JP2014504857A5 - - Google Patents

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Publication number

JP2014504857A5

JP2014504857A5 JP2013544772A JP2013544772A JP2014504857A5 JP 2014504857 A5 JP2014504857 A5 JP 2014504857A5 JP 2013544772 A JP2013544772 A JP 2013544772A JP 2013544772 A JP2013544772 A JP 2013544772A JP 2014504857 A5 JP2014504857 A5 JP 2014504857A5

Authority

JP

Japan

Prior art keywords

locked

nucleotides

oligonucleotide

nucleotide

mir

Prior art date

2011-12-15

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

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• 108091034117 Oligonucleotide Proteins 0.000 claims 25
• 125000001921 locked nucleotide group Chemical group 0.000 claims 23
• 239000002773 nucleotide Substances 0.000 claims 12
• 125000003729 nucleotide group Chemical group 0.000 claims 12
• JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 3
• 108091071651 miR-208 stem-loop Proteins 0.000 claims 3
• 108091084446 miR-208a stem-loop Proteins 0.000 claims 3
• 108091062547 miR-208a-1 stem-loop Proteins 0.000 claims 3
• 108091055375 miR-208a-2 stem-loop Proteins 0.000 claims 3
• 108091047268 miR-208b stem-loop Proteins 0.000 claims 3
• 230000000295 complement effect Effects 0.000 claims 2
• 108091056170 miR-499 stem-loop Proteins 0.000 claims 2
• 108091050885 miR-499-1 stem-loop Proteins 0.000 claims 2
• 108091038523 miR-499-2 stem-loop Proteins 0.000 claims 2
• RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 2
• 206010019280 Heart failures Diseases 0.000 claims 1
• 206010020880 Hypertrophy Diseases 0.000 claims 1
• 108091092539 MiR-208 Proteins 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 125000001475 halogen functional group Chemical group 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1
• 238000003670 luciferase enzyme activity assay Methods 0.000 claims 1
• 230000001404 mediated effect Effects 0.000 claims 1
• 108091070501 miRNA Proteins 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 238000010172 mouse model Methods 0.000 claims 1
• 208000010125 myocardial infarction Diseases 0.000 claims 1
• 230000001575 pathological effect Effects 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1