|
ES2756326T3
(es)
|
2010-07-19 |
2020-04-27 |
Ionis Pharmaceuticals Inc |
Modulación de la expresión de distrofia miotónica-proteína quinasa (DMPK)
|
|
US9920317B2
(en)
|
2010-11-12 |
2018-03-20 |
The General Hospital Corporation |
Polycomb-associated non-coding RNAs
|
|
EP3702460A1
(en)
|
2010-11-12 |
2020-09-02 |
The General Hospital Corporation |
Polycomb-associated non-coding rnas
|
|
US10174315B2
(en)
|
2012-05-16 |
2019-01-08 |
The General Hospital Corporation |
Compositions and methods for modulating hemoglobin gene family expression
|
|
US10837014B2
(en)
|
2012-05-16 |
2020-11-17 |
Translate Bio Ma, Inc. |
Compositions and methods for modulating SMN gene family expression
|
|
EA201492120A1
(ru)
|
2012-05-16 |
2015-10-30 |
Рана Терапьютикс, Инк. |
Композиции и способы для модулирования экспрессии atp2a2
|
|
JP2015523854A
(ja)
|
2012-05-16 |
2015-08-20 |
ラナ セラピューティクス インコーポレイテッド |
Ｓｍｎ遺伝子ファミリー発現を調節するための組成物及び方法
|
|
CN104540946A
(zh)
|
2012-05-16 |
2015-04-22 |
Rana医疗有限公司 |
用于调节utrn表达的组合物和方法
|
|
CN104583402A
(zh)
|
2012-05-16 |
2015-04-29 |
Rana医疗有限公司 |
用于调节mecp2表达的组合物和方法
|
|
CA2913596C
(en)
*
|
2013-06-26 |
2021-05-04 |
Elanco Us Inc. |
Markers to predict macrocyclic lactone resistance in dirofilaria immitis, the causative agent of heartworm disease
|
|
TW201536329A
(zh)
|
2013-08-09 |
2015-10-01 |
Isis Pharmaceuticals Inc |
用於調節失養性肌強直蛋白質激酶(dmpk)表現之化合物及方法
|
|
AU2014317961B2
(en)
|
2013-09-05 |
2020-07-30 |
Murdoch University |
Antisense-induced exon2 inclusion in acid alpha-glucosidase
|
|
EP3052632A4
(en)
|
2013-10-04 |
2017-03-29 |
Rana Therapeutics, Inc. |
Compositions and methods for treating amyotrophic lateral sclerosis
|
|
US11162096B2
(en)
|
2013-10-14 |
2021-11-02 |
Ionis Pharmaceuticals, Inc |
Methods for modulating expression of C9ORF72 antisense transcript
|
|
WO2015143245A1
(en)
|
2014-03-19 |
2015-09-24 |
Isis Pharmaceuticals, Inc. |
Methods for modulating ataxin 2 expression
|
|
SI3119888T1
(sl)
|
2014-03-19 |
2021-11-30 |
Ionis Pharmaceuticals, Inc. |
Sestavki za moduliranje izražanja ataksina 2
|
|
HUE050704T2
(hu)
|
2014-04-01 |
2020-12-28 |
Biogen Ma Inc |
Összetételek a SOD-1 expressziójának modulálására
|
|
WO2016061487A1
(en)
*
|
2014-10-17 |
2016-04-21 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting aminolevulinic acid synthase-1 (alas1) and uses thereof
|
|
WO2016070060A1
(en)
|
2014-10-30 |
2016-05-06 |
The General Hospital Corporation |
Methods for modulating atrx-dependent gene repression
|
|
US10793855B2
(en)
*
|
2015-01-06 |
2020-10-06 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of C9ORF72 antisense transcript
|
|
MX391217B
(es)
|
2015-02-26 |
2025-03-21 |
Ionis Pharmaceuticals Inc |
Moduladores de rodopsina p23h con especificidad de alelo.
|
|
GB201504124D0
(en)
|
2015-03-11 |
2015-04-22 |
Proqr Therapeutics B V |
Oligonucleotides
|
|
US10900036B2
(en)
|
2015-03-17 |
2021-01-26 |
The General Hospital Corporation |
RNA interactome of polycomb repressive complex 1 (PRC1)
|
|
WO2016167780A1
(en)
|
2015-04-16 |
2016-10-20 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of c9orf72 antisense transcript
|
|
US10801024B2
(en)
*
|
2015-05-20 |
2020-10-13 |
Indiana University Research And Technology Corporation |
Inhibition of lncRNA HOTAIR and related materials and methods
|
|
EP3124619B1
(en)
*
|
2015-07-31 |
2019-03-06 |
Menicon Co., Ltd |
Reagents, method and kit for across and within dog breed glaucoma diagnosis
|
|
CA3005247A1
(en)
*
|
2015-12-14 |
2017-06-22 |
Cold Spring Harbor Laboratory |
Antisense oligomers for treatment of polycystic kidney disease
|
|
WO2017117496A1
(en)
|
2015-12-31 |
2017-07-06 |
Ionis Pharmaceuticals, Inc. |
Methods for reducing ataxin-2 expression
|
|
KR20180103166A
(ko)
|
2016-01-29 |
2018-09-18 |
교와 핫꼬 기린 가부시키가이샤 |
핵산 복합체
|
|
WO2017134252A1
(en)
*
|
2016-02-05 |
2017-08-10 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Antisense oligonucleotides effective to reduce the expression of menin in cancer cells of a subject
|
|
US11060089B2
(en)
|
2016-04-18 |
2021-07-13 |
Sarepta Therapeutics, Inc. |
Antisense oligomers and methods of using the same for treating diseases associated with the acid alpha-glucosidase gene
|
|
WO2017184883A1
(en)
*
|
2016-04-20 |
2017-10-26 |
JBS Science Inc. |
Kit and method for detecting mutations in ctnnb1 and htert, and use thereof in hcc detection and disease management
|
|
AU2017286811A1
(en)
|
2016-06-17 |
2018-11-22 |
Ionis Pharmaceuticals, Inc. |
Modulation of gys1 expression
|
|
AU2017287536B9
(en)
|
2016-06-30 |
2021-03-25 |
Kyowa Kirin Co., Ltd. |
Nucleic acid complex
|
|
RU2019101298A
(ru)
|
2016-07-01 |
2020-08-03 |
Ф. Хоффманн-Ля Рош Аг |
Антисмысловые олигонуклеотиды для модулирования экспрессии htra1
|
|
US11655470B2
(en)
*
|
2016-07-05 |
2023-05-23 |
The Usa, As Represented By The Secretary, Dept. Of Health And Human Services |
Diagnosing COL6-related disorders and methods for treating same
|
|
JOP20190104A1
(ar)
|
2016-11-10 |
2019-05-07 |
Ionis Pharmaceuticals Inc |
مركبات وطرق لتقليل التعبير عن atxn3
|
|
EP3541939A4
(en)
*
|
2016-11-17 |
2020-06-24 |
Ramot at Tel-Aviv University Ltd. |
HUMAN KAI1 METASTASE SUPPRESSOR MODULATORS METHOD AND USES THEREOF
|
|
US20180193270A1
(en)
|
2016-11-29 |
2018-07-12 |
PureTech Health LLC |
Exosomes for delivery of therapeutic agents
|
|
WO2018132755A1
(en)
*
|
2017-01-12 |
2018-07-19 |
Duke University |
Compositions and methods for disrupting the molecular mechanisms associated with mitochondrial dysfunction and neurodegenerative disease
|
|
WO2018180005A1
(ja)
*
|
2017-03-31 |
2018-10-04 |
国立研究開発法人日本医療研究開発機構 |
コンドロイチン硫酸生合成を阻害するアンチセンス核酸
|
|
GB201706009D0
(en)
*
|
2017-04-13 |
2017-05-31 |
Proqr Therapeutics Ii Bv |
Antisense oligonucleotides for the treatment of stargardt disease
|
|
US20190055564A1
(en)
*
|
2017-06-01 |
2019-02-21 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides for modulating htra1 expression
|
|
WO2019048645A1
(en)
|
2017-09-08 |
2019-03-14 |
Mina Therapeutics Limited |
STABILIZED COMPOSITIONS OF SMALL ACTIVATOR RNA (PARNA) FROM CEBPA AND METHODS OF USE
|
|
WO2019048632A1
(en)
|
2017-09-08 |
2019-03-14 |
Mina Therapeutics Limited |
STABILIZED COMPOSITIONS OF SMALL ACTIVATORY RNA (PARNA) OF HNF4A AND METHODS OF USE
|
|
US20230201357A1
(en)
*
|
2017-11-08 |
2023-06-29 |
Aptamer Diagnostic, Inc. |
D-dimer-specific aptamers and methods of use in diagnostics, therapeutic and theranostic purposes
|
|
TWI809004B
(zh)
|
2017-11-09 |
2023-07-21 |
美商Ionis製藥公司 |
用於降低snca表現之化合物及方法
|
|
PL3717646T3
(pl)
|
2017-12-01 |
2025-10-27 |
The Texas A&M University System |
Leczenie antysensowe zespołu angelmana
|
|
BR112020016170A2
(pt)
*
|
2018-02-09 |
2020-12-15 |
Genentech, Inc. |
Oligonucleotídeos terapêutico e antissenso, conjugado, sal farmaceuticamente aceitável, composição farmacêutica, método in vitro ou in vivo para modular a expressão de tmem106b, método para tratar ou prevenir uma doença, uso do oligonucleotídeo e uso ou método
|
|
WO2019165067A1
(en)
*
|
2018-02-21 |
2019-08-29 |
Bristol-Myers Squibb Company |
Camk2d antisense oligonucleotides and uses thereof
|
|
WO2019169243A1
(en)
|
2018-03-02 |
2019-09-06 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for the modulation of amyloid-beta precursor protein
|
|
TWI840345B
(zh)
|
2018-03-02 |
2024-05-01 |
美商Ionis製藥公司 |
Irf4表現之調節劑
|
|
WO2019200172A1
(en)
|
2018-04-11 |
2019-10-17 |
Ionis Pharmaceuticals, Inc. |
Modulators of ezh2 expression
|
|
JP2021522800A
(ja)
|
2018-05-09 |
2021-09-02 |
アイオーニス ファーマシューティカルズ， インコーポレーテッドＩｏｎｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． |
Ａｔｘｎ３発現を低減するための化合物及び方法
|
|
TWI851574B
(zh)
|
2018-05-14 |
2024-08-11 |
美商阿尼拉製藥公司 |
血管收縮素原（ＡＧＴ）ｉＲＮＡ組成物及其使用方法
|
|
WO2020007700A1
(en)
*
|
2018-07-02 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting spi1
|
|
WO2020007772A1
(en)
*
|
2018-07-02 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting gbp-1
|
|
WO2020011653A1
(en)
*
|
2018-07-09 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting kynu
|
|
WO2020015959A1
(en)
*
|
2018-07-19 |
2020-01-23 |
Stichting Katholieke Universiteit |
Antisense oligonucleotides rescue aberrant splicing of abca4.
|
|
AU2019310097A1
(en)
|
2018-07-25 |
2021-02-04 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for reducing ATXN2 expression
|
|
JP7529286B2
(ja)
*
|
2018-10-26 |
2024-08-06 |
フリーイェ・ユニヴェルシテイト・ブリュッセル |
肝特異的核酸調節エレメント並びにその方法及び使用
|
|
TW202028222A
(zh)
|
2018-11-14 |
2020-08-01 |
美商Ionis製藥公司 |
Foxp3表現之調節劑
|
|
TW202214854A
(zh)
|
2019-01-31 |
2022-04-16 |
美商Ionis製藥公司 |
Yap1表現之調節劑
|
|
CA3133241A1
(en)
*
|
2019-03-15 |
2020-09-24 |
University Of Massachusetts |
Oligonucleotides for tissue specific apoe modulation
|
|
TW202536179A
(zh)
*
|
2019-03-29 |
2025-09-16 |
美商Ionis製藥公司 |
用於調節ube3a-ats之化合物及方法
|
|
US11739324B2
(en)
|
2019-06-25 |
2023-08-29 |
Stichting Katholieke Universiteit |
Antisense oligonucleotides rescue aberrant splicing of ABCA4
|
|
CN114585633A
(zh)
|
2019-08-19 |
2022-06-03 |
米纳治疗有限公司 |
寡核苷酸缀合物组合物和使用方法
|
|
KR20220049619A
(ko)
*
|
2019-08-30 |
2022-04-21 |
베이롤 칼리지 오브 메드신 |
유전자 발현 조절 시스템
|
|
EP3822370A1
(en)
*
|
2019-11-15 |
2021-05-19 |
Curiosity Diagnostics Sp. z o.o. |
Method of determining the presence of a hyper-virulent clostridioides difficile strain of the b1/nap1/027 group in a sample
|
|
WO2021126997A1
(en)
*
|
2019-12-18 |
2021-06-24 |
Petdx, Inc. |
Methods and compositions for cancer detection, characterization or management in companion animals
|
|
CN114929876A
(zh)
*
|
2020-01-31 |
2022-08-19 |
株式会社三和化学研究所 |
Atn1的反义寡核苷酸
|
|
CN115812102B
(zh)
*
|
2020-02-12 |
2025-07-04 |
广州安天圣施医药有限公司 |
反义寡核苷酸及其在治疗耳聋-甲状腺肿综合征中的应用
|
|
WO2021177418A1
(ja)
*
|
2020-03-04 |
2021-09-10 |
日産化学株式会社 |
Ｃａｌｍ２のアンチセンスオリゴヌクレオチド
|
|
CA3175197A1
(en)
*
|
2020-04-29 |
2021-11-04 |
Joseph J. HIGGINS |
Compositions and methods for treatment of inherited macular degeneration
|
|
TW202216996A
(zh)
|
2020-06-29 |
2022-05-01 |
美商Ionis製藥公司 |
調節ｐｌｐ１之化合物及方法
|
|
CN116368227A
(zh)
*
|
2020-07-22 |
2023-06-30 |
弗洛里神经科学与心理健康研究所 |
用于治疗与scn2a中功能失去突变相关的障碍的组合物和方法
|
|
MX2023001222A
(es)
|
2020-07-28 |
2023-04-26 |
Ionis Pharmaceuticals Inc |
Compuestos y metodos para reducir la expresion de app.
|
|
WO2022032017A2
(en)
*
|
2020-08-07 |
2022-02-10 |
The General Hospital Corporation |
Human xist antisense oligonucleotides for x reactivation therapy
|
|
GB2603454A
(en)
|
2020-12-09 |
2022-08-10 |
Ucl Business Ltd |
Novel therapeutics for the treatment of neurodegenerative disorders
|
|
EP4015040A1
(en)
*
|
2020-12-16 |
2022-06-22 |
Fundación para la Formación e Investigación Sanitarias de la Región de Murcia |
Method for treating blood diseases
|
|
AR124408A1
(es)
|
2020-12-18 |
2023-03-22 |
Ionis Pharmaceuticals Inc |
Compuestos y métodos para modular el factor xii
|
|
EP4329799A4
(en)
*
|
2021-04-30 |
2025-04-30 |
Greenlight Biosciences, Inc. |
Messenger rna therapeutics and compositions
|
|
US11753644B2
(en)
|
2021-06-18 |
2023-09-12 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for reducing IFNAR1 expression
|
|
WO2023004049A1
(en)
*
|
2021-07-21 |
2023-01-26 |
AcuraStem, Inc. |
Unc13a antisense oligonucleotides
|
|
US11833221B2
(en)
|
2021-09-01 |
2023-12-05 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds for reducing DMPK expression
|
|
CN118541484A
(zh)
*
|
2021-12-17 |
2024-08-23 |
豪夫迈·罗氏有限公司 |
反义寡核苷酸
|
|
WO2023139360A1
(en)
*
|
2022-01-19 |
2023-07-27 |
Autolus Limited |
Nucleic acid construct
|
|
WO2024064608A2
(en)
*
|
2022-09-20 |
2024-03-28 |
Intergalactic Therapeutics, Inc. |
Best1 vectors and uses thereof
|
|
KR20260021596A
(ko)
|
2023-04-05 |
2026-02-13 |
아이오니스 파마수티컬즈, 인코포레이티드 |
Pln 발현을 감소시키는 화합물 및 방법
|
|
GB202312098D0
(en)
*
|
2023-08-08 |
2023-09-20 |
Ucl Business Ltd |
Therapeutic molecules
|
|
AU2024339330A1
(en)
*
|
2023-09-13 |
2026-04-02 |
Haya Therapeutics Sa |
Compositions and methods for modulating wisp2 super-enhancer-associated rna
|
|
EP4784753A2
(en)
*
|
2023-09-27 |
2026-08-05 |
Judo Bio Inc. |
Slc6a19-targeting modulatory nucleic acid agents
|
|
GB202401412D0
(en)
*
|
2024-02-02 |
2024-03-20 |
Harness Therapeutics Ltd |
Functional nucleic acid
|
|
WO2026033502A1
(en)
*
|
2024-08-09 |
2026-02-12 |
Associação Biopolis |
Kit, method, and uses thereof
|
|
WO2026074434A1
(en)
*
|
2024-10-01 |
2026-04-09 |
Fondazione Istituto Italiano Di Tecnologia |
Rad51/brca2 complex aptamers and uses thereof
|
|
WO2026133251A1
(en)
|
2024-12-20 |
2026-06-25 |
Novartis Ag |
Combinations of antisense agents, pharmaceutical compositions and methods of use
|