CR20180590A - MOLÉCULAS DE ÁCIDO NUCLEICO PARA LA REDUCCIÓN DE ARNm DE PAPD5 O PAPD7 PARA TRATAR LA INFECCIÓN POR HEPATITIS B - Google Patents

MOLÉCULAS DE ÁCIDO NUCLEICO PARA LA REDUCCIÓN DE ARNm DE PAPD5 O PAPD7 PARA TRATAR LA INFECCIÓN POR HEPATITIS B

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Publication number
CR20180590A
CR20180590A CR20180590A CR20180590A CR20180590A CR 20180590 A CR20180590 A CR 20180590A CR 20180590 A CR20180590 A CR 20180590A CR 20180590 A CR20180590 A CR 20180590A CR 20180590 A CR20180590 A CR 20180590A
Authority
CR
Costa Rica
Prior art keywords
papd5
infection
papd7
treatment
hbv infection
Prior art date
Application number
CR20180590A
Other languages
English (en)
Inventor
Hassan; Javanbakht
Søren Ottosen
Lykke Pedersen
Henrik; Mueller
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CR20180590A publication Critical patent/CR20180590A/es

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Abstract

La presente invención se refiere a un método para identificar un compuesto que previene, alivia y/o inhibe una infección por virus de la hepatitis B (VHB), en donde un compuesto que reduce la expresión y/o actividad de proteína que contiene dominio asociado a PAP 5 (PAPD5) y/o que contiene dominio asociado a PAP 7 (PAPD7) se identifica como un compuesto que previene, alivia y/o inhibe una infección por VHB. La invención también proporciona inhibidores de PAPD5 o PAPD7 para su uso en el tratamiento y/o la prevención de una infección por VHB; así como un preparado combinado que comprende un inhibidor de PAPD5 y un inhibidor de PAPD7 para su uso simultáneo o secuencial en el tratamiento o la prevención de una infección por VHB. La presente invención también comprende una composición farmacéutica para su uso en el tratamiento y/o la prevención de una infección por VHB y un método para supervisar el éxito terapéutico durante el tratamiento de una infección por VHB.
CR20180590A 2016-06-17 2017-06-19 MOLÉCULAS DE ÁCIDO NUCLEICO PARA LA REDUCCIÓN DE ARNm DE PAPD5 O PAPD7 PARA TRATAR LA INFECCIÓN POR HEPATITIS B CR20180590A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16175045 2016-06-17
PCT/EP2017/064980 WO2017216390A1 (en) 2016-06-17 2017-06-19 Nucleic acid molecules for reduction of papd5 or papd7 mrna for treating hepatitis b infection

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CR20180590A true CR20180590A (es) 2019-03-05

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CR20180590A CR20180590A (es) 2016-06-17 2017-06-19 MOLÉCULAS DE ÁCIDO NUCLEICO PARA LA REDUCCIÓN DE ARNm DE PAPD5 O PAPD7 PARA TRATAR LA INFECCIÓN POR HEPATITIS B

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US (4) US11191775B2 (es)
EP (3) EP3472362B1 (es)
JP (5) JP7258558B2 (es)
KR (3) KR102381682B1 (es)
CN (3) CN109328237B (es)
AU (3) AU2017285350A1 (es)
BR (2) BR112018075960A2 (es)
CA (2) CA3027811A1 (es)
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