MX368155B - Modulación de la expresión de apolipoproteína c-iii (apociii) en poblaciones con deficiencia de lipoproteína lipasa (lpld). - Google Patents

Modulación de la expresión de apolipoproteína c-iii (apociii) en poblaciones con deficiencia de lipoproteína lipasa (lpld).

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Publication number
MX368155B
MX368155B MX2015010487A MX2015010487A MX368155B MX 368155 B MX368155 B MX 368155B MX 2015010487 A MX2015010487 A MX 2015010487A MX 2015010487 A MX2015010487 A MX 2015010487A MX 368155 B MX368155 B MX 368155B
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MX
Mexico
Prior art keywords
lpld
expression
apociii
apolipoprotein
populations
Prior art date
Application number
MX2015010487A
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English (en)
Other versions
MX2015010487A (es
Inventor
J Alexander Veronica
J Viney Nicholas
L Witztum Joseph
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Ionis Pharmaceuticals Inc
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Publication date
Application filed by Ionis Pharmaceuticals Inc filed Critical Ionis Pharmaceuticals Inc
Publication of MX2015010487A publication Critical patent/MX2015010487A/es
Publication of MX368155B publication Critical patent/MX368155B/es

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Abstract

Se proporcionan métodos, compuestos y composiciones para reducir la expresión de proteína y ARNm de ApoClII para tratar, prevenir, retrasar o mejorar la dislipidemia tipo I de Fredrickson/FCS/LPLD en un paciente. Diochos métodos, compuestos y composiciones aumentan los niveles de HDL y/o mejoran la relación de TG con respecto a HDL y reducen los lípidos en plasma y la glucosa en plasma en el paciente, y son útiles para tratar, prevenir, retrasar o mejorar una o más de pancreatitis, enfermedad cardiovascular, trastorno metabólico y síntomas asociados.
MX2015010487A 2013-02-14 2014-02-14 Modulación de la expresión de apolipoproteína c-iii (apociii) en poblaciones con deficiencia de lipoproteína lipasa (lpld). MX368155B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361764969P 2013-02-14 2013-02-14
US201361880779P 2013-09-20 2013-09-20
PCT/US2014/016546 WO2014127268A2 (en) 2013-02-14 2014-02-14 Modulation of apolipoprotein c-iii (apociii) expression in lipoprotein lipase deficient (lpld) populations

Publications (2)

Publication Number Publication Date
MX2015010487A MX2015010487A (es) 2015-10-30
MX368155B true MX368155B (es) 2019-09-20

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ID=51354689

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Application Number Title Priority Date Filing Date
MX2015010487A MX368155B (es) 2013-02-14 2014-02-14 Modulación de la expresión de apolipoproteína c-iii (apociii) en poblaciones con deficiencia de lipoproteína lipasa (lpld).
MX2019011188A MX2019011188A (es) 2013-02-14 2015-08-13 Modulacion de la expresion de apolipoproteina c-iii (apociii) en poblaciones con deficiencia de lipoproteina lipasa (lpld).

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MX2019011188A MX2019011188A (es) 2013-02-14 2015-08-13 Modulacion de la expresion de apolipoproteina c-iii (apociii) en poblaciones con deficiencia de lipoproteina lipasa (lpld).

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US (4) US9593333B2 (es)
EP (2) EP3400947B1 (es)
JP (3) JP6313789B2 (es)
KR (2) KR20200123263A (es)
CN (2) CN104994884B (es)
AU (3) AU2014216137B2 (es)
BR (1) BR112015019515A8 (es)
CA (2) CA2901119C (es)
DK (1) DK2956176T3 (es)
ES (2) ES2680599T3 (es)
HK (1) HK1217441A1 (es)
IL (2) IL240338B (es)
MX (2) MX368155B (es)
NZ (1) NZ631119A (es)
RU (2) RU2018121529A (es)
WO (1) WO2014127268A2 (es)
ZA (1) ZA201505628B (es)

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