JP2014513954A5 - - Google Patents
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- JP2014513954A5 JP2014513954A5 JP2014506595A JP2014506595A JP2014513954A5 JP 2014513954 A5 JP2014513954 A5 JP 2014513954A5 JP 2014506595 A JP2014506595 A JP 2014506595A JP 2014506595 A JP2014506595 A JP 2014506595A JP 2014513954 A5 JP2014513954 A5 JP 2014513954A5
- Authority
- JP
- Japan
- Prior art keywords
- wing segment
- linked nucleosides
- modified oligonucleotide
- sugar
- stranded modified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000002777 nucleoside Substances 0.000 claims 46
- 125000003835 nucleoside group Chemical group 0.000 claims 36
- 108091034117 Oligonucleotide Proteins 0.000 claims 34
- 150000001875 compounds Chemical class 0.000 claims 26
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 18
- LRSASMSXMSNRBT-UHFFFAOYSA-N 5-methylcytosine Chemical group CC1=CNC(=O)N=C1N LRSASMSXMSNRBT-UHFFFAOYSA-N 0.000 claims 10
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 10
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 10
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 10
- 229940104302 cytosine Drugs 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 3
- 208000019425 cirrhosis of liver Diseases 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 150000008266 deoxy sugars Chemical class 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 208000036066 Hemophagocytic Lymphohistiocytosis Diseases 0.000 claims 1
- 206010019663 Hepatic failure Diseases 0.000 claims 1
- 208000032672 Histiocytosis haematophagic Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 206010023126 Jaundice Diseases 0.000 claims 1
- 206010058874 Viraemia Diseases 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 230000007882 cirrhosis Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000014752 hemophagocytic syndrome Diseases 0.000 claims 1
- 208000006454 hepatitis Diseases 0.000 claims 1
- 231100000283 hepatitis Toxicity 0.000 claims 1
- 208000002672 hepatitis B Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000019423 liver disease Diseases 0.000 claims 1
- 208000007903 liver failure Diseases 0.000 claims 1
- 231100000835 liver failure Toxicity 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161478038P | 2011-04-21 | 2011-04-21 | |
| US201161478040P | 2011-04-21 | 2011-04-21 | |
| US61/478,038 | 2011-04-21 | ||
| US61/478,040 | 2011-04-21 | ||
| US201261596692P | 2012-02-08 | 2012-02-08 | |
| US201261596690P | 2012-02-08 | 2012-02-08 | |
| US61/596,692 | 2012-02-08 | ||
| US61/596,690 | 2012-02-08 | ||
| PCT/US2012/034550 WO2012145697A1 (en) | 2011-04-21 | 2012-04-20 | Modulation of hepatitis b virus (hbv) expression |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016219348A Division JP6426678B2 (ja) | 2011-04-21 | 2016-11-10 | Ｂ型肝炎ウイルス（ｈｂｖ）発現の調節 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014513954A JP2014513954A (ja) | 2014-06-19 |
| JP2014513954A5 true JP2014513954A5 (enExample) | 2015-05-14 |
| JP6042871B2 JP6042871B2 (ja) | 2016-12-14 |
Family
ID=47041953
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014506595A Active JP6042871B2 (ja) | 2011-04-21 | 2012-04-20 | Ｂ型肝炎ウイルス（ｈｂｖ）発現の調節 |
| JP2016219348A Active JP6426678B2 (ja) | 2011-04-21 | 2016-11-10 | Ｂ型肝炎ウイルス（ｈｂｖ）発現の調節 |
| JP2018199169A Active JP6743106B2 (ja) | 2011-04-21 | 2018-10-23 | Ｂ型肝炎ウイルス（ｈｂｖ）発現の調節 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016219348A Active JP6426678B2 (ja) | 2011-04-21 | 2016-11-10 | Ｂ型肝炎ウイルス（ｈｂｖ）発現の調節 |
| JP2018199169A Active JP6743106B2 (ja) | 2011-04-21 | 2018-10-23 | Ｂ型肝炎ウイルス（ｈｂｖ）発現の調節 |
Country Status (35)
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