JP2019530441A5 - - Google Patents
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- JP2019530441A5 JP2019530441A5 JP2019512782A JP2019512782A JP2019530441A5 JP 2019530441 A5 JP2019530441 A5 JP 2019530441A5 JP 2019512782 A JP2019512782 A JP 2019512782A JP 2019512782 A JP2019512782 A JP 2019512782A JP 2019530441 A5 JP2019530441 A5 JP 2019530441A5
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- Prior art keywords
- domain
- car
- cancer
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- variant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 12
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 5
- 230000035772 mutation Effects 0.000 claims 4
- 125000000539 amino acid group Chemical group 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- -1 ICOS-1 Proteins 0.000 claims 2
- 102000015271 Intercellular Adhesion Molecule-1 Human genes 0.000 claims 2
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 101710145634 Antigen 1 Proteins 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 102100027207 CD27 antigen Human genes 0.000 claims 1
- 102100029360 Hematopoietic cell signal transducer Human genes 0.000 claims 1
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 1
- 101000990188 Homo sapiens Hematopoietic cell signal transducer Proteins 0.000 claims 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 1
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims 1
- 238000011467 adoptive cell therapy Methods 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662383139P | 2016-09-02 | 2016-09-02 | |
| US62/383,139 | 2016-09-02 | ||
| US201662419817P | 2016-11-09 | 2016-11-09 | |
| US62/419,817 | 2016-11-09 | ||
| PCT/US2017/046630 WO2018052594A1 (en) | 2016-09-02 | 2017-08-11 | I domain chimeric antigen receptor specific to icam-1 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019530441A JP2019530441A (ja) | 2019-10-24 |
| JP2019530441A5 true JP2019530441A5 (enExample) | 2020-09-17 |
| JP6996772B2 JP6996772B2 (ja) | 2022-02-21 |
Family
ID=61281980
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019512782A Active JP6996772B2 (ja) | 2016-09-02 | 2017-08-11 | Ｉｃａｍ－１に特異的なｉドメインキメラ抗原受容体 |
Country Status (10)
| Country | Link |
|---|---|
| US (6) | US10428136B2 (enExample) |
| EP (1) | EP3522718B1 (enExample) |
| JP (1) | JP6996772B2 (enExample) |
| KR (1) | KR102613109B1 (enExample) |
| CN (1) | CN108697096B (enExample) |
| AU (1) | AU2017325678B2 (enExample) |
| CA (1) | CA3033846C (enExample) |
| ES (1) | ES2971550T3 (enExample) |
| SG (1) | SG11201901505SA (enExample) |
| WO (2) | WO2018044534A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102613109B1 (ko) | 2016-09-02 | 2023-12-13 | 코넬 유니버시티 | Icam-1 특이적 i 도메인 키메라 항원 수용체 |
| EP3571221A2 (en) | 2017-01-20 | 2019-11-27 | Juno Therapeutics GmbH | Cell surface conjugates and related cell compositions and methods |
| MX2019012017A (es) * | 2017-04-07 | 2020-02-12 | Juno Therapeutics Inc | Celulas modificadas que expresan antigeno de membrana especifico de prostata (psma) o una forma modificada del mismo y metodos relacionados. |
| US11866494B2 (en) * | 2018-08-31 | 2024-01-09 | Innovative Cellular Therapeutics Holdings, Ltd. | CAR T therapy through uses of co-stimulation |
| EP4259285A4 (en) * | 2020-12-09 | 2024-12-11 | Affyimmune Therapeutics, Inc. | DUAL CHIMERIC ANTIGEN RECEPTOR TARGETING EPCAM AND ICAM-1 |
| CN114907485B (zh) * | 2021-02-08 | 2024-04-26 | 浙江大学 | 一种以内源性蛋白质分子替代单结构域抗体的嵌合抗原受体 |
| CN120187461A (zh) * | 2022-09-14 | 2025-06-20 | 生物权威(澳大利亚)有限责任公司 | 免疫细胞的体内检测 |
| US12385818B2 (en) | 2023-02-14 | 2025-08-12 | Saudi Arabian Oil Company | Modeling gas desorption in a subsurface reservoir |
| WO2024206155A1 (en) | 2023-03-24 | 2024-10-03 | Cornell University | Utilizing t cells derived from tumor draining lymph nodes for chimeric antigen receptor (car) t cell therapy for the treatment of cancer |
| US20250288611A1 (en) * | 2024-03-04 | 2025-09-18 | AffyImmune Therapeutics Inc. | Icam-1 targeted car constructs and methods of treatment |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU685693B2 (en) | 1994-11-01 | 1998-01-22 | Targeted Genetics Corporation | Chimeric receptors for the generation of selectively-activatable TH-independent cytotoxic T cells |
| US5712149A (en) | 1995-02-03 | 1998-01-27 | Cell Genesys, Inc. | Chimeric receptor molecules for delivery of co-stimulatory signals |
| US6737056B1 (en) * | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| JP2002541845A (ja) | 1999-04-16 | 2002-12-10 | セルテック セラピューティックス リミテッド | 合成膜貫通成分 |
| MXPA02012157A (es) | 2000-06-09 | 2003-06-06 | Bristol Myers Squibb Co | Metodos para regular una respuesta inmune mediada por celulas al bloquear se°ales linfociticas y al bloquear la adhesion mediada por el antigeno 1 asociado con la funcion de linfocitos. |
| US7176187B2 (en) | 2001-02-15 | 2007-02-13 | Board Of Regents, The University Of Texas System | Fusion proteins based upon somatostatin receptors |
| WO2007070488A2 (en) * | 2005-12-12 | 2007-06-21 | The Cbr Institute For Biomedical Research, Inc. | Integrin alpha l i domain mutants with increased binding affinity |
| BR112013005711A2 (pt) * | 2010-09-08 | 2017-06-13 | Univ Texas | método para tratar um tumor, mutante, molécula de ácido nucleico isolada, construção de expressão, composição, e, método para administrar uma terapia |
| JP6053688B2 (ja) * | 2011-10-07 | 2016-12-27 | 国立大学法人三重大学 | キメラ抗原受容体 |
| US10144770B2 (en) * | 2013-10-17 | 2018-12-04 | National University Of Singapore | Chimeric receptors and uses thereof in immune therapy |
| WO2016152786A1 (ja) * | 2015-03-20 | 2016-09-29 | 国立大学法人三重大学 | 細胞傷害性ｔ細胞放出エキソソームによる癌間質間葉系細胞を標的とした腫瘍増殖及び転移抑制に係る治療薬 |
| KR102613109B1 (ko) * | 2016-09-02 | 2023-12-13 | 코넬 유니버시티 | Icam-1 특이적 i 도메인 키메라 항원 수용체 |
-
2017
- 2017-08-11 KR KR1020197009375A patent/KR102613109B1/ko active Active
- 2017-08-11 EP EP17851258.8A patent/EP3522718B1/en active Active
- 2017-08-11 CN CN201780004619.1A patent/CN108697096B/zh active Active
- 2017-08-11 JP JP2019512782A patent/JP6996772B2/ja active Active
- 2017-08-11 AU AU2017325678A patent/AU2017325678B2/en active Active
- 2017-08-11 US US15/675,508 patent/US10428136B2/en active Active
- 2017-08-11 US US15/675,419 patent/US10577408B2/en active Active
- 2017-08-11 CA CA3033846A patent/CA3033846C/en active Active
- 2017-08-11 SG SG11201901505SA patent/SG11201901505SA/en unknown
- 2017-08-11 WO PCT/US2017/046618 patent/WO2018044534A1/en not_active Ceased
- 2017-08-11 WO PCT/US2017/046630 patent/WO2018052594A1/en not_active Ceased
- 2017-08-11 ES ES17851258T patent/ES2971550T3/es active Active
-
2019
- 2019-09-25 US US16/582,206 patent/US11046748B2/en active Active
-
2020
- 2020-02-11 US US16/787,539 patent/US11634471B2/en active Active
-
2021
- 2021-06-21 US US17/304,412 patent/US12410235B2/en active Active
-
2023
- 2023-03-21 US US18/187,268 patent/US12325736B2/en active Active
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