JP2006141402A5 - - Google Patents
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- JP2006141402A5 JP2006141402A5 JP2006000258A JP2006000258A JP2006141402A5 JP 2006141402 A5 JP2006141402 A5 JP 2006141402A5 JP 2006000258 A JP2006000258 A JP 2006000258A JP 2006000258 A JP2006000258 A JP 2006000258A JP 2006141402 A5 JP2006141402 A5 JP 2006141402A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- antisense compound
- antisense
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 230000000692 anti-sense effect Effects 0.000 claims description 33
- 150000001875 compounds Chemical class 0.000 claims description 33
- 239000008194 pharmaceutical composition Substances 0.000 claims description 16
- 201000010099 disease Diseases 0.000 claims description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 9
- 108091034117 Oligonucleotide Proteins 0.000 claims description 8
- 101000994375 Homo sapiens Integrin alpha-4 Proteins 0.000 claims description 5
- 239000000074 antisense oligonucleotide Substances 0.000 claims description 5
- 238000012230 antisense oligonucleotides Methods 0.000 claims description 5
- 201000006417 multiple sclerosis Diseases 0.000 claims description 3
- 108020004707 nucleic acids Proteins 0.000 claims description 3
- 150000007523 nucleic acids Chemical class 0.000 claims description 3
- 102000039446 nucleic acids Human genes 0.000 claims description 3
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 3
- LRSASMSXMSNRBT-UHFFFAOYSA-N 5-methylcytosine Chemical group CC1=CNC(=O)N=C1N LRSASMSXMSNRBT-UHFFFAOYSA-N 0.000 claims description 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 2
- 206010027476 Metastases Diseases 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 208000006673 asthma Diseases 0.000 claims description 2
- 206010012601 diabetes mellitus Diseases 0.000 claims description 2
- 208000006454 hepatitis Diseases 0.000 claims description 2
- 231100000283 hepatitis Toxicity 0.000 claims description 2
- 230000009401 metastasis Effects 0.000 claims description 2
- 239000002773 nucleotide Substances 0.000 claims description 2
- 125000003729 nucleotide group Chemical group 0.000 claims description 2
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 1
- 238000000034 method Methods 0.000 description 20
- 210000004027 cell Anatomy 0.000 description 11
- 102100032818 Integrin alpha-4 Human genes 0.000 description 8
- 108010041012 Integrin alpha4 Proteins 0.000 description 8
- 210000005260 human cell Anatomy 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 108010008212 Integrin alpha4beta1 Proteins 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 2
- 201000001441 melanoma Diseases 0.000 description 2
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 238000001246 colloidal dispersion Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 206010061289 metastatic neoplasm Diseases 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- -1 oligonucleotides Chemical class 0.000 description 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/166,203 US5968826A (en) | 1998-10-05 | 1998-10-05 | Antisense inhibition of integrin α4 expression |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000574727A Division JP3834204B2 (ja) | 1998-10-05 | 1999-08-19 | インテグリンα４発現のアンチセンス調節 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006141402A JP2006141402A (ja) | 2006-06-08 |
| JP2006141402A5 true JP2006141402A5 (enExample) | 2007-06-14 |
| JP4168285B2 JP4168285B2 (ja) | 2008-10-22 |
Family
ID=22602243
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000574727A Expired - Fee Related JP3834204B2 (ja) | 1998-10-05 | 1999-08-19 | インテグリンα４発現のアンチセンス調節 |
| JP2006000258A Expired - Fee Related JP4168285B2 (ja) | 1998-10-05 | 2006-01-04 | インテグリンα４発現のアンチセンス調節 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000574727A Expired - Fee Related JP3834204B2 (ja) | 1998-10-05 | 1999-08-19 | インテグリンα４発現のアンチセンス調節 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US5968826A (enExample) |
| EP (1) | EP1123414B1 (enExample) |
| JP (2) | JP3834204B2 (enExample) |
| AT (1) | ATE352639T1 (enExample) |
| AU (1) | AU759938B2 (enExample) |
| CA (1) | CA2345209C (enExample) |
| DE (1) | DE69934998T2 (enExample) |
| DK (1) | DK1123414T3 (enExample) |
| ES (1) | ES2279632T3 (enExample) |
| WO (1) | WO2000020635A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002515513A (ja) * | 1998-05-21 | 2002-05-28 | アイシス・ファーマシューティカルス・インコーポレーテッド | 核酸の肺送達のための組成物および方法 |
| US5968826A (en) * | 1998-10-05 | 1999-10-19 | Isis Pharmaceuticals Inc. | Antisense inhibition of integrin α4 expression |
| DE19860642A1 (de) * | 1998-12-29 | 2000-07-06 | Deutsches Krebsforsch | Antisense-Oligonukleotid zur Hemmung der Expression des Adhäsionsmoleküls very late antigen 4 (VLA-4) in menschlichen Zellen |
| GB0112617D0 (en) | 2001-05-23 | 2001-07-18 | Hoffmann La Roche | Antiviral nucleoside derivatives |
| US20030154499A1 (en) * | 2001-06-08 | 2003-08-14 | Monika Wasel-Nielen | Mouse unable to express functional alpha-4 integrin protein, and methods for assaying compounds or agents for alpha-4 integrin protein antagonist activity and a genetic marker for evaluating efficacy of modulators of signaling activity of a VLA-4 receptor |
| AU2003288898A1 (en) * | 2002-08-19 | 2004-03-29 | Pharmacia Corporation | Antisense modulation of endothelial specific molecule 1 expression |
| CA2545248A1 (en) * | 2003-09-29 | 2005-04-14 | The Regents Of The University Of California | Methods for altering hematopoietic progenitor cell adhesion, differentiation, and migration |
| US7419666B1 (en) | 2004-02-23 | 2008-09-02 | Massachusetts Eye And Ear Infirmary | Treatment of ocular disorders |
| AU2005327506B2 (en) * | 2004-10-20 | 2010-07-08 | Antisense Therapeutics Ltd | Antisense modulation of integrin alpha4 expression |
| WO2006133092A1 (en) * | 2005-06-07 | 2006-12-14 | Yale University | Methods of treating cancer and other conditions or disease states using lfmau and ldt |
| JP5547637B2 (ja) * | 2007-10-05 | 2014-07-16 | インデックス・ファーマシューティカルズ・アクチエボラーグ | 浮腫を治療または軽減するための新規な化合物およびその使用方法 |
| EP2318424B1 (en) | 2008-06-23 | 2015-02-25 | Antisense Therapeutics Ltd | Methods for treating multiple sclerosis using antisense oligonucleotides |
| CA2811228C (en) * | 2010-09-17 | 2023-03-14 | Antisense Therapeutics Ltd | Method for reducing circulating leukocytes in a human subject |
| WO2014193625A1 (en) * | 2013-05-30 | 2014-12-04 | R-Pharm Overseas, Inc. | Fully human antibodies against human receptor integrin alpha-4 |
| US10376536B2 (en) * | 2015-05-11 | 2019-08-13 | Murdoch University | Multiple sclerosis treatment |
| ES2938883T3 (es) | 2015-11-05 | 2023-04-17 | Los Angeles Childrens Hospital | Oligo antisentido para su uso en el tratamiento de la leucemia mieloide aguda |
| US20200038428A1 (en) * | 2017-03-23 | 2020-02-06 | Napajen Pharma, Inc. | Cancer cell adhesion activity inhibitor |
| WO2023039643A1 (en) * | 2021-09-20 | 2023-03-23 | Antisense Therapeutics Ltd | Methods and kits therefor |
| EP4230196A1 (en) | 2022-02-21 | 2023-08-23 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of dystrophinopathies |
| CN114887034B (zh) * | 2022-07-14 | 2022-10-28 | 中山莱博瑞辰生物医药有限公司 | LLP2A-Ale在制备用于治疗和/或预防外周血淋巴细胞减少症的药物中的用途 |
| WO2024036373A1 (en) * | 2022-08-16 | 2024-02-22 | Antisense Therapeutics Ltd | Biomarkers and uses thereof in diagnosis and treatment of neurological post acute sequelae of covid 19 (npasc) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5696248A (en) * | 1994-06-15 | 1997-12-09 | Hoechst Aktiengesellschaft | 3'-modified oligonucleotide derivatives |
| US5968826A (en) * | 1998-10-05 | 1999-10-19 | Isis Pharmaceuticals Inc. | Antisense inhibition of integrin α4 expression |
-
1998
- 1998-10-05 US US09/166,203 patent/US5968826A/en not_active Expired - Lifetime
-
1999
- 1999-08-19 EP EP99942290A patent/EP1123414B1/en not_active Expired - Lifetime
- 1999-08-19 DK DK99942290T patent/DK1123414T3/da active
- 1999-08-19 JP JP2000574727A patent/JP3834204B2/ja not_active Expired - Fee Related
- 1999-08-19 ES ES99942290T patent/ES2279632T3/es not_active Expired - Lifetime
- 1999-08-19 WO PCT/US1999/018796 patent/WO2000020635A1/en not_active Ceased
- 1999-08-19 AT AT99942290T patent/ATE352639T1/de not_active IP Right Cessation
- 1999-08-19 US US09/377,309 patent/US6258790B1/en not_active Expired - Lifetime
- 1999-08-19 CA CA2345209A patent/CA2345209C/en not_active Expired - Fee Related
- 1999-08-19 DE DE69934998T patent/DE69934998T2/de not_active Expired - Lifetime
- 1999-08-19 AU AU55703/99A patent/AU759938B2/en not_active Ceased
-
2006
- 2006-01-04 JP JP2006000258A patent/JP4168285B2/ja not_active Expired - Fee Related
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