JP2004513626A5 - - Google Patents
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- Publication number
- JP2004513626A5 JP2004513626A5 JP2002526886A JP2002526886A JP2004513626A5 JP 2004513626 A5 JP2004513626 A5 JP 2004513626A5 JP 2002526886 A JP2002526886 A JP 2002526886A JP 2002526886 A JP2002526886 A JP 2002526886A JP 2004513626 A5 JP2004513626 A5 JP 2004513626A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- clusterin
- disease
- antisense oligonucleotide
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 16
- 108091034117 Oligonucleotide Proteins 0.000 claims 7
- 239000000074 antisense oligonucleotide Substances 0.000 claims 7
- 238000012230 antisense oligonucleotides Methods 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 102000003780 Clusterin Human genes 0.000 claims 6
- 108090000197 Clusterin Proteins 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 230000000692 anti-sense effect Effects 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- LRSASMSXMSNRBT-UHFFFAOYSA-N 5-methylcytosine Chemical group CC1=CNC(=O)N=C1N LRSASMSXMSNRBT-UHFFFAOYSA-N 0.000 claims 1
- 108020000948 Antisense Oligonucleotides Proteins 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 108091026890 Coding region Proteins 0.000 claims 1
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- 108091036066 Three prime untranslated region Proteins 0.000 claims 1
- 238000001246 colloidal dispersion Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000003463 hyperproliferative effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/659,791 US6383808B1 (en) | 2000-09-11 | 2000-09-11 | Antisense inhibition of clusterin expression |
| PCT/US2001/028235 WO2002022635A1 (en) | 2000-09-11 | 2001-09-10 | Antisense modulation of clusterin expression |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009191924A Division JP2010043086A (ja) | 2000-09-11 | 2009-08-21 | クラスタリン発現のアンチセンスモジュレーション |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004513626A JP2004513626A (ja) | 2004-05-13 |
| JP2004513626A5 true JP2004513626A5 (enExample) | 2005-03-17 |
| JP4397585B2 JP4397585B2 (ja) | 2010-01-13 |
Family
ID=24646855
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002526886A Expired - Fee Related JP4397585B2 (ja) | 2000-09-11 | 2001-09-10 | クラスタリン発現のアンチセンスモジュレーション |
| JP2009191924A Pending JP2010043086A (ja) | 2000-09-11 | 2009-08-21 | クラスタリン発現のアンチセンスモジュレーション |
| JP2013156811A Pending JP2014027936A (ja) | 2000-09-11 | 2013-07-29 | クラスタリン発現のアンチセンスモジュレーション |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009191924A Pending JP2010043086A (ja) | 2000-09-11 | 2009-08-21 | クラスタリン発現のアンチセンスモジュレーション |
| JP2013156811A Pending JP2014027936A (ja) | 2000-09-11 | 2013-07-29 | クラスタリン発現のアンチセンスモジュレーション |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6383808B1 (enExample) |
| EP (1) | EP1325019B1 (enExample) |
| JP (3) | JP4397585B2 (enExample) |
| AT (1) | ATE496127T1 (enExample) |
| AU (1) | AU2001290706A1 (enExample) |
| DE (1) | DE60143901D1 (enExample) |
| WO (1) | WO2002022635A1 (enExample) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040121973A1 (en) * | 2002-02-05 | 2004-06-24 | Monia Brett P | Antisense modulation of protein phosphatase 2 Catalytic subunit alpha expression |
| US6444650B1 (en) * | 1996-10-01 | 2002-09-03 | Geron Corporation | Antisense compositions for detecting and inhibiting telomerase reverse transcriptase |
| CA2850318A1 (en) | 1999-02-26 | 2000-08-31 | The University Of British Columbia | Trpm-2 antisense therapy |
| US6900187B2 (en) * | 1999-02-26 | 2005-05-31 | The University Of British Columbia | TRPM-2 antisense therapy using an oligonucleotide having 2′-O-(2-methoxy)ethyl modifications |
| US7569551B2 (en) | 2000-02-25 | 2009-08-04 | The University Of British Columbia | Chemo- and radiation-sensitization of cancer by antisense TRPM-2 oligodeoxynucleotides |
| US7199102B2 (en) | 2000-08-24 | 2007-04-03 | The Regents Of The University Of California | Orally administered peptides synergize statin activity |
| US7148197B2 (en) * | 2000-08-24 | 2006-12-12 | The Regents Of The University Of California | Orally administered small peptides synergize statin activity |
| US8568766B2 (en) | 2000-08-24 | 2013-10-29 | Gattadahalli M. Anantharamaiah | Peptides and peptide mimetics to treat pathologies associated with eye disease |
| US7723303B2 (en) * | 2000-08-24 | 2010-05-25 | The Regents Of The University Of California | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response |
| US7407943B2 (en) * | 2001-08-01 | 2008-08-05 | Isis Pharmaceuticals, Inc. | Antisense modulation of apolipoprotein B expression |
| AU2003237616B2 (en) * | 2002-01-17 | 2007-07-05 | The University Of British Columbia | Bispecific antisense oligonucleotides that inhibit IGFBP-2 and IGFBP-5 and methods of using same |
| US20040102401A1 (en) * | 2002-11-22 | 2004-05-27 | Isis Pharmaceuticals Inc. | Modulation of jagged 1 expression |
| JP2005532052A (ja) * | 2002-07-01 | 2005-10-27 | ファルマシア・コーポレーション | Ｌｒｈ１発現のアンチセンス調節 |
| US7285541B2 (en) | 2002-08-21 | 2007-10-23 | The University Of British Columbia | Treatment of melanoma by reduction in clusterin levels |
| CA2882443C (en) * | 2002-08-21 | 2016-12-13 | The University Of British Columbia | Rnai probes targeting cancer-related proteins |
| JP2007523839A (ja) * | 2003-04-18 | 2007-08-23 | ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア | 血管新生性障害の治療法 |
| US20040220131A1 (en) * | 2003-04-18 | 2004-11-04 | The University Of British Columbia | Method for treatment of cancerous angiogenic disorders |
| US7825235B2 (en) | 2003-08-18 | 2010-11-02 | Isis Pharmaceuticals, Inc. | Modulation of diacylglycerol acyltransferase 2 expression |
| EP1708730A2 (en) * | 2004-01-20 | 2006-10-11 | DeveloGen Aktiengesellschaft | Use of a dg147 protein product for preventing and treating metabolic disorders |
| US20050164271A1 (en) * | 2004-01-20 | 2005-07-28 | Sanjay Bhanot | Modulation of glucocorticoid receptor expression |
| US8710020B2 (en) | 2004-04-02 | 2014-04-29 | The University Of British Columbia | Clusterin antisense therapy for treatment of cancer |
| AU2005287004B2 (en) * | 2004-09-16 | 2011-03-17 | The Regents Of The University Of California | G-type peptides and other agents to ameliorate atherosclerosis and other pathologies |
| ITBZ20040048A1 (it) * | 2004-10-06 | 2005-01-06 | Genprofiler | Metodo per l'identificazione della trasformazione neoplastica, con particolare riferimento al cancro prostatico |
| ES2456017T3 (es) * | 2004-11-23 | 2014-04-21 | The University Of British Columbia | Tratamiento del cáncer con una combinación de un agente que perturba la ruta de señalización de EGF y un oligonucleótido que reduce los niveles de clusterina |
| CN101115496B (zh) | 2004-12-06 | 2012-03-07 | 加州大学评议会 | 改善微动脉的结构和功能的方法 |
| US20080293639A1 (en) * | 2005-04-29 | 2008-11-27 | The Regents Of The University Of California | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response |
| SG173373A1 (en) * | 2005-04-29 | 2011-08-29 | The University Of California | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response |
| CA2621363C (en) | 2005-09-13 | 2015-07-07 | National Research Council Of Canada | Methods and compositions for modulating tumor cell activity |
| AU2008230886B9 (en) | 2007-03-24 | 2014-09-04 | Kastle Therapeutics, Llc | Administering antisense oligonucleotides complementary to human apolipoprotein B |
| JP2010538005A (ja) | 2007-08-28 | 2010-12-09 | ユーエービー リサーチ ファウンデーション | 合成アポリポ蛋白質ｅ模倣ポリペプチドおよび使用方法 |
| WO2009032702A2 (en) | 2007-08-28 | 2009-03-12 | Uab Research Foundation | Synthetic apolipoprotein e mimicking polypeptides and methods of use |
| EP2222851B1 (en) * | 2007-11-20 | 2017-06-28 | Ionis Pharmaceuticals, Inc. | Modulation of cd40 expression |
| SG171914A1 (en) | 2008-12-02 | 2011-07-28 | Chiralgen Ltd | Method for the synthesis of phosphorus atom modified nucleic acids |
| US9744183B2 (en) | 2009-07-06 | 2017-08-29 | Wave Life Sciences Ltd. | Nucleic acid prodrugs and methods of use thereof |
| RU2627163C2 (ru) | 2009-11-24 | 2017-08-03 | Алетиа Байотерапьютикс Инк. | Антикластериновые антитела и антигенсвязывающие фрагменты и их использование для уменьшения объема новообразований |
| DK2620428T3 (da) | 2010-09-24 | 2019-07-01 | Wave Life Sciences Ltd | Asymmetrisk hjælpegruppe |
| CA2825981A1 (en) | 2011-02-03 | 2012-08-09 | Mirna Therapeutics, Inc. | Synthetic mimics of mir-34 |
| AU2012212105A1 (en) | 2011-02-03 | 2013-09-12 | Mirna Therapeutics, Inc. | Synthetic mimics of miR-124 |
| BR112013023452A2 (pt) | 2011-03-15 | 2016-12-06 | Univ British Columbia | combinação de oligonucleotídeo anti-clusterina com inibidor de hsp90 para o tratamento de câncer de próstata |
| RU2014105311A (ru) | 2011-07-19 | 2015-08-27 | Уэйв Лайф Сайенсес Пте. Лтд. | Способы синтеза функционализованных нуклеиновых кислот |
| EP2756080B1 (en) | 2011-09-14 | 2019-02-20 | Translate Bio MA, Inc. | Multimeric oligonucleotide compounds |
| NZ626742A (en) | 2012-02-22 | 2016-06-24 | Alethia Biotherapeutics Inc | Co-use of a clusterin inhibitor with an egfr inhibitor to treat cancer |
| US10837014B2 (en) | 2012-05-16 | 2020-11-17 | Translate Bio Ma, Inc. | Compositions and methods for modulating SMN gene family expression |
| EA201492116A1 (ru) | 2012-05-16 | 2015-05-29 | Рана Терапьютикс, Инк. | Композиции и способы для модулирования экспрессии mecp2 |
| KR102712879B1 (ko) | 2012-07-13 | 2024-10-04 | 웨이브 라이프 사이언시스 리미티드 | 키랄 제어 |
| BR112015000723A2 (pt) | 2012-07-13 | 2017-06-27 | Shin Nippon Biomedical Laboratories Ltd | adjuvante de ácido nucléico quiral |
| PT2872485T (pt) | 2012-07-13 | 2021-03-05 | Wave Life Sciences Ltd | Grupo auxiliar assimétrico |
| CA2884608C (en) | 2012-09-14 | 2025-05-20 | Translate Bio Ma, Inc. | MULTIMERIC OLIGONUCLEOTIDE COMPOUNDS |
| JPWO2015108048A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| JPWO2015108047A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| JPWO2015108046A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤 |
| PT3094728T (pt) | 2014-01-16 | 2022-05-19 | Wave Life Sciences Ltd | Desenho quiral |
| WO2016018665A1 (en) | 2014-07-31 | 2016-02-04 | Uab Research Foundation | Apoe mimetic peptides and higher potency to clear plasma cholesterol |
| US20180055869A1 (en) * | 2015-02-13 | 2018-03-01 | Translate Bio Ma, Inc. | Compositions and methods for modulating rna |
| WO2016130943A1 (en) | 2015-02-13 | 2016-08-18 | Rana Therapeutics, Inc. | Hybrid oligonucleotides and uses thereof |
| JP2018515142A (ja) * | 2015-05-15 | 2018-06-14 | ダーマコン，インコーポレイテッド． | Ｃａｓ９介在遺伝子編集用の合成シングルガイドｒｎａ |
| EP4092119A3 (en) | 2015-07-10 | 2023-03-22 | Ionis Pharmaceuticals, Inc. | Modulators of diacyglycerol acyltransferase 2 (dgat2) |
| FR3069156B1 (fr) * | 2017-07-21 | 2019-08-09 | Universite de Bordeaux | Clusterine pour son utilisation dans le traitement des micro-angiopathies thrombotiques |
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| US5235033A (en) | 1985-03-15 | 1993-08-10 | Anti-Gene Development Group | Alpha-morpholino ribonucleoside derivatives and polymers thereof |
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| US5216141A (en) | 1988-06-06 | 1993-06-01 | Benner Steven A | Oligonucleotide analogs containing sulfur linkages |
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| AUPM301293A0 (en) | 1993-12-17 | 1994-01-20 | University Of Melbourne, The | Methods and reagents for sperm analysis |
| US5695995A (en) * | 1994-05-06 | 1997-12-09 | Fred Hutchinson Cancer Research Center | Neurogenic differentiation (neurod) genes |
| US5786213A (en) * | 1996-04-18 | 1998-07-28 | Board Of Regents, The University Of Texas System | Inhibition of endogenous gastrin expression for treatment of colorectal cancer |
| US5739310A (en) * | 1996-04-23 | 1998-04-14 | Fred Hutchinson Cancer Research Center | Ribosomes as vectors for RNA |
| US5945290A (en) * | 1998-09-18 | 1999-08-31 | Isis Pharmaceuticals, Inc. | Antisense modulation of RhoA expression |
| US5959097A (en) * | 1998-11-20 | 1999-09-28 | Isis Pharmaceuticals, Inc. | Antisense modulation of MEK2 expression |
| AU3116800A (en) * | 1998-12-11 | 2000-06-26 | Research Foundation Of The State University Of New York, The | Compositions and methods for altering cell migration |
| US5948680A (en) * | 1998-12-17 | 1999-09-07 | Isis Pharmaceuticals Inc. | Antisense inhibition of Elk-1 expression |
| US5958773A (en) * | 1998-12-17 | 1999-09-28 | Isis Pharmaceuticals Inc. | Antisense modulation of AKT-1 expression |
| CA2850318A1 (en) | 1999-02-26 | 2000-08-31 | The University Of British Columbia | Trpm-2 antisense therapy |
| US5998148A (en) * | 1999-04-08 | 1999-12-07 | Isis Pharmaceuticals Inc. | Antisense modulation of microtubule-associated protein 4 expression |
-
2000
- 2000-09-11 US US09/659,791 patent/US6383808B1/en not_active Expired - Lifetime
-
2001
- 2001-09-10 US US10/380,124 patent/US20040053874A1/en not_active Abandoned
- 2001-09-10 JP JP2002526886A patent/JP4397585B2/ja not_active Expired - Fee Related
- 2001-09-10 AT AT01970728T patent/ATE496127T1/de not_active IP Right Cessation
- 2001-09-10 EP EP01970728A patent/EP1325019B1/en not_active Expired - Lifetime
- 2001-09-10 DE DE60143901T patent/DE60143901D1/de not_active Expired - Lifetime
- 2001-09-10 WO PCT/US2001/028235 patent/WO2002022635A1/en not_active Ceased
- 2001-09-10 AU AU2001290706A patent/AU2001290706A1/en not_active Abandoned
-
2009
- 2009-08-21 JP JP2009191924A patent/JP2010043086A/ja active Pending
-
2013
- 2013-07-29 JP JP2013156811A patent/JP2014027936A/ja active Pending