JP2009525757A5 - - Google Patents
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- Publication number
- JP2009525757A5 JP2009525757A5 JP2008554373A JP2008554373A JP2009525757A5 JP 2009525757 A5 JP2009525757 A5 JP 2009525757A5 JP 2008554373 A JP2008554373 A JP 2008554373A JP 2008554373 A JP2008554373 A JP 2008554373A JP 2009525757 A5 JP2009525757 A5 JP 2009525757A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- acid molecule
- amino acid
- protein
- phosphatase inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000039446 nucleic acids Human genes 0.000 claims 9
- 108020004707 nucleic acids Proteins 0.000 claims 9
- 150000007523 nucleic acids Chemical class 0.000 claims 9
- 150000001413 amino acids Chemical group 0.000 claims 8
- 102000004097 Protein phosphatase inhibitor 1 Human genes 0.000 claims 7
- 108090000506 Protein phosphatase inhibitor 1 Proteins 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 4
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 4
- 235000004279 alanine Nutrition 0.000 claims 4
- 235000001014 amino acid Nutrition 0.000 claims 4
- 235000003704 aspartic acid Nutrition 0.000 claims 4
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 4
- 235000018417 cysteine Nutrition 0.000 claims 4
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 206010019280 Heart failures Diseases 0.000 claims 2
- 239000011575 calcium Substances 0.000 claims 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 210000004165 myocardium Anatomy 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical group [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 241000702421 Dependoparvovirus Species 0.000 claims 1
- 241000700588 Human alphaherpesvirus 1 Species 0.000 claims 1
- 241000713666 Lentivirus Species 0.000 claims 1
- 230000005856 abnormality Effects 0.000 claims 1
- 230000006793 arrhythmia Effects 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000010247 heart contraction Effects 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 230000006371 metabolic abnormality Effects 0.000 claims 1
- 230000002107 myocardial effect Effects 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000004904 shortening Methods 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
- 241001430294 unidentified retrovirus Species 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77232706P | 2006-02-10 | 2006-02-10 | |
| PCT/US2007/003470 WO2007100465A2 (en) | 2006-02-10 | 2007-02-09 | Phosphatase inhibitor protein-1 as a regulator of cardiac function |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012207821A Division JP2013027398A (ja) | 2006-02-10 | 2012-09-21 | 心機能のレギュレータとしてのホスファターゼインヒビタープロテイン−１ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009525757A JP2009525757A (ja) | 2009-07-16 |
| JP2009525757A5 true JP2009525757A5 (enExample) | 2010-04-30 |
Family
ID=38459499
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008554373A Pending JP2009525757A (ja) | 2006-02-10 | 2007-02-09 | 心機能のレギュレータとしてのホスファターゼインヒビタープロテイン−１ |
| JP2012207821A Pending JP2013027398A (ja) | 2006-02-10 | 2012-09-21 | 心機能のレギュレータとしてのホスファターゼインヒビタープロテイン−１ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012207821A Pending JP2013027398A (ja) | 2006-02-10 | 2012-09-21 | 心機能のレギュレータとしてのホスファターゼインヒビタープロテイン−１ |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7989606B2 (enExample) |
| EP (2) | EP1994043A4 (enExample) |
| JP (2) | JP2009525757A (enExample) |
| CN (1) | CN101437833A (enExample) |
| AU (1) | AU2007221470B2 (enExample) |
| CA (1) | CA2638913A1 (enExample) |
| WO (1) | WO2007100465A2 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006029319A2 (en) | 2004-09-09 | 2006-03-16 | The General Hospital Corporation | Modulating phosphatase activity in cardiac cells |
| WO2009090049A1 (en) * | 2008-01-14 | 2009-07-23 | European Molecular Biology Laboratory | Peptides for the specific binding and regulation of protein targets |
| ES2634118T3 (es) | 2009-02-11 | 2017-09-26 | The University Of North Carolina At Chapel Hill | Vectores de virus modificados y métodos para fabricar y utilizar los mismos |
| CN101942481B (zh) * | 2009-04-30 | 2012-07-25 | 中南大学 | 一种针对PKC γ基因RNA干扰的重组慢病毒载体的构建及其应用 |
| CA2810668A1 (en) | 2010-09-08 | 2012-03-15 | Halozyme, Inc. | Methods for assessing and identifying or evolving conditionally active therapeutic proteins |
| EP4234571A3 (en) | 2011-02-10 | 2023-09-27 | The University of North Carolina at Chapel Hill | Viral vectors with modified transduction profiles and methods of making and using the same |
| AU2013229786B2 (en) | 2012-03-08 | 2017-06-22 | Halozyme, Inc. | Conditionally active anti-epidermal growth factor receptor antibodies and methods of use thereof |
| WO2014007584A1 (en) * | 2012-07-05 | 2014-01-09 | Gwangju Institute Of Science And Technology | Decoy peptides inhibiting protein phosphatase 1-mediated dephosphorylation of phospholamban |
| CA2904396A1 (en) | 2013-03-15 | 2014-09-18 | The University Of North Carolina At Chapel Hill | Methods and compositions for dual glycan binding aav vectors |
| WO2016115382A1 (en) | 2015-01-14 | 2016-07-21 | The University Of North Carolina At Chapel Hill | Methods and compositions for targeted gene transfer |
| CA2977071A1 (en) | 2015-02-20 | 2016-08-25 | Board Of Regents, The University Of Texas System | Methods and compositions for attenuated chlamydia as vaccine and vector |
| EP3831842A1 (en) | 2015-09-28 | 2021-06-09 | The University of North Carolina at Chapel Hill | Methods and compositions for antibody-evading virus vectors |
| EP4303225B1 (en) | 2017-03-15 | 2025-11-26 | The University of North Carolina at Chapel Hill | Polyploid adeno-associated virus vectors and methods of making and using the same |
| CN112041442A (zh) | 2018-02-28 | 2020-12-04 | 北卡罗来纳大学查佩尔希尔分校 | 用于逃避抗体的病毒载体的方法和组合物 |
| EP3773743A1 (en) | 2018-04-03 | 2021-02-17 | Stridebio, Inc. | Virus vectors for targeting ophthalmic tissues |
| CN112543766A (zh) | 2018-04-03 | 2021-03-23 | 斯特里迪比奥公司 | 抗体逃避性病毒载体 |
| WO2019195449A1 (en) | 2018-04-03 | 2019-10-10 | Stridebio, Inc. | Antibody-evading virus vectors |
| CN113727992A (zh) | 2019-03-21 | 2021-11-30 | 斯特里迪比奥公司 | 重组腺相关病毒载体 |
| WO2020219656A1 (en) | 2019-04-26 | 2020-10-29 | The University Of North Carolina At Chapel Hill | Methods and compositions for dual glycan binding aav2.5 vector |
| TW202128736A (zh) | 2019-10-17 | 2021-08-01 | 美商史崔德生物公司 | 用於治療ｃ型尼曼—匹克病之腺相關病毒載體 |
| TW202227632A (zh) | 2020-08-19 | 2022-07-16 | 美商史崔德生物公司 | 用於治療雷特症候群之腺相關病毒載體 |
| WO2022093769A1 (en) | 2020-10-28 | 2022-05-05 | The University Of North Carolina At Chapel Hill | Methods and compositions for dual glycan binding aav2.5 vector |
| JP2023547992A (ja) | 2020-10-28 | 2023-11-15 | ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | 二重グリカン結合ａａｖ２．５ベクターのための方法および組成物 |
| TW202242124A (zh) | 2021-01-14 | 2022-11-01 | 美商史崔德生物公司 | 靶向ｔ細胞之ａａｖ載體 |
| WO2022221529A1 (en) | 2021-04-16 | 2022-10-20 | Asklepios Biopharmaceutical, Inc. | Rational polyploid aav virions that cross the blood brain barrier and elicit reduced humoral response |
| WO2023150687A1 (en) | 2022-02-04 | 2023-08-10 | Ginkgo Bioworks, Inc. | Recombinant adeno-associated virus vectors, and methods of use thereof |
| WO2024124019A2 (en) | 2022-12-07 | 2024-06-13 | Ginkgo Bioworks, Inc. | Aav vectors targeting hematopoietic stem cells |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5223263A (en) | 1988-07-07 | 1993-06-29 | Vical, Inc. | Liponucleotide-containing liposomes |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5328470A (en) | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| US5753258A (en) | 1990-10-19 | 1998-05-19 | University Of Florida | Artificial viral envelopes |
| US5252348A (en) | 1990-10-19 | 1993-10-12 | Univ. Of Florida Research Foundation, Inc. | Artificial viral envelopes |
| US5858784A (en) | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
| CA2203809C (en) | 1994-10-28 | 2008-06-03 | James M. Wilson | Recombinant adenovirus and methods of use thereof |
| EP0821740A1 (en) | 1995-04-20 | 1998-02-04 | Chiron Corporation | High efficiency ex vivo transduction of hematopoietic stem cells by recombinant retroviral preparations |
| WO1997015679A1 (en) | 1995-10-27 | 1997-05-01 | The Trustees Of The University Of Pennsylvania | Recombinant viruses containing mobile genetic elements and methods of use in gene therapy |
| CA2263705C (en) | 1996-08-19 | 2007-12-04 | Nancy Smyth-Templeton | Novel sandwich liposome complexes comprising a biologically active agent |
| AU5153498A (en) * | 1996-10-23 | 1998-05-15 | Duke University | Human phosphatase inhibitor-1 gene and methods of screening for non-insulin dependent diabetes mellitus |
| AU780231B2 (en) | 1998-11-10 | 2005-03-10 | University Of North Carolina At Chapel Hill, The | Virus vectors and methods of making and administering the same |
| AU6814901A (en) | 2000-06-01 | 2001-12-11 | Univ North Carolina | Methods and compounds for controlled release of recombinant parvovirus vectors |
| ES2256265T3 (es) | 2000-06-01 | 2006-07-16 | University Of North Carolina At Chapel Hill | Vectores de parvovirus duplicados. |
| WO2002022177A2 (en) | 2000-09-11 | 2002-03-21 | The Regents Of The University Of California | High efficiency cardiac gene transfer |
| AU2002249947A1 (en) | 2001-01-15 | 2002-07-30 | Henry Ford Health System | Inhibition of protein-phosphatases for the treatment of heart failure |
| US20020159978A1 (en) * | 2001-02-06 | 2002-10-31 | James Allen | Muscle-directed gene transfer by use of recombinant AAV-1 and AAV-6 virions |
| MXPA05005653A (es) * | 2002-11-27 | 2005-11-23 | Artesian Therapeutics Inc | Determinacion y seleccion terapeutica de genes de insuficiencia cardiaca. |
| WO2005027629A2 (en) | 2003-09-19 | 2005-03-31 | Children's Hospital Medical Center | Regulation of cardiac contractility and heart failure propensity |
| WO2006029319A2 (en) * | 2004-09-09 | 2006-03-16 | The General Hospital Corporation | Modulating phosphatase activity in cardiac cells |
-
2007
- 2007-02-09 EP EP07750317A patent/EP1994043A4/en not_active Withdrawn
- 2007-02-09 US US12/162,499 patent/US7989606B2/en active Active
- 2007-02-09 EP EP11181884A patent/EP2441770A1/en not_active Withdrawn
- 2007-02-09 WO PCT/US2007/003470 patent/WO2007100465A2/en not_active Ceased
- 2007-02-09 AU AU2007221470A patent/AU2007221470B2/en not_active Ceased
- 2007-02-09 JP JP2008554373A patent/JP2009525757A/ja active Pending
- 2007-02-09 CA CA002638913A patent/CA2638913A1/en not_active Abandoned
- 2007-02-09 CN CNA2007800120069A patent/CN101437833A/zh active Pending
-
2011
- 2011-08-02 US US13/196,450 patent/US8524683B2/en active Active
-
2012
- 2012-09-21 JP JP2012207821A patent/JP2013027398A/ja active Pending
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