AU2007221470B2 - Phosphatase inhibitor Protein-1 as a regulator of cardiac function - Google Patents

Phosphatase inhibitor Protein-1 as a regulator of cardiac function Download PDF

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Publication number
AU2007221470B2
AU2007221470B2 AU2007221470A AU2007221470A AU2007221470B2 AU 2007221470 B2 AU2007221470 B2 AU 2007221470B2 AU 2007221470 A AU2007221470 A AU 2007221470A AU 2007221470 A AU2007221470 A AU 2007221470A AU 2007221470 B2 AU2007221470 B2 AU 2007221470B2
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AU
Australia
Prior art keywords
seq
nucleic acid
protein
amino acid
acid molecule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2007221470A
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English (en)
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AU2007221470A1 (en
Inventor
Evangelia Kranias
Bryan Mitton
Patricia Rodriguez
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University of Cincinnati
Original Assignee
University of Cincinnati
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Publication date
Application filed by University of Cincinnati filed Critical University of Cincinnati
Publication of AU2007221470A1 publication Critical patent/AU2007221470A1/en
Application granted granted Critical
Publication of AU2007221470B2 publication Critical patent/AU2007221470B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • C07K14/4703Inhibitors; Suppressors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
AU2007221470A 2006-02-10 2007-02-09 Phosphatase inhibitor Protein-1 as a regulator of cardiac function Ceased AU2007221470B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77232706P 2006-02-10 2006-02-10
US60/772,327 2006-02-10
PCT/US2007/003470 WO2007100465A2 (en) 2006-02-10 2007-02-09 Phosphatase inhibitor protein-1 as a regulator of cardiac function

Publications (2)

Publication Number Publication Date
AU2007221470A1 AU2007221470A1 (en) 2007-09-07
AU2007221470B2 true AU2007221470B2 (en) 2013-02-14

Family

ID=38459499

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007221470A Ceased AU2007221470B2 (en) 2006-02-10 2007-02-09 Phosphatase inhibitor Protein-1 as a regulator of cardiac function

Country Status (7)

Country Link
US (2) US7989606B2 (enExample)
EP (2) EP1994043A4 (enExample)
JP (2) JP2009525757A (enExample)
CN (1) CN101437833A (enExample)
AU (1) AU2007221470B2 (enExample)
CA (1) CA2638913A1 (enExample)
WO (1) WO2007100465A2 (enExample)

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WO2006029319A2 (en) 2004-09-09 2006-03-16 The General Hospital Corporation Modulating phosphatase activity in cardiac cells
WO2009090049A1 (en) * 2008-01-14 2009-07-23 European Molecular Biology Laboratory Peptides for the specific binding and regulation of protein targets
ES2634118T3 (es) 2009-02-11 2017-09-26 The University Of North Carolina At Chapel Hill Vectores de virus modificados y métodos para fabricar y utilizar los mismos
CN101942481B (zh) * 2009-04-30 2012-07-25 中南大学 一种针对PKC γ基因RNA干扰的重组慢病毒载体的构建及其应用
CA2810668A1 (en) 2010-09-08 2012-03-15 Halozyme, Inc. Methods for assessing and identifying or evolving conditionally active therapeutic proteins
EP4234571A3 (en) 2011-02-10 2023-09-27 The University of North Carolina at Chapel Hill Viral vectors with modified transduction profiles and methods of making and using the same
AU2013229786B2 (en) 2012-03-08 2017-06-22 Halozyme, Inc. Conditionally active anti-epidermal growth factor receptor antibodies and methods of use thereof
WO2014007584A1 (en) * 2012-07-05 2014-01-09 Gwangju Institute Of Science And Technology Decoy peptides inhibiting protein phosphatase 1-mediated dephosphorylation of phospholamban
CA2904396A1 (en) 2013-03-15 2014-09-18 The University Of North Carolina At Chapel Hill Methods and compositions for dual glycan binding aav vectors
WO2016115382A1 (en) 2015-01-14 2016-07-21 The University Of North Carolina At Chapel Hill Methods and compositions for targeted gene transfer
CA2977071A1 (en) 2015-02-20 2016-08-25 Board Of Regents, The University Of Texas System Methods and compositions for attenuated chlamydia as vaccine and vector
EP3831842A1 (en) 2015-09-28 2021-06-09 The University of North Carolina at Chapel Hill Methods and compositions for antibody-evading virus vectors
EP4303225B1 (en) 2017-03-15 2025-11-26 The University of North Carolina at Chapel Hill Polyploid adeno-associated virus vectors and methods of making and using the same
CN112041442A (zh) 2018-02-28 2020-12-04 北卡罗来纳大学查佩尔希尔分校 用于逃避抗体的病毒载体的方法和组合物
EP3773743A1 (en) 2018-04-03 2021-02-17 Stridebio, Inc. Virus vectors for targeting ophthalmic tissues
CN112543766A (zh) 2018-04-03 2021-03-23 斯特里迪比奥公司 抗体逃避性病毒载体
WO2019195449A1 (en) 2018-04-03 2019-10-10 Stridebio, Inc. Antibody-evading virus vectors
CN113727992A (zh) 2019-03-21 2021-11-30 斯特里迪比奥公司 重组腺相关病毒载体
WO2020219656A1 (en) 2019-04-26 2020-10-29 The University Of North Carolina At Chapel Hill Methods and compositions for dual glycan binding aav2.5 vector
TW202128736A (zh) 2019-10-17 2021-08-01 美商史崔德生物公司 用於治療c型尼曼—匹克病之腺相關病毒載體
TW202227632A (zh) 2020-08-19 2022-07-16 美商史崔德生物公司 用於治療雷特症候群之腺相關病毒載體
WO2022093769A1 (en) 2020-10-28 2022-05-05 The University Of North Carolina At Chapel Hill Methods and compositions for dual glycan binding aav2.5 vector
JP2023547992A (ja) 2020-10-28 2023-11-15 ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル 二重グリカン結合aav2.5ベクターのための方法および組成物
TW202242124A (zh) 2021-01-14 2022-11-01 美商史崔德生物公司 靶向t細胞之aav載體
WO2022221529A1 (en) 2021-04-16 2022-10-20 Asklepios Biopharmaceutical, Inc. Rational polyploid aav virions that cross the blood brain barrier and elicit reduced humoral response
WO2023150687A1 (en) 2022-02-04 2023-08-10 Ginkgo Bioworks, Inc. Recombinant adeno-associated virus vectors, and methods of use thereof
WO2024124019A2 (en) 2022-12-07 2024-06-13 Ginkgo Bioworks, Inc. Aav vectors targeting hematopoietic stem cells

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2004050894A2 (en) * 2002-11-27 2004-06-17 Artesian Therapeutics, Inc. Heart failure gene determination and therapeutic screening

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US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5223263A (en) 1988-07-07 1993-06-29 Vical, Inc. Liponucleotide-containing liposomes
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
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US5328470A (en) 1989-03-31 1994-07-12 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
US5859205A (en) 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
US5753258A (en) 1990-10-19 1998-05-19 University Of Florida Artificial viral envelopes
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US5858784A (en) 1991-12-17 1999-01-12 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol- and liposome-based delivery
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WO1997015679A1 (en) 1995-10-27 1997-05-01 The Trustees Of The University Of Pennsylvania Recombinant viruses containing mobile genetic elements and methods of use in gene therapy
CA2263705C (en) 1996-08-19 2007-12-04 Nancy Smyth-Templeton Novel sandwich liposome complexes comprising a biologically active agent
AU5153498A (en) * 1996-10-23 1998-05-15 Duke University Human phosphatase inhibitor-1 gene and methods of screening for non-insulin dependent diabetes mellitus
AU780231B2 (en) 1998-11-10 2005-03-10 University Of North Carolina At Chapel Hill, The Virus vectors and methods of making and administering the same
AU6814901A (en) 2000-06-01 2001-12-11 Univ North Carolina Methods and compounds for controlled release of recombinant parvovirus vectors
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WO2002022177A2 (en) 2000-09-11 2002-03-21 The Regents Of The University Of California High efficiency cardiac gene transfer
AU2002249947A1 (en) 2001-01-15 2002-07-30 Henry Ford Health System Inhibition of protein-phosphatases for the treatment of heart failure
US20020159978A1 (en) * 2001-02-06 2002-10-31 James Allen Muscle-directed gene transfer by use of recombinant AAV-1 and AAV-6 virions
WO2005027629A2 (en) 2003-09-19 2005-03-31 Children's Hospital Medical Center Regulation of cardiac contractility and heart failure propensity
WO2006029319A2 (en) * 2004-09-09 2006-03-16 The General Hospital Corporation Modulating phosphatase activity in cardiac cells

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004050894A2 (en) * 2002-11-27 2004-06-17 Artesian Therapeutics, Inc. Heart failure gene determination and therapeutic screening

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Bibb, J. A. et al., The Journal of Biological Chemistry 2001, vol. 276, pages 14490-14497 *
Endo, S. et al., Biochemistry 1996, vol. 35, pages 5220-5228 *

Also Published As

Publication number Publication date
EP2441770A1 (en) 2012-04-18
JP2009525757A (ja) 2009-07-16
US8524683B2 (en) 2013-09-03
US20090203596A1 (en) 2009-08-13
US7989606B2 (en) 2011-08-02
US20120053125A1 (en) 2012-03-01
CA2638913A1 (en) 2007-09-07
EP1994043A2 (en) 2008-11-26
JP2013027398A (ja) 2013-02-07
WO2007100465A2 (en) 2007-09-07
EP1994043A4 (en) 2009-05-20
WO2007100465A3 (en) 2008-07-31
AU2007221470A1 (en) 2007-09-07
CN101437833A (zh) 2009-05-20

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired