US20110111014A1 (en) 2007-06-26 2011-05-12 Parkinson's Institute Methods and compositions for treatment of neurological disorders
US9233107B2 (en) 2007-09-14 2016-01-12 Biogen Ma Inc. Compositions and methods for the treatment of progressive multifocal leukoencephalopathy (PML)
CA2701202C (en) 2007-10-04 2018-01-02 The Hospital For Sick Children Biomarkers for autism spectrum disorders
US20130190190A1 (en) 2007-12-04 2013-07-25 Stephen G. Schwartz Molecular targets for modulating intraoccular pressure and differentiation of steroid responses versus non-responders
EP2229458B1 (en) 2007-12-28 2012-02-08 Pioneer Hi-Bred International, Inc. Using structural variation to analyze genomic differences for the prediction of heterosis
US8470594B2 (en) 2008-04-15 2013-06-25 President And Fellows Of Harvard College Methods for identifying agents that affect the survival of motor neurons
EP2300827B1 (en) * 2008-06-12 2014-12-17 Institut National De La Sante Et De La Recherche Medicale (Inserm) Tet2 as a new diagnostic and pronostic marker in hematopoietic neoplasms
US8669048B2 (en) 2008-06-24 2014-03-11 Parkinson's Institute Pluripotent cell lines and methods of use thereof
AU2009265105A1 (en) 2008-07-04 2010-01-07 Decode Genetics Ehf Copy number variations predictive of risk of schizophrenia
EP2149613A1 (en) 2008-07-28 2010-02-03 Greenwood Genetic Center, Inc. Methods for determining dysregulation of methylation of brain expressed genes on the X chromosome to diagnose autism spectrum disorders
US20100035252A1 (en) 2008-08-08 2010-02-11 Ion Torrent Systems Incorporated Methods for sequencing individual nucleic acids under tension
US20100089287A1 (en) 2008-09-25 2010-04-15 Thames Shelby F Soy protein adhesive and uses thereof
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
CN101403008B (zh) 2008-11-07 2011-07-27 北京市神经外科研究所 一种检测成人早衰老综合症的基因诊断试剂盒
EP2963129A3 (en) 2008-11-12 2016-05-11 University of Utah Research Foundation Autism associated genetic markers
WO2010057112A2 (en) 2008-11-14 2010-05-20 The Children's Hospital Of Philadelphia Genetic variants underlying human cognition and methods of use thereof as diagnostic and therapeutic targets
CN102348798A (zh) 2009-01-16 2012-02-08 麻省理工学院 孤独症谱系障碍的诊断和治疗
ES2581178T3 (es) 2009-07-29 2016-09-01 Pharnext Nuevas herramientas de diagnóstico para enfermedad de Alzheimer
JP5686335B2 (ja) 2009-08-25 2015-03-18 国立大学法人広島大学 筋萎縮性側索硬化症の診断マーカー、及び、方法、並びに、筋萎縮性側索硬化症を発症するモデル動物、及び、モデル細胞
US20120172251A1 (en) 2009-09-16 2012-07-05 The Regents Of The University Of Colorado, A Body Corporate Methods and compositions for diagnosing heart failure
CA2782207A1 (en) 2009-11-30 2011-06-03 23Andme, Inc. Polymorphisms associated with parkinson's disease
WO2011112961A1 (en) 2010-03-12 2011-09-15 Children's Medical Center Corporation Methods and compositions for characterizing autism spectrum disorder based on gene expression patterns
EP2591433A4 (en) 2010-07-06 2017-05-17 Life Technologies Corporation Systems and methods to detect copy number variation
US8862410B2 (en) 2010-08-02 2014-10-14 Population Diagnostics, Inc. Compositions and methods for discovery of causative mutations in genetic disorders
EP2608274A1 (en) 2010-08-17 2013-06-26 Toppan Printing Co., Ltd. Ink for production of compound semiconductor thin film, compound semiconductor thin film produced using the ink, solar cell equipped with the compound semiconductor thin film, and process for production of the solar cell
JP6216486B2 (ja) 2010-08-24 2017-10-18 ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィアＴｈｅ Ｃｈｉｌｄｒｅｎ’Ｓ Ｈｏｓｐｉｔａｌ Ｏｆ Ｐｈｉｌａｄｅｌｐｈｉａ 低頻度反復性遺伝的変異の注意欠陥多動性障害への関連ならびに診断および治療のためのその使用方法
US20120048778A1 (en) 2010-08-25 2012-03-01 Catalytic Distillation Technologies Selective desulfurization of fcc gasoline
CA2744424A1 (en) 2010-09-14 2012-03-14 The Hospital For Sick Children Biomarkers for autism spectrum disorders
US20140127685A1 (en) 2010-10-07 2014-05-08 The Johns Hopkins University Compositions and methods for diagnosing autism
ES2387358B1 (es) 2011-02-25 2013-08-02 Fundación Alzheimur Procedimiento para la determinación de la predisposición genética a la enfermedad de parkinson.
US20140208449A1 (en) 2011-03-29 2014-07-24 Cornell University Genetics of gender discrimination in date palm
WO2013054200A2 (en) 2011-10-10 2013-04-18 The Hospital For Sick Children Methods and compositions for screening and treating developmental disorders
WO2013059739A1 (en) 2011-10-19 2013-04-25 Cognionics, Inc. Apparatuses, systems and methods for biopotential sensing with dry electrodes
EP2773779B1 (en) 2011-11-04 2020-10-14 Population Bio, Inc. Methods and compositions for diagnosing, prognosing, and treating neurological conditions
MX2014005683A (es) 2011-11-10 2015-01-22 Genentech Inc Metodos para tratar, diagnosticar y vigilar enfermedad de alzheimer.
WO2013120018A1 (en) 2012-02-09 2013-08-15 Population Diagnostics, Inc. Methods and compositions for screening and treating developmental disorders
MY154507A (en) 2012-03-19 2015-06-22 Malaysian Palm Oil Board Gene Controlling Shell Phenotype in Palm
US10995342B2 (en) 2012-05-11 2021-05-04 Wisconsin Alumni Research Foundation Rhg1 mediated resistance to soybean cyst nematode
US9976180B2 (en) 2012-09-14 2018-05-22 Population Bio, Inc. Methods for detecting a genetic variation in subjects with parkinsonism
US10233495B2 (en) 2012-09-27 2019-03-19 The Hospital For Sick Children Methods and compositions for screening and treating developmental disorders
CN103436606B (zh) 2013-08-01 2014-10-29 中山大学附属肿瘤医院 一种用于食管癌辅助诊断和/或预后判断的试剂盒
EP3110976B1 (en) 2014-02-27 2020-05-13 Biogen MA Inc. Method of assessing risk of pml
JP2016031772A (ja) 2014-07-30 2016-03-07 株式会社日立ハイテクファインシステムズ 熱アシスト磁気ヘッド素子の検査方法及びその装置

Also Published As

Publication number Publication date
US20190144935A1 (en) 2019-05-16
WO2014043519A1 (en) 2014-03-20
EP2895621A4 (en) 2016-10-05
US9976180B2 (en) 2018-05-22
US20140162933A1 (en) 2014-06-12
US20230020697A1 (en) 2023-01-19
US11008614B2 (en) 2021-05-18
EP2895621B1 (en) 2020-10-21
EP2895621A1 (en) 2015-07-22

Similar Documents

Publication Publication Date Title
DK2895621T3 (da) Fremgangsmåder og sammensætning til diagnosticering, prognose og behandling af neurologiske tilstande
LTC2785706I2 (lt) Pakeistieji 4-fenil-piridinai, skirti su nk-receptoriumi susijusių ligų gydymui
DK2773779T3 (da) Fremgangsmåder og sammensætninger til diagnosticering, prognose og forebyggelse af neurologiske tilstande
DK2726511T3 (da) Sammensætninger, anvendelser og fremgangsmåder til behandling af stofskiftesygdomme og -lidelser
DK2699553T3 (da) Substituerede diaminocarboxamid- og diaminocarbonitrilpyrimidiner, sammensætninger deraf og fremgangsmåder til behandling dermed
DK2885010T3 (da) Fremgangsmåder til behandling med tauopati
DK3444342T3 (da) Fremgangsmåder og sammensætninger til behandlingen af lysosomale aflejringssygdomme
DK3520805T3 (da) Sammensætninger til behandling af myelofibrose
DK2898061T3 (da) Probiotiske sammensætninger til behandlingen af fedme og fedme-relaterede tilstande
DK2776567T3 (da) Sammensætninger og fremgangsmåder til behandling af cytomegalovirus.
DK3329884T3 (da) Implanterbar indretning til behandling af glaukom
DK2558105T3 (da) Bardoxolonmethyl til behandling af fedme
BR112013033811A2 (pt) composição, método de preparação da composição, e, composto
DK2585088T3 (da) Sammensætning til forbedring af seksuel sundhed
DK2688557T3 (da) Fremgangsmåder og sammensætninger til behandling af forstyrelse af opmærksomhed
DK2872152T3 (da) Acellulære pro-tolerogene sammensætninger til behandling/forebyggelse af transplantatafstødning
DK2701733T3 (da) Forbindelser til behandling af neuropsykiatriske forstyrrelser
BR112014004192A2 (pt) composição de tratamento de sementes, e, método de tratamento de sementes
DK3581199T3 (da) Fremgangsmåder til behandling eller reduktion af ødematøs fibrosklerotisk pannikulitis
DK2818241T3 (da) Fremgangsmåde til fremstilling af behandlingsapparat udstyret med katalysatorbærende honeycombstruktur
DK2830654T3 (da) Metoder og sammensætninger til behandling af inflammation
BR112014016108A2 (pt) método de tratamento de perda óssea alvelar
BR112013022820A2 (pt) método de tratamento
DK2326332T3 (da) Fremgangsmåde til behandling af sygdomme
DK2903432T3 (da) Fremgangsmåde til behandling af sædceller til kønsortering