MX2021000404A - Oligonucleotidos para modular la expresion de rtel1. - Google Patents
Oligonucleotidos para modular la expresion de rtel1.Info
- Publication number
- MX2021000404A MX2021000404A MX2021000404A MX2021000404A MX2021000404A MX 2021000404 A MX2021000404 A MX 2021000404A MX 2021000404 A MX2021000404 A MX 2021000404A MX 2021000404 A MX2021000404 A MX 2021000404A MX 2021000404 A MX2021000404 A MX 2021000404A
- Authority
- MX
- Mexico
- Prior art keywords
- rtel1
- oligonucleotides
- modulating
- relates
- hbv infection
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
Abstract
La presente invención se refiere a un inhibidor de RTEL1 para usar en el tratamiento de una infección por HBV, en particular, una infección por HBV crónica. La invención se refiere, en particular, al uso de inhibidores de RTEL1 para desestabilizar cccADN, tal como cccADN de HBV. La invención también se refiere a oligonucleótidos antisentido que son complementarios de RTEL1 y que pueden reducir el mARN de RTEL1. La presente invención también abarca una composición farmacéutica y su uso en el tratamiento y/o prevención de una infección por HBV.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18183477 | 2018-07-13 | ||
PCT/EP2019/068639 WO2020011902A1 (en) | 2018-07-13 | 2019-07-11 | Oligonucleotides for modulating rtel1 expression |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021000404A true MX2021000404A (es) | 2021-03-25 |
Family
ID=62951968
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021000404A MX2021000404A (es) | 2018-07-13 | 2019-07-11 | Oligonucleotidos para modular la expresion de rtel1. |
Country Status (16)
Country | Link |
---|---|
US (1) | US20210147850A1 (es) |
EP (1) | EP3821013A1 (es) |
JP (1) | JP2021524277A (es) |
KR (1) | KR20210033004A (es) |
CN (1) | CN112534055A (es) |
AU (1) | AU2019300324A1 (es) |
BR (1) | BR112021000538A2 (es) |
CA (1) | CA3106288A1 (es) |
CL (1) | CL2021000018A1 (es) |
CR (1) | CR20210015A (es) |
IL (1) | IL279929A (es) |
MX (1) | MX2021000404A (es) |
PE (1) | PE20211306A1 (es) |
SG (1) | SG11202100348SA (es) |
TW (1) | TWI791868B (es) |
WO (1) | WO2020011902A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW202246500A (zh) | 2021-02-02 | 2022-12-01 | 瑞士商赫孚孟拉羅股份公司 | 用於抑制 rtel1 表現之增強型寡核苷酸 |
WO2023111210A1 (en) | 2021-12-17 | 2023-06-22 | F. Hoffmann-La Roche Ag | Combination of oligonucleotides for modulating rtel1 and fubp1 |
Family Cites Families (45)
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ATE239484T1 (de) | 1991-10-24 | 2003-05-15 | Isis Pharmaceuticals Inc | Derivatisierte oligonukleotide mit verbessertem aufnahmevermögen |
JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
CN1273476C (zh) | 1997-09-12 | 2006-09-06 | 埃克西康有限公司 | 寡核苷酸类似物 |
ES2234563T5 (es) | 1999-02-12 | 2018-01-17 | Daiichi Sankyo Company, Limited | Nuevos análogos de nucleósidos y oligonucleótidos |
NZ514348A (en) | 1999-05-04 | 2004-05-28 | Exiqon As | L-ribo-LNA analogues |
US6617442B1 (en) | 1999-09-30 | 2003-09-09 | Isis Pharmaceuticals, Inc. | Human Rnase H1 and oligonucleotide compositions thereof |
US7393950B2 (en) * | 2002-08-29 | 2008-07-01 | Hong Kong University Of Science & Technology | Antisense oligonucleotides targeted to human CDC45 |
EP1569661B1 (en) | 2002-11-18 | 2009-09-09 | Santaris Pharma A/S | Antisense design |
AU2004221760B2 (en) | 2003-03-21 | 2010-03-18 | Roche Innovation Center Copenhagen A/S | Short interfering RNA (siRNA) analogues |
BRPI0411219A (pt) | 2003-06-12 | 2006-07-18 | Nucleonics Inc | seqüências de hbv e hcv conservadas úteis para silenciamento de gene |
US20090221679A1 (en) | 2005-08-10 | 2009-09-03 | Amy Espeseth | Novel HIV Targets |
WO2007031091A2 (en) | 2005-09-15 | 2007-03-22 | Santaris Pharma A/S | Rna antagonist compounds for the modulation of p21 ras expression |
JP2009524419A (ja) | 2006-01-27 | 2009-07-02 | サンタリス ファーマ アー/エス | Lna修飾したホスホロチオール化オリゴヌクレオチド |
PL2314594T3 (pl) | 2006-01-27 | 2014-12-31 | Isis Pharmaceuticals Inc | Zmodyfikowane w pozycji 6 analogi bicykliczne kwasów nukleinowych |
EP2002004B1 (en) | 2006-03-23 | 2015-10-14 | Roche Innovation Center Copenhagen A/S | Small internally segmented interfering rna |
US7666854B2 (en) | 2006-05-11 | 2010-02-23 | Isis Pharmaceuticals, Inc. | Bis-modified bicyclic nucleic acid analogs |
DK2066684T3 (da) | 2006-05-11 | 2012-10-22 | Isis Pharmaceuticals Inc | 5´-Modificerede bicycliske nukleinsyreanaloge |
ES2388590T3 (es) | 2007-05-30 | 2012-10-16 | Isis Pharmaceuticals, Inc. | Análogos de ácidos nucleicos bicíclicos con puente aminometileno N-sustituido. |
ES2386492T3 (es) | 2007-06-08 | 2012-08-21 | Isis Pharmaceuticals, Inc. | Análogos de ácidos nucleicos bicíclicos carbocíclicos |
ES2376507T5 (es) | 2007-07-05 | 2015-08-31 | Isis Pharmaceuticals, Inc. | Análogos de ácidos nucleicos bicíclicos 6-disustituidos |
US8546556B2 (en) | 2007-11-21 | 2013-10-01 | Isis Pharmaceuticals, Inc | Carbocyclic alpha-L-bicyclic nucleic acid analogs |
EP2356129B1 (en) | 2008-09-24 | 2013-04-03 | Isis Pharmaceuticals, Inc. | Substituted alpha-l-bicyclic nucleosides |
US20100249214A1 (en) | 2009-02-11 | 2010-09-30 | Dicerna Pharmaceuticals | Multiplex dicer substrate rna interference molecules having joining sequences |
CA3151965A1 (en) | 2008-12-18 | 2010-07-15 | Dicerna Pharmaceuticals, Inc. | Extended dicer substrate agents and methods for the specific inhibition of gene expression |
US9012421B2 (en) | 2009-08-06 | 2015-04-21 | Isis Pharmaceuticals, Inc. | Bicyclic cyclohexose nucleic acid analogs |
WO2011156202A1 (en) | 2010-06-08 | 2011-12-15 | Isis Pharmaceuticals, Inc. | Substituted 2 '-amino and 2 '-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom |
KR102072631B1 (ko) | 2010-08-17 | 2020-02-03 | 시르나 쎄러퓨틱스 인코퍼레이티드 | 짧은 간섭 핵산 (siNA)을 사용한 B형 간염 바이러스 (HBV) 유전자 발현의 RNA 간섭 매개 억제 |
PL3124610T3 (pl) | 2010-10-28 | 2019-09-30 | Benitec Biopharma Limited | Leczenie hbv |
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CN112263682A (zh) | 2013-06-27 | 2021-01-26 | 罗氏创新中心哥本哈根有限公司 | 靶向pcsk9的反义寡聚体和缀合物 |
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-
2019
- 2019-07-11 AU AU2019300324A patent/AU2019300324A1/en not_active Abandoned
- 2019-07-11 JP JP2021500833A patent/JP2021524277A/ja active Pending
- 2019-07-11 CR CR20210015A patent/CR20210015A/es unknown
- 2019-07-11 BR BR112021000538-2A patent/BR112021000538A2/pt unknown
- 2019-07-11 PE PE2020002231A patent/PE20211306A1/es unknown
- 2019-07-11 WO PCT/EP2019/068639 patent/WO2020011902A1/en unknown
- 2019-07-11 CN CN201980047097.2A patent/CN112534055A/zh active Pending
- 2019-07-11 KR KR1020217004297A patent/KR20210033004A/ko not_active Application Discontinuation
- 2019-07-11 CA CA3106288A patent/CA3106288A1/en active Pending
- 2019-07-11 EP EP19739971.0A patent/EP3821013A1/en active Pending
- 2019-07-11 MX MX2021000404A patent/MX2021000404A/es unknown
- 2019-07-11 SG SG11202100348SA patent/SG11202100348SA/en unknown
- 2019-07-12 TW TW108124604A patent/TWI791868B/zh active
-
2021
- 2021-01-03 IL IL279929A patent/IL279929A/en unknown
- 2021-01-05 CL CL2021000018A patent/CL2021000018A1/es unknown
- 2021-01-13 US US17/147,797 patent/US20210147850A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
TWI791868B (zh) | 2023-02-11 |
WO2020011902A1 (en) | 2020-01-16 |
TW202020152A (zh) | 2020-06-01 |
CR20210015A (es) | 2021-03-22 |
CA3106288A1 (en) | 2020-01-16 |
SG11202100348SA (en) | 2021-02-25 |
KR20210033004A (ko) | 2021-03-25 |
EP3821013A1 (en) | 2021-05-19 |
AU2019300324A1 (en) | 2021-01-21 |
CL2021000018A1 (es) | 2021-07-09 |
PE20211306A1 (es) | 2021-07-20 |
BR112021000538A2 (pt) | 2021-04-06 |
IL279929A (en) | 2021-03-01 |
CN112534055A (zh) | 2021-03-19 |
JP2021524277A (ja) | 2021-09-13 |
US20210147850A1 (en) | 2021-05-20 |
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