RU2667524C2 - Модулирование экспрессии вируса гепатита b (hbv) - Google Patents

Модулирование экспрессии вируса гепатита b (hbv) Download PDF

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RU2667524C2
RU2667524C2 RU2013151843A RU2013151843A RU2667524C2 RU 2667524 C2 RU2667524 C2 RU 2667524C2 RU 2013151843 A RU2013151843 A RU 2013151843A RU 2013151843 A RU2013151843 A RU 2013151843A RU 2667524 C2 RU2667524 C2 RU 2667524C2
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wing segment
linked nucleosides
modified oligonucleotide
sugar
segment
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RU2013151843A
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Russian (ru)
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RU2013151843A (ru
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Эрик Е. СУЭЙЗИ
Сьюзан М. Фрайер
Майкл Л. МАККАЛЕБ
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Ионис Фармасьютикалз, Инк.
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/30—Chemical structure
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RU2013151843A 2011-04-21 2012-04-20 Модулирование экспрессии вируса гепатита b (hbv) RU2667524C2 (ru)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201161478038P 2011-04-21 2011-04-21
US201161478040P 2011-04-21 2011-04-21
US61/478,040 2011-04-21
US61/478,038 2011-04-21
US201261596690P 2012-02-08 2012-02-08
US201261596692P 2012-02-08 2012-02-08
US61/596,690 2012-02-08
US61/596,692 2012-02-08
PCT/US2012/034550 WO2012145697A1 (en) 2011-04-21 2012-04-20 Modulation of hepatitis b virus (hbv) expression

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RU2013151843A RU2013151843A (ru) 2015-05-27
RU2667524C2 true RU2667524C2 (ru) 2018-09-21

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