BR112018075682A2 - inibidores de papd5 e papd7 para tratamento de infecção pela hepatite b - Google Patents
inibidores de papd5 e papd7 para tratamento de infecção pela hepatite bInfo
- Publication number
- BR112018075682A2 BR112018075682A2 BR112018075682-2A BR112018075682A BR112018075682A2 BR 112018075682 A2 BR112018075682 A2 BR 112018075682A2 BR 112018075682 A BR112018075682 A BR 112018075682A BR 112018075682 A2 BR112018075682 A2 BR 112018075682A2
- Authority
- BR
- Brazil
- Prior art keywords
- infection
- papd7
- papd5
- hbv
- treatment
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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Abstract
refere-se a presente invenção a um método para identificar um composto que previne, melhora e/ou inibe uma infecção pelo vírus da hepatite b (hbv), em que um composto que (i) reduz a expressão e/ou atividade de domínio associado a pap que contém 5 (papd5) e/ou domínio associado a pap que contém 7 (papd7); e/ou (ii) se liga a papd5 e/ou papd7 e inibe a propagação de hbv; é identificado como um composto que previne, melhora e/ou inibe uma infecção pelo hbv. a invenção também proporciona um agente de inibição de papd5 e/ou papd7 para o uso no tratamento e/ou prevenção de uma infecção pelo hbv; bem como uma preparação combinada que compreende um agente de inibição de papd5 e um agente de inibição de papd7 para o uso simultâneo ou subsequente no tratamento ou prevenção de uma infecção pelo hbv. igualmente compreendida na presente invenção está uma composição farmacêutica para o uso no tratamento e/ou prevenção de uma infecção pelo hbv, e um método para monitorar o êxito terapêutico durante o tratamento de uma infecção pelo hbv.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16175045 | 2016-06-17 | ||
EP16175045.0 | 2016-06-17 | ||
PCT/EP2017/064981 WO2017216391A1 (en) | 2016-06-17 | 2017-06-19 | Papd5 and papd7 inhibitors for treating a hepatitis b infection |
Publications (1)
Publication Number | Publication Date |
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BR112018075682A2 true BR112018075682A2 (pt) | 2019-04-02 |
Family
ID=56321739
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018075682-2A BR112018075682A2 (pt) | 2016-06-17 | 2017-06-19 | inibidores de papd5 e papd7 para tratamento de infecção pela hepatite b |
BR112018075960A BR112018075960A2 (pt) | 2016-06-17 | 2017-06-19 | moléculas de ácido nucleico para a redução de mrna de papd5 ou papd7 para o tratamento de infecção pela hepatite b |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018075960A BR112018075960A2 (pt) | 2016-06-17 | 2017-06-19 | moléculas de ácido nucleico para a redução de mrna de papd5 ou papd7 para o tratamento de infecção pela hepatite b |
Country Status (19)
Country | Link |
---|---|
US (4) | US11534452B2 (pt) |
EP (3) | EP3472362B1 (pt) |
JP (5) | JP7007304B2 (pt) |
KR (3) | KR102381682B1 (pt) |
CN (3) | CN109414448B (pt) |
AU (3) | AU2017285350A1 (pt) |
BR (2) | BR112018075682A2 (pt) |
CA (2) | CA3027811A1 (pt) |
CL (3) | CL2018003561A1 (pt) |
CR (1) | CR20180590A (pt) |
ES (1) | ES2942407T3 (pt) |
IL (2) | IL263558A (pt) |
MA (1) | MA45496A (pt) |
MX (2) | MX367541B (pt) |
PE (1) | PE20190443A1 (pt) |
PL (1) | PL3472346T3 (pt) |
RU (1) | RU2768699C2 (pt) |
SG (1) | SG11201810594RA (pt) |
WO (2) | WO2017216391A1 (pt) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016183266A1 (en) | 2015-05-13 | 2016-11-17 | Enanta Pharmaceuticals, Inc. | Ehpatitis b antiviral agents |
AU2017229007B2 (en) | 2016-03-07 | 2021-04-01 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
MA45496A (fr) | 2016-06-17 | 2019-04-24 | Hoffmann La Roche | Molécules d'acide nucléique pour la réduction de l'arnm de padd5 ou pad7 pour le traitement d'une infection par l'hépatite b |
CN110066278B (zh) * | 2017-06-01 | 2021-06-08 | 广东东阳光药业有限公司 | 稠合三环类化合物及其在药物中的应用 |
KR102556744B1 (ko) | 2017-08-28 | 2023-07-18 | 이난타 파마슈티칼스, 인코포레이티드 | B형 간염 항바이러스제 |
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