DK2956176T3 - MODULATION OF APOLIPOPROTEIN C-III (APOCIII) EXPRESSION IN LIPOPROTEIN LIPASE DEFICIENT (LPLD) POPULATIONS - Google Patents

MODULATION OF APOLIPOPROTEIN C-III (APOCIII) EXPRESSION IN LIPOPROTEIN LIPASE DEFICIENT (LPLD) POPULATIONS Download PDF

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DK2956176T3
DK2956176T3 DK14751357.6T DK14751357T DK2956176T3 DK 2956176 T3 DK2956176 T3 DK 2956176T3 DK 14751357 T DK14751357 T DK 14751357T DK 2956176 T3 DK2956176 T3 DK 2956176T3
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apociii
certain embodiments
compound
modified oligonucleotide
modified
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DK14751357.6T
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Danish (da)
English (en)
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Veronica J Alexander
Nicholas J Viney
Joseph L Witztum
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Ionis Pharmaceuticals Inc
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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    • A61P3/06—Antihyperlipidemics
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3525—MOE, methoxyethoxy
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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DK14751357.6T 2013-02-14 2014-02-14 MODULATION OF APOLIPOPROTEIN C-III (APOCIII) EXPRESSION IN LIPOPROTEIN LIPASE DEFICIENT (LPLD) POPULATIONS DK2956176T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361764969P 2013-02-14 2013-02-14
US201361880779P 2013-09-20 2013-09-20
PCT/US2014/016546 WO2014127268A2 (en) 2013-02-14 2014-02-14 Modulation of apolipoprotein c-iii (apociii) expression in lipoprotein lipase deficient (lpld) populations

Publications (1)

Publication Number Publication Date
DK2956176T3 true DK2956176T3 (en) 2018-08-27

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DK14751357.6T DK2956176T3 (en) 2013-02-14 2014-02-14 MODULATION OF APOLIPOPROTEIN C-III (APOCIII) EXPRESSION IN LIPOPROTEIN LIPASE DEFICIENT (LPLD) POPULATIONS

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US (4) US9593333B2 (enExample)
EP (2) EP2956176B1 (enExample)
JP (3) JP6313789B2 (enExample)
KR (2) KR102169899B1 (enExample)
CN (2) CN108743943A (enExample)
AU (3) AU2014216137B2 (enExample)
BR (1) BR112015019515A8 (enExample)
CA (2) CA3170716A1 (enExample)
DK (1) DK2956176T3 (enExample)
ES (2) ES2680599T3 (enExample)
IL (2) IL240338B (enExample)
MX (2) MX368155B (enExample)
NZ (1) NZ631119A (enExample)
RU (2) RU2018121529A (enExample)
WO (1) WO2014127268A2 (enExample)
ZA (1) ZA201505628B (enExample)

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SG11202010131QA (en) 2018-05-11 2020-11-27 Wave Life Sciences Ltd Oligonucleotide compositions and methods of use thereof
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CN121271867A (zh) * 2022-08-05 2026-01-06 厦门甘宝利生物医药有限公司 一种抑制apoc3基因表达的rna抑制剂及其应用
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