JP2017537926A5 - - Google Patents

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Publication number
JP2017537926A5
JP2017537926A5 JP2017529778A JP2017529778A JP2017537926A5 JP 2017537926 A5 JP2017537926 A5 JP 2017537926A5 JP 2017529778 A JP2017529778 A JP 2017529778A JP 2017529778 A JP2017529778 A JP 2017529778A JP 2017537926 A5 JP2017537926 A5 JP 2017537926A5
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JP
Japan
Prior art keywords
seq
composition according
pharmaceutical composition
fusion polypeptide
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2017529778A
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English (en)
Japanese (ja)
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JP2017537926A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/IB2015/059294 external-priority patent/WO2016088059A1/en
Publication of JP2017537926A publication Critical patent/JP2017537926A/ja
Publication of JP2017537926A5 publication Critical patent/JP2017537926A5/ja
Pending legal-status Critical Current

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JP2017529778A 2014-12-04 2015-12-02 Klotho変種ポリペプチドを使用する方法および組成物 Pending JP2017537926A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462087516P 2014-12-04 2014-12-04
US62/087,516 2014-12-04
PCT/IB2015/059294 WO2016088059A1 (en) 2014-12-04 2015-12-02 Methods and compositions using klotho variant polypeptides

Publications (2)

Publication Number Publication Date
JP2017537926A JP2017537926A (ja) 2017-12-21
JP2017537926A5 true JP2017537926A5 (enExample) 2019-01-17

Family

ID=55024183

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017529778A Pending JP2017537926A (ja) 2014-12-04 2015-12-02 Klotho変種ポリペプチドを使用する方法および組成物

Country Status (12)

Country Link
US (2) US10654909B2 (enExample)
EP (1) EP3227319B1 (enExample)
JP (1) JP2017537926A (enExample)
KR (1) KR20170084332A (enExample)
CN (1) CN107810201A (enExample)
AU (1) AU2015356643B2 (enExample)
BR (1) BR112017011398A2 (enExample)
CA (1) CA2969307A1 (enExample)
EA (1) EA201791238A1 (enExample)
MX (2) MX2017007303A (enExample)
TW (1) TW201628641A (enExample)
WO (1) WO2016088059A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3031839B1 (fr) 2015-01-19 2020-03-13 Areva Stockage D'energie Systeme electrique comprenant un empilement de cellules electrochimiques et procede de pilotage de ce systeme
EP3253403B1 (en) 2015-02-06 2021-09-01 The Regents of The University of California Methods and compositions for improved cognition
WO2018098375A1 (en) * 2016-11-22 2018-05-31 Klotho Therapeutics, Inc. Novel recombinant klotho proteins and compositions and methods involving the same
CA3069143A1 (en) 2017-07-06 2019-01-10 Yale University Compositions and methods for treating or preventing endocrine fgf-linked diseases
JP2021506792A (ja) * 2017-12-13 2021-02-22 イエール ユニバーシティ 内分泌型fgf23関連疾患を処置または防止するための組成物および方法
US12227777B2 (en) * 2018-01-12 2025-02-18 New York University Soluble alpha-Klotho proteins, protein fragments, and uses thereof
US20220008520A1 (en) * 2018-11-21 2022-01-13 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods and materials for reducing age-related striated muscle and cognitive decline
CN112695049A (zh) * 2020-08-20 2021-04-23 山东兴瑞生物科技有限公司 修饰间充质干细胞的融合基因、质粒、修饰得到干细胞及制备方法
CN112915193B (zh) * 2021-03-05 2022-09-13 南方医科大学南方医院 Kp-1在制备治疗慢性肺病的药物中的用途
CN112915192B (zh) * 2021-03-05 2022-10-25 南方医科大学南方医院 Kp-1在制备治疗慢性肝病的药物中的用途
EP4395807A4 (en) * 2021-09-03 2025-09-24 Uab Res Found COMPOUNDS MODULATING FIBROBLAST GROWTH FACTOR 23
WO2024168241A2 (en) * 2023-02-10 2024-08-15 The Trustees Of Indiana University Stabilized fgf23 fusion proteins, compositions and a targeted therapy for hyperphosphatemia
EP4434534A1 (en) 2023-03-22 2024-09-25 ADvantage Therapeutics, Inc. Klotho mrna
AU2024377885A1 (en) * 2023-11-10 2026-05-28 Regeneron Pharmaceuticals, Inc. Engineered alpha klotho polypeptides and uses thereof
US20250376667A1 (en) * 2024-06-07 2025-12-11 Regeneron Pharmaceuticals, Inc. Engineered alpha klotho polypeptides and uses thereof
CN122356258B (zh) * 2026-06-05 2026-08-11 广州集妍化妆品科技有限公司 寡肽及其在制备抗衰老的产品中的应用

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL71691A (en) 1984-04-27 1991-04-15 Yeda Res & Dev Production of interferon-ypsilon
US5128326A (en) 1984-12-06 1992-07-07 Biomatrix, Inc. Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same
US5266561A (en) 1988-01-11 1993-11-30 Amylin Pharmaceuticals, Inc. Treatment of type 2 diabetes mellitus
SE509359C2 (sv) * 1989-08-01 1999-01-18 Cemu Bioteknik Ab Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel
CA2071867A1 (en) 1989-11-06 1991-05-07 Edith Mathiowitz Method for producing protein microspheres
JPH06507782A (ja) 1990-06-15 1994-09-08 サイオス ノバ インコーポレイテッド アルツハイマー病のアミロイド形成開症状を示すヒト以外の組換え哺乳動物
US5408038A (en) 1991-10-09 1995-04-18 The Scripps Research Institute Nonnatural apolipoprotein B-100 peptides and apolipoprotein B-100-apolipoprotein A-I fusion peptides
FR2686899B1 (fr) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US5912015A (en) 1992-03-12 1999-06-15 Alkermes Controlled Therapeutics, Inc. Modulated release from biocompatible polymers
US5420112A (en) 1992-06-12 1995-05-30 Lewis; Michael E. Prevention and treatment of peripheral neuropathy
US5541094A (en) 1992-09-25 1996-07-30 E. I. Du Pont De Nemours And Company Glyoxylic acid/aminomethylphosphonic acid mixtures prepared using a microbial transformant
US5877399A (en) 1994-01-27 1999-03-02 Johns Hopkins University Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
US6187992B1 (en) 1994-12-05 2001-02-13 Merck & Co., Inc. Transgenic mouse having a disrupted amyloid precursor protein gene
AU710347B2 (en) 1995-08-31 1999-09-16 Alkermes Controlled Therapeutics, Inc. Composition for sustained release of an agent
US6194177B1 (en) 1996-02-20 2001-02-27 Applied Research Systems Ars Holding N.V. DNA encoding a hybrid heterodimeric protein
CA2244253C (en) 1996-03-15 2002-11-12 Somerset Pharmaceuticals, Inc. Method for preventing and treating peripheral neuropathy by administering selegiline
US6358752B1 (en) 1996-09-27 2002-03-19 Cornell Research Foundation, Inc. Liposome-enhanced test device and method
KR20000062345A (ko) 1996-12-26 2000-10-25 히라타 다다시 신규 폴리펩타이드, 신규 dna 및 신규 항체
US6127598A (en) 1997-07-25 2000-10-03 The Regents Of The University Of California NKX-2.2 and NKX-6.1 transgenic mouse models for diabetes, depression, and obesity
US5989463A (en) 1997-09-24 1999-11-23 Alkermes Controlled Therapeutics, Inc. Methods for fabricating polymer-based controlled release devices
SE512663C2 (sv) 1997-10-23 2000-04-17 Biogram Ab Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer
EP1068356B8 (en) 1998-04-03 2007-01-03 Adnexus Therapeutics, Inc. Addressable protein arrays
US7060479B2 (en) 1999-12-08 2006-06-13 Serono Genetics Institute, S.A. Full-length human cDNAs encoding potentially secreted proteins
US20030055231A1 (en) 1998-10-28 2003-03-20 Jian Ni 12 human secreted proteins
EP1171778B1 (en) 1999-04-22 2006-03-01 Liposcience, Inc. Nmr-method for determining the risk of developing type 2 diabetes
AU6069900A (en) 1999-06-30 2001-01-31 Microsoft Corporation Methods and systems for reporting and resolving support incidents
US6569832B1 (en) 1999-11-12 2003-05-27 Novo Nordisk A/S Inhibition of beta cell degeneration
US6716626B1 (en) 1999-11-18 2004-04-06 Chiron Corporation Human FGF-21 nucleic acids
US6406853B1 (en) 1999-12-23 2002-06-18 The Regents Of The University Of California Interventions to mimic the effects of calorie restriction
JP2006238894A (ja) 2000-02-15 2006-09-14 Amgen Inc 線維芽細胞成長因子−23分子およびその使用
US20060160181A1 (en) 2000-02-15 2006-07-20 Amgen Inc. Fibroblast Growth Factor-23 molecules and uses thereof
CA2398603A1 (en) 2000-02-15 2001-08-23 Amgen, Inc. Fibroblast growth factor-23 molecules and uses thereof
WO2001066595A2 (en) 2000-03-08 2001-09-13 Chiron Corporation Human fgf-23 gene and gene expression products
JP2004504063A (ja) 2000-07-19 2004-02-12 アドバンスド リサーチ & テクノロジー インスティテュート 新規線維芽細胞増殖因子(fgf23)および使用方法
US20030129686A1 (en) 2001-01-30 2003-07-10 Glass David J. Novel nucleic acid and polypeptide molecules
US7588757B2 (en) 2001-03-14 2009-09-15 Genzyme Corporation Methods of treating Parkinson's disease using recombinant adeno-associated virus virions
WO2002088358A2 (en) 2001-04-26 2002-11-07 Geneprot, Inc. Human fibroblast growth factor-related compositions
EP1327443A1 (en) 2001-12-21 2003-07-16 Kyowa Hakko Kogyo Co., Ltd. Therapeutic or preventing agent for the diseases caused by a decrease in the expression level of the klotho protein
US20050004348A1 (en) 2002-12-23 2005-01-06 Miyamoto Ken-Ichi Novel type II Na/Pi cotransporters and type II Na/Pi cotransporter expression regulatory factors
EP1673395A1 (en) 2003-10-15 2006-06-28 PDL BioPharma, Inc. Alteration of fc-fusion protein serum half-lives by mutagenesis of positions 250, 314 and/or 428 of the heavy chain constant region of ig
TW200936156A (en) 2008-01-28 2009-09-01 Novartis Ag Methods and compositions using Klotho-FGF fusion polypeptides
US8420088B2 (en) * 2008-01-28 2013-04-16 Novartis Ag Methods and compositions using FGF23 fusion polypeptides
US20170233446A1 (en) 2008-01-28 2017-08-17 Novartis Ag Methods and compositions using klotho-fgf fusion polypeptides
WO2009117622A2 (en) 2008-03-19 2009-09-24 Ambrx, Inc. Modified fgf-23 polypeptides and their uses
NZ592009A (en) 2008-10-10 2012-11-30 Amgen Inc Fgf21 mutants and uses thereof
US8461111B2 (en) 2009-05-20 2013-06-11 Florida State University Research Foundation Fibroblast growth factor mutants having improved functional half-life and methods of their use
US20110195077A1 (en) 2010-01-29 2011-08-11 Novartis Ag Methods and compositions using fgf23 fusion ppolypeptides
WO2013027191A1 (en) * 2011-08-25 2013-02-28 Novartis Ag Methods and compositions using fgf23 fusion polypeptides
CN104023726A (zh) 2011-10-21 2014-09-03 艾伯维公司 用于治疗hcv的一种或多种daa的联合治疗(例如,与abt-072或abt-333)
US10588980B2 (en) 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules

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