|
US6346614B1
(en)
*
|
1992-07-23 |
2002-02-12 |
Hybridon, Inc. |
Hybrid oligonucleotide phosphorothioates
|
|
US6608035B1
(en)
*
|
1994-10-25 |
2003-08-19 |
Hybridon, Inc. |
Method of down-regulating gene expression
|
|
US6645943B1
(en)
|
1994-10-25 |
2003-11-11 |
Hybridon, Inc. |
Method of down-regulating gene expression
|
|
WO1997030067A1
(en)
|
1996-02-14 |
1997-08-21 |
Isis Pharmaceuticals, Inc. |
Sugar-modified gapped oligonucleotides
|
|
US20030036516A1
(en)
*
|
1997-09-10 |
2003-02-20 |
Sudhir Agrawal |
Method for using oligonucleotides having modified cpg dinucleotides
|
|
US20010049436A1
(en)
*
|
1998-04-01 |
2001-12-06 |
Wen-Qiang Zhou |
Mixed-backbone oligonucleotides containing pops blocks to obtain reduced phosphorothioate content
|
|
US20040186071A1
(en)
|
1998-04-13 |
2004-09-23 |
Bennett C. Frank |
Antisense modulation of CD40 expression
|
|
US20040063618A1
(en)
*
|
2002-09-30 |
2004-04-01 |
Muthiah Manoharan |
Peptide nucleic acids having improved uptake and tissue distribution
|
|
US20030220486A1
(en)
*
|
1999-04-01 |
2003-11-27 |
Wen-Qiang Zhou |
Mixed backbone oligonucleotides containing pops blocks to obtain reduced phosphorothioate content
|
|
US7276489B2
(en)
*
|
2002-10-24 |
2007-10-02 |
Idera Pharmaceuticals, Inc. |
Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends
|
|
US20050196382A1
(en)
*
|
2002-09-13 |
2005-09-08 |
Replicor, Inc. |
Antiviral oligonucleotides targeting viral families
|
|
CN1694959B
(zh)
*
|
2002-09-13 |
2013-09-18 |
雷普利瑟公司 |
非序列互补的抗病毒寡核苷酸
|
|
MXPA05007652A
(es)
*
|
2003-01-16 |
2006-02-22 |
Hybridon Inc |
Modulacion de propiedades inmunoestimulantes de compuestos basados en oligonucleotido mediante la utilizacion de dinucleotidos inmunoestimulantes modificados.
|
|
WO2004103301A2
(en)
*
|
2003-05-16 |
2004-12-02 |
Hybridon, Inc. |
Synergistic treatment of cancer using immunomers in conjunction with chemotherapeutic agents
|
|
ES2569927T3
(es)
|
2003-06-11 |
2016-05-13 |
Idera Pharmaceuticals, Inc. |
Oligonucleótidos inmunomoduladores estabilizados
|
|
EP1648913A4
(en)
|
2003-07-15 |
2008-09-10 |
Idera Pharmaceuticals Inc |
SYNERGISTIC STIMULATION OF THE IMMUNE SYSTEM WITH IMMUNOSTIMULATING OLIGONUCLEOTIDES AND / OR IMMUNOMER COMPOUNDS RELATED TO CYTOKINES AND / OR CHEMOTHERAPEAN MEDICAMENTS OR RADIATION THERAPY
|
|
EP2060269A3
(en)
|
2003-12-08 |
2009-08-19 |
Hybridon, Inc. |
Modulation of immunostimulatory properties by small oligonucleotide-based compounds
|
|
JP2007523173A
(ja)
*
|
2004-02-20 |
2007-08-16 |
イデラ ファーマシューティカルズ インコーポレイテッド |
修飾免疫調節オリゴヌクレオチドにより誘導された強力な粘膜免疫応答
|
|
KR101147147B1
(ko)
*
|
2004-04-01 |
2012-05-25 |
머크 샤프 앤드 돔 코포레이션 |
Rna 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드
|
|
US7498425B2
(en)
*
|
2004-06-15 |
2009-03-03 |
Idera Pharmaceuticals, Inc. |
Immunostimulatory oligonucleotide multimers
|
|
HRP20070012A2
(hr)
*
|
2004-06-15 |
2007-10-31 |
Idera Pharmaceuticals |
Imunostimulatorski oligonukleotidni multimeri
|
|
US7923207B2
(en)
|
2004-11-22 |
2011-04-12 |
Dharmacon, Inc. |
Apparatus and system having dry gene silencing pools
|
|
US20060166234A1
(en)
|
2004-11-22 |
2006-07-27 |
Barbara Robertson |
Apparatus and system having dry control gene silencing compositions
|
|
US7935811B2
(en)
|
2004-11-22 |
2011-05-03 |
Dharmacon, Inc. |
Apparatus and system having dry gene silencing compositions
|
|
CA2589406A1
(en)
|
2004-12-09 |
2006-06-15 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inducing an immune response in a mammal and methods of avoiding an immune response to oligonucleotide agents such as short interfering rnas
|
|
CA2591586A1
(en)
|
2005-05-05 |
2006-11-09 |
Antisense Pharma Gmbh |
Dosage of oligonucleotides
|
|
DK2179737T3
(da)
*
|
2005-07-01 |
2013-11-11 |
Index Pharmaceuticals Ab |
Modulering af respons på steroider
|
|
DK2380584T3
(da)
|
2005-07-01 |
2014-01-20 |
Index Pharmaceuticals Ab |
Immunstimulerende fremgangsmåde
|
|
US8895522B2
(en)
*
|
2005-10-28 |
2014-11-25 |
Index Pharmaceuticals Ab |
Composition and method for the prevention, treatment and/or alleviation of an inflammatory disease
|
|
EP2402442B1
(en)
|
2005-11-07 |
2013-07-31 |
Idera Pharmaceuticals |
Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides
|
|
US7776834B2
(en)
*
|
2005-11-07 |
2010-08-17 |
Idera Pharmaceuticals, Inc. |
Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides
|
|
US7470674B2
(en)
*
|
2005-11-07 |
2008-12-30 |
Idera Pharmaceuticals, Inc. |
Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides
|
|
AU2006336242A1
(en)
*
|
2005-12-20 |
2007-07-26 |
Idera Pharmaceuticals, Inc. |
Novel synthetic agonists of toll-like receptors containing CG dinucleotide modifications
|
|
JP2009521218A
(ja)
*
|
2005-12-20 |
2009-06-04 |
イデラ ファーマシューティカルズ インコーポレイテッド |
異なる長さのパリンドロームセグメントを含むパリンドローム免疫調節オリゴヌクレオチド(imo(tm))の免疫賦活作用
|
|
LT2056845T
(lt)
|
2006-08-08 |
2017-11-27 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
5` fosfato oligonukleotidų struktūra ir panaudojimas
|
|
WO2008036841A2
(en)
|
2006-09-22 |
2008-03-27 |
Dharmacon, Inc. |
Tripartite oligonucleotide complexes and methods for gene silencing by rna interference
|
|
EP2338499A1
(en)
|
2006-10-10 |
2011-06-29 |
Gunther Hartmann |
5' triphosphate oligonucleotide induces anti-viral response
|
|
ES2641290T3
(es)
|
2007-11-20 |
2017-11-08 |
Ionis Pharmaceuticals, Inc |
Modulación de la expresión de CD40
|
|
US8188060B2
(en)
|
2008-02-11 |
2012-05-29 |
Dharmacon, Inc. |
Duplex oligonucleotides with enhanced functionality in gene regulation
|
|
WO2009141146A1
(en)
|
2008-05-21 |
2009-11-26 |
Gunther Hartmann |
5' triphosphate oligonucleotide with blunt end and uses thereof
|
|
HRP20150566T1
(hr)
|
2009-08-27 |
2015-07-17 |
Idera Pharmaceuticals, Inc. |
Kompozicija za inhibiciju ekspresije gena i njegova upotreba
|
|
US20120270930A1
(en)
|
2009-10-29 |
2012-10-25 |
Academisch Ziekenhuis Leiden H.O.D.N. Lumc |
Methods and compositions for dysferlin exon-skipping
|
|
WO2011109427A2
(en)
|
2010-03-01 |
2011-09-09 |
Alnylam Pharmaceuticals, Inc. |
Improving the biological activity of sirna through modulation of its thermodynamic profile
|
|
EP2453017A1
(en)
|
2010-11-12 |
2012-05-16 |
Antisense Pharma GmbH |
Oligonucleotides for use in prophylaxis and/or treatment of TGF-beta1 and TGF-beta2, TGF-beta2 and TGF-beta3, TGF-beta1 and TGF-beta3, or TGF-beta1, TGF-beta2, and TGF-beta3 mRNA overexpressing diseases
|
|
US9920317B2
(en)
|
2010-11-12 |
2018-03-20 |
The General Hospital Corporation |
Polycomb-associated non-coding RNAs
|
|
JP6336755B2
(ja)
|
2010-11-12 |
2018-06-06 |
ザ ジェネラル ホスピタル コーポレイション |
ポリコームに関連する非コードrna
|
|
US8877722B2
(en)
|
2011-03-25 |
2014-11-04 |
Idera Pharmaceuticals, Inc. |
Compositions for inhibiting gene expression and uses thereof
|
|
EP2508530A1
(en)
|
2011-03-28 |
2012-10-10 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
Purification of triphosphorylated oligonucleotides using capture tags
|
|
EP3533873A1
(en)
|
2011-09-14 |
2019-09-04 |
Translate Bio MA, Inc. |
Multimeric oligonucleotide compounds
|
|
US10837014B2
(en)
|
2012-05-16 |
2020-11-17 |
Translate Bio Ma, Inc. |
Compositions and methods for modulating SMN gene family expression
|
|
CA2873797A1
(en)
|
2012-05-16 |
2013-11-21 |
Rana Therapeutics Inc. |
Compositions and methods for modulating utrn expression
|
|
AU2013262699A1
(en)
|
2012-05-16 |
2015-01-22 |
Rana Therapeutics, Inc. |
Compositions and methods for modulating ATP2A2 expression
|
|
DK2850186T3
(en)
|
2012-05-16 |
2019-04-08 |
Translate Bio Ma Inc |
COMPOSITIONS AND PROCEDURES FOR MODULATING SMN GENFAMILY EXPRESSION
|
|
CA2873779A1
(en)
|
2012-05-16 |
2013-11-21 |
Rana Therapeutics Inc. |
Compositions and methods for modulating mecp2 expression
|
|
BR112014028631A2
(pt)
|
2012-05-16 |
2017-10-17 |
Rana Therapeutics Inc |
composições e métodos para modulação da expressão da família de genes da hemoglobina
|
|
WO2014030066A2
(en)
|
2012-08-22 |
2014-02-27 |
Bernitz Mats Nilsson |
Methods for identifying nucleic acid sequences
|
|
JP2015529469A
(ja)
|
2012-09-14 |
2015-10-08 |
ラナ セラピューティクス インコーポレイテッド |
多量体オリゴヌクレオチド化合物
|
|
EP2712870A1
(en)
|
2012-09-27 |
2014-04-02 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
Novel RIG-I ligands and methods for producing them
|
|
MX391478B
(es)
|
2014-10-10 |
2025-03-21 |
Idera Pharmaceuticals Inc |
Composiciones de agonista de tlr9 e inhibidores de punto de control para usarse en la respuesta inmune contra el cáncer.
|
|
US10858650B2
(en)
|
2014-10-30 |
2020-12-08 |
The General Hospital Corporation |
Methods for modulating ATRX-dependent gene repression
|
|
WO2016130943A1
(en)
|
2015-02-13 |
2016-08-18 |
Rana Therapeutics, Inc. |
Hybrid oligonucleotides and uses thereof
|
|
US10900036B2
(en)
|
2015-03-17 |
2021-01-26 |
The General Hospital Corporation |
RNA interactome of polycomb repressive complex 1 (PRC1)
|
|
EP3337516A4
(en)
|
2015-08-21 |
2019-04-03 |
Pfizer Inc |
THERAPEUTIC NANOPARTICLES WITH A THERAPEUTIC PROCESS AND METHOD FOR THE PRODUCTION AND USE THEREOF
|
|
AR125267A1
(es)
|
2021-04-01 |
2023-06-28 |
Biogen Ma Inc |
Administración de ácido nucleico al sistema nervioso central
|
|
WO2025088117A1
(en)
|
2023-10-25 |
2025-05-01 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
Ribonucleic acid construct capable of inducing an immune response, as well as pharmaceutical composition and kit comprising same
|
|
WO2025158069A1
(en)
|
2024-01-25 |
2025-07-31 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
CONSTRUCT COMPRISING mRNA-STRAND AND RETINOIC ACID-INDUCIBLE GENE I (RIG-I)-LIGAND(S), PHARMACEUTICAL COMPOSITION AND KIT COMPRISING THE SAME
|