|
US627170A
(en)
|
|
1899-06-20 |
|
Tripod |
|
US1159588A
(en)
|
1913-08-19 |
1915-11-09 |
Jeddie Jubert |
Fruit-picker.
|
|
US5981505A
(en)
|
1993-01-26 |
1999-11-09 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for delivery of genetic material
|
|
AU7404994A
(en)
|
1993-07-30 |
1995-02-28 |
Regents Of The University Of California, The |
Endocardial infusion catheter
|
|
US5837533A
(en)
|
1994-09-28 |
1998-11-17 |
American Home Products Corporation |
Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent
|
|
US5840710A
(en)
|
1994-12-09 |
1998-11-24 |
Genzyme Corporation |
Cationic amphiphiles containing ester or ether-linked lipophilic groups for intracellular delivery of therapeutic molecules
|
|
US6770748B2
(en)
|
1997-03-07 |
2004-08-03 |
Takeshi Imanishi |
Bicyclonucleoside and oligonucleotide analogue
|
|
JP3756313B2
(ja)
|
1997-03-07 |
2006-03-15 |
武 今西 |
新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
|
|
US6416510B1
(en)
|
1997-03-13 |
2002-07-09 |
Biocardia, Inc. |
Drug delivery catheters that attach to tissue and methods for their use
|
|
US6217900B1
(en)
|
1997-04-30 |
2001-04-17 |
American Home Products Corporation |
Vesicular complexes and methods of making and using the same
|
|
EP1012331B1
(en)
|
1997-07-01 |
2006-03-29 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for the delivery of oligonucleotides via the alimentary canal
|
|
US6794499B2
(en)
|
1997-09-12 |
2004-09-21 |
Exiqon A/S |
Oligonucleotide analogues
|
|
US6749617B1
(en)
|
1997-11-04 |
2004-06-15 |
Scimed Life Systems, Inc. |
Catheter and implants for the delivery of therapeutic agents to tissues
|
|
WO1999060855A1
(en)
|
1998-05-26 |
1999-12-02 |
Icn Pharmaceuticals, Inc. |
Novel nucleosides having bicyclic sugar moiety
|
|
US6833361B2
(en)
|
1998-05-26 |
2004-12-21 |
Ribapharm, Inc. |
Nucleosides having bicyclic sugar moiety
|
|
AU3274500A
(en)
|
1999-03-18 |
2000-10-09 |
Exiqon A/S |
Detection of mutations in genes by specific lna primers
|
|
ATE325806T1
(de)
|
2000-10-04 |
2006-06-15 |
Santaris Pharma As |
Verbesserte synthese von purin-blockierten nukleinsäure-analoga
|
|
JP4371812B2
(ja)
|
2001-09-28 |
2009-11-25 |
マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ |
マイクロｒｎａ分子
|
|
EP2298358A1
(en)
|
2002-05-06 |
2011-03-23 |
Alnylam Pharmaceuticals Inc. |
Methods for delivery of nucleic acids
|
|
US20080214437A1
(en)
|
2002-09-06 |
2008-09-04 |
Mohapatra Shyam S |
Methods and compositions for reducing activity of the atrial natriuretic peptide receptor and for treatment of diseases
|
|
EP2752488B1
(en)
|
2002-11-18 |
2020-02-12 |
Roche Innovation Center Copenhagen A/S |
Antisense design
|
|
WO2005013901A2
(en)
|
2003-07-31 |
2005-02-17 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and compositions for use in modulation of small non-coding rnas
|
|
WO2005017145A1
(ja)
|
2003-08-13 |
2005-02-24 |
Japan Biological Informatics Consortium |
機能性ｒｎａが制御する被制御遺伝子の同定・予測方法及びその利用方法
|
|
WO2005078096A2
(en)
|
2004-02-09 |
2005-08-25 |
University Of Massachusetts |
Dual functional oligonucleotides for use in repressing mutant gene expression
|
|
WO2005078139A2
(en)
|
2004-02-09 |
2005-08-25 |
Thomas Jefferson University |
DIAGNOSIS AND TREATMENT OF CANCERS WITH MicroRNA LOCATED IN OR NEAR CANCER-ASSOCIATED CHROMOSOMAL FEATURES
|
|
WO2005079397A2
(en)
|
2004-02-13 |
2005-09-01 |
Rockefeller University |
Anti-microrna oligonucleotide molecules
|
|
US20070203445A1
(en)
|
2004-02-26 |
2007-08-30 |
V-Kardia Pty Ltd |
Isolating cardiac circulation
|
|
AU2005216564A1
(en)
|
2004-02-26 |
2005-09-09 |
Osprey Medical Inc. |
Isolating cardiac circulation
|
|
US7722596B2
(en)
|
2004-02-26 |
2010-05-25 |
Osprey Medical, Inc. |
Regional cardiac tissue treatment
|
|
EP2290072B1
(en)
|
2004-05-28 |
2014-12-17 |
Asuragen, Inc. |
Methods and compositions involving microRNA
|
|
ES2534304T3
(es)
|
2004-11-12 |
2015-04-21 |
Asuragen, Inc. |
Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN
|
|
WO2006063356A1
(en)
|
2004-12-10 |
2006-06-15 |
Isis Phamaceuticals, Inc. |
Regulation of epigenetic control of gene expression
|
|
US20060185027A1
(en)
|
2004-12-23 |
2006-08-17 |
David Bartel |
Systems and methods for identifying miRNA targets and for altering miRNA and target expression
|
|
US20070099196A1
(en)
|
2004-12-29 |
2007-05-03 |
Sakari Kauppinen |
Novel oligonucleotide compositions and probe sequences useful for detection and analysis of micrornas and their target mRNAs
|
|
US8071306B2
(en)
|
2005-01-25 |
2011-12-06 |
Merck Sharp & Dohme Corp. |
Methods for quantitating small RNA molecules
|
|
US7404969B2
(en)
|
2005-02-14 |
2008-07-29 |
Sirna Therapeutics, Inc. |
Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules
|
|
WO2006089340A2
(en)
|
2005-02-23 |
2006-08-31 |
V-Kardia Pty Ltd |
Polynucleotide delivery to cardiac tissue
|
|
BRPI0608829A2
(pt)
|
2005-04-19 |
2011-03-15 |
Basf Plant Science Gmbh |
método para a expressão transgênica com especificidade intensificada em uma planta, uso de um construto de ácido nucleico quimérico, seqüência de ribonucleotìdeo quimérica, construto de expressão, vetor de expressão, organismo não-humano ou célula transformada, semente transformada, e, preparação farmacêutica
|
|
SG162726A1
(en)
|
2005-05-27 |
2010-07-29 |
San Raffaele Centro Fond |
Gene vector comprising mi-rna
|
|
PL1969125T3
(pl)
|
2005-12-12 |
2012-11-30 |
Univ North Carolina Chapel Hill |
Mikrorna, które regulują proliferację i różnicowanie komórek mięśniowych
|
|
JP5213723B2
(ja)
|
2006-01-27 |
2013-06-19 |
アイシス ファーマシューティカルズ， インコーポレーテッド |
マイクロｒｎａの調節に使用するためのオリゴマー化合物及び組成物
|
|
ES2715625T3
(es)
|
2006-04-03 |
2019-06-05 |
Roche Innovation Ct Copenhagen As |
Composición farmacéutica que comprende oligonucleótidos antisentido anti-miARN
|
|
ES2397439T3
(es)
*
|
2006-08-01 |
2013-03-07 |
Board Of Regents Of The University Of Texas System |
Identificación de un microARN que activa la expresión de la cadena pesada beta de la miosina
|
|
WO2008042231A2
(en)
|
2006-09-29 |
2008-04-10 |
Children's Medical Center Corporation |
Compositions and methods for evaluating and treating heart failure
|
|
AU2007306594A1
(en)
|
2006-10-09 |
2008-04-17 |
Julius-Maximilians-Universitat Wurzburg |
MicroRNA (miRNA) for the diagnosis and treatment of heart diseases
|
|
WO2008147430A2
(en)
|
2006-10-11 |
2008-12-04 |
Nucleonics, Inc. |
Microrna-formatted multitarget interfering rna vector constructs and methods of using the same
|
|
AU2007323469B2
(en)
|
2006-11-23 |
2014-07-24 |
Guangdong Maijinjia Biotechnology Co., Ltd |
Oligonucleotides for modulating target RNA activity
|
|
EP2104733A2
(en)
|
2006-12-14 |
2009-09-30 |
Novartis AG |
Compositions and methods to treat muscular and cardiovascular disorders
|
|
EP2113567B1
(en)
|
2006-12-21 |
2019-04-03 |
QIAGEN GmbH |
MicroRNA target site blocking oligos and uses thereof
|
|
WO2008074328A2
(en)
|
2006-12-21 |
2008-06-26 |
Exiqon A/S |
Microrna target site blocking oligos and uses thereof
|
|
US8580756B2
(en)
|
2007-03-22 |
2013-11-12 |
Santaris Pharma A/S |
Short oligomer antagonist compounds for the modulation of target mRNA
|
|
WO2008131191A2
(en)
*
|
2007-04-20 |
2008-10-30 |
Amgen Inc. |
Nucleic acids hybridizable to micro rna and precursors thereof
|
|
WO2008147839A1
(en)
|
2007-05-23 |
2008-12-04 |
Dharmacon, Inc. |
Micro-rna scaffolds and non-naturally occurring micro-rnas
|
|
US8481507B2
(en)
|
2007-07-31 |
2013-07-09 |
The Board Of Regents, The University Of Texas System |
Micro-RNAs that control myosin expression and myofiber identity
|
|
EP2192925A4
(en)
|
2007-08-23 |
2013-04-03 |
Keren Pharmaceuticals |
TARGETING RNA WITH EXTERNAL GUIDE SEQUENCES
|
|
JP5624470B2
(ja)
|
2007-09-14 |
2014-11-12 |
ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイションＴｈｅ Ｏｈｉｏ Ｓｔａｔｅ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ |
ヒト末梢血微小胞におけるｍｉＲＮＡの発現およびその使用
|
|
DK2205737T3
(da)
|
2007-10-04 |
2013-05-21 |
Santaris Pharma As |
Mikromirer
|
|
WO2009058818A2
(en)
|
2007-10-29 |
2009-05-07 |
The Board Of Regents Of The University Of Texas System |
Compositions comprising a micro-rna and methods of their use in regulating cardiac remodeling
|
|
CN101424640B
(zh)
|
2007-11-02 |
2012-07-25 |
江苏命码生物科技有限公司 |
血清中微小核糖核酸的检测方法和用于检测的试剂盒、生物芯片及其制作和应用方法
|
|
JP5654352B2
(ja)
|
2007-11-09 |
2015-01-14 |
ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム |
ｍｉＲ−１５ファミリーのマイクロＲＮＡによる心筋細胞生存及び心臓修復の調節
|
|
US8404658B2
(en)
|
2007-12-31 |
2013-03-26 |
Nanocor Therapeutics, Inc. |
RNA interference for the treatment of heart failure
|
|
EP2096171A1
(en)
*
|
2008-02-27 |
2009-09-02 |
Julius-Maximilians-Universität Würzburg |
MicroRNA (miRNA) and down-stream targets for diagnostic and therapeutic purposes
|
|
WO2009114681A2
(en)
|
2008-03-13 |
2009-09-17 |
Dharmacon, Inc. |
Identification of mirna profiles that are diagnostic of hypertrophic cardiomyopathy
|
|
US20090326049A1
(en)
|
2008-04-04 |
2009-12-31 |
Alexander Aristarkhov |
Blocking oligos for inhibition of microrna and sirna activity and uses thereof
|
|
CA2726052A1
(en)
|
2008-06-04 |
2009-12-10 |
The Board Of Regents Of The University Of Texas System |
Modulation of gene expression through endogenous small rna targeting of gene promoters
|
|
US20110152352A1
(en)
|
2008-06-10 |
2011-06-23 |
Tufts University |
Smad proteins control drosha-mediated mirna maturation
|
|
CN101386848A
(zh)
*
|
2008-08-12 |
2009-03-18 |
南京大学 |
细胞微粒子所载微小核糖核酸及其制备研究方法和应用
|
|
EP2346883B1
(en)
|
2008-09-23 |
2016-03-23 |
Scott G. Petersen |
Self delivering bio-labile phosphate protected pro-oligos for oligonucleotide based therapeutics and mediating rna interference
|
|
US8987435B2
(en)
|
2008-10-24 |
2015-03-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and methods
|
|
US20100249214A1
(en)
|
2009-02-11 |
2010-09-30 |
Dicerna Pharmaceuticals |
Multiplex dicer substrate rna interference molecules having joining sequences
|
|
MX2011008190A
(es)
*
|
2009-02-04 |
2011-10-06 |
Univ Texas |
Direccionamiento dual de mir-208 y mir-499 en el tratamiento de trastornos cardiacos.
|
|
WO2010129672A1
(en)
|
2009-05-05 |
2010-11-11 |
Miragen Therapeutics |
Lipophilic polynucleotide conjugates
|
|
EA022757B1
(ru)
*
|
2009-06-08 |
2016-02-29 |
Мираджен Терапьютикс |
МОТИВЫ ХИМИЧЕСКИХ МОДИФИКАЦИЙ ДЛЯ ИНГИБИТОРОВ И МИМЕТИКОВ мкРНК
|
|
US9078914B2
(en)
|
2009-09-10 |
2015-07-14 |
Velin-Pharma A/S |
Method for the preparation of micro-RNA and its therapeutic application
|
|
EP2490699A1
(en)
|
2009-10-20 |
2012-08-29 |
Santaris Pharma A/S |
Oral delivery of therapeutically effective lna oligonucleotides
|
|
US8592151B2
(en)
|
2009-11-17 |
2013-11-26 |
Musc Foundation For Research Development |
Assessing left ventricular remodeling via temporal detection and measurement of microRNA in body fluids
|
|
US20130109738A1
(en)
|
2010-02-24 |
2013-05-02 |
The Board Of Trustees Of The Leland Stanford Junior University |
Control of Cardiac Growth, Differentiation and Hypertrophy
|
|
WO2011117353A1
(en)
|
2010-03-24 |
2011-09-29 |
Mirrx Therapeutics A/S |
Bivalent antisense oligonucleotides
|
|
WO2011127625A1
(zh)
|
2010-04-13 |
2011-10-20 |
江苏命码生物科技有限公司 |
一种调节生物体内微小核糖核酸含量的方法及其用途
|
|
EP2865765B1
(en)
|
2010-04-20 |
2016-08-17 |
Hummingbird Diagnostics GmbH |
Complex miRNA sets as novel biomarkers for an acute coronary syndrome
|
|
WO2011139911A2
(en)
|
2010-04-29 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
Lipid formulated single stranded rna
|
|
EP2580328A2
(en)
|
2010-06-11 |
2013-04-17 |
Cellartis AB |
Micrornas for the detection and isolaton of human embryonic stem cell-derived cardiac cell types
|
|
ITMI20101089A1
(it)
|
2010-06-16 |
2011-12-17 |
Istituto Naz Di Genetica Molecolare Ingm |
Profili di espressione di micro-rna nel sangue periferico per il monitoraggio del sistema immunitario
|
|
CA2804791C
(en)
|
2010-07-08 |
2019-07-30 |
Duke University |
Direct reprogramming of cells to cardiac myocyte fate
|
|
US20130137753A1
(en)
|
2010-08-03 |
2013-05-30 |
University Of South Alabama |
Methods and compositions for the diagnosis and treatment of breast cancer
|
|
EP2603592A2
(en)
|
2010-08-13 |
2013-06-19 |
The University Court of the University of Glasgow |
Therapeutic uses of microvesicles and related micrornas
|
|
WO2012027206A1
(en)
|
2010-08-24 |
2012-03-01 |
Merck Sharp & Dohme Corp. |
SINGLE-STRANDED RNAi AGENTS CONTAINING AN INTERNAL, NON-NUCLEIC ACID SPACER
|
|
CN103380215A
(zh)
*
|
2010-12-15 |
2013-10-30 |
米拉根医疗公司 |
包含锁定核苷酸的微rna抑制剂
|
|
WO2012149646A1
(en)
|
2011-05-05 |
2012-11-08 |
Sunnybrook Research Institute |
Mirna inhibitors and their uses
|
|
JP6177243B2
(ja)
|
2011-10-06 |
2017-08-09 |
ミラゲン セラピューティクス， インコーポレイテッド |
マイクロｒｎａの調節による全身エネルギーホメオスタシスの制御
|
|
GB201117482D0
(en)
|
2011-10-11 |
2011-11-23 |
Univ Dundee |
Targetiing of miRNA precursors
|
|
EP2584040A1
(en)
|
2011-10-17 |
2013-04-24 |
Pharmahungary 2000 Kft. |
Compounds for treatment of ischemic injury
|
|
ES2897565T3
(es)
|
2011-10-18 |
2022-03-01 |
Dicerna Pharmaceuticals Inc |
Lípidos catiónicos de amina y uso de los mismos
|
|
JP2015502365A
(ja)
|
2011-12-12 |
2015-01-22 |
オンコイミューニン，インコーポレイティド |
オリゴヌクレオチドのイン−ビボ送達
|
|
EP2604690A1
(en)
|
2011-12-15 |
2013-06-19 |
Oncostamen S.r.l. |
MicroRNAs and uses thereof
|
|
EP2791337A1
(en)
|
2011-12-15 |
2014-10-22 |
Oncostamen S.r.l. |
Micrornas and uses therof
|
|
FR2984358A1
(fr)
|
2011-12-16 |
2013-06-21 |
Genethon |
Methodes pour le diagnostic de dystrophies musculaires
|
|
DK3354734T3
(da)
*
|
2012-06-21 |
2020-06-29 |
Miragen Therapeutics Inc |
Oligonukleotid-baserede hæmmere omfattende låst nukleinsyremønster
|