JP2020111594A5 - - Google Patents
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- JP2020111594A5 JP2020111594A5 JP2020050456A JP2020050456A JP2020111594A5 JP 2020111594 A5 JP2020111594 A5 JP 2020111594A5 JP 2020050456 A JP2020050456 A JP 2020050456A JP 2020050456 A JP2020050456 A JP 2020050456A JP 2020111594 A5 JP2020111594 A5 JP 2020111594A5
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- Prior art keywords
- pharmaceutical composition
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- animals
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- fragment
- Prior art date
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- 239000012634 fragment Substances 0.000 claims 36
- 239000002777 nucleoside Substances 0.000 claims 22
- 239000008194 pharmaceutical composition Substances 0.000 claims 22
- 108091034117 Oligonucleotide Proteins 0.000 claims 18
- 241001465754 Metazoa Species 0.000 claims 17
- 238000000034 method Methods 0.000 claims 13
- 125000003835 nucleoside group Chemical group 0.000 claims 13
- 239000003795 chemical substances by application Substances 0.000 claims 8
- 239000003112 inhibitor Substances 0.000 claims 7
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 6
- 208000024891 symptom Diseases 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 4
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 4
- 208000024172 Cardiovascular disease Diseases 0.000 claims 3
- 206010033645 Pancreatitis Diseases 0.000 claims 3
- -1 antibody Chemical class 0.000 claims 3
- 229940104302 cytosine Drugs 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 230000002526 effect on cardiovascular system Effects 0.000 claims 3
- 208000030159 metabolic disease Diseases 0.000 claims 3
- 230000000692 anti-sense effect Effects 0.000 claims 2
- 239000003529 anticholesteremic agent Substances 0.000 claims 2
- 229940127226 anticholesterol agent Drugs 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- HWPZZUQOWRWFDB-UHFFFAOYSA-N 1-methylcytosine Chemical compound CN1C=CC(N)=NC1=O HWPZZUQOWRWFDB-UHFFFAOYSA-N 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 239000004131 EU approved raising agent Substances 0.000 claims 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 1
- 239000003472 antidiabetic agent Substances 0.000 claims 1
- 229940125708 antidiabetic agent Drugs 0.000 claims 1
- 239000003524 antilipemic agent Substances 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 229940125753 fibrate Drugs 0.000 claims 1
- 229940013317 fish oils Drugs 0.000 claims 1
- 235000010855 food raising agent Nutrition 0.000 claims 1
- 238000010448 genetic screening Methods 0.000 claims 1
- 230000010030 glucose lowering effect Effects 0.000 claims 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 229960003512 nicotinic acid Drugs 0.000 claims 1
- 235000001968 nicotinic acid Nutrition 0.000 claims 1
- 239000011664 nicotinic acid Substances 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361764969P | 2013-02-14 | 2013-02-14 | |
| US61/764,969 | 2013-02-14 | ||
| US201361880779P | 2013-09-20 | 2013-09-20 | |
| US61/880,779 | 2013-09-20 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018054633A Division JP6681422B2 (ja) | 2013-02-14 | 2018-03-22 | リポタンパク質リパーゼ欠損（ｌｐｌｄ）集団におけるアポリポタンパク質ｃ−ｉｉｉ（ａｐｏｃｉｉｉ）発現の調節 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020111594A JP2020111594A (ja) | 2020-07-27 |
| JP2020111594A5 true JP2020111594A5 (enExample) | 2020-09-24 |
Family
ID=51354689
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015558162A Active JP6313789B2 (ja) | 2013-02-14 | 2014-02-14 | リポタンパク質リパーゼ欠損（ｌｐｌｄ）集団におけるアポリポタンパク質ｃ−ｉｉｉ（ａｐｏｃｉｉｉ）発現の調節 |
| JP2018054633A Active JP6681422B2 (ja) | 2013-02-14 | 2018-03-22 | リポタンパク質リパーゼ欠損（ｌｐｌｄ）集団におけるアポリポタンパク質ｃ−ｉｉｉ（ａｐｏｃｉｉｉ）発現の調節 |
| JP2020050456A Withdrawn JP2020111594A (ja) | 2013-02-14 | 2020-03-23 | リポタンパク質リパーゼ欠損（ｌｐｌｄ）集団におけるアポリポタンパク質ｃ−ｉｉｉ（ａｐｏｃｉｉｉ）発現の調節 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015558162A Active JP6313789B2 (ja) | 2013-02-14 | 2014-02-14 | リポタンパク質リパーゼ欠損（ｌｐｌｄ）集団におけるアポリポタンパク質ｃ−ｉｉｉ（ａｐｏｃｉｉｉ）発現の調節 |
| JP2018054633A Active JP6681422B2 (ja) | 2013-02-14 | 2018-03-22 | リポタンパク質リパーゼ欠損（ｌｐｌｄ）集団におけるアポリポタンパク質ｃ−ｉｉｉ（ａｐｏｃｉｉｉ）発現の調節 |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US9593333B2 (enExample) |
| EP (2) | EP3400947B1 (enExample) |
| JP (3) | JP6313789B2 (enExample) |
| KR (2) | KR20200123263A (enExample) |
| CN (2) | CN104994884B (enExample) |
| AU (3) | AU2014216137B2 (enExample) |
| BR (1) | BR112015019515A8 (enExample) |
| CA (2) | CA2901119C (enExample) |
| DK (1) | DK2956176T3 (enExample) |
| ES (2) | ES2961686T3 (enExample) |
| IL (2) | IL240338B (enExample) |
| MX (2) | MX368155B (enExample) |
| NZ (1) | NZ631119A (enExample) |
| RU (2) | RU2661781C2 (enExample) |
| WO (1) | WO2014127268A2 (enExample) |
| ZA (1) | ZA201505628B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG194671A1 (en) * | 2011-04-27 | 2013-12-30 | Isis Pharmaceuticals Inc | Modulation of apolipoprotein ciii (apociii) expression |
| CA2901119C (en) * | 2013-02-14 | 2022-10-18 | Isis Pharmaceuticals, Inc. | Modulation of apolipoprotein c-iii (apociii) expression in lipoprotein lipase deficient (lpld) populations |
| EP3564374A1 (en) * | 2013-06-21 | 2019-11-06 | Ionis Pharmaceuticals, Inc. | Compositions and methods for modulation of target nucleic acids |
| HK1248522A1 (zh) * | 2015-02-27 | 2018-10-19 | Ionis Pharmaceuticals, Inc. | 调节脂肪代谢障碍群体中的载脂蛋白c-iii(apociii)表达 |
| MA45602A (fr) | 2016-07-08 | 2019-05-15 | Staten Biotechnology B V | Anticorps anti-apoc3 et leurs méthodes d'utilisation |
| EP3548005A4 (en) | 2016-11-29 | 2020-06-17 | Puretech Health LLC | Exosomes for delivery of therapeutic agents |
| CN110506056A (zh) | 2017-04-21 | 2019-11-26 | 斯塔滕生物技术有限公司 | 抗apoc3抗体和其使用方法 |
| JP2020522510A (ja) | 2017-06-02 | 2020-07-30 | ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． | オリゴヌクレオチド組成物及びその使用方法 |
| US10538583B2 (en) | 2017-10-31 | 2020-01-21 | Staten Biotechnology B.V. | Anti-APOC3 antibodies and compositions thereof |
| MX2020004512A (es) | 2017-10-31 | 2020-08-13 | Anticuerpos anti apolipoproteina c-iii (anti-apoc3) y metodos de uso de los mismos. | |
| CA3098624A1 (en) | 2018-05-11 | 2019-11-14 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods of use thereof |
| IL300882A (en) * | 2020-10-02 | 2023-04-01 | Ionis Pharmaceuticals Inc | Methods for reducing APOCIII expression |
| CN116814621B (zh) * | 2022-08-05 | 2025-09-09 | 厦门甘宝利生物医药有限公司 | 一种抑制apoc3基因表达的rna抑制剂及其应用 |
| WO2025110984A1 (en) * | 2023-11-21 | 2025-05-30 | Hydrogene Therapeutics, Inc. | Compositions and methods for treating wilson's disease |
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-
2014
- 2014-02-14 CA CA2901119A patent/CA2901119C/en active Active
- 2014-02-14 CN CN201480007862.5A patent/CN104994884B/zh active Active
- 2014-02-14 EP EP18179911.5A patent/EP3400947B1/en active Active
- 2014-02-14 RU RU2015139055A patent/RU2661781C2/ru active
- 2014-02-14 KR KR1020207029914A patent/KR20200123263A/ko not_active Withdrawn
- 2014-02-14 ES ES18179911T patent/ES2961686T3/es active Active
- 2014-02-14 MX MX2015010487A patent/MX368155B/es active IP Right Grant
- 2014-02-14 DK DK14751357.6T patent/DK2956176T3/en active
- 2014-02-14 KR KR1020157023995A patent/KR102169899B1/ko active Active
- 2014-02-14 AU AU2014216137A patent/AU2014216137B2/en active Active
- 2014-02-14 US US14/768,180 patent/US9593333B2/en active Active
- 2014-02-14 WO PCT/US2014/016546 patent/WO2014127268A2/en not_active Ceased
- 2014-02-14 RU RU2018121529A patent/RU2018121529A/ru not_active Application Discontinuation
- 2014-02-14 BR BR112015019515A patent/BR112015019515A8/pt not_active Application Discontinuation
- 2014-02-14 NZ NZ631119A patent/NZ631119A/en unknown
- 2014-02-14 CN CN201810652342.XA patent/CN108743943A/zh active Pending
- 2014-02-14 CA CA3170716A patent/CA3170716A1/en active Pending
- 2014-02-14 ES ES14751357.6T patent/ES2680599T3/es active Active
- 2014-02-14 JP JP2015558162A patent/JP6313789B2/ja active Active
- 2014-02-14 EP EP14751357.6A patent/EP2956176B1/en active Active
-
2015
- 2015-08-03 IL IL240338A patent/IL240338B/en not_active IP Right Cessation
- 2015-08-04 ZA ZA201505628A patent/ZA201505628B/en unknown
- 2015-08-13 MX MX2019011188A patent/MX2019011188A/es unknown
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2017
- 2017-01-25 US US15/415,408 patent/US20170233732A1/en not_active Abandoned
-
2018
- 2018-03-22 JP JP2018054633A patent/JP6681422B2/ja active Active
- 2018-08-03 AU AU2018211325A patent/AU2018211325B2/en active Active
-
2019
- 2019-02-25 US US16/284,998 patent/US20200017854A1/en not_active Abandoned
-
2020
- 2020-03-23 JP JP2020050456A patent/JP2020111594A/ja not_active Withdrawn
- 2020-03-31 AU AU2020202300A patent/AU2020202300A1/en not_active Withdrawn
- 2020-06-09 IL IL275246A patent/IL275246A/en unknown
-
2021
- 2021-07-09 US US17/372,173 patent/US20220213472A1/en active Pending
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