|
US3687808A
(en)
|
1969-08-14 |
1972-08-29 |
Univ Leland Stanford Junior |
Synthetic polynucleotides
|
|
US4469863A
(en)
|
1980-11-12 |
1984-09-04 |
Ts O Paul O P |
Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
|
|
ATE75483T1
(de)
|
1981-10-23 |
1992-05-15 |
Molecular Biosystems Inc |
Oligonukleotides heilmittel und dessen herstellungsverfahren.
|
|
US5023243A
(en)
|
1981-10-23 |
1991-06-11 |
Molecular Biosystems, Inc. |
Oligonucleotide therapeutic agent and method of making same
|
|
US4476301A
(en)
|
1982-04-29 |
1984-10-09 |
Centre National De La Recherche Scientifique |
Oligonucleotides, a process for preparing the same and their application as mediators of the action of interferon
|
|
JPS5927900A
(ja)
|
1982-08-09 |
1984-02-14 |
Wakunaga Seiyaku Kk |
固定化オリゴヌクレオチド
|
|
FR2540122B1
(fr)
|
1983-01-27 |
1985-11-29 |
Centre Nat Rech Scient |
Nouveaux composes comportant une sequence d'oligonucleotide liee a un agent d'intercalation, leur procede de synthese et leur application
|
|
US4605735A
(en)
|
1983-02-14 |
1986-08-12 |
Wakunaga Seiyaku Kabushiki Kaisha |
Oligonucleotide derivatives
|
|
US4948882A
(en)
|
1983-02-22 |
1990-08-14 |
Syngene, Inc. |
Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis
|
|
US4824941A
(en)
|
1983-03-10 |
1989-04-25 |
Julian Gordon |
Specific antibody to the native form of 2'5'-oligonucleotides, the method of preparation and the use as reagents in immunoassays or for binding 2'5'-oligonucleotides in biological systems
|
|
DE3329892A1
(de)
|
1983-08-18 |
1985-03-07 |
Köster, Hubert, Prof. Dr., 2000 Hamburg |
Verfahren zur herstellung von oligonucleotiden
|
|
US4587044A
(en)
|
1983-09-01 |
1986-05-06 |
The Johns Hopkins University |
Linkage of proteins to nucleic acids
|
|
US5118802A
(en)
|
1983-12-20 |
1992-06-02 |
California Institute Of Technology |
DNA-reporter conjugates linked via the 2' or 5'-primary amino group of the 5'-terminal nucleoside
|
|
US5550111A
(en)
|
1984-07-11 |
1996-08-27 |
Temple University-Of The Commonwealth System Of Higher Education |
Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof
|
|
US5258506A
(en)
|
1984-10-16 |
1993-11-02 |
Chiron Corporation |
Photolabile reagents for incorporation into oligonucleotide chains
|
|
US5367066A
(en)
|
1984-10-16 |
1994-11-22 |
Chiron Corporation |
Oligonucleotides with selectably cleavable and/or abasic sites
|
|
US5430136A
(en)
|
1984-10-16 |
1995-07-04 |
Chiron Corporation |
Oligonucleotides having selectably cleavable and/or abasic sites
|
|
US4828979A
(en)
|
1984-11-08 |
1989-05-09 |
Life Technologies, Inc. |
Nucleotide analogs for nucleic acid labeling and detection
|
|
FR2575751B1
(fr)
|
1985-01-08 |
1987-04-03 |
Pasteur Institut |
Nouveaux nucleosides de derives de l'adenosine, leur preparation et leurs applications biologiques
|
|
US5235033A
(en)
|
1985-03-15 |
1993-08-10 |
Anti-Gene Development Group |
Alpha-morpholino ribonucleoside derivatives and polymers thereof
|
|
US5405938A
(en)
|
1989-12-20 |
1995-04-11 |
Anti-Gene Development Group |
Sequence-specific binding polymers for duplex nucleic acids
|
|
US5034506A
(en)
|
1985-03-15 |
1991-07-23 |
Anti-Gene Development Group |
Uncharged morpholino-based polymers having achiral intersubunit linkages
|
|
US5185444A
(en)
|
1985-03-15 |
1993-02-09 |
Anti-Gene Deveopment Group |
Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
|
|
US5166315A
(en)
|
1989-12-20 |
1992-11-24 |
Anti-Gene Development Group |
Sequence-specific binding polymers for duplex nucleic acids
|
|
US4762779A
(en)
|
1985-06-13 |
1988-08-09 |
Amgen Inc. |
Compositions and methods for functionalizing nucleic acids
|
|
US5317098A
(en)
|
1986-03-17 |
1994-05-31 |
Hiroaki Shizuya |
Non-radioisotope tagging of fragments
|
|
JPS638396A
(ja)
|
1986-06-30 |
1988-01-14 |
Wakunaga Pharmaceut Co Ltd |
ポリ標識化オリゴヌクレオチド誘導体
|
|
EP0260032B1
(en)
|
1986-09-08 |
1994-01-26 |
Ajinomoto Co., Inc. |
Compounds for the cleavage at a specific position of RNA, oligomers employed for the formation of said compounds, and starting materials for the synthesis of said oligomers
|
|
US5276019A
(en)
|
1987-03-25 |
1994-01-04 |
The United States Of America As Represented By The Department Of Health And Human Services |
Inhibitors for replication of retroviruses and for the expression of oncogene products
|
|
US5264423A
(en)
|
1987-03-25 |
1993-11-23 |
The United States Of America As Represented By The Department Of Health And Human Services |
Inhibitors for replication of retroviruses and for the expression of oncogene products
|
|
US4904582A
(en)
|
1987-06-11 |
1990-02-27 |
Synthetic Genetics |
Novel amphiphilic nucleic acid conjugates
|
|
EP0366685B1
(en)
|
1987-06-24 |
1994-10-19 |
Howard Florey Institute Of Experimental Physiology And Medicine |
Nucleoside derivatives
|
|
US5585481A
(en)
|
1987-09-21 |
1996-12-17 |
Gen-Probe Incorporated |
Linking reagents for nucleotide probes
|
|
US5188897A
(en)
|
1987-10-22 |
1993-02-23 |
Temple University Of The Commonwealth System Of Higher Education |
Encapsulated 2',5'-phosphorothioate oligoadenylates
|
|
US4924624A
(en)
|
1987-10-22 |
1990-05-15 |
Temple University-Of The Commonwealth System Of Higher Education |
2,',5'-phosphorothioate oligoadenylates and plant antiviral uses thereof
|
|
US5525465A
(en)
|
1987-10-28 |
1996-06-11 |
Howard Florey Institute Of Experimental Physiology And Medicine |
Oligonucleotide-polyamide conjugates and methods of production and applications of the same
|
|
DE3738460A1
(de)
|
1987-11-12 |
1989-05-24 |
Max Planck Gesellschaft |
Modifizierte oligonukleotide
|
|
US5403711A
(en)
|
1987-11-30 |
1995-04-04 |
University Of Iowa Research Foundation |
Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved
|
|
ATE151467T1
(de)
|
1987-11-30 |
1997-04-15 |
Univ Iowa Res Found |
Durch modifikationen an der 3'-terminalen phosphodiesterbindung stabilisierte dna moleküle, ihre verwendung als nukleinsäuresonden sowie als therapeutische mittel zur hemmung der expression spezifischer zielgene
|
|
US5082830A
(en)
|
1988-02-26 |
1992-01-21 |
Enzo Biochem, Inc. |
End labeled nucleotide probe
|
|
WO1989009221A1
(en)
|
1988-03-25 |
1989-10-05 |
University Of Virginia Alumni Patents Foundation |
Oligonucleotide n-alkylphosphoramidates
|
|
US5278302A
(en)
|
1988-05-26 |
1994-01-11 |
University Patents, Inc. |
Polynucleotide phosphorodithioates
|
|
US5109124A
(en)
|
1988-06-01 |
1992-04-28 |
Biogen, Inc. |
Nucleic acid probe linked to a label having a terminal cysteine
|
|
US5216141A
(en)
|
1988-06-06 |
1993-06-01 |
Benner Steven A |
Oligonucleotide analogs containing sulfur linkages
|
|
US5175273A
(en)
|
1988-07-01 |
1992-12-29 |
Genentech, Inc. |
Nucleic acid intercalating agents
|
|
US5262536A
(en)
|
1988-09-15 |
1993-11-16 |
E. I. Du Pont De Nemours And Company |
Reagents for the preparation of 5'-tagged oligonucleotides
|
|
US5512439A
(en)
|
1988-11-21 |
1996-04-30 |
Dynal As |
Oligonucleotide-linked magnetic particles and uses thereof
|
|
US5599923A
(en)
|
1989-03-06 |
1997-02-04 |
Board Of Regents, University Of Tx |
Texaphyrin metal complexes having improved functionalization
|
|
US5457183A
(en)
|
1989-03-06 |
1995-10-10 |
Board Of Regents, The University Of Texas System |
Hydroxylated texaphyrins
|
|
US5391723A
(en)
|
1989-05-31 |
1995-02-21 |
Neorx Corporation |
Oligonucleotide conjugates
|
|
US5256775A
(en)
|
1989-06-05 |
1993-10-26 |
Gilead Sciences, Inc. |
Exonuclease-resistant oligonucleotides
|
|
US4958013A
(en)
|
1989-06-06 |
1990-09-18 |
Northwestern University |
Cholesteryl modified oligonucleotides
|
|
US5451463A
(en)
|
1989-08-28 |
1995-09-19 |
Clontech Laboratories, Inc. |
Non-nucleoside 1,3-diol reagents for labeling synthetic oligonucleotides
|
|
US5134066A
(en)
|
1989-08-29 |
1992-07-28 |
Monsanto Company |
Improved probes using nucleosides containing 3-dezauracil analogs
|
|
US5254469A
(en)
|
1989-09-12 |
1993-10-19 |
Eastman Kodak Company |
Oligonucleotide-enzyme conjugate that can be used as a probe in hybridization assays and polymerase chain reaction procedures
|
|
US5399676A
(en)
|
1989-10-23 |
1995-03-21 |
Gilead Sciences |
Oligonucleotides with inverted polarity
|
|
US5264564A
(en)
|
1989-10-24 |
1993-11-23 |
Gilead Sciences |
Oligonucleotide analogs with novel linkages
|
|
US5264562A
(en)
|
1989-10-24 |
1993-11-23 |
Gilead Sciences, Inc. |
Oligonucleotide analogs with novel linkages
|
|
US5292873A
(en)
|
1989-11-29 |
1994-03-08 |
The Research Foundation Of State University Of New York |
Nucleic acids labeled with naphthoquinone probe
|
|
US5177198A
(en)
|
1989-11-30 |
1993-01-05 |
University Of N.C. At Chapel Hill |
Process for preparing oligoribonucleoside and oligodeoxyribonucleoside boranophosphates
|
|
US5130302A
(en)
|
1989-12-20 |
1992-07-14 |
Boron Bilogicals, Inc. |
Boronated nucleoside, nucleotide and oligonucleotide compounds, compositions and methods for using same
|
|
US5486603A
(en)
|
1990-01-08 |
1996-01-23 |
Gilead Sciences, Inc. |
Oligonucleotide having enhanced binding affinity
|
|
US5587470A
(en)
|
1990-01-11 |
1996-12-24 |
Isis Pharmaceuticals, Inc. |
3-deazapurines
|
|
US5578718A
(en)
|
1990-01-11 |
1996-11-26 |
Isis Pharmaceuticals, Inc. |
Thiol-derivatized nucleosides
|
|
US5681941A
(en)
|
1990-01-11 |
1997-10-28 |
Isis Pharmaceuticals, Inc. |
Substituted purines and oligonucleotide cross-linking
|
|
US6753423B1
(en)
|
1990-01-11 |
2004-06-22 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for enhanced biostability and altered biodistribution of oligonucleotides in mammals
|
|
US5587361A
(en)
|
1991-10-15 |
1996-12-24 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having phosphorothioate linkages of high chiral purity
|
|
US6395492B1
(en)
|
1990-01-11 |
2002-05-28 |
Isis Pharmaceuticals, Inc. |
Derivatized oligonucleotides having improved uptake and other properties
|
|
US5459255A
(en)
|
1990-01-11 |
1995-10-17 |
Isis Pharmaceuticals, Inc. |
N-2 substituted purines
|
|
US5623065A
(en)
|
1990-08-13 |
1997-04-22 |
Isis Pharmaceuticals, Inc. |
Gapped 2' modified oligonucleotides
|
|
US6005087A
(en)
|
1995-06-06 |
1999-12-21 |
Isis Pharmaceuticals, Inc. |
2'-modified oligonucleotides
|
|
US5914396A
(en)
|
1990-01-11 |
1999-06-22 |
Isis Pharmaceuticals, Inc. |
2'-O-modified nucleosides and phosphoramidites
|
|
US5220007A
(en)
|
1990-02-15 |
1993-06-15 |
The Worcester Foundation For Experimental Biology |
Method of site-specific alteration of RNA and production of encoded polypeptides
|
|
US5149797A
(en)
|
1990-02-15 |
1992-09-22 |
The Worcester Foundation For Experimental Biology |
Method of site-specific alteration of rna and production of encoded polypeptides
|
|
US5214136A
(en)
|
1990-02-20 |
1993-05-25 |
Gilead Sciences, Inc. |
Anthraquinone-derivatives oligonucleotides
|
|
WO1991013080A1
(en)
|
1990-02-20 |
1991-09-05 |
Gilead Sciences, Inc. |
Pseudonucleosides and pseudonucleotides and their polymers
|
|
US5321131A
(en)
|
1990-03-08 |
1994-06-14 |
Hybridon, Inc. |
Site-specific functionalization of oligodeoxynucleotides for non-radioactive labelling
|
|
US5470967A
(en)
|
1990-04-10 |
1995-11-28 |
The Dupont Merck Pharmaceutical Company |
Oligonucleotide analogs with sulfamate linkages
|
|
DE69032425T2
(de)
|
1990-05-11 |
1998-11-26 |
Microprobe Corp., Bothell, Wash. |
Teststreifen zum Eintauchen für Nukleinsäure-Hybridisierungsassays und Verfahren zur kovalenten Immobilisierung von Oligonucleotiden
|
|
AU8196791A
(en)
|
1990-06-27 |
1992-01-23 |
Trustees Of Columbia University In The City Of New York, The |
Methods for detecting spinal muscular atrophy type i and types ii/iii and marker therefor
|
|
US5218105A
(en)
|
1990-07-27 |
1993-06-08 |
Isis Pharmaceuticals |
Polyamine conjugated oligonucleotides
|
|
US5688941A
(en)
|
1990-07-27 |
1997-11-18 |
Isis Pharmaceuticals, Inc. |
Methods of making conjugated 4' desmethyl nucleoside analog compounds
|
|
US5618704A
(en)
|
1990-07-27 |
1997-04-08 |
Isis Pharmacueticals, Inc. |
Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling
|
|
US5489677A
(en)
|
1990-07-27 |
1996-02-06 |
Isis Pharmaceuticals, Inc. |
Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms
|
|
US5602240A
(en)
|
1990-07-27 |
1997-02-11 |
Ciba Geigy Ag. |
Backbone modified oligonucleotide analogs
|
|
US5623070A
(en)
|
1990-07-27 |
1997-04-22 |
Isis Pharmaceuticals, Inc. |
Heteroatomic oligonucleoside linkages
|
|
US5610289A
(en)
|
1990-07-27 |
1997-03-11 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogues
|
|
US5677437A
(en)
|
1990-07-27 |
1997-10-14 |
Isis Pharmaceuticals, Inc. |
Heteroatomic oligonucleoside linkages
|
|
US5138045A
(en)
|
1990-07-27 |
1992-08-11 |
Isis Pharmaceuticals |
Polyamine conjugated oligonucleotides
|
|
US5541307A
(en)
|
1990-07-27 |
1996-07-30 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogs and solid phase synthesis thereof
|
|
EP0544824B1
(en)
|
1990-07-27 |
1997-06-11 |
Isis Pharmaceuticals, Inc. |
Nuclease resistant, pyrimidine modified oligonucleotides that detect and modulate gene expression
|
|
US5608046A
(en)
|
1990-07-27 |
1997-03-04 |
Isis Pharmaceuticals, Inc. |
Conjugated 4'-desmethyl nucleoside analog compounds
|
|
ES2083593T3
(es)
|
1990-08-03 |
1996-04-16 |
Sterling Winthrop Inc |
Compuestos y metodos para inhibir la expresion de genes.
|
|
US5245022A
(en)
|
1990-08-03 |
1993-09-14 |
Sterling Drug, Inc. |
Exonuclease resistant terminally substituted oligonucleotides
|
|
US5177196A
(en)
|
1990-08-16 |
1993-01-05 |
Microprobe Corporation |
Oligo (α-arabinofuranosyl nucleotides) and α-arabinofuranosyl precursors thereof
|
|
US5512667A
(en)
|
1990-08-28 |
1996-04-30 |
Reed; Michael W. |
Trifunctional intermediates for preparing 3'-tailed oligonucleotides
|
|
US5214134A
(en)
|
1990-09-12 |
1993-05-25 |
Sterling Winthrop Inc. |
Process of linking nucleosides with a siloxane bridge
|
|
US5561225A
(en)
|
1990-09-19 |
1996-10-01 |
Southern Research Institute |
Polynucleotide analogs containing sulfonate and sulfonamide internucleoside linkages
|
|
JPH06505704A
(ja)
|
1990-09-20 |
1994-06-30 |
ギリアド サイエンシズ,インコーポレイテッド |
改変ヌクレオシド間結合
|
|
US5432272A
(en)
|
1990-10-09 |
1995-07-11 |
Benner; Steven A. |
Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases
|
|
CA2095212A1
(en)
|
1990-11-08 |
1992-05-09 |
Hybridon, Inc. |
Incorporation of multiple reporter groups on synthetic oligonucleotides
|
|
JP3514779B2
(ja)
|
1991-04-17 |
2004-03-31 |
株式会社アズウェル |
アポリポプロテインe遺伝子タイプの検査方法及びその検査に好適なプライマー及びプローブ
|
|
US5965722A
(en)
|
1991-05-21 |
1999-10-12 |
Isis Pharmaceuticals, Inc. |
Antisense inhibition of ras gene with chimeric and alternating oligonucleotides
|
|
WO1994008003A1
(en)
|
1991-06-14 |
1994-04-14 |
Isis Pharmaceuticals, Inc. |
ANTISENSE OLIGONUCLEOTIDE INHIBITION OF THE ras GENE
|
|
US7015315B1
(en)
|
1991-12-24 |
2006-03-21 |
Isis Pharmaceuticals, Inc. |
Gapped oligonucleotides
|
|
US5714331A
(en)
|
1991-05-24 |
1998-02-03 |
Buchardt, Deceased; Ole |
Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
|
|
US5719262A
(en)
|
1993-11-22 |
1998-02-17 |
Buchardt, Deceased; Ole |
Peptide nucleic acids having amino acid side chains
|
|
US5539082A
(en)
|
1993-04-26 |
1996-07-23 |
Nielsen; Peter E. |
Peptide nucleic acids
|
|
US5371241A
(en)
|
1991-07-19 |
1994-12-06 |
Pharmacia P-L Biochemicals Inc. |
Fluorescein labelled phosphoramidites
|
|
US5571799A
(en)
|
1991-08-12 |
1996-11-05 |
Basco, Ltd. |
(2'-5') oligoadenylate analogues useful as inhibitors of host-v5.-graft response
|
|
US5661134A
(en)
|
1991-10-15 |
1997-08-26 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides for modulating Ha-ras or Ki-ras having phosphorothioate linkages of high chiral purity
|
|
US6831166B2
(en)
|
1992-10-23 |
2004-12-14 |
Isis Pharmaceuticals, Inc. |
Derivatized oligonucleotides having improved uptake and other properties
|
|
US8153602B1
(en)
|
1991-11-19 |
2012-04-10 |
Isis Pharmaceuticals, Inc. |
Composition and methods for the pulmonary delivery of nucleic acids
|
|
US5484908A
(en)
|
1991-11-26 |
1996-01-16 |
Gilead Sciences, Inc. |
Oligonucleotides containing 5-propynyl pyrimidines
|
|
US20060270624A1
(en)
|
1991-12-24 |
2006-11-30 |
Isis Pharmaceuticals, Inc. |
Gapped 2' modified oligonucleotides
|
|
US5700922A
(en)
|
1991-12-24 |
1997-12-23 |
Isis Pharmaceuticals, Inc. |
PNA-DNA-PNA chimeric macromolecules
|
|
EP1044987B1
(en)
|
1991-12-24 |
2006-02-15 |
Isis Pharmaceuticals, Inc. |
Gapped 2'-modified oligonucleotides
|
|
US5565552A
(en)
|
1992-01-21 |
1996-10-15 |
Pharmacyclics, Inc. |
Method of expanded porphyrin-oligonucleotide conjugate synthesis
|
|
US5595726A
(en)
|
1992-01-21 |
1997-01-21 |
Pharmacyclics, Inc. |
Chromophore probe for detection of nucleic acid
|
|
US5633360A
(en)
|
1992-04-14 |
1997-05-27 |
Gilead Sciences, Inc. |
Oligonucleotide analogs capable of passive cell membrane permeation
|
|
US5434257A
(en)
|
1992-06-01 |
1995-07-18 |
Gilead Sciences, Inc. |
Binding compentent oligomers containing unsaturated 3',5' and 2',5' linkages
|
|
US5272250A
(en)
|
1992-07-10 |
1993-12-21 |
Spielvogel Bernard F |
Boronated phosphoramidate compounds
|
|
TW244371B
(enExample)
|
1992-07-23 |
1995-04-01 |
Tri Clover Inc |
|
|
US5652355A
(en)
|
1992-07-23 |
1997-07-29 |
Worcester Foundation For Experimental Biology |
Hybrid oligonucleotide phosphorothioates
|
|
US6346614B1
(en)
|
1992-07-23 |
2002-02-12 |
Hybridon, Inc. |
Hybrid oligonucleotide phosphorothioates
|
|
WO1994002499A1
(en)
|
1992-07-27 |
1994-02-03 |
Hybridon, Inc. |
Oligonucleotide alkylphosphonothioates
|
|
US5574142A
(en)
|
1992-12-15 |
1996-11-12 |
Microprobe Corporation |
Peptide linkers for improved oligonucleotide delivery
|
|
AU6165494A
(en)
|
1993-01-25 |
1994-08-15 |
Hybridon, Inc. |
Oligonucleotide alkylphosphonates and alkylphosphonothioates
|
|
US5476925A
(en)
|
1993-02-01 |
1995-12-19 |
Northwestern University |
Oligodeoxyribonucleotides including 3'-aminonucleoside-phosphoramidate linkages and terminal 3'-amino groups
|
|
GB9304618D0
(en)
|
1993-03-06 |
1993-04-21 |
Ciba Geigy Ag |
Chemical compounds
|
|
AU6412794A
(en)
|
1993-03-31 |
1994-10-24 |
Sterling Winthrop Inc. |
Oligonucleotides with amide linkages replacing phosphodiester linkages
|
|
DE69435005T2
(de)
|
1993-05-11 |
2008-04-17 |
The University Of North Carolina At Chapel Hill |
Antisense Oligonukleotide die anomales Splicing verhindern und deren Verwendung
|
|
US5502177A
(en)
|
1993-09-17 |
1996-03-26 |
Gilead Sciences, Inc. |
Pyrimidine derivatives for labeled binding partners
|
|
US5457187A
(en)
|
1993-12-08 |
1995-10-10 |
Board Of Regents University Of Nebraska |
Oligonucleotides containing 5-fluorouracil
|
|
PT733059E
(pt)
|
1993-12-09 |
2001-03-30 |
Univ Jefferson |
Compostos e metodos para mutacoes dirigidas ao local em celulas eucarioticas
|
|
US5596091A
(en)
|
1994-03-18 |
1997-01-21 |
The Regents Of The University Of California |
Antisense oligonucleotides comprising 5-aminoalkyl pyrimidine nucleotides
|
|
US5625050A
(en)
|
1994-03-31 |
1997-04-29 |
Amgen Inc. |
Modified oligonucleotides and intermediates useful in nucleic acid therapeutics
|
|
US5525711A
(en)
|
1994-05-18 |
1996-06-11 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Pteridine nucleotide analogs as fluorescent DNA probes
|
|
FR2720757B1
(fr)
|
1994-06-03 |
1996-08-02 |
Inst Nat Sante Rech Med |
Procédé et sondes pour la détection de marqueurs liés au locus des amyotrophies spinales infantiles.
|
|
US5597696A
(en)
|
1994-07-18 |
1997-01-28 |
Becton Dickinson And Company |
Covalent cyanine dye oligonucleotide conjugates
|
|
US5580731A
(en)
|
1994-08-25 |
1996-12-03 |
Chiron Corporation |
N-4 modified pyrimidine deoxynucleotides and oligonucleotide probes synthesized therewith
|
|
EP0708178A1
(en)
|
1994-10-19 |
1996-04-24 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Survival motor neuron (SMN) gene: a gene for spinal muscular atrophy
|
|
US6608035B1
(en)
|
1994-10-25 |
2003-08-19 |
Hybridon, Inc. |
Method of down-regulating gene expression
|
|
US5652356A
(en)
|
1995-08-17 |
1997-07-29 |
Hybridon, Inc. |
Inverted chimeric and hybrid oligonucleotides
|
|
US8217015B2
(en)
|
2003-04-04 |
2012-07-10 |
Arrowhead Madison Inc. |
Endosomolytic polymers
|
|
BR9707529A
(pt)
|
1996-02-14 |
2000-01-04 |
Isis Pharmaceuticals Inc |
Oligunucleotìdeo especificamente hibridizável com dna ou rna.
|
|
US6015710A
(en)
|
1996-04-09 |
2000-01-18 |
The University Of Texas System |
Modulation of mammalian telomerase by peptide nucleic acids
|
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
|
US5912332A
(en)
|
1996-07-26 |
1999-06-15 |
Hybridon, Inc. |
Affinity-based purification of oligonucleotides using soluble multimeric oligonucleotides
|
|
CA2294900A1
(en)
|
1997-07-02 |
1999-01-14 |
Sdg, Inc. |
Targeted liposomal constructs for diagnostic and therapeutic uses
|
|
JPH1133863A
(ja)
|
1997-07-23 |
1999-02-09 |
Howa Mach Ltd |
工具交換装置及び工具交換用の押出し装置
|
|
US6794499B2
(en)
*
|
1997-09-12 |
2004-09-21 |
Exiqon A/S |
Oligonucleotide analogues
|
|
US7572582B2
(en)
|
1997-09-12 |
2009-08-11 |
Exiqon A/S |
Oligonucleotide analogues
|
|
US7715989B2
(en)
|
1998-04-03 |
2010-05-11 |
Elitech Holding B.V. |
Systems and methods for predicting oligonucleotide melting temperature (TmS)
|
|
ATE346918T1
(de)
|
1998-06-19 |
2006-12-15 |
Univ Mcgill |
Auf beta-arabinose, und dessen analogen, basierte antisense oligonukleotide
|
|
US6503754B1
(en)
|
2000-09-07 |
2003-01-07 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of BH3 interacting domain death agonist expression
|
|
US6646113B1
(en)
*
|
1998-09-17 |
2003-11-11 |
The Trustees Of The University Of Pennsylvania |
Nucleic acid molecule encoding human survival of motor neuron-interacting protein 1 (SIP1) deletion mutants
|
|
US6210892B1
(en)
|
1998-10-07 |
2001-04-03 |
Isis Pharmaceuticals, Inc. |
Alteration of cellular behavior by antisense modulation of mRNA processing
|
|
EP0999270A1
(en)
|
1998-10-09 |
2000-05-10 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Method of regulating SMN gene expression
|
|
US6465628B1
(en)
|
1999-02-04 |
2002-10-15 |
Isis Pharmaceuticals, Inc. |
Process for the synthesis of oligomeric compounds
|
|
KR100573231B1
(ko)
|
1999-02-12 |
2006-04-24 |
상꾜 가부시키가이샤 |
신규 뉴클레오시드 및 올리고뉴클레오티드 유사체
|
|
US9029523B2
(en)
|
2000-04-26 |
2015-05-12 |
Ceres, Inc. |
Promoter, promoter control elements, and combinations, and uses thereof
|
|
US20080281041A1
(en)
|
1999-06-07 |
2008-11-13 |
Rozema David B |
Reversibly Masked Polymers
|
|
US20040002153A1
(en)
|
1999-07-21 |
2004-01-01 |
Monia Brett P. |
Modulation of PTEN expression via oligomeric compounds
|
|
US6284538B1
(en)
|
1999-07-21 |
2001-09-04 |
Isis Pharmaceuticals, Inc. |
Antisense inhibition of PTEN expression
|
|
AU6492400A
(en)
|
1999-07-22 |
2001-02-13 |
Genaissance Pharmaceuticals, Inc. |
Drug target isogenes: polymorphisms in the prostaglandin-endoperoxide synthase 2gene
|
|
US6677445B1
(en)
|
1999-08-27 |
2004-01-13 |
Chiron Corporation |
Chimeric antisense oligonucleotides and cell transfecting formulations thereof
|
|
IL132972A0
(en)
|
1999-11-16 |
2001-03-19 |
Yissum Res Dev Co |
Pharmaceutical compositions comprising acetylcholinesterase antisense deoxynucleotides for the treatment of muscular and neuromuscular disorders
|
|
US6187545B1
(en)
*
|
2000-01-19 |
2001-02-13 |
Isis Pharmaceuticals Inc. |
Antisense modulation of pepck-cytosolic expression
|
|
US6287860B1
(en)
|
2000-01-20 |
2001-09-11 |
Isis Pharmaceuticals, Inc. |
Antisense inhibition of MEKK2 expression
|
|
EP1133993A1
(en)
|
2000-03-10 |
2001-09-19 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Substances for the treatment of spinal muscular atrophy
|
|
JP2003528607A
(ja)
|
2000-03-27 |
2003-09-30 |
ユニバーシティー、オブ、デラウェア |
修飾一本鎖オリゴヌクレオチドを使用した標的染色体ゲノム変換
|
|
JP2004509604A
(ja)
|
2000-03-28 |
2004-04-02 |
アイシス・ファーマシューティカルス・インコーポレーテッド |
mRNAプロセッシングのアンチセンスモジュレーションによる、細胞行動の改変
|
|
AU2001250572A1
(en)
|
2000-04-07 |
2001-10-23 |
Epigenomics Ag |
Detection of single nucleotide polymorphisms (snp's) and cytosine-methylations
|
|
US6784291B2
(en)
|
2000-05-04 |
2004-08-31 |
Avi Biopharma, Inc. |
Splice-region antisense composition and method
|
|
US6777439B2
(en)
|
2000-05-30 |
2004-08-17 |
Advanced Research & Technology Institute, Inc. |
Compositions and methods for identifying agents which modulate PTEN function and PI-3 kinase pathways
|
|
US6727355B2
(en)
|
2000-08-25 |
2004-04-27 |
Jcr Pharmaceuticals Co., Ltd. |
Pharmaceutical composition for treatment of Duchenne muscular dystrophy
|
|
WO2002038738A2
(en)
|
2000-11-09 |
2002-05-16 |
Cold Spring Harbor Laboratory |
Chimeric molecules to modulate gene expression
|
|
DK1345959T3
(da)
|
2000-11-20 |
2011-09-05 |
Univ Illinois |
Membranscaffoldproteiner
|
|
US20040058356A1
(en)
|
2001-03-01 |
2004-03-25 |
Warren Mary E. |
Methods for global profiling gene regulatory element activity
|
|
US6825338B2
(en)
*
|
2001-03-30 |
2004-11-30 |
Isis Pharmaceuticals, Inc. |
Labeled oligonucleotides, methods for making same, and compounds useful therefor
|
|
EP1967525B1
(en)
|
2001-05-08 |
2012-11-14 |
Darwin Molecular Corporation |
A method for regulating immune function in primates using the foxp3 protein
|
|
US20050176025A1
(en)
|
2001-05-18 |
2005-08-11 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of B-cell CLL/Lymphoma-2 (BCL-2) gene expression using short interfering nucleic acid (siNA)
|
|
WO2002103015A2
(en)
|
2001-06-14 |
2002-12-27 |
Active Pass Pharmaceuticals, Inc. |
Abca10 transporter
|
|
US7407943B2
(en)
|
2001-08-01 |
2008-08-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein B expression
|
|
US7259150B2
(en)
|
2001-08-07 |
2007-08-21 |
Isis Pharmaceuticals, Inc. |
Modulation of apolipoprotein (a) expression
|
|
WO2003037909A1
(en)
|
2001-10-29 |
2003-05-08 |
Mcgill University |
Acyclic linker-containing oligonucleotides and uses thereof
|
|
EP1472335A4
(en)
*
|
2001-11-08 |
2005-12-28 |
Univ Johns Hopkins |
METHODS AND SYSTEMS FOR SEQUENCING NUCLEIC ACIDS
|
|
US20030198983A1
(en)
|
2002-02-01 |
2003-10-23 |
Affymetrix, Inc. |
Methods of genetic analysis of human genes
|
|
US20080207542A1
(en)
|
2002-03-26 |
2008-08-28 |
Sirna Therapeutics, Inc. |
RNA inteference mediated inhibition of hepatitis C virus (HVC) gene expression using short interfering nucleic acid (siNA)
|
|
WO2003085110A2
(en)
|
2002-04-05 |
2003-10-16 |
Santaris Pharma A/S |
Oligomeric compounds for the modulation hif-1alpha expression
|
|
US20050130924A1
(en)
|
2002-06-26 |
2005-06-16 |
Monia Brett P. |
Antisense inhibition via RNAse H-independent reduction in mRNA
|
|
WO2004011613A2
(en)
|
2002-07-29 |
2004-02-05 |
Epigenesis Pharmaceuticals, Inc. |
Composition & methods for treatment and screening
|
|
US20050003369A1
(en)
|
2002-10-10 |
2005-01-06 |
Affymetrix, Inc. |
Method for depleting specific nucleic acids from a mixture
|
|
US20040219565A1
(en)
|
2002-10-21 |
2004-11-04 |
Sakari Kauppinen |
Oligonucleotides useful for detecting and analyzing nucleic acids of interest
|
|
AU2003295387A1
(en)
*
|
2002-11-05 |
2004-06-03 |
Isis Parmaceuticals, Inc. |
Modified oligonucleotides for use in rna interference
|
|
US8090542B2
(en)
|
2002-11-14 |
2012-01-03 |
Dharmacon Inc. |
Functional and hyperfunctional siRNA
|
|
US7250496B2
(en)
|
2002-11-14 |
2007-07-31 |
Rosetta Genomics Ltd. |
Bioinformatically detectable group of novel regulatory genes and uses thereof
|
|
US7655785B1
(en)
|
2002-11-14 |
2010-02-02 |
Rosetta Genomics Ltd. |
Bioinformatically detectable group of novel regulatory oligonucleotides and uses thereof
|
|
EP2752488B1
(en)
|
2002-11-18 |
2020-02-12 |
Roche Innovation Center Copenhagen A/S |
Antisense design
|
|
AU2004209599A1
(en)
|
2003-02-10 |
2004-08-19 |
Santaris Pharma A/S |
Oligomeric compounds for the modulation of ras expression
|
|
EP2141234B1
(en)
|
2003-03-21 |
2016-04-27 |
Roche Innovation Center Copenhagen A/S |
Short Interfering RNA (siRNA) Analogues
|
|
FR2853663B1
(fr)
|
2003-04-14 |
2007-08-31 |
Aventis Pharma Sa |
Procede d'obtention de lignees de mastocytes a partir de tissus de porcs et procede de production de molecules de type heparine
|
|
WO2005001110A2
(en)
|
2003-05-29 |
2005-01-06 |
The Salk Institute For Biological Studies |
Transcriptional regulation of gene expression by small double-stranded modulatory rna
|
|
WO2004113867A2
(en)
|
2003-06-16 |
2004-12-29 |
University Of Massachusetts |
Exon analysis
|
|
WO2005013901A2
(en)
|
2003-07-31 |
2005-02-17 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and compositions for use in modulation of small non-coding rnas
|
|
US7888497B2
(en)
|
2003-08-13 |
2011-02-15 |
Rosetta Genomics Ltd. |
Bioinformatically detectable group of novel regulatory oligonucleotides and uses thereof
|
|
US20050108783A1
(en)
*
|
2003-09-23 |
2005-05-19 |
Chihiro Koike |
Porcine invariant chain protein, full length cDNA, genomic organization, and regulatory region
|
|
CA2542835A1
(en)
|
2003-10-23 |
2005-05-19 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of gene expression using short interfering nucleic acid (sina)
|
|
GB0324854D0
(en)
|
2003-10-24 |
2003-11-26 |
Expresson Biosystems Ltd |
App/ena antisense
|
|
SG122973A1
(en)
|
2003-10-30 |
2006-06-29 |
Coley Pharm Gmbh |
C-class oligonucleotide analogs with enhanced immunostimulatory potency
|
|
WO2005044091A2
(en)
|
2003-11-05 |
2005-05-19 |
Board Of Regents, The University Of Texas System |
Diagnostic and therapeutic methods and compositions involving pten and breast cancer
|
|
NZ548254A
(en)
|
2003-12-23 |
2008-09-26 |
Santaris Pharma As |
Oligomeric compounds for the modulation of BCL-2
|
|
US20050244851A1
(en)
|
2004-01-13 |
2005-11-03 |
Affymetrix, Inc. |
Methods of analysis of alternative splicing in human
|
|
US20050164209A1
(en)
|
2004-01-23 |
2005-07-28 |
Bennett C. F. |
Hepatocyte free uptake assays
|
|
EP1713332A4
(en)
|
2004-01-23 |
2010-08-18 |
Avi Biopharma Inc |
ANTISENSE OLIGOMERS AND METHOD FOR INDUCTION OF IMMUNOTHERAPY AND IMMUNOSUPPRESSION
|
|
US20080249039A1
(en)
|
2004-01-30 |
2008-10-09 |
Santaris Pharma A/S |
Modified Short Interfering Rna (Modified Sirna)
|
|
WO2005089169A2
(en)
|
2004-03-12 |
2005-09-29 |
Exelixis, Inc. |
Mptens as modifiers of the pten pathway and methods of use
|
|
US8314226B2
(en)
|
2004-03-29 |
2012-11-20 |
The General Hospital Corporation |
Oligonucleotide complex compositions and methods of use as gene alteration tools
|
|
US7374927B2
(en)
|
2004-05-03 |
2008-05-20 |
Affymetrix, Inc. |
Methods of analysis of degraded nucleic acid samples
|
|
AU2005248147A1
(en)
|
2004-05-11 |
2005-12-08 |
Alphagen Co., Ltd. |
Polynucleotides for causing RNA interference and method for inhibiting gene expression using the same
|
|
US7687616B1
(en)
|
2004-05-14 |
2010-03-30 |
Rosetta Genomics Ltd |
Small molecules modulating activity of micro RNA oligonucleotides and micro RNA targets and uses thereof
|
|
US20050265927A1
(en)
|
2004-05-17 |
2005-12-01 |
Yale University |
Intranasal delivery of nucleic acid molecules
|
|
SI2206781T1
(sl)
|
2004-06-28 |
2016-05-31 |
The University Of Western Australia |
Protismiselni oligonukleotidi za induciranje preskakovanja eksona in postopki njihove uporabe
|
|
US8029985B2
(en)
|
2004-09-01 |
2011-10-04 |
Vybion, Inc. |
Amplified bioassay
|
|
US7838657B2
(en)
|
2004-12-03 |
2010-11-23 |
University Of Massachusetts |
Spinal muscular atrophy (SMA) treatment via targeting of SMN2 splice site inhibitory sequences
|
|
WO2006063356A1
(en)
|
2004-12-10 |
2006-06-15 |
Isis Phamaceuticals, Inc. |
Regulation of epigenetic control of gene expression
|
|
US7879992B2
(en)
|
2005-01-31 |
2011-02-01 |
Isis Pharmaceuticals, Inc. |
Modification of MyD88 splicing using modified oligonucleotides
|
|
ES2852549T3
(es)
|
2005-02-09 |
2021-09-13 |
Sarepta Therapeutics Inc |
Composición antisentido para tratamiento de la atrofia muscular
|
|
US8999943B2
(en)
|
2005-03-14 |
2015-04-07 |
Board Of Regents, The University Of Texas System |
Antigene oligomers inhibit transcription
|
|
US7449297B2
(en)
*
|
2005-04-14 |
2008-11-11 |
Euclid Diagnostics Llc |
Methods of copying the methylation pattern of DNA during isothermal amplification and microarrays
|
|
US8877721B2
(en)
|
2005-04-15 |
2014-11-04 |
The Regents Of The University Of California |
Small activating RNA molecules and methods of use
|
|
US8586719B2
(en)
|
2005-04-27 |
2013-11-19 |
Pacific Arrow Limited |
Triterpenes for modulating gene expression and cell membrane, and as antiprotozoal agents
|
|
US8361977B2
(en)
|
2005-06-23 |
2013-01-29 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulation of SMN2 splicing
|
|
US8067571B2
(en)
|
2005-07-13 |
2011-11-29 |
Avi Biopharma, Inc. |
Antibacterial antisense oligonucleotide and method
|
|
WO2007031091A2
(en)
|
2005-09-15 |
2007-03-22 |
Santaris Pharma A/S |
Rna antagonist compounds for the modulation of p21 ras expression
|
|
JP5066095B2
(ja)
|
2005-11-17 |
2012-11-07 |
ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム |
染色体dnaに標的化されるオリゴマーによる遺伝子発現の調節
|
|
AU2006315102A1
(en)
|
2005-11-21 |
2007-05-24 |
Johnson & Johnson Research Pty Limited |
Multitargeting interfering RNAs having two active strands and methods for their design and use
|
|
CN103301475B
(zh)
|
2005-12-28 |
2016-08-03 |
斯克里普斯研究所 |
药物组合物和表达载体以及调节基因表达的方法和核酸分子的应用
|
|
US20090011004A1
(en)
|
2005-12-30 |
2009-01-08 |
Philadelphia Health & Education Corp., D/B/A/ Drexel University Of College Of Medicine |
Improved carriers for delivery of nucleic acid agents to cells and tissues
|
|
US7569686B1
(en)
|
2006-01-27 |
2009-08-04 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for synthesis of bicyclic nucleic acid analogs
|
|
CA2640171C
(en)
|
2006-01-27 |
2014-10-28 |
Isis Pharmaceuticals, Inc. |
6-modified bicyclic nucleic acid analogs
|
|
JP5213723B2
(ja)
|
2006-01-27 |
2013-06-19 |
アイシス ファーマシューティカルズ, インコーポレーテッド |
マイクロrnaの調節に使用するためのオリゴマー化合物及び組成物
|
|
EP1989307B1
(en)
|
2006-02-08 |
2012-08-08 |
Quark Pharmaceuticals, Inc. |
NOVEL TANDEM siRNAS
|
|
ES2715625T3
(es)
|
2006-04-03 |
2019-06-05 |
Roche Innovation Ct Copenhagen As |
Composición farmacéutica que comprende oligonucleótidos antisentido anti-miARN
|
|
WO2007115578A1
(en)
|
2006-04-07 |
2007-10-18 |
Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts |
Synthetic mecp2 sequence for protein substitution therapy
|
|
CA3044969A1
(en)
|
2006-05-05 |
2007-12-21 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating gene expression
|
|
US8629108B2
(en)
|
2006-06-27 |
2014-01-14 |
Opexa Therapeutics, Inc. |
Rheumatoid arthritis T cell vaccine
|
|
CN101500548A
(zh)
|
2006-08-18 |
2009-08-05 |
弗·哈夫曼-拉罗切有限公司 |
用于体内递送多核苷酸的多缀合物
|
|
JP2010501200A
(ja)
|
2006-08-25 |
2010-01-21 |
デューク・ユニヴァーシティ |
microRNAの内在性mRNA標的のインビボでの同定のための方法
|
|
WO2008025069A1
(en)
|
2006-08-28 |
2008-03-06 |
The Walter And Eliza Hall Institute Of Medical Research |
Methods of modulating cellular activity and compositions therefor
|
|
WO2008029619A1
(fr)
|
2006-09-07 |
2008-03-13 |
Daiichi Sankyo Company, Limited |
Oligonucléotide antisens ena ayant une action spécifique de la séquence
|
|
WO2008036282A1
(en)
|
2006-09-18 |
2008-03-27 |
The Regents Of The University Of Californina |
Upregulating activity or expression of bdnf to mitigate cognitive impairment in asymptomatic huntington's subjects
|
|
DK2092065T4
(da)
|
2006-10-18 |
2019-10-21 |
Ionis Pharmaceuticals Inc |
Antisense-forbindelser
|
|
AU2007323469B2
(en)
|
2006-11-23 |
2014-07-24 |
Guangdong Maijinjia Biotechnology Co., Ltd |
Oligonucleotides for modulating target RNA activity
|
|
US8420791B2
(en)
|
2006-11-27 |
2013-04-16 |
Ludwig Institute For Cancer Research Ltd. |
Expression of FoxP3 by cancer cells
|
|
WO2008089397A2
(en)
|
2007-01-19 |
2008-07-24 |
The Regents Of The University Of Michigan |
Adrb2 cancer markers
|
|
ITMI20070127A1
(it)
|
2007-01-29 |
2008-07-30 |
Fond I R C C S |
Proteine e-o peptidi per la prevenzione e-o cura di malattie neurodegenerative
|
|
WO2008103761A2
(en)
|
2007-02-20 |
2008-08-28 |
Sequenom, Inc. |
Methods and compositions for cancer diagnosis and treatment based on nucleic acid methylation
|
|
US7858592B2
(en)
|
2007-02-26 |
2010-12-28 |
The Board Of Regents Of The University Of Texas System |
Interfering RNAs against the promoter region of P53
|
|
US8580756B2
(en)
|
2007-03-22 |
2013-11-12 |
Santaris Pharma A/S |
Short oligomer antagonist compounds for the modulation of target mRNA
|
|
US8158596B2
(en)
|
2007-05-11 |
2012-04-17 |
The Regents Of The University Of Michigan |
Materials and methods for FOXP3 tumor suppression
|
|
US8691965B2
(en)
|
2007-06-14 |
2014-04-08 |
Mirx Therapeutics Aps |
Oligonucleotides for modulating target RNA activity
|
|
US20090082297A1
(en)
|
2007-06-25 |
2009-03-26 |
Lioy Daniel T |
Compositions and Methods for Regulating Gene Expression
|
|
AU2008271050B2
(en)
*
|
2007-06-29 |
2014-11-06 |
Sarepta Therapeutics, Inc. |
Tissue specific peptide conjugates and methods
|
|
EP2195029A2
(en)
|
2007-08-24 |
2010-06-16 |
Oryzon Genomics SA |
Treatment and prevention of neurodegenerative diseases
|
|
JP2010539990A
(ja)
|
2007-10-04 |
2010-12-24 |
ボード オブ リージェンツ ザ ユニバーシティー オブ テキサス システム |
アンチセンス転写物を標的とするagRNAおよびギャップマーを用いた遺伝子発現の調節方法
|
|
DK2205737T3
(da)
|
2007-10-04 |
2013-05-21 |
Santaris Pharma As |
Mikromirer
|
|
ITRM20070523A1
(it)
|
2007-10-05 |
2009-04-06 |
Consiglio Nazionale Ricerche |
Acido nucleico codificante per una proteina regolatrice specifica della trascrizione dell'utrofina proteina da esso codificata e sue applicazioni
|
|
US9029337B2
(en)
|
2007-11-09 |
2015-05-12 |
Isis Pharmaceuticals, Inc. |
Modulation of factor 7 expression
|
|
US8637478B2
(en)
|
2007-11-13 |
2014-01-28 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating protein expression
|
|
US8937217B2
(en)
|
2007-12-18 |
2015-01-20 |
E. I. Du Pont De Nemours And Company |
Down-regulation of gene expression using artificial microRNAs
|
|
WO2009090182A1
(en)
|
2008-01-14 |
2009-07-23 |
Santaris Pharma A/S |
C4'-substituted - dna nucleotide gapmer oligonucleotides
|
|
WO2009109665A1
(en)
|
2008-03-07 |
2009-09-11 |
Santaris Pharma A/S |
Pharmaceutical compositions for treatment of microrna related diseases
|
|
AU2009223615B2
(en)
|
2008-03-07 |
2014-09-11 |
Senesco Technologies, Inc. |
Use of siRNA to achieve down regulation of an endogenous gene in combination with the use of a sense construct to achieve expression of a desired polynucleotide
|
|
EP2274423A2
(en)
|
2008-04-04 |
2011-01-19 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleosides and having reduced toxicity
|
|
AU2009235941A1
(en)
|
2008-04-07 |
2009-10-15 |
Riken |
RNA molecules and uses thereof
|
|
US8916532B2
(en)
|
2008-04-28 |
2014-12-23 |
The Trustees Of The University Of Pennsylvania |
Methods for enhancing utrophin production via inhibition of microRNA
|
|
US8633019B2
(en)
|
2008-05-27 |
2014-01-21 |
Ptc Therapeutics, Inc. |
Methods for treating spinal muscular atrophy
|
|
CA2726052A1
(en)
|
2008-06-04 |
2009-12-10 |
The Board Of Regents Of The University Of Texas System |
Modulation of gene expression through endogenous small rna targeting of gene promoters
|
|
CA2635187A1
(en)
|
2008-06-05 |
2009-12-05 |
The Royal Institution For The Advancement Of Learning/Mcgill University |
Oligonucleotide duplexes and uses thereof
|
|
WO2010000665A1
(en)
|
2008-06-30 |
2010-01-07 |
Santaris Pharma A/S |
Antidote oligomers
|
|
JP2011529686A
(ja)
|
2008-07-29 |
2011-12-15 |
ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム |
ポリグルタミンタンパク質発現の選択的阻害
|
|
JP2012503651A
(ja)
|
2008-09-26 |
2012-02-09 |
エージェンシー フォー サイエンス,テクノロジー アンド リサーチ |
3−デアザネプラノシン誘導体
|
|
CA2739464C
(en)
|
2008-10-03 |
2020-03-31 |
Curna, Inc. |
Treatment of apolipoprotein-a1 related diseases by inhibition of natural antisense transcript to apolipoprotein-a1
|
|
CA2739046A1
(en)
|
2008-10-16 |
2010-04-22 |
Marina Biotech, Inc. |
Process and compositions for liposomal and effective delivery of nucleic acids
|
|
BRPI0921096A8
(pt)
|
2008-11-17 |
2016-05-10 |
Hoffmann La Roche |
Composições e métodos para inibir a expressão dos genes de fator vii
|
|
GB0821457D0
(en)
|
2008-11-24 |
2008-12-31 |
Trillion Genomics Ltd |
Oligonucleotides
|
|
KR101829469B1
(ko)
|
2008-12-04 |
2018-03-30 |
큐알엔에이, 인크. |
Epo에 대한 천연 안티센스 전사체의 억제에 의해 에리트로포에틴(epo) 관련된 질환의 치료
|
|
CN108042560A
(zh)
|
2008-12-04 |
2018-05-18 |
库尔纳公司 |
通过抑制针对沉默调节蛋白1的天然反义转录物来治疗沉默调节蛋白1相关的疾病
|
|
RU2569182C2
(ru)
|
2008-12-04 |
2015-11-20 |
КьюРНА,Инк.,US |
Лечение заболеваний, связанных с фактором роста эндотелия сосудов (vegf), посредством ингибирования природного антисмыслового транскрипта к vegf
|
|
KR101866152B1
(ko)
|
2008-12-04 |
2018-06-08 |
큐알엔에이, 인크. |
종양 억제 유전자에 대한 천연 안티센스 전사체의 억제에 의해 종양 억제 유전자 관련된 질환의 치료
|
|
US9023820B2
(en)
|
2009-01-26 |
2015-05-05 |
Protiva Biotherapeutics, Inc. |
Compositions and methods for silencing apolipoprotein C-III expression
|
|
KR101682735B1
(ko)
|
2009-02-12 |
2016-12-06 |
큐알엔에이, 인크. |
뇌 유래된 신경영양성 인자 (bdnf)에 대한 자연 안티센스 전사체의 저해에 의한 뇌 유래된 신경영양성 인자 (bdnf) 관련된 질환의 치료
|
|
ES2658626T3
(es)
|
2009-02-12 |
2018-03-12 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con el factor neurotrófico derivado de células gliales (GDNF) por inhibición de transcrito antisentido natural a GDNF
|
|
US20120040857A1
(en)
|
2009-02-13 |
2012-02-16 |
The General Hospital Corporation |
Isolation of factors that associate directly or indirectly with chromatin
|
|
EP2403946A4
(en)
|
2009-03-04 |
2012-11-14 |
|
TREATMENT OF SIRTUIN 1 (SIRT1) -HANDLED ILLNESSES BY INHIBITING THE NATURAL ANTISENSE TRANSCRIPT AGAINST SIRT 1
|
|
MX2011009751A
(es)
|
2009-03-16 |
2011-09-29 |
Opko Curna Llc |
Tratamiento de enfermedades relacionadas con factor nuclear (eritroide derivado 2) tipo 2 (nrf2) por inhibicion del transcrito antisentido natural a nrf2.
|
|
JP5904935B2
(ja)
|
2009-03-17 |
2016-04-20 |
クルナ・インコーポレーテッド |
デルタ様1ホモログ(dlk1)に対する天然アンチセンス転写物の抑制によるdlk1関連疾患の治療
|
|
CN102625840A
(zh)
|
2009-04-10 |
2012-08-01 |
肌肉学研究协会 |
用于治疗疾病的三环dna反义寡核苷酸、组合物和方法
|
|
WO2010124231A2
(en)
|
2009-04-24 |
2010-10-28 |
The Board Of Regents Of The University Of Texas System |
Modulation of gene expression using oligomers that target gene regions downstream of 3' untranslated regions
|
|
CA2760589C
(en)
|
2009-05-01 |
2019-08-20 |
Joseph Collard |
Treatment of hemoglobin (hbf/hbg) related diseases by inhibition of natural antisense transcript to hbf/hbg
|
|
JP6250930B2
(ja)
|
2009-05-06 |
2017-12-20 |
クルナ・インコーポレーテッド |
トリステトラプロリン(ttp)に対する天然アンチセンス転写物の抑制によるttp関連疾患の治療
|
|
CN102459596B
(zh)
|
2009-05-06 |
2016-09-07 |
库尔纳公司 |
通过针对脂质转运和代谢基因的天然反义转录物的抑制治疗脂质转运和代谢基因相关疾病
|
|
CA2761248C
(en)
|
2009-05-08 |
2023-03-14 |
Joseph Collard |
Treatment of dystrophin family related diseases by inhibition of natural antisense transcript to dmd family
|
|
JP5922017B2
(ja)
|
2009-05-18 |
2016-05-24 |
クルナ・インコーポレーテッド |
リプログラミング因子に対する天然アンチセンス転写物の抑制によるリプログラミング因子関連疾患の治療
|
|
EP2432882B1
(en)
|
2009-05-22 |
2019-12-25 |
CuRNA, Inc. |
TREATMENT OF TRANSCRIPTION FACTOR E3 (TFE3) and INSULIN RECEPTOR SUBSTRATE 2 (IRS2) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO TFE3
|
|
WO2010138806A2
(en)
|
2009-05-28 |
2010-12-02 |
Curna, Inc. |
Treatment of antiviral gene related diseases by inhibition of natural antisense transcript to an antiviral gene
|
|
JP6128846B2
(ja)
|
2009-06-16 |
2017-05-17 |
クルナ・インコーポレーテッド |
パラオキソナーゼ(pon1)に対する天然アンチセンス転写物の抑制によるpon1遺伝子関連疾患の治療
|
|
JP5944311B2
(ja)
|
2009-06-16 |
2016-07-05 |
クルナ・インコーポレーテッド |
コラーゲン遺伝子に対する天然アンチセンス転写物の抑制によるコラーゲン遺伝子関連疾患の治療
|
|
EP2446036B1
(en)
|
2009-06-24 |
2017-03-01 |
CuRNA, Inc. |
Treatment of tumor necrosis factor receptor 2 (tnfr2) related diseases by inhibition of natural antisense transcript to tnfr2
|
|
US8921330B2
(en)
|
2009-06-26 |
2014-12-30 |
Curna, Inc. |
Treatment of down syndrome gene related diseases by inhibition of natural antisense transcript to a down syndrome gene
|
|
EP2451823A4
(en)
|
2009-07-06 |
2013-07-03 |
Alnylam Pharmaceuticals Inc |
COMPOSITIONS AND METHODS FOR ENHANCING THE PRODUCTION OF A BIOLOGICAL PRODUCT
|
|
EP2456470A1
(en)
|
2009-07-22 |
2012-05-30 |
Cenix Bioscience GmbH |
Delivery system and conjugates for compound delivery via naturally occurring intracellular transport routes
|
|
WO2011010706A1
(ja)
|
2009-07-23 |
2011-01-27 |
武田薬品工業株式会社 |
Fgf21シスエレメント結合物質
|
|
WO2011011700A2
(en)
|
2009-07-24 |
2011-01-27 |
Curna, Inc. |
Treatment of sirtuin (sirt) related diseases by inhibition of natural antisense transcript to a sirtuin (sirt)
|
|
ES2585360T3
(es)
|
2009-08-05 |
2016-10-05 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con un gen de la insulina (INS) por inhibición de la transcripción antisentido natural en un gen de la insulina (INS)
|
|
JP6189594B2
(ja)
|
2009-08-11 |
2017-08-30 |
クルナ・インコーポレーテッド |
アディポネクチン(adipoq)に対する天然アンチセンス転写物の抑制によるアディポネクチン(adipoq)関連疾患の治療
|
|
CN102482670B
(zh)
|
2009-08-21 |
2018-06-15 |
库尔纳公司 |
通过抑制‘hsp70-相互作用蛋白的c末端’(chip)的天然反义转录物而治疗chip相关疾病
|
|
KR101892760B1
(ko)
|
2009-08-25 |
2018-08-28 |
큐알엔에이, 인크. |
IQGAP에 대한 천연 안티센스 전사체의 억제에 의한 GTPase 활성화 단백질을 함유하는 IQ 모티프(IQGAP)와 관련된 질환의 치료
|
|
WO2011025862A2
(en)
|
2009-08-28 |
2011-03-03 |
Curna, Inc. |
Treatment of atp-binding cassette sub-family b member 1 (abcb1) related diseases by inhibition of natural antisense transcript to abcb1
|
|
WO2011032109A1
(en)
*
|
2009-09-11 |
2011-03-17 |
Sma Foundation |
Biomarkers for spinal muscular atrophy
|
|
WO2011038205A2
(en)
|
2009-09-25 |
2011-03-31 |
Curna, Inc. |
Treatment of growth hormone (gh) related diseases by inhibition of natural antisense transcript to gh
|
|
ES2664591T3
(es)
|
2009-09-25 |
2018-04-20 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con la filagrina (flg) mediante la modulación de la expresión y actividad del gen FLG
|
|
EP2490699A1
(en)
|
2009-10-20 |
2012-08-29 |
Santaris Pharma A/S |
Oral delivery of therapeutically effective lna oligonucleotides
|
|
KR101138048B1
(ko)
|
2009-11-06 |
2012-04-23 |
성균관대학교산학협력단 |
Bdnf의 발현을 증가시키는 신규 펩타이드 및 이를 포함하는 알츠하이머병 또는 파킨슨병의 예방 및 치료용 약학 조성물
|
|
CN102712927B
(zh)
|
2009-12-16 |
2017-12-01 |
库尔纳公司 |
通过抑制膜结合转录因子肽酶,位点1(mbtps1)的天然反义转录物来治疗mbtps1相关疾病
|
|
KR101891352B1
(ko)
|
2009-12-23 |
2018-08-24 |
큐알엔에이, 인크. |
간세포 성장 인자(hgf)에 대한 천연 안티센스 전사체의 억제에 의한 hgf 관련 질환의 치료
|
|
JP6031356B2
(ja)
|
2009-12-23 |
2016-11-24 |
カッパーアールエヌエー,インコーポレイテッド |
Ucp2に対する天然アンチセンス転写産物の阻害による脱共役タンパク質2(ucp2)関連疾患の治療
|
|
CA2785177C
(en)
|
2009-12-29 |
2019-09-24 |
Curna, Inc. |
Treatment of tumor protein 63 (p63) related diseases by inhibition of natural antisense transcript to p63
|
|
KR101838305B1
(ko)
|
2009-12-29 |
2018-03-13 |
큐알엔에이, 인크. |
NRF1(Nuclear Respiratory Factor 1)에 대한 천연 안티센스 전사체의 억제에 의한 핵 호흡 인자 1 관련된 질환의 치료
|
|
CN102791862B
(zh)
|
2009-12-31 |
2017-04-05 |
库尔纳公司 |
通过抑制胰岛素受体底物2(irs2)和转录因子e3(tfe3)的天然反义转录物而治疗irs2相关疾病
|
|
JP5886757B2
(ja)
|
2010-01-04 |
2016-03-16 |
カッパーアールエヌエー,インコーポレイテッド |
インターフェロン調節因子8(irf8)に対する天然アンチセンス転写物の阻害によるインターフェロン調節因子8(irf8)関連疾患の治療
|
|
EP2521785B1
(en)
|
2010-01-06 |
2022-03-09 |
CuRNA, Inc. |
Inhibition of natural antisense transcript to a pancreatic developmental gene for use in a treatment of pancreatic developmental gene related diseases
|
|
JP6027893B2
(ja)
|
2010-01-11 |
2016-11-16 |
カッパーアールエヌエー,インコーポレイテッド |
性ホルモン結合グロブリン(shbg)に対する天然アンチセンス転写物の阻害による性ホルモン結合グロブリン(shbg)関連疾患の治療
|
|
EP2529015B1
(en)
|
2010-01-25 |
2017-11-15 |
CuRNA, Inc. |
Treatment of rnase h1 related diseases by inhibition of natural antisense transcript to rnase h1
|
|
US9574191B2
(en)
|
2010-02-03 |
2017-02-21 |
The Board Of Regents Of The University Of Texas System |
Selective inhibition of polyglutamine protein expression
|
|
WO2011097582A2
(en)
|
2010-02-08 |
2011-08-11 |
Opko Curna Llc |
Treatment of arachidonate 12-lipoxygenase, 12r type (alox12b) related diseases by inhibition of natural antisense transcript to alox12b
|
|
WO2011097641A1
(en)
|
2010-02-08 |
2011-08-11 |
Isis Pharmaceuticals, Inc. |
Methods and compositions useful in treatment of diseases or conditions related to repeat expansion
|
|
KR101838308B1
(ko)
|
2010-02-22 |
2018-03-13 |
큐알엔에이, 인크. |
피롤린-5-카르복실레이트 환원효소 1(pycr1)에 대한 천연 안티센스 전사체의 억제에 의한 pycr1과 관련된 질환의 치료
|
|
WO2011117353A1
(en)
|
2010-03-24 |
2011-09-29 |
Mirrx Therapeutics A/S |
Bivalent antisense oligonucleotides
|
|
CA2795145C
(en)
|
2010-04-02 |
2019-01-22 |
Curna, Inc. |
Treatment of colony-stimulating factor 3 (csf3) related diseases by inhibition of natural antisense transcript to csf3
|
|
TWI644675B
(zh)
|
2010-04-09 |
2018-12-21 |
可娜公司 |
藉由抑制纖維母細胞生長因子21(fgf21)之天然反義轉錄物以治療fgf21相關疾病
|
|
WO2011130371A1
(en)
|
2010-04-13 |
2011-10-20 |
Life Technologies Corporation |
Compositions and methods for inhibition of nucleic acids function
|
|
RU2693462C2
(ru)
|
2010-05-03 |
2019-07-03 |
Курна, Инк. |
Лечение заболеваний, связанных с сиртуином (sirt), путем ингибирования природного антисмыслового транскрипта к сиртуину (sirt)
|
|
TWI531370B
(zh)
|
2010-05-14 |
2016-05-01 |
可娜公司 |
藉由抑制par4天然反股轉錄本治療par4相關疾病
|
|
AR081209A1
(es)
|
2010-05-19 |
2012-07-04 |
Opko Curna Llc |
Tratamiento de enfermedades relacionadas con la proteina 11 del tipo linfoma 2 de celulas b, (bcl2, bcl2l11) mediante la inhibicion del transcripto antisentido natural a bcl2l11
|
|
WO2011146675A2
(en)
|
2010-05-19 |
2011-11-24 |
Opko Curna Llc |
Treatment of lim homeobox 2 (lhx2) related diseases by inhibition of natural antisense transcript to lhx2
|
|
EP2576783B1
(en)
|
2010-05-26 |
2017-11-29 |
CuRNA, Inc. |
Treatment of atonal homolog 1 (atoh1) related diseases by inhibition of natural antisense transcript to atoh1
|
|
EP2576784B1
(en)
|
2010-05-26 |
2017-11-15 |
CuRNA, Inc. |
Treatment of methionine sulfoxide reductase a (msra) related diseases by inhibition of natural antisense transcript to msra
|
|
EP2582397A4
(en)
|
2010-06-15 |
2014-10-29 |
Isis Pharmaceuticals Inc |
COMPOUNDS AND METHOD FOR MODULATING INTERACTION BETWEEN PROTEINS AND TARGET NUCLEIC ACIDS
|
|
US20120004278A1
(en)
|
2010-06-18 |
2012-01-05 |
The Board Of Trustees Of The Leland Stanford Junior University |
Linc rnas in cancer diagnosis and treatment
|
|
KR102008708B1
(ko)
|
2010-06-23 |
2019-08-08 |
큐알엔에이, 인크. |
전압 작동 나트륨 통로, 알파 소단위(scna)에 대한 자연 안티센스 전사체의 저해에 의한 전압 작동 나트륨 통로, 알파 소단위(scna) 관련된 질환의 치료
|
|
GB201010557D0
(en)
|
2010-06-23 |
2010-08-11 |
Mina Therapeutics Ltd |
RNA molecules and uses thereof
|
|
WO2012003810A1
(zh)
|
2010-07-09 |
2012-01-12 |
中国科学院上海巴斯德研究所 |
Foxp3及调节性t细胞的调节因子及其应用
|
|
TW201209163A
(en)
|
2010-07-12 |
2012-03-01 |
Opko Curna Llc |
Treatment of BCL2 binding component 3 (BBC3) related diseases by inhibition of natural antisense transcript to BBC3
|
|
CA2805318A1
(en)
|
2010-07-14 |
2012-01-19 |
Curna, Inc. |
Treatment of discs large homolog (dlg) related diseases by inhibition of natural antisense transcript to dlg
|
|
WO2012027033A1
(en)
*
|
2010-07-19 |
2012-03-01 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating target nuclear and sub-nuclear nucleic acid molecules in cells and animals
|
|
US20130225659A1
(en)
|
2010-07-19 |
2013-08-29 |
Isis Pharmaceuticals, Inc. |
Modulation of nuclear-retained rna
|
|
WO2012018881A2
(en)
|
2010-08-03 |
2012-02-09 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for the regulation of rna
|
|
WO2012024478A2
(en)
|
2010-08-19 |
2012-02-23 |
Opko Curna Llc |
Treatment of nicotinamide phosphoribosyltransferase (nampt) related diseases by inhibition of natural antisense transcript to nampt
|
|
BR112013005806B1
(pt)
|
2010-09-10 |
2022-05-10 |
Epizyme, Inc |
Métodos para detectar se um indivíduo é um candidato para o tratamento com ou responsivo a um inibidor de ezh2 e usos terapêuticos do dito inibidor de ezh2
|
|
ES2640755T3
(es)
|
2010-10-06 |
2017-11-06 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con la Sialidasa 4 (neu4) mediante inhibición del transcrito antisentido natural al gen neu4
|
|
US9222088B2
(en)
|
2010-10-22 |
2015-12-29 |
Curna, Inc. |
Treatment of alpha-L-iduronidase (IDUA) related diseases by inhibition of natural antisense transcript to IDUA
|
|
DK2633052T3
(en)
|
2010-10-27 |
2018-07-16 |
Curna Inc |
TREATMENT OF INTERFERON-RELATED DEVELOPMENT REGULATOR 1 (IFRD1) -RELATED DISEASES BY INHIBITION OF NATURAL ANTISENCE TRANSCRIPT TO IFRD1
|
|
WO2012064806A2
(en)
|
2010-11-11 |
2012-05-18 |
The University Of North Carolina At Chapel Hill |
Methods and compositions for unsilencing imprinted genes
|
|
AU2011325956B2
(en)
|
2010-11-12 |
2016-07-14 |
The General Hospital Corporation |
Polycomb-associated non-coding RNAs
|
|
US9920317B2
(en)
|
2010-11-12 |
2018-03-20 |
The General Hospital Corporation |
Polycomb-associated non-coding RNAs
|
|
US10000752B2
(en)
|
2010-11-18 |
2018-06-19 |
Curna, Inc. |
Antagonat compositions and methods of use
|
|
EP2643463B1
(en)
|
2010-11-23 |
2017-09-27 |
CuRNA, Inc. |
Treatment of nanog related diseases by inhibition of natural antisense transcript to nanog
|
|
CA2822462A1
(en)
|
2010-12-20 |
2012-06-28 |
The General Hospital Corporation |
Polycomb-associated non-coding rnas
|
|
WO2012109476A2
(en)
|
2011-02-09 |
2012-08-16 |
The University Of Rochester |
Methods and compositions related to staufen 1 binding sites formed by duplexing alu elements
|
|
WO2012144220A1
(en)
|
2011-04-22 |
2012-10-26 |
Oncotherapy Science, Inc. |
Ezh2 as target gene for cancer therapy and diagnosis
|
|
US8557787B2
(en)
|
2011-05-13 |
2013-10-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
Diagnostic, prognostic and therapeutic uses of long non-coding RNAs for cancer and regenerative medicine
|
|
JP6188686B2
(ja)
|
2011-06-09 |
2017-08-30 |
カッパーアールエヌエー,インコーポレイテッド |
フラタキシン(fxn)への天然アンチセンス転写物の阻害によるfxn関連疾患の治療
|
|
WO2012174610A1
(en)
|
2011-06-24 |
2012-12-27 |
Murdoch Childrens Research Institute |
Treatment and diagnosis of epigenetic disorders and conditions
|
|
EP2729605B1
(en)
|
2011-07-05 |
2017-02-08 |
The General Hospital Corporation |
Rna-yy1 interactions
|
|
BR112014005234A2
(pt)
|
2011-09-06 |
2017-04-11 |
Curna Inc |
tratamento de doenças relacionadas com subunididades alfa dos canais de sódio dependentes de voltagem (scnxa) com pequenas moléculas
|
|
US9580708B2
(en)
|
2011-09-14 |
2017-02-28 |
Rana Therapeutics, Inc. |
Multimeric oligonucleotides compounds
|
|
US9209196B2
(en)
|
2011-11-30 |
2015-12-08 |
Sharp Kabushiki Kaisha |
Memory circuit, method of driving the same, nonvolatile storage device using the same, and liquid crystal display device
|
|
ITMI20120275A1
(it)
|
2012-02-24 |
2013-08-25 |
Biogenera Societa A Responsabilita Limitata |
Oligonucleotidi per la modulazione dell'espressione genica e loro usi
|
|
HUE040179T2
(hu)
|
2012-03-15 |
2019-02-28 |
Curna Inc |
Agyi eredetû neutrotróf faktorral (Brain-derived neurotrophic factor, BDNF) összefüggõ betegségek kezelése a BDNF-fel kapcsolatos természetes antiszensz transzkriptumok gátlása révén
|
|
US20150141320A1
(en)
|
2012-05-16 |
2015-05-21 |
Rana Therapeutics, Inc. |
Compositions and methods for modulating gene expression
|
|
EP3511416A1
(en)
|
2012-05-16 |
2019-07-17 |
Translate Bio MA, Inc. |
Compositions and methods for modulating gene expression
|
|
EP2850183A4
(en)
|
2012-05-16 |
2016-02-10 |
Rana Therapeutics Inc |
COMPOSITIONS AND METHOD FOR MODULATING GENE EXPRESSION
|
|
BR112014028634A2
(pt)
|
2012-05-16 |
2017-06-27 |
Rana Therapeutics Inc |
composições e métodos para modulação da expressão de utrn
|
|
US20150159161A1
(en)
|
2012-05-16 |
2015-06-11 |
Rana Therapeutics, Inc. |
Compositions and methods for modulating pten expression
|
|
CA2873801A1
(en)
|
2012-05-16 |
2013-11-21 |
Rana Therapeutics Inc. |
Compositions and methods for modulating apoa1 and abca1 expression
|
|
CA2873769A1
(en)
|
2012-05-16 |
2013-11-21 |
Rana Therapeutics Inc. |
Compositions and methods for modulating hemoglobin gene family expression
|
|
SG11201407483YA
(en)
|
2012-05-16 |
2014-12-30 |
Rana Therapeutics Inc |
Compositions and methods for modulating smn gene family expression
|
|
AU2013262709A1
(en)
|
2012-05-16 |
2015-01-22 |
Rana Therapeutics, Inc. |
Compositions and methods for modulating MECP2 expression
|
|
BR112014028644A2
(pt)
|
2012-05-16 |
2017-08-15 |
Rana Therapeutics Inc |
Composições e métodos para modulação da expressão de atp2a2
|
|
EA201492117A1
(ru)
|
2012-05-16 |
2015-04-30 |
Рана Терапьютикс, Инк. |
Композиции и способы для модулирования экспрессии bdnf
|
|
WO2014025887A1
(en)
|
2012-08-07 |
2014-02-13 |
The General Hospital Corporation |
Selective reactivation of genes on the inactive x chromosome
|
|
EP2895200B1
(en)
|
2012-09-14 |
2019-11-06 |
Translate Bio MA, Inc. |
Multimeric oligonucleotide compounds
|
|
JP6452614B2
(ja)
|
2012-11-15 |
2019-01-16 |
ロシュ イノベーション センター コペンハーゲン エーエス |
オリゴヌクレオチドコンジュゲート
|
|
WO2014172698A1
(en)
|
2013-04-19 |
2014-10-23 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulation nucleic acids through nonsense mediated decay
|
|
AU2014274730A1
(en)
|
2013-06-07 |
2016-01-21 |
Rana Therapeutics, Inc. |
Compositions and methods for modulating FOXP3 expression
|
|
CA2915443A1
(en)
|
2013-06-16 |
2014-12-24 |
National University Corporation Tokyo Medical And Dental University |
Double-stranded antisense nucleic acid with exon-skipping effect
|
|
WO2015035476A1
(en)
|
2013-09-16 |
2015-03-19 |
University Of Western Sydney |
Modulation of gene expression
|