FR2853663B1 - Procede d'obtention de lignees de mastocytes a partir de tissus de porcs et procede de production de molecules de type heparine - Google Patents

Procede d'obtention de lignees de mastocytes a partir de tissus de porcs et procede de production de molecules de type heparine

Info

Publication number
FR2853663B1
FR2853663B1 FR0304671A FR0304671A FR2853663B1 FR 2853663 B1 FR2853663 B1 FR 2853663B1 FR 0304671 A FR0304671 A FR 0304671A FR 0304671 A FR0304671 A FR 0304671A FR 2853663 B1 FR2853663 B1 FR 2853663B1
Authority
FR
France
Prior art keywords
mastocyte
obtaining
lines
type molecules
producing heparin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0304671A
Other languages
English (en)
Other versions
FR2853663A1 (fr
Inventor
Jean Marc Guillaume
Sandrine Perez
Werner Dittrich
Christine Michele Pie Andreoni
Romain Paillot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0304671A priority Critical patent/FR2853663B1/fr
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Priority to TW093110163A priority patent/TW200506059A/zh
Priority to US10/823,142 priority patent/US20050181484A1/en
Priority to ARP040101235A priority patent/AR043862A1/es
Priority to EP04742485A priority patent/EP1616002A2/fr
Priority to JP2006505794A priority patent/JP2006522597A/ja
Priority to PCT/FR2004/000902 priority patent/WO2004092356A2/fr
Publication of FR2853663A1 publication Critical patent/FR2853663A1/fr
Application granted granted Critical
Publication of FR2853663B1 publication Critical patent/FR2853663B1/fr
Priority to US11/938,422 priority patent/US20080064095A1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0642—Granulocytes, e.g. basopils, eosinophils, neutrophils, mast cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/04—Immortalised cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
FR0304671A 2003-04-14 2003-04-14 Procede d'obtention de lignees de mastocytes a partir de tissus de porcs et procede de production de molecules de type heparine Expired - Fee Related FR2853663B1 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
FR0304671A FR2853663B1 (fr) 2003-04-14 2003-04-14 Procede d'obtention de lignees de mastocytes a partir de tissus de porcs et procede de production de molecules de type heparine
US10/823,142 US20050181484A1 (en) 2003-04-14 2004-04-13 Method for obtaining mastocyte lines from pig tissues and for producing heparin-type molecules
ARP040101235A AR043862A1 (es) 2003-04-14 2004-04-13 Procedimiento para la obtencion de estirpes celulares de mastocitos a partir de tejidos de cerdo y procedimiento para la produccion de moleculas de tipo de la heparina
EP04742485A EP1616002A2 (fr) 2003-04-14 2004-04-13 Procede d obtention de lignees de mastocytes a partir de tis sus de porcs et procede de production de molecules de type heparine
TW093110163A TW200506059A (en) 2003-04-14 2004-04-13 Method for obtaining mastocyte lines from pig tissues and for producing heparin-type molecules
JP2006505794A JP2006522597A (ja) 2003-04-14 2004-04-13 ブタ組織から肥満細胞系統を得る方法およびヘパリンタイプの分子を製造する方法
PCT/FR2004/000902 WO2004092356A2 (fr) 2003-04-14 2004-04-13 Procede d'obtention de lignees de mastocytes a partir de tissus de porcs et procede de production de molecules de type heparine
US11/938,422 US20080064095A1 (en) 2003-04-14 2007-11-12 Method for obtaining mastocyte lines from pig tissues and for producing heparin-type modules

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0304671A FR2853663B1 (fr) 2003-04-14 2003-04-14 Procede d'obtention de lignees de mastocytes a partir de tissus de porcs et procede de production de molecules de type heparine

Publications (2)

Publication Number Publication Date
FR2853663A1 FR2853663A1 (fr) 2004-10-15
FR2853663B1 true FR2853663B1 (fr) 2007-08-31

Family

ID=33041865

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0304671A Expired - Fee Related FR2853663B1 (fr) 2003-04-14 2003-04-14 Procede d'obtention de lignees de mastocytes a partir de tissus de porcs et procede de production de molecules de type heparine

Country Status (7)

Country Link
US (2) US20050181484A1 (fr)
EP (1) EP1616002A2 (fr)
JP (1) JP2006522597A (fr)
AR (1) AR043862A1 (fr)
FR (1) FR2853663B1 (fr)
TW (1) TW200506059A (fr)
WO (1) WO2004092356A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2876386B1 (fr) * 2004-10-12 2007-04-06 Aventis Pharma Sa Lignees de mastocytes porcins produisant des molecules de type heparine
WO2008116887A2 (fr) * 2007-03-26 2008-10-02 Institut Pasteur Utilisation de mastocytes péritonéaux comme source d'héparine
JP2009171895A (ja) * 2008-01-24 2009-08-06 Hitachi Software Eng Co Ltd 核内ノンコーディングｒｎａの機能解析方法
DK2756080T3 (da) 2011-09-14 2019-05-20 Translate Bio Ma Inc Multimeriske oligonukleotidforbindelser
EA201492123A1 (ru) 2012-05-16 2015-10-30 Рана Терапьютикс, Инк. Композиции и способы для модулирования экспрессии семейства генов smn
CA2873797A1 (fr) 2012-05-16 2013-11-21 Rana Therapeutics Inc. Compositions et methodes pour moduler l'expression de utrn
JP2015518714A (ja) * 2012-05-16 2015-07-06 ラナ セラピューティクス インコーポレイテッド 遺伝子発現を調節するための組成物及び方法
CA2873779A1 (fr) 2012-05-16 2013-11-21 Rana Therapeutics Inc. Compositions et methodes pour moduler l'expression de mecp2
US10837014B2 (en) 2012-05-16 2020-11-17 Translate Bio Ma, Inc. Compositions and methods for modulating SMN gene family expression
AU2013262699A1 (en) 2012-05-16 2015-01-22 Rana Therapeutics, Inc. Compositions and methods for modulating ATP2A2 expression
AP2014008100A0 (en) 2012-05-16 2014-12-31 Gen Hospital Corp Compositions and methods for modulating hemoglobingene family expression
US20150247141A1 (en) 2012-09-14 2015-09-03 Rana Therapeutics, Inc. Multimeric oligonucleotide compounds
US20200291358A1 (en) * 2017-09-08 2020-09-17 Otsuka Pharmaceutical Factory, Inc. Stem cell derived from young pig and method for producing same
NL2035425A (en) * 2023-07-19 2023-08-07 Univ China Agricultural Method for isolating and culturing bone marrow-derived mast cells of newborn piglets

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990014418A1 (fr) * 1989-05-19 1990-11-29 The Uab Research Foundation Lignees cellulaires de mastocytome murine produisant l'heparine
US20030125519A1 (en) * 1990-08-27 2003-07-03 Peter Besmer Ligand for the c-kit receptor and methods of use thereof
US6383480B1 (en) * 1996-07-10 2002-05-07 Meiji Milk Products, Co., Ltd. Composition comprising midkine or pleiotrophin protein and method of increasing hematopoietic cells
CN1263559A (zh) * 1997-05-30 2000-08-16 猪改良英国有限公司 分析动物产品的方法
FI974321A0 (fi) * 1997-11-25 1997-11-25 Jenny Ja Antti Wihurin Rahasto Multipel heparinglykosaminoglykan och en proteoglykan innehaollande dessa
FR2831186B1 (fr) * 2001-10-22 2004-06-18 Aventis Pharma Sa Production d'heparine a partir de cultures de mastocytes
FR2831184B1 (fr) * 2001-10-22 2004-01-02 Agronomique Inst Nat Rech Cultures de mastocytes de porc et leurs utilisations

Also Published As

Publication number Publication date
WO2004092356A3 (fr) 2005-05-26
AR043862A1 (es) 2005-08-17
FR2853663A1 (fr) 2004-10-15
EP1616002A2 (fr) 2006-01-18
JP2006522597A (ja) 2006-10-05
US20050181484A1 (en) 2005-08-18
US20080064095A1 (en) 2008-03-13
WO2004092356A2 (fr) 2004-10-28
TW200506059A (en) 2005-02-16

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Effective date: 20091231