CL2020003330A1 - Moléculas de ácido nucleico para la reducción de arnm de papd5 o papd7 para tratar la infección por hepatitis b (divisional solicitud no. 3561-2018) - Google Patents

Moléculas de ácido nucleico para la reducción de arnm de papd5 o papd7 para tratar la infección por hepatitis b (divisional solicitud no. 3561-2018)

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Publication number
CL2020003330A1
CL2020003330A1 CL2020003330A CL2020003330A CL2020003330A1 CL 2020003330 A1 CL2020003330 A1 CL 2020003330A1 CL 2020003330 A CL2020003330 A CL 2020003330A CL 2020003330 A CL2020003330 A CL 2020003330A CL 2020003330 A1 CL2020003330 A1 CL 2020003330A1
Authority
CL
Chile
Prior art keywords
infection
papd7
papd5
hbv
nucleic acid
Prior art date
Application number
CL2020003330A
Other languages
English (en)
Inventor
Hassan Javanbakht
Søren Ottosen
Lykke Pedersen
Henrik Mueller
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CL2020003330A1 publication Critical patent/CL2020003330A1/es

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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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Abstract

La presente invención se refiere a un método para identificar un compuesto que previene, alivia y/o inhibe una infección por virus de la hepatitis B (VHB), en donde un compuesto que reduce la expresión y/o actividad de proteína que contiene dominio asociado a PAP 5 (PAPD5) y/o que contiene dominio asociado a PAP 7 (PAPD7) se identifica como un compuesto que previene, alivia y/o inhibe una infección por VHB. La invención también proporciona inhibidores de PAPD5 o PAPD7 para su uso en el tratamiento y/o la prevención de una infección por VHB; así como un preparado combinado que comprende un inhibidor de PAPD5 y un inhibidor de PAPD7 para su uso simultáneo o secuencial en el tratamiento o la prevención de una infección por VHB. La presente invención también comprende una composición farmacéutica para su uso en el tratamiento y/o la prevención de una infección por VHB y un método para supervisar el éxito terapéutico durante el tratamiento de una infección por VHB.
CL2020003330A 2016-06-17 2020-12-21 Moléculas de ácido nucleico para la reducción de arnm de papd5 o papd7 para tratar la infección por hepatitis b (divisional solicitud no. 3561-2018) CL2020003330A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16175045 2016-06-17
CL2018003561A CL2018003561A1 (es) 2016-06-17 2018-12-11 Moléculas de ácido nucleico para la reducción de arnm de papd5 o papd7 para tratar la infección por hepatitis b

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CL2020003330A1 true CL2020003330A1 (es) 2021-06-04

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Application Number Title Priority Date Filing Date
CL2018003561A CL2018003561A1 (es) 2016-06-17 2018-12-11 Moléculas de ácido nucleico para la reducción de arnm de papd5 o papd7 para tratar la infección por hepatitis b
CL2020003329A CL2020003329A1 (es) 2016-06-17 2020-12-21 Moléculas de ácido nucleico para la reducción de arnm de papd5 o papd7 para tratar la infección por hepatitis b (divisional solicitud no. 3561-2018)
CL2020003330A CL2020003330A1 (es) 2016-06-17 2020-12-21 Moléculas de ácido nucleico para la reducción de arnm de papd5 o papd7 para tratar la infección por hepatitis b (divisional solicitud no. 3561-2018)

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