JP2018538356A5 - - Google Patents
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- JP2018538356A5 JP2018538356A5 JP2018536700A JP2018536700A JP2018538356A5 JP 2018538356 A5 JP2018538356 A5 JP 2018538356A5 JP 2018536700 A JP2018536700 A JP 2018536700A JP 2018536700 A JP2018536700 A JP 2018536700A JP 2018538356 A5 JP2018538356 A5 JP 2018538356A5
- Authority
- JP
- Japan
- Prior art keywords
- variant
- igf
- mutations
- bispecific protein
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102000004169 proteins and genes Human genes 0.000 claims 30
- 108090000623 proteins and genes Proteins 0.000 claims 30
- 230000035772 mutation Effects 0.000 claims 27
- 210000004027 cell Anatomy 0.000 claims 24
- 102000004121 Annexin A5 Human genes 0.000 claims 13
- 108090000672 Annexin A5 Proteins 0.000 claims 13
- 230000008685 targeting Effects 0.000 claims 12
- 210000001519 tissue Anatomy 0.000 claims 12
- 108010031794 IGF Type 1 Receptor Proteins 0.000 claims 10
- 150000001413 amino acids Chemical group 0.000 claims 10
- 102000038455 IGF Type 1 Receptor Human genes 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 238000006467 substitution reaction Methods 0.000 claims 9
- 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 claims 8
- 239000012190 activator Substances 0.000 claims 8
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 6
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 6
- 102000044162 human IGF1 Human genes 0.000 claims 6
- 102000005962 receptors Human genes 0.000 claims 6
- 108020003175 receptors Proteins 0.000 claims 6
- 230000004913 activation Effects 0.000 claims 5
- 101000780122 Homo sapiens Annexin A5 Proteins 0.000 claims 4
- 210000000170 cell membrane Anatomy 0.000 claims 4
- 230000006378 damage Effects 0.000 claims 4
- 108020001507 fusion proteins Proteins 0.000 claims 4
- 102000037865 fusion proteins Human genes 0.000 claims 4
- 102000054215 human ANXA5 Human genes 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 230000026731 phosphorylation Effects 0.000 claims 4
- 238000006366 phosphorylation reaction Methods 0.000 claims 4
- 230000004083 survival effect Effects 0.000 claims 4
- 102000008100 Human Serum Albumin Human genes 0.000 claims 3
- 108091006905 Human Serum Albumin Proteins 0.000 claims 3
- 230000006907 apoptotic process Effects 0.000 claims 3
- 230000017423 tissue regeneration Effects 0.000 claims 3
- 101000976075 Homo sapiens Insulin Proteins 0.000 claims 2
- 108091008611 Protein Kinase B Proteins 0.000 claims 2
- 102100033810 RAC-alpha serine/threonine-protein kinase Human genes 0.000 claims 2
- 230000024245 cell differentiation Effects 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 239000012636 effector Substances 0.000 claims 2
- 239000003102 growth factor Substances 0.000 claims 2
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 230000001737 promoting effect Effects 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 claims 1
- 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 claims 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 1
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 1
- 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 claims 1
- 101710150709 Serine/threonine-protein kinase B Proteins 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 210000005013 brain tissue Anatomy 0.000 claims 1
- 230000005779 cell damage Effects 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 208000037887 cell injury Diseases 0.000 claims 1
- 230000009087 cell motility Effects 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 210000005003 heart tissue Anatomy 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 210000005084 renal tissue Anatomy 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021159345A JP7365715B2 (ja) | 2015-10-02 | 2021-09-29 | 組織修復のための二重特異性治療用タンパク質 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562236169P | 2015-10-02 | 2015-10-02 | |
| US62/236,169 | 2015-10-02 | ||
| US201562237889P | 2015-10-06 | 2015-10-06 | |
| US62/237,889 | 2015-10-06 | ||
| US201662322910P | 2016-04-15 | 2016-04-15 | |
| US62/322,910 | 2016-04-15 | ||
| PCT/US2016/054744 WO2017059231A1 (en) | 2015-10-02 | 2016-09-30 | Bi-specific therapeutic proteins for tissue repair |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021159345A Division JP7365715B2 (ja) | 2015-10-02 | 2021-09-29 | 組織修復のための二重特異性治療用タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018538356A JP2018538356A (ja) | 2018-12-27 |
| JP2018538356A5 true JP2018538356A5 (enExample) | 2019-12-26 |
| JP7005019B2 JP7005019B2 (ja) | 2022-02-04 |
Family
ID=58427983
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018536700A Active JP7005019B2 (ja) | 2015-10-02 | 2016-09-30 | 組織修復のための二重特異性治療用タンパク質 |
| JP2021159345A Active JP7365715B2 (ja) | 2015-10-02 | 2021-09-29 | 組織修復のための二重特異性治療用タンパク質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021159345A Active JP7365715B2 (ja) | 2015-10-02 | 2021-09-29 | 組織修復のための二重特異性治療用タンパク質 |
Country Status (7)
| Country | Link |
|---|---|
| US (6) | US10040840B2 (enExample) |
| EP (2) | EP3865147B1 (enExample) |
| JP (2) | JP7005019B2 (enExample) |
| CN (2) | CN108367048B (enExample) |
| CA (1) | CA3000742A1 (enExample) |
| ES (1) | ES2863278T3 (enExample) |
| WO (1) | WO2017059231A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103124788B (zh) * | 2010-05-21 | 2016-01-13 | 梅里麦克制药股份有限公司 | 双特异性融合蛋白 |
| CN108367048B (zh) | 2015-10-02 | 2022-08-12 | 银溪制药股份有限公司 | 用于组织修复的双特异性治疗性蛋白质 |
| CN111763680A (zh) * | 2019-05-22 | 2020-10-13 | 杭州杰迪生物科技有限公司 | 一种人胰岛素样生长因子-i或其类似物的制备方法、编码基因、表达载体及宿主细胞 |
| JP7355326B2 (ja) * | 2019-08-05 | 2023-10-03 | デンカ株式会社 | 経粘膜投与薬剤 |
| MX2022002637A (es) * | 2019-09-06 | 2022-03-25 | Novartis Ag | Proteinas de fusion terapeuticas. |
| CN112584507B (zh) | 2019-09-30 | 2022-05-17 | 华为技术有限公司 | 一种数据处理方法、装置及存储介质 |
| US12358963B2 (en) | 2019-12-24 | 2025-07-15 | Juvena Therapeutics, Inc. | Regenerative polypeptides and uses thereof |
| CN111195350A (zh) * | 2020-01-15 | 2020-05-26 | 重庆大学 | IGF1和IGF1Ec24联合在制备促进组织修复与再生的药物中的应用 |
| WO2022026902A2 (en) | 2020-07-30 | 2022-02-03 | Silver Creek Pharmaceuticals, Inc. | Chimeric proteins and methods of use for treatment of central nervous system disorders |
| KR20240021898A (ko) * | 2021-06-14 | 2024-02-19 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 돌연변이된 아넥신 a5 폴리펩타이드 및 치료 목적을 위한 이의 용도 |
| KR20240029031A (ko) | 2021-06-21 | 2024-03-05 | 쥬베나 테라퓨틱스, 인크. | 재생 폴리펩티드 및 이의 용도 |
| WO2023278786A1 (en) * | 2021-06-30 | 2023-01-05 | Silver Creek Pharmaceuticals, Inc. | Chimeric proteins for targeted delivery of growth factors to the glomerulus |
| WO2023159067A2 (en) * | 2022-02-15 | 2023-08-24 | Silver Creek Pharmaceuticals, Inc. | Chimeric proteins for treatment of acute radiation syndrome |
| WO2025207443A1 (en) * | 2024-03-25 | 2025-10-02 | Cavalry Biosciences, Inc. | Igf-1-related compositions and uses of the same |
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-
2016
- 2016-09-30 CN CN201680070850.6A patent/CN108367048B/zh active Active
- 2016-09-30 WO PCT/US2016/054744 patent/WO2017059231A1/en not_active Ceased
- 2016-09-30 CA CA3000742A patent/CA3000742A1/en active Pending
- 2016-09-30 EP EP21152085.3A patent/EP3865147B1/en active Active
- 2016-09-30 US US15/281,795 patent/US10040840B2/en active Active
- 2016-09-30 ES ES16852701T patent/ES2863278T3/es active Active
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