JP6313789B2 - リポタンパク質リパーゼ欠損（ｌｐｌｄ）集団におけるアポリポタンパク質ｃ−ｉｉｉ（ａｐｏｃｉｉｉ）発現の調節 - Google Patents

リポタンパク質リパーゼ欠損（ｌｐｌｄ）集団におけるアポリポタンパク質ｃ−ｉｉｉ（ａｐｏｃｉｉｉ）発現の調節 Download PDF

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JP6313789B2
JP6313789B2 JP2015558162A JP2015558162A JP6313789B2 JP 6313789 B2 JP6313789 B2 JP 6313789B2 JP 2015558162 A JP2015558162 A JP 2015558162A JP 2015558162 A JP2015558162 A JP 2015558162A JP 6313789 B2 JP6313789 B2 JP 6313789B2
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certain embodiments
apociii
modified
lpld
antisense
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JP2016513110A5 (enExample
JP2016513110A (ja
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アレクサンダー，ベロニカ・ジェイ
バイニー，ニコラス・ジェイ
ウィツタム，ジョゼフ・エル
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Ionis Pharmaceuticals Inc
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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JP2015558162A 2013-02-14 2014-02-14 リポタンパク質リパーゼ欠損（ｌｐｌｄ）集団におけるアポリポタンパク質ｃ−ｉｉｉ（ａｐｏｃｉｉｉ）発現の調節 Active JP6313789B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361764969P 2013-02-14 2013-02-14
US61/764,969 2013-02-14
US201361880779P 2013-09-20 2013-09-20
US61/880,779 2013-09-20
PCT/US2014/016546 WO2014127268A2 (en) 2013-02-14 2014-02-14 Modulation of apolipoprotein c-iii (apociii) expression in lipoprotein lipase deficient (lpld) populations

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JP2018054633A Division JP6681422B2 (ja) 2013-02-14 2018-03-22 リポタンパク質リパーゼ欠損（ｌｐｌｄ）集団におけるアポリポタンパク質ｃ−ｉｉｉ（ａｐｏｃｉｉｉ）発現の調節

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JP2016513110A JP2016513110A (ja) 2016-05-12
JP2016513110A5 JP2016513110A5 (enExample) 2017-03-16
JP6313789B2 true JP6313789B2 (ja) 2018-04-18

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JP2015558162A Active JP6313789B2 (ja) 2013-02-14 2014-02-14 リポタンパク質リパーゼ欠損（ｌｐｌｄ）集団におけるアポリポタンパク質ｃ−ｉｉｉ（ａｐｏｃｉｉｉ）発現の調節
JP2018054633A Active JP6681422B2 (ja) 2013-02-14 2018-03-22 リポタンパク質リパーゼ欠損（ｌｐｌｄ）集団におけるアポリポタンパク質ｃ−ｉｉｉ（ａｐｏｃｉｉｉ）発現の調節
JP2020050456A Withdrawn JP2020111594A (ja) 2013-02-14 2020-03-23 リポタンパク質リパーゼ欠損（ｌｐｌｄ）集団におけるアポリポタンパク質ｃ−ｉｉｉ（ａｐｏｃｉｉｉ）発現の調節

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JP2020050456A Withdrawn JP2020111594A (ja) 2013-02-14 2020-03-23 リポタンパク質リパーゼ欠損（ｌｐｌｄ）集団におけるアポリポタンパク質ｃ−ｉｉｉ（ａｐｏｃｉｉｉ）発現の調節

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US (4) US9593333B2 (enExample)
EP (2) EP3400947B1 (enExample)
JP (3) JP6313789B2 (enExample)
KR (2) KR102169899B1 (enExample)
CN (2) CN108743943A (enExample)
AU (3) AU2014216137B2 (enExample)
BR (1) BR112015019515A8 (enExample)
CA (2) CA3170716A1 (enExample)
DK (1) DK2956176T3 (enExample)
ES (2) ES2680599T3 (enExample)
IL (2) IL240338B (enExample)
MX (2) MX368155B (enExample)
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RU (2) RU2018121529A (enExample)
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JP2018135341A (ja) * 2013-02-14 2018-08-30 アイオーニス ファーマシューティカルズ， インコーポレーテッドＩｏｎｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． リポタンパク質リパーゼ欠損（ｌｐｌｄ）集団におけるアポリポタンパク質ｃ−ｉｉｉ（ａｐｏｃｉｉｉ）発現の調節

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AU2014284152B2 (en) * 2013-06-21 2020-01-23 Ionis Pharmaceuticals, Inc. Compositions and methods for modulation of target nucleic acids
HK1248522A1 (zh) * 2015-02-27 2018-10-19 Ionis Pharmaceuticals, Inc. 调节脂肪代谢障碍群体中的载脂蛋白c-iii(apociii)表达
CA3030099A1 (en) 2016-07-08 2018-01-11 Staten Biotechnology B.V. Anti-apoc3 antibodies and methods of use thereof
AU2017368050A1 (en) 2016-11-29 2019-06-20 Puretech Lyt, Inc. Exosomes for delivery of therapeutic agents
JP2020517242A (ja) 2017-04-21 2020-06-18 スターテン・バイオテクノロジー・ベー・フェー 抗ＡｐｏＣ３抗体およびその使用方法
WO2018223056A1 (en) 2017-06-02 2018-12-06 Wave Life Sciences Ltd. Oligonucleotide compositions and methods of use thereof
BR112020008514A2 (pt) 2017-10-31 2020-10-20 Staten Biotechnology B.V. anticorpos anti-apoc3 e métodos de uso dos mesmos
US10538583B2 (en) 2017-10-31 2020-01-21 Staten Biotechnology B.V. Anti-APOC3 antibodies and compositions thereof
CA3098624A1 (en) 2018-05-11 2019-11-14 Wave Life Sciences Ltd. Oligonucleotide compositions and methods of use thereof
US20240033280A1 (en) * 2020-10-02 2024-02-01 Ionis Pharmaceuticals, Inc. Methods for reducing apociii expression
CN116814621B (zh) * 2022-08-05 2025-09-09 厦门甘宝利生物医药有限公司 一种抑制apoc3基因表达的rna抑制剂及其应用
WO2025110984A1 (en) * 2023-11-21 2025-05-30 Hydrogene Therapeutics, Inc. Compositions and methods for treating wilson's disease

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