MX366774B - Uso de oligonucleótidos antisentido en la inhibición de transcrito antisentido natural para sirtuina 1. - Google Patents

Uso de oligonucleótidos antisentido en la inhibición de transcrito antisentido natural para sirtuina 1.

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Publication number
MX366774B
MX366774B MX2011005914A MX2011005914A MX366774B MX 366774 B MX366774 B MX 366774B MX 2011005914 A MX2011005914 A MX 2011005914A MX 2011005914 A MX2011005914 A MX 2011005914A MX 366774 B MX366774 B MX 366774B
Authority
MX
Mexico
Prior art keywords
sirtuin
sirt1
inhibition
antisense transcript
natural antisense
Prior art date
Application number
MX2011005914A
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English (en)
Other versions
MX2011005914A (es
Inventor
Collard Joseph
Khorkova Sherman Olga
Coito Carlos
De Leon Belinda
Original Assignee
Curna Inc
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Filing date
Publication date
Application filed by Curna Inc filed Critical Curna Inc
Publication of MX2011005914A publication Critical patent/MX2011005914A/es
Publication of MX366774B publication Critical patent/MX366774B/es

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    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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Abstract

La presente invención se refiere a compuestos oligonucleótidos que modulan la expresión y/o función de polinucleótidos de Sirtuina 1 (SIRT1) y productos codificados de los mismos. Se describen también métodos para tratar enfermedades asociadas con Sirtuina 1 (SIRT1) que comprenden administrar uno o más compuestos oligonucleótidos diseñados para inhibir el transcrito antisentido natural de SIRT1 a pacientes.
MX2011005914A 2008-12-04 2009-12-02 Uso de oligonucleótidos antisentido en la inhibición de transcrito antisentido natural para sirtuina 1. MX366774B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11996508P 2008-12-04 2008-12-04
US15725509P 2009-03-04 2009-03-04
US25907209P 2009-11-06 2009-11-06
PCT/US2009/066445 WO2010065662A2 (en) 2008-12-04 2009-12-02 Treatment of sirtuin 1 (sirt1) related diseases by inhibition of natural antisense transcript to sirtuin 1

Publications (2)

Publication Number Publication Date
MX2011005914A MX2011005914A (es) 2011-06-17
MX366774B true MX366774B (es) 2019-07-24

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Application Number Title Priority Date Filing Date
MX2011005914A MX366774B (es) 2008-12-04 2009-12-02 Uso de oligonucleótidos antisentido en la inhibición de transcrito antisentido natural para sirtuina 1.

Country Status (10)

Country Link
US (1) US20110237649A1 (es)
EP (1) EP2370580B1 (es)
JP (2) JP6099868B2 (es)
KR (1) KR101749352B1 (es)
CN (2) CN108042560A (es)
CA (1) CA2746001C (es)
ES (1) ES2760912T3 (es)
MX (1) MX366774B (es)
RU (1) RU2551234C2 (es)
WO (1) WO2010065662A2 (es)

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KR101801407B1 (ko) * 2009-07-24 2017-11-24 큐알엔에이, 인크. 시르투인 (ｓｉｒｔ)에 대한 천연 안티센스 전사체의 억제에 의한 시르투인 관련된 질환의 치료
ES2854004T3 (es) * 2009-07-24 2021-09-20 Curna Inc Tratamiento de enfermedades relacionadas con Sirtuina 6 (SIRT6) mediante inhibición del transcrito antisentido natural para SIRT6
CN107988228B (zh) * 2010-05-03 2022-01-25 库尔纳公司 通过抑制沉默调节蛋白(sirt)的天然反义转录物而治疗沉默调节蛋白(sirt)相关疾病
US9771579B2 (en) * 2010-06-23 2017-09-26 Curna, Inc. Treatment of sodium channel, voltage-gated, alpha subunit (SCNA) related diseases by inhibition of natural antisense transcript to SCNA
CA2815212A1 (en) * 2010-10-22 2012-04-26 Curna, Inc. Treatment of alpha-l-iduronidase (idua) related diseases by inhibition of natural antisense transcript to idua
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WO2013166502A1 (en) * 2012-05-04 2013-11-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Regulation of cardiac sodium channels by sirt1 and sirt1 activators
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KR20150030205A (ko) 2012-05-16 2015-03-19 라나 테라퓨틱스, 인크. Smn 유전자 패밀리 발현을 조절하기 위한 조성물 및 방법
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CN104583401A (zh) 2012-05-16 2015-04-29 Rana医疗有限公司 用于调节atp2a2表达的组合物和方法
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CN103837679B (zh) * 2014-02-20 2016-06-08 浙江大学 Sirt-1蛋白在诊断、预测骨肉瘤转移产品的应用
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KR20170139439A (ko) * 2016-06-09 2017-12-19 단국대학교 천안캠퍼스 산학협력단 각질형성세포에서의 sirt1 발현 억제제 및 이를 이용한 sirt1 발현억제 방법
CN110290794A (zh) 2016-11-01 2019-09-27 纽约州州立大学研究基金会 5-卤代尿嘧啶修饰的微rna及其在癌症治疗中的用途
JP7141621B2 (ja) * 2017-03-31 2022-09-26 学校法人 愛知医科大学 コンドロイチン硫酸生合成を阻害するアンチセンス核酸
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