JP2008523094A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008523094A5 JP2008523094A5 JP2007545671A JP2007545671A JP2008523094A5 JP 2008523094 A5 JP2008523094 A5 JP 2008523094A5 JP 2007545671 A JP2007545671 A JP 2007545671A JP 2007545671 A JP2007545671 A JP 2007545671A JP 2008523094 A5 JP2008523094 A5 JP 2008523094A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- sequence
- pharmaceutical composition
- oligonucleotide
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63484904P | 2004-12-09 | 2004-12-09 | |
| US60/634,849 | 2004-12-09 | ||
| PCT/US2005/044662 WO2006063252A2 (en) | 2004-12-09 | 2005-12-09 | Compositions and methods for inducing an immune response in a mammal and methods of avoiding an immune response to oligonucleotide agents such as short interfering rnas |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011221109A Division JP2012031191A (ja) | 2004-12-09 | 2011-10-05 | 哺乳類における免疫応答誘導組成物および方法、ならびに短鎖干渉rnaなどのオリゴヌクレオチド剤に対する免疫応答の回避方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008523094A JP2008523094A (ja) | 2008-07-03 |
| JP2008523094A5 true JP2008523094A5 (enExample) | 2011-11-24 |
| JP4981681B2 JP4981681B2 (ja) | 2012-07-25 |
Family
ID=36578622
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007545671A Expired - Lifetime JP4981681B2 (ja) | 2004-12-09 | 2005-12-09 | 哺乳類における免疫応答誘導組成物および方法、ならびに短鎖干渉rnaなどのオリゴヌクレオチド剤に対する免疫応答の回避方法 |
| JP2011221109A Pending JP2012031191A (ja) | 2004-12-09 | 2011-10-05 | 哺乳類における免疫応答誘導組成物および方法、ならびに短鎖干渉rnaなどのオリゴヌクレオチド剤に対する免疫応答の回避方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011221109A Pending JP2012031191A (ja) | 2004-12-09 | 2011-10-05 | 哺乳類における免疫応答誘導組成物および方法、ならびに短鎖干渉rnaなどのオリゴヌクレオチド剤に対する免疫応答の回避方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8003619B2 (enExample) |
| EP (1) | EP1819365B1 (enExample) |
| JP (2) | JP4981681B2 (enExample) |
| AU (1) | AU2005313883B2 (enExample) |
| CA (1) | CA2589406A1 (enExample) |
| WO (1) | WO2006063252A2 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6977245B2 (en) * | 1999-04-12 | 2005-12-20 | The United States Of America As Represented By The Department Of Health And Human Services | Oligodeoxynucleotide and its use to induce an immune response |
| CA2480775C (en) | 2002-04-04 | 2016-05-31 | Coley Pharmaceutical Gmbh | Immunostimulatory g,u-containing oligoribonucleotides |
| MXPA05013658A (es) * | 2003-06-11 | 2006-03-02 | Hybridon Inc | Oligonucleotidos inmunomoduladores estabilizados. |
| US20060134189A1 (en) * | 2004-11-17 | 2006-06-22 | Protiva Biotherapeutics, Inc | siRNA silencing of apolipoprotein B |
| US20070054873A1 (en) * | 2005-08-26 | 2007-03-08 | Protiva Biotherapeutics, Inc. | Glucocorticoid modulation of nucleic acid-mediated immune stimulation |
| WO2007051303A1 (en) | 2005-11-02 | 2007-05-10 | Protiva Biotherapeutics, Inc. | MODIFIED siRNA MOLECULES AND USES THEREOF |
| ES2536103T3 (es) | 2005-11-25 | 2015-05-20 | Zoetis Belgium S.A. | Oligorribonucleótidos inmunoestimuladores |
| US7915399B2 (en) * | 2006-06-09 | 2011-03-29 | Protiva Biotherapeutics, Inc. | Modified siRNA molecules and uses thereof |
| SI2056845T1 (en) * | 2006-08-08 | 2018-02-28 | Rheinische Friedrich-Wilhelms-Universitaet Bonn | STRUCTURE AND USE 5 'PHOSPHATE OF OLIGONUCLEOTES |
| US20080171716A1 (en) * | 2006-08-16 | 2008-07-17 | Protiva Biotherapeutics, Inc. | Nucleic acid modulation of toll-like receptor-mediated immune stimulation |
| US8188060B2 (en) | 2008-02-11 | 2012-05-29 | Dharmacon, Inc. | Duplex oligonucleotides with enhanced functionality in gene regulation |
| EP2297323A1 (en) | 2008-05-21 | 2011-03-23 | Hartmann, Gunther | 5' triphosphate oligonucleotide with blunt end and uses thereof |
| SG171914A1 (en) | 2008-12-02 | 2011-07-28 | Chiralgen Ltd | Method for the synthesis of phosphorus atom modified nucleic acids |
| CA2764158A1 (en) | 2009-06-01 | 2010-12-09 | Halo-Bio Rnai Therapeutics, Inc. | Polynucleotides for multivalent rna interference, compositions and methods of use thereof |
| US8236943B2 (en) * | 2009-07-01 | 2012-08-07 | Protiva Biotherapeutics, Inc. | Compositions and methods for silencing apolipoprotein B |
| EP2451461A4 (en) | 2009-07-06 | 2013-05-29 | Ontorii Inc | NOVEL NUCLEIC ACID PRODRUGS AND METHOD OF USE THEREOF |
| GEP20156313B (en) | 2010-09-22 | 2015-07-10 | Alios Biopharma Inc | Substituted nucleotide analogs |
| DK2620428T3 (da) | 2010-09-24 | 2019-07-01 | Wave Life Sciences Ltd | Asymmetrisk hjælpegruppe |
| WO2012079115A1 (en) * | 2010-12-14 | 2012-06-21 | Commonwealth Scientific And Industrial Research Organisation | Immunostimulatory oligonucleotides |
| EP2508530A1 (en) | 2011-03-28 | 2012-10-10 | Rheinische Friedrich-Wilhelms-Universität Bonn | Purification of triphosphorylated oligonucleotides using capture tags |
| US9605019B2 (en) | 2011-07-19 | 2017-03-28 | Wave Life Sciences Ltd. | Methods for the synthesis of functionalized nucleic acids |
| US8980865B2 (en) | 2011-12-22 | 2015-03-17 | Alios Biopharma, Inc. | Substituted nucleotide analogs |
| US8916538B2 (en) | 2012-03-21 | 2014-12-23 | Vertex Pharmaceuticals Incorporated | Solid forms of a thiophosphoramidate nucleotide prodrug |
| EP2827876A4 (en) | 2012-03-22 | 2015-10-28 | Alios Biopharma Inc | PHARMACEUTICAL COMBINATIONS WITH A THIONUCLEOTIDE ANALOG |
| CN112007045B (zh) | 2012-07-13 | 2026-01-06 | 波涛生命科学有限公司 | 手性控制 |
| JP6246121B2 (ja) * | 2012-07-13 | 2017-12-13 | 株式会社新日本科学 | キラル核酸アジュバント |
| DK2872485T3 (da) | 2012-07-13 | 2021-03-08 | Wave Life Sciences Ltd | Asymmetrisk hjælpegruppe |
| EP2712870A1 (en) | 2012-09-27 | 2014-04-02 | Rheinische Friedrich-Wilhelms-Universität Bonn | Novel RIG-I ligands and methods for producing them |
| US20150366890A1 (en) | 2013-02-25 | 2015-12-24 | Trustees Of Boston University | Compositions and methods for treating fungal infections |
| US10322173B2 (en) | 2014-01-15 | 2019-06-18 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent |
| WO2015108048A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| EP3095461A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator |
| KR102423317B1 (ko) | 2014-01-16 | 2022-07-22 | 웨이브 라이프 사이언시스 리미티드 | 키랄 디자인 |
| WO2017035278A1 (en) | 2015-08-24 | 2017-03-02 | Halo-Bio Rnai Therapeutics, Inc. | Polynucleotide nanoparticles for the modulation of gene expression and uses thereof |
| HUE064227T2 (hu) | 2015-09-21 | 2024-02-28 | Trilink Biotechnologies Llc | Módszer 5'-sapkával ellátott rns-ek szintetizálására |
| AU2016332266B2 (en) * | 2015-09-30 | 2020-05-07 | Shionogi & Co., Ltd. | Nucleic acid derivative having immunostimulatory activity |
| US10940201B2 (en) | 2015-09-30 | 2021-03-09 | Shionogi & Co., Ltd. | Nucleic acid derivative having immunostimulatory activity |
| WO2018067302A2 (en) * | 2016-09-19 | 2018-04-12 | North Western University | Therapeutic effects of cellular delivery of small molecules and macromolecules with liposomal spherical nucleic acids |
| JP7366057B2 (ja) | 2018-04-19 | 2023-10-20 | チェックメイト ファーマシューティカルズ, インコーポレイテッド | 合成rig-i様受容体アゴニスト |
| EP3909612A1 (en) | 2020-05-12 | 2021-11-17 | Life Science Inkubator Betriebs GmbH & Co. KG | Composition of nanoparticles |
| WO2021231845A1 (en) * | 2020-05-15 | 2021-11-18 | Howard University | Compositions and methods for treating and detecting coronavirus infection |
| CN115916978A (zh) | 2020-05-19 | 2023-04-04 | 哈德森医学研究所 | 寡核苷酸 |
| WO2022221736A2 (en) * | 2021-04-16 | 2022-10-20 | Genentech, Inc. | Optimized tlr7 ligands and uses thereof |
| WO2024145478A1 (en) * | 2022-12-30 | 2024-07-04 | Salk Institute For Biological Studies | Transcription factors controlling t cell differentiation and disruption for tumor and virus control |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5149797A (en) | 1990-02-15 | 1992-09-22 | The Worcester Foundation For Experimental Biology | Method of site-specific alteration of rna and production of encoded polypeptides |
| TW244371B (enExample) | 1992-07-23 | 1995-04-01 | Tri Clover Inc | |
| US6346614B1 (en) | 1992-07-23 | 2002-02-12 | Hybridon, Inc. | Hybrid oligonucleotide phosphorothioates |
| US5652355A (en) | 1992-07-23 | 1997-07-29 | Worcester Foundation For Experimental Biology | Hybrid oligonucleotide phosphorothioates |
| EP0755454B1 (en) | 1994-04-13 | 2008-02-13 | The Rockefeller University | Aav-mediated delivery of dna to cells of the nervous system |
| US5753613A (en) | 1994-09-30 | 1998-05-19 | Inex Pharmaceuticals Corporation | Compositions for the introduction of polyanionic materials into cells |
| US5820873A (en) | 1994-09-30 | 1998-10-13 | The University Of British Columbia | Polyethylene glycol modified ceramide lipids and liposome uses thereof |
| US5885613A (en) | 1994-09-30 | 1999-03-23 | The University Of British Columbia | Bilayer stabilizing components and their use in forming programmable fusogenic liposomes |
| US6235310B1 (en) | 1997-04-04 | 2001-05-22 | Valentis, Inc. | Methods of delivery using cationic lipids and helper lipids |
| EP2138191A1 (en) | 1998-01-05 | 2009-12-30 | University Of Washington | Enhanced transport using membrane disruptive agents |
| WO2000003683A2 (en) | 1998-07-20 | 2000-01-27 | Inex Pharmaceuticals Corporation | Liposomal encapsulated nucleic acid-complexes |
| EP1252307B1 (en) * | 2000-01-26 | 2008-01-02 | Idera Pharmaceuticals, Inc. | MODULATION OF OLIGONUCLEOTIDE CpG-MEDIATED IMMUNE STIMULATION BY POSITIONAL MODIFICATION OF NUCLEOSIDES |
| WO2003070918A2 (en) * | 2002-02-20 | 2003-08-28 | Ribozyme Pharmaceuticals, Incorporated | Rna interference by modified short interfering nucleic acid |
| US6413881B1 (en) * | 2000-03-09 | 2002-07-02 | Lsi Logic Corporation | Process for forming thin gate oxide with enhanced reliability by nitridation of upper surface of gate of oxide to form barrier of nitrogen atoms in upper surface region of gate oxide, and resulting product |
| EP1292331A2 (en) | 2000-06-07 | 2003-03-19 | Biosynexus Incorporated | Immunostimulatory rna/dna hybrid molecules |
| US20030077829A1 (en) | 2001-04-30 | 2003-04-24 | Protiva Biotherapeutics Inc.. | Lipid-based formulations |
| US20050159376A1 (en) * | 2002-02-20 | 2005-07-21 | Slrna Therapeutics, Inc. | RNA interference mediated inhibition 5-alpha reductase and androgen receptor gene expression using short interfering nucleic acid (siNA) |
| US20030130186A1 (en) | 2001-07-20 | 2003-07-10 | Chandra Vargeese | Conjugates and compositions for cellular delivery |
| WO2003070910A2 (en) * | 2002-02-20 | 2003-08-28 | Ribozyme Pharmaceuticals, Incorporated | INHIBITION OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) AND VEGF RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| US6586524B2 (en) | 2001-07-19 | 2003-07-01 | Expression Genetics, Inc. | Cellular targeting poly(ethylene glycol)-grafted polymeric gene carrier |
| CA2464626A1 (en) * | 2001-11-05 | 2003-05-15 | Janssen Pharmaceutica N.V. | Method for the in vitro synthesis of short double stranded rnas |
| AU2003207708A1 (en) * | 2002-02-20 | 2003-09-09 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of map kinase genes |
| US6683366B1 (en) | 2002-06-04 | 2004-01-27 | Newport Fab, Llc | Bipolar transistor and related structure |
| DE10229872A1 (de) * | 2002-07-03 | 2004-01-29 | Curevac Gmbh | Immunstimulation durch chemisch modifizierte RNA |
| US20050106731A1 (en) | 2002-08-05 | 2005-05-19 | Davidson Beverly L. | siRNA-mediated gene silencing with viral vectors |
| AU2003301348A1 (en) * | 2002-10-18 | 2004-05-04 | Wyeth | Compositions and methods for diagnosing and treating autoimmune disease |
| JP2006507841A (ja) * | 2002-11-14 | 2006-03-09 | ダーマコン, インコーポレイテッド | 機能的siRNAおよび超機能的siRNA |
| US20040180848A1 (en) | 2003-03-10 | 2004-09-16 | Fesik Stephen W. | Method of killing cancer cells |
| ES2216707B1 (es) | 2003-04-08 | 2005-12-16 | Josep Maria Aran Perramon | Secuencia oligoribonucleotidica homologa a una region del cdna que codifica para el receptor cd40 humano y oligoribonucleotidos duplex, vectores, composiciones farmaceuticas y usos correspondientes. |
| CA2558417A1 (en) | 2004-03-05 | 2005-09-22 | Holland Lp | Multipurpose lading tie anchor system for securing cargo |
-
2005
- 2005-12-09 JP JP2007545671A patent/JP4981681B2/ja not_active Expired - Lifetime
- 2005-12-09 US US11/298,850 patent/US8003619B2/en not_active Expired - Lifetime
- 2005-12-09 WO PCT/US2005/044662 patent/WO2006063252A2/en not_active Ceased
- 2005-12-09 EP EP05853546.9A patent/EP1819365B1/en not_active Expired - Lifetime
- 2005-12-09 CA CA002589406A patent/CA2589406A1/en not_active Abandoned
- 2005-12-09 AU AU2005313883A patent/AU2005313883B2/en not_active Expired
-
2011
- 2011-07-08 US US13/179,421 patent/US20120045461A1/en not_active Abandoned
- 2011-10-05 JP JP2011221109A patent/JP2012031191A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Kang et al. | Small interfering RNA (siRNA)-based therapeutic applications against viruses: principles, potential, and challenges | |
| JP7108011B2 (ja) | 5’リン酸オリゴヌクレオチドの構造および使用 | |
| CN109843902B (zh) | 用于B型肝炎病毒感染的RNAi剂 | |
| KR101343489B1 (ko) | 안정화된 면역 조절성 rna(simra)화합물 | |
| JP5805088B2 (ja) | 遺伝子発現を阻害する組成物およびその使用 | |
| KR101221589B1 (ko) | Tlr7 및 tlr8에 대한 안정화된 면역 조절성 rna〔simra〕 화합물 | |
| CN103333890B (zh) | 治疗乙型病毒性肝炎的rna干扰制剂 | |
| JP4981681B2 (ja) | 哺乳類における免疫応答誘導組成物および方法、ならびに短鎖干渉rnaなどのオリゴヌクレオチド剤に対する免疫応答の回避方法 | |
| US8288358B2 (en) | Therapeutic targets and molecules | |
| CN111511914B (zh) | 减少PAPD5和PAPD7 mRNA的核酸分子用于治疗乙型肝炎感染 | |
| AU2010213795A1 (en) | Synthetic RNA-based agonists of TLR7 | |
| CN113507920A (zh) | 用于乙型肝炎病毒感染的RNAi剂 | |
| AU2014205544B2 (en) | Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response | |
| WO2016149323A1 (en) | Immunomodulatory spherical nucleic acids | |
| JP2023506546A (ja) | B型肝炎ウイルス感染症を処置するためのsept9阻害剤の使用 | |
| TW202020152A (zh) | 調節rtel1表現之寡核苷酸 | |
| KR20210144601A (ko) | 이중가닥 올리고뉴클레오티드 및 이를 포함하는 코로나바이러스감염증-19〔covid-19〕치료용 조성물 | |
| JP2023506547A (ja) | B型肝炎ウイルス感染を処置するためのcops3阻害剤の使用 | |
| Richardt‐Pargmann et al. | Stimulation of the immune system by therapeutic antisense oligodeoxynucleotides and small interfering RNAs via nucleic acid receptors: How to avoid immune activation | |
| CN111154755A (zh) | 一种双链寡核苷酸dna及其应用 | |
| Mehrotra et al. | Therapeutic potential of miRNAs in parasitic infectious diseases | |
| CN121773209A (zh) | 可用于雾化吸入协同治疗特发性肺纤维化的siTGF-β1/siGAS6共递送系统 | |
| TW202444904A (zh) | 用於抑制粒線體醯胺肟還原組分1(MARC1)之表現之RNAi藥劑、其醫藥組合物及使用方法 | |
| CN117957321A (zh) | 产品和组合物 | |
| AU2008251037A1 (en) | Suppression of viruses involved in respiratory infection or disease |