JP2009513162A5 - - Google Patents
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- JP2009513162A5 JP2009513162A5 JP2008539077A JP2008539077A JP2009513162A5 JP 2009513162 A5 JP2009513162 A5 JP 2009513162A5 JP 2008539077 A JP2008539077 A JP 2008539077A JP 2008539077 A JP2008539077 A JP 2008539077A JP 2009513162 A5 JP2009513162 A5 JP 2009513162A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- seq
- pharmaceutical composition
- nucleic acid
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 28
- 229920001184 polypeptide Polymers 0.000 claims 27
- 102000004196 processed proteins & peptides Human genes 0.000 claims 27
- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- 150000007523 nucleic acids Chemical class 0.000 claims 13
- 108091033319 polynucleotide Proteins 0.000 claims 13
- 102000040430 polynucleotide Human genes 0.000 claims 13
- 239000002157 polynucleotide Substances 0.000 claims 13
- 102000039446 nucleic acids Human genes 0.000 claims 12
- 108020004707 nucleic acids Proteins 0.000 claims 12
- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
- 235000018102 proteins Nutrition 0.000 claims 11
- 102000004169 proteins and genes Human genes 0.000 claims 11
- 108090000623 proteins and genes Proteins 0.000 claims 11
- 102100039939 Growth/differentiation factor 8 Human genes 0.000 claims 7
- 108010056852 Myostatin Proteins 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 6
- 108010059616 Activins Proteins 0.000 claims 6
- 102100026818 Inhibin beta E chain Human genes 0.000 claims 6
- 239000000488 activin Substances 0.000 claims 6
- 101710194452 Growth/differentiation factor 11 Proteins 0.000 claims 5
- 102100040898 Growth/differentiation factor 11 Human genes 0.000 claims 5
- 108010023082 activin A Proteins 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 102000005962 receptors Human genes 0.000 claims 5
- 108020003175 receptors Proteins 0.000 claims 5
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims 4
- 210000003205 muscle Anatomy 0.000 claims 4
- 239000013598 vector Substances 0.000 claims 4
- 206010028289 Muscle atrophy Diseases 0.000 claims 3
- 208000030159 metabolic disease Diseases 0.000 claims 3
- 201000000585 muscular atrophy Diseases 0.000 claims 3
- 230000002103 transcriptional effect Effects 0.000 claims 3
- 206010006895 Cachexia Diseases 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 238000005406 washing Methods 0.000 claims 2
- 239000013607 AAV vector Substances 0.000 claims 1
- 208000030507 AIDS Diseases 0.000 claims 1
- 206010003694 Atrophy Diseases 0.000 claims 1
- 208000037157 Azotemia Diseases 0.000 claims 1
- 206010065687 Bone loss Diseases 0.000 claims 1
- 206010007558 Cardiac failure chronic Diseases 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000011623 Obstructive Lung disease Diseases 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 208000020339 Spinal injury Diseases 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 239000003098 androgen Substances 0.000 claims 1
- 230000037444 atrophy Effects 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 201000001421 hyperglycemia Diseases 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 230000007774 longterm Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000020763 muscle atrophy Effects 0.000 claims 1
- 201000006938 muscular dystrophy Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 208000001076 sarcopenia Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 208000009852 uremia Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73227005P | 2005-11-01 | 2005-11-01 | |
| US60/732,270 | 2005-11-01 | ||
| PCT/US2006/043044 WO2007053775A1 (en) | 2005-11-01 | 2006-11-01 | Novel activin receptor and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012171705A Division JP2013027391A (ja) | 2005-11-01 | 2012-08-02 | 新規アクチビン受容体およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009513162A JP2009513162A (ja) | 2009-04-02 |
| JP2009513162A5 true JP2009513162A5 (enExample) | 2010-09-24 |
| JP5349966B2 JP5349966B2 (ja) | 2013-11-20 |
Family
ID=37762538
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008539077A Expired - Fee Related JP5349966B2 (ja) | 2005-11-01 | 2006-11-01 | 新規アクチビン受容体およびその使用 |
| JP2012171705A Pending JP2013027391A (ja) | 2005-11-01 | 2012-08-02 | 新規アクチビン受容体およびその使用 |
| JP2014136375A Expired - Fee Related JP6072731B2 (ja) | 2005-11-01 | 2014-07-02 | 新規アクチビン受容体およびその使用 |
| JP2016155127A Pending JP2016187361A (ja) | 2005-11-01 | 2016-08-08 | 新規アクチビン受容体およびその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012171705A Pending JP2013027391A (ja) | 2005-11-01 | 2012-08-02 | 新規アクチビン受容体およびその使用 |
| JP2014136375A Expired - Fee Related JP6072731B2 (ja) | 2005-11-01 | 2014-07-02 | 新規アクチビン受容体およびその使用 |
| JP2016155127A Pending JP2016187361A (ja) | 2005-11-01 | 2016-08-08 | 新規アクチビン受容体およびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US8067562B2 (enExample) |
| EP (1) | EP1943273B1 (enExample) |
| JP (4) | JP5349966B2 (enExample) |
| AT (1) | ATE554101T1 (enExample) |
| AU (1) | AU2006308614B2 (enExample) |
| CA (1) | CA2627200C (enExample) |
| ES (1) | ES2385581T3 (enExample) |
| WO (1) | WO2007053775A1 (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2272864A3 (en) | 2002-12-20 | 2011-02-16 | Amgen Inc. | Binding agents which inhibit myostatin |
| ES2551852T3 (es) | 2004-07-23 | 2015-11-24 | Acceleron Pharma Inc. | Polipéptidos del receptor ActRII |
| US8067562B2 (en) * | 2005-11-01 | 2011-11-29 | Amgen Inc. | Isolated nucleic acid molecule comprising the amino acid sequence of SEQ ID NO:1 |
| EA201692543A1 (ru) | 2005-11-23 | 2017-08-31 | Акселерон Фарма Инк. | Антагонисты активина-actriia и их применение для стимулирования роста кости |
| US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
| ES2569365T3 (es) * | 2006-11-29 | 2016-05-10 | Nationwide Children's Hospital | Inhibición de miostatina para la potenciación de músculo y/o la mejora de la función muscular |
| EP2468291B1 (en) | 2006-12-18 | 2017-11-22 | Acceleron Pharma, Inc. | Activin-actrii antagonists and uses for increasing red blood cell levels |
| US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
| CA2677007A1 (en) | 2007-02-01 | 2008-08-07 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for treating or preventing breast cancer |
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| CA3039330C (en) | 2007-02-09 | 2021-11-09 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for promoting bone growth in cancer patients |
| TWI573802B (zh) * | 2007-03-06 | 2017-03-11 | 安美基公司 | 變異之活動素受體多肽及其用途 |
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| EP2387412A4 (en) | 2009-01-13 | 2013-04-03 | Acceleron Pharma Inc | PROCESS FOR INCREASING THE ADIPONECTIN MIRROR |
| NO2424895T3 (enExample) * | 2009-04-27 | 2018-02-03 | ||
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| EP2440577A4 (en) | 2009-06-12 | 2013-01-23 | Acceleron Pharma Inc | SHORTEN ACTRIIB FC FUSION PROTEINS |
| ES2796121T3 (es) * | 2009-08-13 | 2020-11-25 | Acceleron Pharma Inc | Uso combinado de trampas de GDF y activadores del receptor de la eritropoyetina para aumentar los niveles de glóbulos rojos |
| CA2779472C (en) * | 2009-11-03 | 2021-03-16 | Acceleron Pharma Inc. | The use of a composition comprising an activin type iib receptor polypeptide in the treatment of fatty liver disease |
| ES2658292T3 (es) | 2009-11-17 | 2018-03-09 | Acceleron Pharma, Inc. | Proteínas ActRIIB y variantes y usos de las mismas con respecto a la inducción de la utrofina para el tratamiento de la distrofia muscular |
| CA2808382A1 (en) | 2010-08-16 | 2012-02-23 | Amgen Inc. | Antibodies that bind myostatin, compositions and methods |
| CN103298832A (zh) | 2010-11-08 | 2013-09-11 | 阿塞勒隆制药公司 | Actriia结合剂及其用途 |
| CA2852683A1 (en) | 2011-10-17 | 2013-04-25 | Acceleron Pharma, Inc. | Methods and compositions for treating ineffective erythropoiesis |
| JP6145112B2 (ja) | 2011-12-19 | 2017-06-07 | アムジエン・インコーポレーテツド | 単独でのまたは化学療法と組み合わされた変異アクチビン受容体ポリペプチド、およびその使用 |
| CN104968801B (zh) * | 2012-10-24 | 2021-06-15 | 细胞基因公司 | 用于治疗贫血症的生物标志物 |
| MX366336B (es) | 2012-11-02 | 2019-07-05 | Celgene Corp | Antagonistas de activina - actrii y usos para el tratar trastornos oseos y otros. |
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| JP2016518357A (ja) | 2013-04-08 | 2016-06-23 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 骨格筋幹細胞を若返らせる方法および組成物 |
| JP6601687B2 (ja) * | 2014-03-31 | 2019-11-06 | 大日本住友製薬株式会社 | 進行性骨化性線維異形成症の予防剤及び治療剤 |
| JP6649895B2 (ja) | 2014-04-18 | 2020-02-19 | アクセルロン ファーマ， インコーポレイテッド | 赤血球レベルを増加させ、そして鎌状赤血球症を処置するための方法 |
| AU2015274277B2 (en) | 2014-06-13 | 2021-03-18 | Acceleron Pharma, Inc. | Methods and compositions for treating ulcers |
| MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
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| RS61881B1 (sr) | 2015-04-22 | 2021-06-30 | Biogen Ma Inc | Novi hibridni actriib proteini zamke za ligand za lečenje bolesti gubljenja mišića |
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| CA3005975A1 (en) | 2015-11-23 | 2017-06-01 | Acceleron Pharma Inc. | Methods for treating eye disorders |
| CA3010799A1 (en) | 2016-01-06 | 2017-07-13 | President And Fellows Of Harvard College | Treatment with gdf11 prevents weight gain, improves glucose tolerance and reduces hepatosteatosis |
| AU2017296040C1 (en) | 2016-07-15 | 2023-06-22 | Acceleron Pharma Inc. | Compositions and methods for treating pulmonary hypertension |
| MX2019001043A (es) | 2016-07-27 | 2019-09-26 | Acceleron Pharma Inc | Metodos y composiciones para el tratamiento de la mielofibrosis. |
| JOP20190085A1 (ar) | 2016-10-20 | 2019-04-17 | Biogen Ma Inc | طرق علاج الضمور العضلي ومرض العظام باستخدام بروتينات احتجاز مركب ترابطي actriib هجين حديثة |
| EP3538123A4 (en) | 2016-11-10 | 2020-10-14 | Keros Therapeutics, Inc. | ACTIVIN RECEPTOR TYPE IIA VARIANTS AND THEIR METHODS OF USE |
| CA3082146A1 (en) | 2017-11-09 | 2019-05-16 | Keros Therapeutics, Inc. | Activin receptor type iia variants and methods of use thereof |
| CN120399032A (zh) | 2018-01-12 | 2025-08-01 | 科乐斯疗法公司 | 激活素受体iib型变体及其使用方法 |
| EP3790572A4 (en) | 2018-05-09 | 2022-03-16 | Keros Therapeutics, Inc. | ACTIVIN RECEPTOR TYPE IIA VARIANTS AND METHODS OF USE THEREOF |
| CN109293763B (zh) * | 2018-10-26 | 2021-10-26 | 中国农业科学院特产研究所 | 水貂激活素b蛋白及其制备与应用 |
| EP4121088A4 (en) | 2020-03-20 | 2024-07-03 | Keros Therapeutics, Inc. | Methods of using activin receptor type iib variants |
| AU2024231427A1 (en) * | 2023-03-09 | 2025-09-04 | Merck Sharp & Dohme Llc | Formulations comprising actriia polypeptide variants |
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| CN102482339B (zh) | 2009-06-08 | 2015-06-17 | 阿塞勒隆制药公司 | 用于增加产热脂肪细胞的方法 |
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-
2006
- 2006-10-31 US US11/590,962 patent/US8067562B2/en active Active
- 2006-11-01 CA CA2627200A patent/CA2627200C/en not_active Expired - Fee Related
- 2006-11-01 AU AU2006308614A patent/AU2006308614B2/en not_active Ceased
- 2006-11-01 WO PCT/US2006/043044 patent/WO2007053775A1/en not_active Ceased
- 2006-11-01 JP JP2008539077A patent/JP5349966B2/ja not_active Expired - Fee Related
- 2006-11-01 EP EP06827481A patent/EP1943273B1/en active Active
- 2006-11-01 ES ES06827481T patent/ES2385581T3/es active Active
- 2006-11-01 AT AT06827481T patent/ATE554101T1/de active
-
2011
- 2011-07-25 US US13/190,255 patent/US8614292B2/en active Active
-
2012
- 2012-08-02 JP JP2012171705A patent/JP2013027391A/ja active Pending
-
2013
- 2013-11-20 US US14/085,056 patent/US9284364B2/en active Active
-
2014
- 2014-07-02 JP JP2014136375A patent/JP6072731B2/ja not_active Expired - Fee Related
-
2016
- 2016-02-03 US US15/014,889 patent/US20160152683A1/en not_active Abandoned
- 2016-08-08 JP JP2016155127A patent/JP2016187361A/ja active Pending
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