SG11201808964PA - Antisense oligomers and methods of using the same for treating diseases associated with the acid alpha-glucosidase gene - Google Patents
Antisense oligomers and methods of using the same for treating diseases associated with the acid alpha-glucosidase geneInfo
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- SG11201808964PA SG11201808964PA SG11201808964PA SG11201808964PA SG11201808964PA SG 11201808964P A SG11201808964P A SG 11201808964PA SG 11201808964P A SG11201808964P A SG 11201808964PA SG 11201808964P A SG11201808964P A SG 11201808964PA SG 11201808964P A SG11201808964P A SG 11201808964PA
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/314—Phosphoramidates
- C12N2310/3145—Phosphoramidates with the nitrogen in 3' or 5'-position
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3233—Morpholino-type ring
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3513—Protein; Peptide
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- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/33—Alteration of splicing
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/0102—Alpha-glucosidase (3.2.1.20)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
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Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER (19) World Intellectual Property Organization International Bureau (43) International Publication Date .....0\"\" 26 October 2017 (26.10.2017) WIPO I PCT THE PATENT COOPERATION TREATY (PCT) 1111111111101110111111111111111111111 011101110111111111110111101111111111011111 (10) International Publication Number WO 2017/184529 Al — (51) (21) (22) (25) Filing Language: (26) (30) (71) (72) International Patent Classification: (74) A61K 48/00 (2006.01) C07H 21/02 (2006.01) International Application Number: PCT/US2017/028002 (81) International Filing Date: 17 April 2017 (17.04.2017) English Publication Language: English Priority Data: 62/324,185 18 April 2016 (18.04.2016) US Applicant: SAREPTA THERAPEUTICS, INC. [US/US]; 215 First Street, Cambridge, MA 02142 (US). (84) Inventor: SCHNELL, Frederick, Joseph; 1654 NW Crest PL, Corvallis, OR 97330 (US). 85004 (US). Agent: MULHOLLAND, William F.; Snell & Wilmer LLP, One Arizona Center, 400 E. Van Buren, Phoenix, AZ Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, = Title: ANTISENSE OLIGOMERS THE ACID ALPHA-GLUCOSIDASE GENE \"IT 0 as ' a ,2 .... 8 .> -5 15 = Ca c t 1, Ni cl. ' c 1 d c 0 ,0 ' 2 o 0 * A,C/ c..P„,: e,- 4,— Z 3C q l O .?. , s t.f.: cP : The present disclosure and include a targeting (GAA) gene. The least one additional nucleobase has no complementary nucleobase in the targeting sequence, and wherein the at least one additional is internal to the target region. WITH c)1: 1-1 nucleobases ---- glucosidase 0 nucleobase slk* s? ' v`k ‘.. 11 / 4 °) c ,, ,, -- • ,..,, \ - A - 4 - ,..\.! i ? ? ' 4 C1 relates sequence complementary target region N FIG. AND dr v ? METHODS 111111 5 = CU , 43\ , (1 l5 1 \"ti 'ti 0 1 '\" 4 4‘ Aki AV , tk t v y t v ._ \" l r° ,f , ,..fo . to modified antisense includes at least one additional nucleobase compared to the targeting sequence, wherein the uM 's GP s, P.,.. _ uM OF USING THE SAME FOR TREATING DISEASES ASSOCIATED = (54) = = = = = _ _ = = 15 1 '15' 15\" cl, 15' 15 * , IP 1 \"ti \", \"ti 'ti \"ti - ti N '', -' na \" .b?' P P .t.\" slx P .0 >'` ,A % . 2/ ,„'\ \" cS 0 0 0 § 3 N..... NJ. v. S' NS\" N S ' '\" N S N sf 2 4 r ° -f , .10 4c , 4. c ° -.3 c -4 c ° 1. z ..N ii ..? 1 oligonucleotides. The nucleotides described herein are of 10 to 40 to a target region within intron 1 of a pre-mRNA of the human alpha _ = = 1-1 c:7 kin 7r (57) IN at ei o [Continued on next page] WO 2017/184529 Al MIDEDIM01101 DIDIRMEM3111111111111111111111111111011111111111111111 MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event amendments (Rule 48.2(h)) of receipt of
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662324185P | 2016-04-18 | 2016-04-18 | |
PCT/US2017/028002 WO2017184529A1 (en) | 2016-04-18 | 2017-04-17 | Antisense oligomers and methods of using the same for treating diseases associated with the acid alpha-glucosidase gene |
Publications (1)
Publication Number | Publication Date |
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SG11201808964PA true SG11201808964PA (en) | 2018-11-29 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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SG11201808964PA SG11201808964PA (en) | 2016-04-18 | 2017-04-17 | Antisense oligomers and methods of using the same for treating diseases associated with the acid alpha-glucosidase gene |
Country Status (14)
Country | Link |
---|---|
US (2) | US11060089B2 (en) |
EP (1) | EP3445405A4 (en) |
JP (3) | JP7033547B2 (en) |
KR (1) | KR102522059B1 (en) |
CN (1) | CN109414511B (en) |
AU (1) | AU2017254106A1 (en) |
BR (1) | BR112018071477A2 (en) |
CA (1) | CA3021267A1 (en) |
EA (1) | EA201892366A1 (en) |
MX (1) | MX2018012695A (en) |
SA (1) | SA518400251B1 (en) |
SG (1) | SG11201808964PA (en) |
TW (1) | TWI766861B (en) |
WO (1) | WO2017184529A1 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3445405A4 (en) | 2016-04-18 | 2019-12-18 | Sarepta Therapeutics, Inc. | Antisense oligomers and methods of using the same for treating diseases associated with the acid alpha-glucosidase gene |
JP7394753B2 (en) | 2017-10-18 | 2023-12-08 | サレプタ セラピューティクス, インコーポレイテッド | antisense oligomer compounds |
CA3108289A1 (en) | 2018-08-02 | 2020-02-06 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
EA202190417A1 (en) * | 2018-08-02 | 2021-06-23 | Дайн Терапьютикс, Инк. | MUSCLE-SPECIFIC COMPLEXES AND THEIR APPLICATION FOR TREATMENT OF PUMP'S DISEASE |
US11638761B2 (en) | 2021-07-09 | 2023-05-02 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy |
WO2023055774A1 (en) * | 2021-09-30 | 2023-04-06 | Sarepta Therapeutics, Inc. | Antisense oligonucleotides having one or more abasic units |
WO2024016003A2 (en) | 2022-07-14 | 2024-01-18 | The Broad Institute, Inc. | Aav capsids that enable cns-wide gene delivery through interactions with the transferrin receptor |
WO2024073404A1 (en) * | 2022-09-28 | 2024-04-04 | Sarepta Therapeutics, Inc. | Pompe disease mouse model generation, characterization and methods of use |
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