BRPI0616370A2 - modulaÇço da expressço de receptor de glucocorticàide - Google Patents
modulaÇço da expressço de receptor de glucocorticàide Download PDFInfo
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- BRPI0616370A2 BRPI0616370A2 BRPI0616370-0A BRPI0616370A BRPI0616370A2 BR PI0616370 A2 BRPI0616370 A2 BR PI0616370A2 BR PI0616370 A BRPI0616370 A BR PI0616370A BR PI0616370 A2 BRPI0616370 A2 BR PI0616370A2
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- Prior art keywords
- antisense oligonucleotide
- oligonucleotide according
- region
- methoxyethyl
- nucleotides
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| TW201102091A (en) * | 2009-05-15 | 2011-01-16 | Hoffmann La Roche | Compositions and methods for inhibiting expression of glucocorticoid receptor (GCR) genes |
| CN109157742B (zh) | 2009-08-03 | 2022-04-05 | 因卡伯实验室有限责任公司 | 用于刺激肠道内肠促胰岛素产生的吞咽式囊和方法 |
| US8721620B2 (en) | 2009-12-24 | 2014-05-13 | Rani Therapeutics, Llc | Swallowable drug delivery device and methods of drug delivery |
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| US9068185B2 (en) | 2010-03-12 | 2015-06-30 | Sarepta Therapeutics, Inc. | Antisense modulation of nuclear hormone receptors |
| US9284367B2 (en) | 2010-12-23 | 2016-03-15 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9402807B2 (en) | 2010-12-23 | 2016-08-02 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US10639272B2 (en) | 2010-12-23 | 2020-05-05 | Rani Therapeutics, Llc | Methods for delivering etanercept preparations into a lumen of the intestinal tract using a swallowable drug delivery device |
| US8809269B2 (en) | 2010-12-23 | 2014-08-19 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising insulin for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US8969293B2 (en) | 2010-12-23 | 2015-03-03 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising exenatide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9149617B2 (en) | 2010-12-23 | 2015-10-06 | Rani Therapeutics, Llc | Device, system and methods for the oral delivery of therapeutic compounds |
| US9861683B2 (en) | 2010-12-23 | 2018-01-09 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US8734429B2 (en) | 2010-12-23 | 2014-05-27 | Rani Therapeutics, Llc | Device, system and methods for the oral delivery of therapeutic compounds |
| US9415004B2 (en) | 2010-12-23 | 2016-08-16 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9259386B2 (en) | 2010-12-23 | 2016-02-16 | Rani Therapeutics, Llc | Therapeutic preparation comprising somatostatin or somatostatin analogoue for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US8764733B2 (en) | 2010-12-23 | 2014-07-01 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US8980822B2 (en) | 2010-12-23 | 2015-03-17 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising pramlintide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9629799B2 (en) | 2010-12-23 | 2017-04-25 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US8846040B2 (en) | 2010-12-23 | 2014-09-30 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising etanercept for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9402806B2 (en) | 2010-12-23 | 2016-08-02 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9283179B2 (en) | 2010-12-23 | 2016-03-15 | Rani Therapeutics, Llc | GnRH preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US8809271B2 (en) | 2010-12-23 | 2014-08-19 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising liraglutide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US8901098B2 (en) * | 2011-10-25 | 2014-12-02 | Isis Pharmaceuticals, Inc. | Antisense modulation of GCCR expression |
| JP6049143B2 (ja) * | 2011-12-15 | 2016-12-21 | 国立大学法人東京農工大学 | オリゴヌクレオチド、グルココルチコイド感受性増強剤、医薬組成物、及び発現ベクター |
| RU2015119411A (ru) | 2012-11-15 | 2017-01-10 | Рош Инновейшен Сентер Копенгаген А/С | Конъюгаты антисмысловых соединений, направленные на аполипопротеин в |
| WO2014118267A1 (en) | 2013-01-30 | 2014-08-07 | Santaris Pharma A/S | Lna oligonucleotide carbohydrate conjugates |
| PL2992098T3 (pl) | 2013-05-01 | 2019-09-30 | Ionis Pharmaceuticals, Inc. | Kompozycje i sposoby modulowania ekspresji hbv i ttr |
| EP3730614A3 (en) * | 2013-07-02 | 2020-12-30 | Ionis Pharmaceuticals, Inc. | Modulators of growth hormone receptor |
| EP3137605B1 (en) | 2014-05-01 | 2020-10-28 | Ionis Pharmaceuticals, Inc. | Compositions and methods for modulating angiopoietin-like 3 expression |
| MX373283B (es) | 2014-05-01 | 2020-05-20 | Ionis Pharmaceuticals Inc | Composiciones y metodos para modular la expresion del receptor de la hormona del crecimiento. |
| PH12016502062B1 (en) | 2014-05-01 | 2023-01-27 | Ionis Pharmaceuticals Inc | Compositions and methods for modulating complement factor b expression |
| US10570169B2 (en) | 2014-05-22 | 2020-02-25 | Ionis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
| PT3206692T (pt) * | 2014-10-15 | 2024-04-30 | Corcept Therapeutics Inc | Tratamento da doença hepática gordurosa utilizando antagonistas dos recetores de glicocorticoides e mineralocorticoides |
| BR112017028194B1 (pt) * | 2015-07-10 | 2023-03-14 | Ionis Pharmaceuticals, Inc | Composto oligomérico modulador de diaciglicerol aciltransferase 2 (dgat2), composição, e seus usos |
| KR20250078597A (ko) | 2015-11-06 | 2025-06-02 | 아이오니스 파마수티컬즈, 인코포레이티드 | 아포리포프로테인 (a) 발현 조정 |
| CN109661233A (zh) | 2016-10-06 | 2019-04-19 | Ionis 制药公司 | 缀合低聚化合物的方法 |
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-
2006
- 2006-09-19 EP EP06814959A patent/EP1941040A1/en not_active Withdrawn
- 2006-09-19 WO PCT/US2006/036527 patent/WO2007035759A1/en not_active Ceased
- 2006-09-19 EA EA200800868A patent/EA200800868A1/ru unknown
- 2006-09-19 AU AU2006292293A patent/AU2006292293B2/en not_active Ceased
- 2006-09-19 KR KR1020087009278A patent/KR20080065617A/ko not_active Withdrawn
- 2006-09-19 US US11/524,507 patent/US20070066557A1/en not_active Abandoned
- 2006-09-19 CN CNA2006800432422A patent/CN101313066A/zh active Pending
- 2006-09-19 EP EP11152132A patent/EP2368988A1/en not_active Withdrawn
- 2006-09-19 CA CA002623772A patent/CA2623772A1/en not_active Abandoned
- 2006-09-19 JP JP2008532324A patent/JP2009508527A/ja active Pending
- 2006-09-19 BR BRPI0616370-0A patent/BRPI0616370A2/pt not_active IP Right Cessation
-
2008
- 2008-03-18 IL IL190281A patent/IL190281A0/en unknown
- 2008-03-19 EC EC2008008298A patent/ECSP088298A/es unknown
- 2008-04-18 NO NO20081883A patent/NO20081883L/no not_active Application Discontinuation
- 2008-04-18 ZA ZA200803452A patent/ZA200803452B/xx unknown
- 2008-04-21 CR CR9906A patent/CR9906A/es not_active Application Discontinuation
-
2010
- 2010-01-14 US US12/687,533 patent/US20100222412A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007035759A1 (en) | 2007-03-29 |
| EP1941040A1 (en) | 2008-07-09 |
| CR9906A (es) | 2009-01-16 |
| ZA200803452B (en) | 2009-10-28 |
| US20070066557A1 (en) | 2007-03-22 |
| AU2006292293B2 (en) | 2012-09-13 |
| EA200800868A1 (ru) | 2008-10-30 |
| EP2368988A1 (en) | 2011-09-28 |
| ECSP088298A (es) | 2008-05-30 |
| CA2623772A1 (en) | 2007-03-29 |
| IL190281A0 (en) | 2011-08-01 |
| AU2006292293A1 (en) | 2007-03-29 |
| KR20080065617A (ko) | 2008-07-14 |
| NO20081883L (no) | 2008-06-11 |
| JP2009508527A (ja) | 2009-03-05 |
| CN101313066A (zh) | 2008-11-26 |
| US20100222412A1 (en) | 2010-09-02 |
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