JP2009508527A5 - - Google Patents
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- Publication number
- JP2009508527A5 JP2009508527A5 JP2008532324A JP2008532324A JP2009508527A5 JP 2009508527 A5 JP2009508527 A5 JP 2009508527A5 JP 2008532324 A JP2008532324 A JP 2008532324A JP 2008532324 A JP2008532324 A JP 2008532324A JP 2009508527 A5 JP2009508527 A5 JP 2009508527A5
- Authority
- JP
- Japan
- Prior art keywords
- antisense oligonucleotide
- methylcytosine
- cytosine
- methoxyethyl
- nucleotides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71868505P | 2005-09-19 | 2005-09-19 | |
| PCT/US2006/036527 WO2007035759A1 (en) | 2005-09-19 | 2006-09-19 | Modulation of glucocorticoid receptor expression |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009508527A JP2009508527A (ja) | 2009-03-05 |
| JP2009508527A5 true JP2009508527A5 (enExample) | 2009-11-05 |
Family
ID=37491694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008532324A Pending JP2009508527A (ja) | 2005-09-19 | 2006-09-19 | グルココルチコイド受容体発現の調節 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20070066557A1 (enExample) |
| EP (2) | EP1941040A1 (enExample) |
| JP (1) | JP2009508527A (enExample) |
| KR (1) | KR20080065617A (enExample) |
| CN (1) | CN101313066A (enExample) |
| AU (1) | AU2006292293B2 (enExample) |
| BR (1) | BRPI0616370A2 (enExample) |
| CA (1) | CA2623772A1 (enExample) |
| CR (1) | CR9906A (enExample) |
| EA (1) | EA200800868A1 (enExample) |
| EC (1) | ECSP088298A (enExample) |
| IL (1) | IL190281A0 (enExample) |
| NO (1) | NO20081883L (enExample) |
| WO (1) | WO2007035759A1 (enExample) |
| ZA (1) | ZA200803452B (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3044969A1 (en) * | 2006-05-05 | 2007-12-21 | Ionis Pharmaceuticals, Inc. | Compounds and methods for modulating gene expression |
| EP2429657A2 (en) * | 2009-05-15 | 2012-03-21 | F. Hoffmann-La Roche AG | Compositions and methods for inhibiting expression of glucocorticoid receptor (gcr) genes |
| JP5854513B2 (ja) | 2009-08-03 | 2016-02-09 | インキューブ ラブズ, エルエルシー | 腸管内でインクレチン生産を刺激するための嚥下可能カプセルおよび方法 |
| US8759284B2 (en) | 2009-12-24 | 2014-06-24 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| EP2529015B1 (en) * | 2010-01-25 | 2017-11-15 | CuRNA, Inc. | Treatment of rnase h1 related diseases by inhibition of natural antisense transcript to rnase h1 |
| WO2011113015A2 (en) * | 2010-03-12 | 2011-09-15 | Avi Biopharma, Inc. | Antisense modulation of nuclear hormone receptors |
| US9861683B2 (en) | 2010-12-23 | 2018-01-09 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9402806B2 (en) | 2010-12-23 | 2016-08-02 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9149617B2 (en) | 2010-12-23 | 2015-10-06 | Rani Therapeutics, Llc | Device, system and methods for the oral delivery of therapeutic compounds |
| US10639272B2 (en) | 2010-12-23 | 2020-05-05 | Rani Therapeutics, Llc | Methods for delivering etanercept preparations into a lumen of the intestinal tract using a swallowable drug delivery device |
| US8809269B2 (en) | 2010-12-23 | 2014-08-19 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising insulin for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9402807B2 (en) | 2010-12-23 | 2016-08-02 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US8846040B2 (en) | 2010-12-23 | 2014-09-30 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising etanercept for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US8809271B2 (en) | 2010-12-23 | 2014-08-19 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising liraglutide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US8980822B2 (en) | 2010-12-23 | 2015-03-17 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising pramlintide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9283179B2 (en) | 2010-12-23 | 2016-03-15 | Rani Therapeutics, Llc | GnRH preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9629799B2 (en) | 2010-12-23 | 2017-04-25 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9259386B2 (en) | 2010-12-23 | 2016-02-16 | Rani Therapeutics, Llc | Therapeutic preparation comprising somatostatin or somatostatin analogoue for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US8734429B2 (en) | 2010-12-23 | 2014-05-27 | Rani Therapeutics, Llc | Device, system and methods for the oral delivery of therapeutic compounds |
| US9415004B2 (en) | 2010-12-23 | 2016-08-16 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US8764733B2 (en) | 2010-12-23 | 2014-07-01 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9284367B2 (en) | 2010-12-23 | 2016-03-15 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US8969293B2 (en) | 2010-12-23 | 2015-03-03 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising exenatide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| WO2013063313A1 (en) | 2011-10-25 | 2013-05-02 | Isis Pharmaceuticals, Inc. | Antisense modulation of gccr expression |
| US9234200B2 (en) * | 2011-12-15 | 2016-01-12 | National University Of Corporation Tokyo University Of Agriculture And Technology | Oligonucleotide, glucocorticoid sensitivity enhancer, pharmaceutical composition, and expression vector |
| JP6452614B2 (ja) | 2012-11-15 | 2019-01-16 | ロシュ イノベーション センター コペンハーゲン エーエス | オリゴヌクレオチドコンジュゲート |
| DK2951305T3 (en) | 2013-01-30 | 2018-10-29 | Hoffmann La Roche | LNA oligonucleotide KULHYDRATKONJUGATER |
| PE20152002A1 (es) | 2013-05-01 | 2016-01-21 | Isis Pharmaceuticals Inc | Composiciones y metodos para modular la expresion de ttr y vhb |
| WO2015002971A2 (en) * | 2013-07-02 | 2015-01-08 | Isis Pharmaceuticals, Inc. | Modulators of growth hormone receptor |
| ES2812099T3 (es) | 2014-05-01 | 2021-03-16 | Ionis Pharmaceuticals Inc | Composiciones y métodos para modular la expresión del receptor de la hormona del crecimiento |
| RS59182B1 (sr) | 2014-05-01 | 2019-10-31 | Ionis Pharmaceuticals Inc | Kompozicije i postupci za modulaciju ekspresije faktora b komplementa |
| ES2844593T3 (es) | 2014-05-01 | 2021-07-22 | Ionis Pharmaceuticals Inc | Composiciones y procedimientos para modular la expresión de la angiopoyetina de tipo 3 |
| WO2015179693A1 (en) | 2014-05-22 | 2015-11-26 | Isis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
| KR102435956B1 (ko) * | 2014-10-15 | 2022-08-23 | 코어셉트 쎄라퓨틱스 인코포레이티드 | 글루코코르티코이드 및 미네랄로코르티코이드 수용체 길항제를 사용한 지방간 질환 치료법 |
| MY192997A (en) * | 2015-07-10 | 2022-09-20 | Ionis Pharmaceuticals Inc | Modulators of diacyglycerol acyltransferase 2 (dgat2) |
| KR20250078597A (ko) | 2015-11-06 | 2025-06-02 | 아이오니스 파마수티컬즈, 인코포레이티드 | 아포리포프로테인 (a) 발현 조정 |
| KR20190065341A (ko) | 2016-10-06 | 2019-06-11 | 아이오니스 파마수티컬즈, 인코포레이티드 | 올리고머 화합물들의 접합 방법 |
Family Cites Families (60)
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| US3687808A (en) | 1969-08-14 | 1972-08-29 | Univ Leland Stanford Junior | Synthetic polynucleotides |
| US5367066A (en) | 1984-10-16 | 1994-11-22 | Chiron Corporation | Oligonucleotides with selectably cleavable and/or abasic sites |
| FR2575751B1 (fr) | 1985-01-08 | 1987-04-03 | Pasteur Institut | Nouveaux nucleosides de derives de l'adenosine, leur preparation et leurs applications biologiques |
| EP0366685B1 (en) | 1987-06-24 | 1994-10-19 | Howard Florey Institute Of Experimental Physiology And Medicine | Nucleoside derivatives |
| US5175273A (en) | 1988-07-01 | 1992-12-29 | Genentech, Inc. | Nucleic acid intercalating agents |
| US5134066A (en) | 1989-08-29 | 1992-07-28 | Monsanto Company | Improved probes using nucleosides containing 3-dezauracil analogs |
| US5130302A (en) | 1989-12-20 | 1992-07-14 | Boron Bilogicals, Inc. | Boronated nucleoside, nucleotide and oligonucleotide compounds, compositions and methods for using same |
| US5681941A (en) | 1990-01-11 | 1997-10-28 | Isis Pharmaceuticals, Inc. | Substituted purines and oligonucleotide cross-linking |
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| US5432272A (en) | 1990-10-09 | 1995-07-11 | Benner; Steven A. | Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases |
| US6582908B2 (en) * | 1990-12-06 | 2003-06-24 | Affymetrix, Inc. | Oligonucleotides |
| US5594121A (en) | 1991-11-07 | 1997-01-14 | Gilead Sciences, Inc. | Enhanced triple-helix and double-helix formation with oligomers containing modified purines |
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| TW393513B (en) | 1991-11-26 | 2000-06-11 | Isis Pharmaceuticals Inc | Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines |
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| US5434257A (en) | 1992-06-01 | 1995-07-18 | Gilead Sciences, Inc. | Binding compentent oligomers containing unsaturated 3',5' and 2',5' linkages |
| US5985558A (en) * | 1997-04-14 | 1999-11-16 | Isis Pharmaceuticals Inc. | Antisense oligonucleotide compositions and methods for the inibition of c-Jun and c-Fos |
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| AU9509798A (en) * | 1997-09-25 | 1999-04-12 | University Of Florida | Antisense oligonucleotide compositions targeted to angiotensi n converting enzy me mrna and methods of use |
| US6007992A (en) | 1997-11-10 | 1999-12-28 | Gilead Sciences, Inc. | Pyrimidine derivatives for labeled binding partners |
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| US20030203862A1 (en) * | 1998-03-26 | 2003-10-30 | Miraglia Loren J. | Antisense modulation of MDM2 expression |
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| US20030228597A1 (en) * | 1998-04-13 | 2003-12-11 | Cowsert Lex M. | Identification of genetic targets for modulation by oligonucleotides and generation of oligonucleotides for gene modulation |
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| US6900187B2 (en) * | 1999-02-26 | 2005-05-31 | The University Of British Columbia | TRPM-2 antisense therapy using an oligonucleotide having 2′-O-(2-methoxy)ethyl modifications |
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| EP1546180B1 (en) * | 2002-08-16 | 2013-07-03 | Rexahn Pharmaceuticals, Inc. | Use of antisense oligonucleotides to inhibit the expression of akt-1 |
| CA2494764C (en) * | 2002-08-21 | 2013-04-23 | The University Of British Columbia | Treatment of melanoma by reduction in clusterin levels |
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| US20050074801A1 (en) * | 2003-09-09 | 2005-04-07 | Monia Brett P. | Chimeric oligomeric compounds comprising alternating regions of northern and southern conformational geometry |
| US8012944B2 (en) * | 2003-10-30 | 2011-09-06 | Pharmascience Inc. | Method for treating cancer using IAP antisense oligomer and chemotherapeutic agent |
| NZ548254A (en) * | 2003-12-23 | 2008-09-26 | Santaris Pharma As | Oligomeric compounds for the modulation of BCL-2 |
| US20050164271A1 (en) * | 2004-01-20 | 2005-07-28 | Sanjay Bhanot | Modulation of glucocorticoid receptor expression |
| EP2397563A3 (en) * | 2004-09-17 | 2012-07-18 | Isis Pharmaceuticals, Inc. | Enhanced antisense oligonucleotides |
-
2006
- 2006-09-19 EP EP06814959A patent/EP1941040A1/en not_active Withdrawn
- 2006-09-19 BR BRPI0616370-0A patent/BRPI0616370A2/pt not_active IP Right Cessation
- 2006-09-19 WO PCT/US2006/036527 patent/WO2007035759A1/en not_active Ceased
- 2006-09-19 KR KR1020087009278A patent/KR20080065617A/ko not_active Withdrawn
- 2006-09-19 CA CA002623772A patent/CA2623772A1/en not_active Abandoned
- 2006-09-19 EP EP11152132A patent/EP2368988A1/en not_active Withdrawn
- 2006-09-19 US US11/524,507 patent/US20070066557A1/en not_active Abandoned
- 2006-09-19 AU AU2006292293A patent/AU2006292293B2/en not_active Ceased
- 2006-09-19 CN CNA2006800432422A patent/CN101313066A/zh active Pending
- 2006-09-19 EA EA200800868A patent/EA200800868A1/ru unknown
- 2006-09-19 JP JP2008532324A patent/JP2009508527A/ja active Pending
-
2008
- 2008-03-18 IL IL190281A patent/IL190281A0/en unknown
- 2008-03-19 EC EC2008008298A patent/ECSP088298A/es unknown
- 2008-04-18 ZA ZA200803452A patent/ZA200803452B/xx unknown
- 2008-04-18 NO NO20081883A patent/NO20081883L/no not_active Application Discontinuation
- 2008-04-21 CR CR9906A patent/CR9906A/es not_active Application Discontinuation
-
2010
- 2010-01-14 US US12/687,533 patent/US20100222412A1/en not_active Abandoned
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