JP2010519931A5 - - Google Patents
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- JP2010519931A5 JP2010519931A5 JP2009552758A JP2009552758A JP2010519931A5 JP 2010519931 A5 JP2010519931 A5 JP 2010519931A5 JP 2009552758 A JP2009552758 A JP 2009552758A JP 2009552758 A JP2009552758 A JP 2009552758A JP 2010519931 A5 JP2010519931 A5 JP 2010519931A5
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- Japan
- Prior art keywords
- substitution
- polypeptide
- seq
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- protein
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90545907P | 2007-03-06 | 2007-03-06 | |
| US60/905,459 | 2007-03-06 | ||
| US6547408P | 2008-02-11 | 2008-02-11 | |
| US61/065,474 | 2008-02-11 | ||
| PCT/US2008/003119 WO2008109167A2 (en) | 2007-03-06 | 2008-03-06 | Variant activin receptor polypeptides and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010519931A JP2010519931A (ja) | 2010-06-10 |
| JP2010519931A5 true JP2010519931A5 (enExample) | 2012-03-08 |
| JP5496682B2 JP5496682B2 (ja) | 2014-05-21 |
Family
ID=39739001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009552758A Active JP5496682B2 (ja) | 2007-03-06 | 2008-03-06 | バリアントアクチビン受容体ポリペプチドおよびその使用 |
Country Status (29)
| Country | Link |
|---|---|
| US (5) | US7947646B2 (enExample) |
| EP (2) | EP2132314B1 (enExample) |
| JP (1) | JP5496682B2 (enExample) |
| KR (5) | KR20160075861A (enExample) |
| CN (2) | CN101679980B8 (enExample) |
| AR (1) | AR065611A1 (enExample) |
| AU (1) | AU2008223338C9 (enExample) |
| BR (1) | BRPI0808332A2 (enExample) |
| CA (1) | CA2679841C (enExample) |
| CL (2) | CL2008000664A1 (enExample) |
| CR (2) | CR11054A (enExample) |
| CY (1) | CY1118857T1 (enExample) |
| DK (1) | DK2132314T3 (enExample) |
| EA (2) | EA020510B1 (enExample) |
| ES (1) | ES2613043T3 (enExample) |
| HR (1) | HRP20170323T1 (enExample) |
| HU (1) | HUE032260T2 (enExample) |
| IL (2) | IL200605A (enExample) |
| LT (1) | LT2132314T (enExample) |
| MX (3) | MX348286B (enExample) |
| NZ (1) | NZ579369A (enExample) |
| PE (3) | PE20130615A1 (enExample) |
| PH (1) | PH12013502308A1 (enExample) |
| PL (1) | PL2132314T3 (enExample) |
| PT (1) | PT2132314T (enExample) |
| RS (1) | RS55726B1 (enExample) |
| SI (1) | SI2132314T1 (enExample) |
| TW (3) | TW201718635A (enExample) |
| WO (1) | WO2008109167A2 (enExample) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2332977T3 (en) | 2004-07-23 | 2016-02-29 | Acceleron Pharma Inc | ActRII receptor polypeptides |
| CN101277976B (zh) | 2005-10-06 | 2012-04-11 | 伊莱利利公司 | 抗肌抑制素抗体 |
| UA92504C2 (en) | 2005-10-12 | 2010-11-10 | Эли Лилли Энд Компани | Anti-myostatin monoclonal antibody |
| US8067562B2 (en) | 2005-11-01 | 2011-11-29 | Amgen Inc. | Isolated nucleic acid molecule comprising the amino acid sequence of SEQ ID NO:1 |
| CA3045808C (en) | 2005-11-23 | 2022-08-16 | Acceleron Pharma, Inc. | Activin-actriia antagonists and uses for promoting bone growth |
| US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
| WO2008030706A2 (en) | 2006-09-05 | 2008-03-13 | Eli Lilly And Company | Anti-myostatin antibodies |
| MX373050B (es) | 2006-12-18 | 2020-05-21 | Acceleron Pharma Inc | Antagonistas de activina-actrii y usos para incrementar los niveles de globulos rojos. |
| US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
| RU2473362C2 (ru) | 2007-02-01 | 2013-01-27 | Акселерон Фарма Инк. | АНТАГОНИСТЫ АКТИВИНА-ActRIIa-Fc И ИХ ПРИМЕНЕНИЕ ДЛЯ ЛЕЧЕНИЯ ИЛИ ПРОФИЛАКТИКИ РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ |
| TW201907946A (zh) | 2007-02-02 | 2019-03-01 | 美商艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
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| TW201919685A (zh) | 2008-08-14 | 2019-06-01 | 美商艾瑟勒朗法瑪公司 | 使用gdf阱以增加紅血球水平 |
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| CA2749544A1 (en) | 2009-01-13 | 2010-07-22 | Acceleron Pharma Inc. | Methods for increasing adiponectin |
| EP3275900A1 (en) | 2009-04-27 | 2018-01-31 | Novartis AG | Compositions and methods for increasing muscle growth |
| CA2764890A1 (en) | 2009-06-08 | 2010-12-16 | Acceleron Pharma Inc. | Methods for increasing thermogenic adipocytes |
| CN104805105A (zh) | 2009-06-12 | 2015-07-29 | 阿塞勒隆制药公司 | 截短的actriib-fc融合蛋白 |
| ES2869864T3 (es) | 2009-11-03 | 2021-10-26 | Acceleron Pharma Inc | Procedimientos para el tratamiento de la enfermedad del hígado graso |
| EP2501400B1 (en) | 2009-11-17 | 2017-11-01 | Acceleron Pharma, Inc. | Actriib proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy |
| JO3340B1 (ar) | 2010-05-26 | 2019-03-13 | Regeneron Pharma | مضادات حيوية لـعامل تمايز النمو 8 البشري |
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| CA2890217C (en) | 2012-11-02 | 2021-07-20 | Yifu FANG | Activin-actrii antagonists and uses for treating bone and other disorders |
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| TWI655207B (zh) | 2013-07-30 | 2019-04-01 | 再生元醫藥公司 | 抗活化素a之抗體及其用途 |
| US10017566B2 (en) | 2013-11-12 | 2018-07-10 | The Brigham And Women's Hospital, Inc. | Growth differentiation factor (GDF) for treatment of diastolic heart failure |
| AP2017009674A0 (en) | 2014-06-13 | 2017-01-31 | Acceleron Pharma Inc | Methods and compositions for treating ulcers |
| PE20170471A1 (es) * | 2014-06-13 | 2017-05-14 | Santa Maria Biotherapeutics Inc | Polipeptidos receptores formulados y metodos relacionados |
| MA41052A (fr) * | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
| LT3227675T (lt) | 2014-12-03 | 2023-06-12 | Celgene Corporation | Aktivino actrii antagonistai ir naudojimas mielodisplastiniam sindromui gydyti |
| MX2017007519A (es) * | 2014-12-08 | 2017-08-22 | Novartis Ag | Antagonistas de miostatina o activina para el tratamiento de sarcopenia. |
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| US9744985B2 (en) | 2015-02-17 | 2017-08-29 | Hyundai Motor Company | Rack bar unit of vehicle steering device |
| KR20180002659A (ko) | 2015-04-06 | 2018-01-08 | 악셀레론 파마 인코포레이티드 | Tgf-베타 슈퍼패밀리 유형 i 및 유형 ii 수용체 이형다합체들과 이의 용도 |
| MA41919A (fr) | 2015-04-06 | 2018-02-13 | Acceleron Pharma Inc | Hétéromultimères alk4:actriib et leurs utilisations |
| US10358476B2 (en) | 2015-04-06 | 2019-07-23 | Acceleron Pharma Inc. | Single arm type I and type II receptor fusion proteins and uses thereof |
| KR20170135967A (ko) | 2015-04-15 | 2017-12-08 | 리제너론 파마슈티칼스 인코포레이티드 | Gdf8 억제제를 사용하여 강도 및 기능을 증가시키는 방법 |
| RU2733492C2 (ru) | 2015-04-22 | 2020-10-02 | Байоджен Ма Инк. | Новые гибридные ActRIIB белки-ловушки лигандов для лечения заболеваний, связанных с мышечной атрофией |
| RU2651776C2 (ru) * | 2015-12-01 | 2018-04-23 | Общество с ограниченной ответственностью "Международный биотехнологический центр "Генериум" ("МБЦ "Генериум") | Биспецифические антитела против cd3*cd19 |
| CN116059320A (zh) | 2016-01-06 | 2023-05-05 | 哈佛学院校长同事会 | 使用gdf11的治疗防止体重增加、提高葡萄糖耐量并减轻脂肪肝 |
| AU2017230091B2 (en) | 2016-03-10 | 2022-04-07 | Acceleron Pharma Inc. | Activin type 2 receptor binding proteins and uses thereof |
| KR20190075078A (ko) | 2016-10-05 | 2019-06-28 | 악셀레론 파마 인코포레이티드 | ALK4:ActRIIB 이형다량체 및 이의 용도 |
| JOP20190085A1 (ar) | 2016-10-20 | 2019-04-17 | Biogen Ma Inc | طرق علاج الضمور العضلي ومرض العظام باستخدام بروتينات احتجاز مركب ترابطي actriib هجين حديثة |
| CN110461349B (zh) | 2016-11-10 | 2024-08-13 | 科乐斯疗法公司 | 激活素受体iia型变体及其使用方法 |
| EP3706777B1 (en) | 2017-11-09 | 2024-05-22 | Keros Therapeutics, Inc. | Activin receptor type iia variants and methods of use thereof |
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| CN111787981B (zh) | 2018-03-01 | 2025-12-30 | 瑞泽恩制药公司 | 增加肌肉量和减少脂肪量的方法 |
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