JP2016511751A5 - - Google Patents

Info

Publication number

JP2016511751A5

JP2016511751A5 JP2015555353A JP2015555353A JP2016511751A5 JP 2016511751 A5 JP2016511751 A5 JP 2016511751A5 JP 2015555353 A JP2015555353 A JP 2015555353A JP 2015555353 A JP2015555353 A JP 2015555353A JP 2016511751 A5 JP2016511751 A5 JP 2016511751A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

follistatin

protein

seq

recombinant follistatin

Prior art date

2014-01-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 102000016970 Follistatin Human genes 0.000 claims 55
• 108010014612 Follistatin Proteins 0.000 claims 55
• 239000008194 pharmaceutical composition Substances 0.000 claims 40
• 125000003275 alpha amino acid group Chemical group 0.000 claims 22
• 108020001507 fusion proteins Proteins 0.000 claims 22
• 102000037865 fusion proteins Human genes 0.000 claims 22
• 108090000765 processed proteins & peptides Proteins 0.000 claims 13
• 101000931668 Homo sapiens Follistatin Proteins 0.000 claims 11
• 102000050536 human FST Human genes 0.000 claims 11
• 229920001184 polypeptide Polymers 0.000 claims 11
• 102000004196 processed proteins & peptides Human genes 0.000 claims 11
• 206010013801 Duchenne Muscular Dystrophy Diseases 0.000 claims 5
• 238000007910 systemic administration Methods 0.000 claims 5
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
• 230000037430 deletion Effects 0.000 claims 3
• 238000012217 deletion Methods 0.000 claims 3
• 210000004962 mammalian cell Anatomy 0.000 claims 3
• 210000003205 muscle Anatomy 0.000 claims 3
• 206010028320 muscle necrosis Diseases 0.000 claims 3
• 230000035772 mutation Effects 0.000 claims 3
• 108010059616 Activins Proteins 0.000 claims 2
• 102100039939 Growth/differentiation factor 8 Human genes 0.000 claims 2
• 102100026818 Inhibin beta E chain Human genes 0.000 claims 2
• 208000010428 Muscle Weakness Diseases 0.000 claims 2
• 206010028372 Muscular weakness Diseases 0.000 claims 2
• 108010056852 Myostatin Proteins 0.000 claims 2
• 101000690429 Panax ginseng Floral homeotic protein AGAMOUS Proteins 0.000 claims 2
• 101000828148 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Transposon Ty3-G Gag polyprotein Proteins 0.000 claims 2
• 101000790437 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Transposon Ty3-I Gag polyprotein Proteins 0.000 claims 2
• 239000000488 activin Substances 0.000 claims 2
• 125000000539 amino acid group Chemical group 0.000 claims 2
• 150000001413 amino acids Chemical class 0.000 claims 2
• 210000004027 cell Anatomy 0.000 claims 2
• 230000004064 dysfunction Effects 0.000 claims 2
• 238000001727 in vivo Methods 0.000 claims 2
• 238000001990 intravenous administration Methods 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• 210000002027 skeletal muscle Anatomy 0.000 claims 2
• 238000007920 subcutaneous administration Methods 0.000 claims 2
• 208000024891 symptom Diseases 0.000 claims 2
• 210000001519 tissue Anatomy 0.000 claims 2
• 206010069632 Bladder dysfunction Diseases 0.000 claims 1
• 208000031229 Cardiomyopathies Diseases 0.000 claims 1
• 208000032170 Congenital Abnormalities Diseases 0.000 claims 1
• 206010061619 Deformity Diseases 0.000 claims 1
• 208000019505 Deglutition disease Diseases 0.000 claims 1
• 201000000628 Gas Gangrene Diseases 0.000 claims 1
• 102100040898 Growth/differentiation factor 11 Human genes 0.000 claims 1
• 101710194452 Growth/differentiation factor 11 Proteins 0.000 claims 1
• 206010023201 Joint contracture Diseases 0.000 claims 1
• 206010028289 Muscle atrophy Diseases 0.000 claims 1
• 206010048654 Muscle fibrosis Diseases 0.000 claims 1
• 230000003110 anti-inflammatory effect Effects 0.000 claims 1
• 230000006741 behavioral dysfunction Effects 0.000 claims 1
• 230000017531 blood circulation Effects 0.000 claims 1
• 230000019771 cognition Effects 0.000 claims 1
• 208000010877 cognitive disease Diseases 0.000 claims 1
• 230000003111 delayed effect Effects 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 230000003203 everyday effect Effects 0.000 claims 1
• 206010016256 fatigue Diseases 0.000 claims 1
• 210000005260 human cell Anatomy 0.000 claims 1
• 230000037431 insertion Effects 0.000 claims 1
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• 230000000968 intestinal effect Effects 0.000 claims 1
• 238000007918 intramuscular administration Methods 0.000 claims 1
• 230000001788 irregular Effects 0.000 claims 1
• 208000028867 ischemia Diseases 0.000 claims 1
• 230000009756 muscle regeneration Effects 0.000 claims 1
• 201000000585 muscular atrophy Diseases 0.000 claims 1
• 230000017074 necrotic cell death Effects 0.000 claims 1
• 239000002773 nucleotide Substances 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1
• 230000009325 pulmonary function Effects 0.000 claims 1
• 210000001139 rectus abdominis Anatomy 0.000 claims 1
• 230000000241 respiratory effect Effects 0.000 claims 1
• 206010039722 scoliosis Diseases 0.000 claims 1
• 230000000699 topical effect Effects 0.000 claims 1