JP2018516092A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018516092A5 JP2018516092A5 JP2018503725A JP2018503725A JP2018516092A5 JP 2018516092 A5 JP2018516092 A5 JP 2018516092A5 JP 2018503725 A JP2018503725 A JP 2018503725A JP 2018503725 A JP2018503725 A JP 2018503725A JP 2018516092 A5 JP2018516092 A5 JP 2018516092A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- target
- rlx
- amino acid
- mgswx
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 129
- 229920001184 polypeptide Polymers 0.000 claims description 123
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 123
- 230000027455 binding Effects 0.000 claims description 104
- 206010028980 Neoplasm Diseases 0.000 claims description 56
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 44
- 210000004027 cell Anatomy 0.000 claims description 41
- 201000011510 cancer Diseases 0.000 claims description 40
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 38
- 238000000034 method Methods 0.000 claims description 33
- 238000006467 substitution reaction Methods 0.000 claims description 28
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 24
- 235000001014 amino acid Nutrition 0.000 claims description 24
- 210000002865 immune cell Anatomy 0.000 claims description 19
- 239000000427 antigen Substances 0.000 claims description 17
- 102000036639 antigens Human genes 0.000 claims description 17
- 108091007433 antigens Proteins 0.000 claims description 17
- 150000001413 amino acids Chemical class 0.000 claims description 16
- 108020001507 fusion proteins Proteins 0.000 claims description 16
- 102000037865 fusion proteins Human genes 0.000 claims description 16
- 230000009870 specific binding Effects 0.000 claims description 16
- 101000998120 Homo sapiens Interleukin-3 receptor subunit alpha Proteins 0.000 claims description 15
- 102100033493 Interleukin-3 receptor subunit alpha Human genes 0.000 claims description 15
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 12
- 235000018417 cysteine Nutrition 0.000 claims description 12
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 12
- 150000007523 nucleic acids Chemical class 0.000 claims description 12
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 10
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 10
- 230000004048 modification Effects 0.000 claims description 10
- 238000012986 modification Methods 0.000 claims description 10
- 108020004707 nucleic acids Proteins 0.000 claims description 10
- 102000039446 nucleic acids Human genes 0.000 claims description 10
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims description 8
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims description 8
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims description 8
- 108010087408 alpha-beta T-Cell Antigen Receptors Proteins 0.000 claims description 8
- 125000000539 amino acid group Chemical group 0.000 claims description 8
- 230000003834 intracellular effect Effects 0.000 claims description 8
- 230000004068 intracellular signaling Effects 0.000 claims description 8
- 108010074708 B7-H1 Antigen Proteins 0.000 claims description 6
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims description 6
- 235000018102 proteins Nutrition 0.000 claims description 6
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 230000011664 signaling Effects 0.000 claims description 6
- 239000013598 vector Substances 0.000 claims description 6
- -1 DBDpp Proteins 0.000 claims description 5
- 230000000139 costimulatory effect Effects 0.000 claims description 5
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical group N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 4
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims description 4
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims description 4
- 102100026964 M1-specific T cell receptor beta chain Human genes 0.000 claims description 4
- 102000006707 alpha-beta T-Cell Antigen Receptors Human genes 0.000 claims description 4
- 230000002163 immunogen Effects 0.000 claims description 4
- 230000019491 signal transduction Effects 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 102100026882 Alpha-synuclein Human genes 0.000 claims description 3
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims description 3
- 102100025570 Cancer/testis antigen 1 Human genes 0.000 claims description 3
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims description 3
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims description 3
- 229930186217 Glycolipid Natural products 0.000 claims description 3
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims description 3
- 101000834898 Homo sapiens Alpha-synuclein Proteins 0.000 claims description 3
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims description 3
- 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 claims description 3
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims description 3
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims description 3
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 claims description 3
- 101001103039 Homo sapiens Inactive tyrosine-protein kinase transmembrane receptor ROR1 Proteins 0.000 claims description 3
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 claims description 3
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims description 3
- 101001103036 Homo sapiens Nuclear receptor ROR-alpha Proteins 0.000 claims description 3
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 claims description 3
- 101000652359 Homo sapiens Spermatogenesis-associated protein 2 Proteins 0.000 claims description 3
- 101000610604 Homo sapiens Tumor necrosis factor receptor superfamily member 10B Proteins 0.000 claims description 3
- 102100039615 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Human genes 0.000 claims description 3
- 102000002698 KIR Receptors Human genes 0.000 claims description 3
- 108010043610 KIR Receptors Proteins 0.000 claims description 3
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims description 3
- 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 claims description 3
- 102000003735 Mesothelin Human genes 0.000 claims description 3
- 108090000015 Mesothelin Proteins 0.000 claims description 3
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims description 3
- 102100040112 Tumor necrosis factor receptor superfamily member 10B Human genes 0.000 claims description 3
- 108010087914 epidermal growth factor receptor VIII Proteins 0.000 claims description 3
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims description 3
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims description 3
- 238000012737 microarray-based gene expression Methods 0.000 claims description 3
- 238000012243 multiplex automated genomic engineering Methods 0.000 claims description 3
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 claims description 3
- 230000008685 targeting Effects 0.000 claims description 3
- 102100023990 60S ribosomal protein L17 Human genes 0.000 claims description 2
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims description 2
- 102100027207 CD27 antigen Human genes 0.000 claims description 2
- 102100038078 CD276 antigen Human genes 0.000 claims description 2
- 101710185679 CD276 antigen Proteins 0.000 claims description 2
- 101150013553 CD40 gene Proteins 0.000 claims description 2
- 102100035793 CD83 antigen Human genes 0.000 claims description 2
- 208000002250 Hematologic Neoplasms Diseases 0.000 claims description 2
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims description 2
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims description 2
- 101000946856 Homo sapiens CD83 antigen Proteins 0.000 claims description 2
- 101001109503 Homo sapiens NKG2-C type II integral membrane protein Proteins 0.000 claims description 2
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims description 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims description 2
- 102100022683 NKG2-C type II integral membrane protein Human genes 0.000 claims description 2
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims description 2
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 2
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims description 2
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims description 2
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims description 2
- 230000005809 anti-tumor immunity Effects 0.000 claims description 2
- 229960002685 biotin Drugs 0.000 claims description 2
- 235000020958 biotin Nutrition 0.000 claims description 2
- 239000011616 biotin Substances 0.000 claims description 2
- 229940127089 cytotoxic agent Drugs 0.000 claims description 2
- 239000002254 cytotoxic agent Substances 0.000 claims description 2
- 231100000599 cytotoxic agent Toxicity 0.000 claims description 2
- 238000010494 dissociation reaction Methods 0.000 claims description 2
- 230000005593 dissociations Effects 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000007850 fluorescent dye Substances 0.000 claims description 2
- 201000005787 hematologic cancer Diseases 0.000 claims description 2
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims description 2
- 239000003446 ligand Substances 0.000 claims description 2
- 210000004698 lymphocyte Anatomy 0.000 claims description 2
- 239000002773 nucleotide Substances 0.000 claims description 2
- 125000003729 nucleotide group Chemical group 0.000 claims description 2
- 238000012216 screening Methods 0.000 claims description 2
- 229940124597 therapeutic agent Drugs 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 description 13
- 230000001472 cytotoxic effect Effects 0.000 description 13
- 108091008874 T cell receptors Proteins 0.000 description 3
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 3
- 230000001086 cytosolic effect Effects 0.000 description 3
- 210000004962 mammalian cell Anatomy 0.000 description 3
- 210000000822 natural killer cell Anatomy 0.000 description 3
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 101710145634 Antigen 1 Proteins 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021068754A JP7244567B2 (ja) | 2015-04-06 | 2021-04-15 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
| JP2023007753A JP2023052563A (ja) | 2015-04-06 | 2023-01-23 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
| JP2024049923A JP2024075751A (ja) | 2015-04-06 | 2024-03-26 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562143772P | 2015-04-06 | 2015-04-06 | |
| US62/143,772 | 2015-04-06 | ||
| PCT/US2016/025868 WO2016164305A1 (en) | 2015-04-06 | 2016-04-04 | De novo binding domain containing polypeptides and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021068754A Division JP7244567B2 (ja) | 2015-04-06 | 2021-04-15 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018516092A JP2018516092A (ja) | 2018-06-21 |
| JP2018516092A5 true JP2018516092A5 (enExample) | 2019-05-09 |
| JP6871232B2 JP6871232B2 (ja) | 2021-05-12 |
Family
ID=57072017
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018503725A Active JP6871232B2 (ja) | 2015-04-06 | 2016-04-04 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
| JP2018503726A Active JP6873101B2 (ja) | 2015-04-06 | 2016-04-04 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
| JP2021068754A Active JP7244567B2 (ja) | 2015-04-06 | 2021-04-15 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
| JP2023007753A Withdrawn JP2023052563A (ja) | 2015-04-06 | 2023-01-23 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
| JP2024049923A Pending JP2024075751A (ja) | 2015-04-06 | 2024-03-26 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018503726A Active JP6873101B2 (ja) | 2015-04-06 | 2016-04-04 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
| JP2021068754A Active JP7244567B2 (ja) | 2015-04-06 | 2021-04-15 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
| JP2023007753A Withdrawn JP2023052563A (ja) | 2015-04-06 | 2023-01-23 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
| JP2024049923A Pending JP2024075751A (ja) | 2015-04-06 | 2024-03-26 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
Country Status (26)
| Country | Link |
|---|---|
| US (9) | US10647775B2 (enExample) |
| EP (3) | EP3280433B1 (enExample) |
| JP (5) | JP6871232B2 (enExample) |
| KR (2) | KR102788389B1 (enExample) |
| CN (4) | CN107708720A (enExample) |
| AU (4) | AU2016246426B2 (enExample) |
| BR (1) | BR112017021308A2 (enExample) |
| CA (2) | CA2981616C (enExample) |
| CY (1) | CY1124453T1 (enExample) |
| DK (2) | DK3280432T3 (enExample) |
| EA (1) | EA201792226A1 (enExample) |
| ES (2) | ES2901273T3 (enExample) |
| HR (1) | HRP20210498T1 (enExample) |
| HU (1) | HUE054435T2 (enExample) |
| IL (2) | IL254907B (enExample) |
| LT (1) | LT3280432T (enExample) |
| MX (2) | MX387517B (enExample) |
| PH (1) | PH12017501834B1 (enExample) |
| PL (1) | PL3280432T3 (enExample) |
| PT (1) | PT3280432T (enExample) |
| RS (1) | RS61907B1 (enExample) |
| SG (2) | SG11201708257UA (enExample) |
| SI (1) | SI3280432T1 (enExample) |
| SM (1) | SMT202100285T1 (enExample) |
| WO (3) | WO2016164305A1 (enExample) |
| ZA (1) | ZA201706875B (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| DK3280432T3 (da) | 2015-04-06 | 2021-04-26 | Subdomain Llc | Polypeptider indeholdende de novo-bindingsdomæner og anvendelser deraf |
| WO2018075586A1 (en) * | 2016-10-18 | 2018-04-26 | Memorial Sloan-Kettering Cancer Center | Antigen-binding proteins targeting melanoma differentiation antigens and uses thereof |
| KR20190118172A (ko) | 2017-02-08 | 2019-10-17 | 드래곤플라이 쎄라퓨틱스, 인크. | 천연 킬러 세포의 활성화를 위한 다중-특이적 결합 단백질 및 암 치료에서의 그의 치료적 용도 |
| US20200024353A1 (en) * | 2017-02-10 | 2020-01-23 | Dragonfly Therapeutics, Inc. | Proteins binding psma, nkg2d and cd16 |
| CA3054642A1 (en) * | 2017-02-10 | 2018-08-16 | Dragonfly Therapeutics, Inc. | Proteins binding bcma, nkg2d and cd16 |
| EP4273258A3 (en) | 2017-02-20 | 2024-01-17 | Dragonfly Therapeutics, Inc. | Proteins binding her2, nkg2d and cd16 |
| EP3592381A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Cancer vaccine |
| CN110914310A (zh) | 2017-03-10 | 2020-03-24 | 哈佛大学的校长及成员们 | 胞嘧啶至鸟嘌呤碱基编辑器 |
| JP7161940B2 (ja) * | 2017-05-10 | 2022-10-27 | ウェルスタット イミューノ セラピューティクス， エルエルシー | がんの治療のための、補体不活性化に耐性のエンベロープウイルス |
| CN107216395B (zh) * | 2017-07-03 | 2018-07-20 | 上海科医联创生物科技有限公司 | 一种tm4sf1特异性嵌合抗原受体及其应用 |
| US11732274B2 (en) | 2017-07-28 | 2023-08-22 | President And Fellows Of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (PACE) |
| WO2019060750A2 (en) | 2017-09-23 | 2019-03-28 | Memorial Sloan Kettering Cancer Center | A33 ANTIBODY COMPOSITIONS AND METHODS OF USE IN RADIOIMMUNOTHERAPY |
| WO2019094648A1 (en) | 2017-11-08 | 2019-05-16 | L.E.A.F. Holdings Group Llc | Platinum complexes and uses thereof |
| TWI701259B (zh) * | 2017-11-09 | 2020-08-11 | 大陸商上海懷越生物科技有限公司 | ４﹘１ｂｂ抗體及其製備方法和應用 |
| US11464803B2 (en) | 2017-11-14 | 2022-10-11 | Arcellx, Inc. | D-domain containing polypeptides and uses thereof |
| US11377482B2 (en) * | 2017-11-14 | 2022-07-05 | Arcellx, Inc. | D-domain containing polypeptides and uses thereof |
| IL274677B2 (en) * | 2017-11-14 | 2025-01-01 | Arcellx Inc | Therapies with multifunctional immune system cells |
| WO2019118949A1 (en) | 2017-12-15 | 2019-06-20 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| WO2019157366A1 (en) | 2018-02-08 | 2019-08-15 | Dragonfly Therapeutics, Inc. | Antibody variable domains targeting the nkg2d receptor |
| MX2020008333A (es) | 2018-02-08 | 2020-09-21 | Dragonfly Therapeutics Inc | Terapia de combinacion del cancer que incluye proteinas de union multiespecificas que activan a las celulas asesinas naturales. |
| MX2020008684A (es) | 2018-02-20 | 2020-12-07 | Dragonfly Therapeutics Inc | Proteinas de union multiespecificas que se unen a cd33, nkg2d y cd16 y metodos de uso. |
| WO2019178518A1 (en) * | 2018-03-16 | 2019-09-19 | The Regents Of The University Of California | Cellular signaling domain engineering in chimeric antigen receptor-modified regulatory t cells |
| MX2020011844A (es) | 2018-05-08 | 2021-04-13 | Amgen Inc | Anticuerpos bispecificos con marcadores con emparejamiento de cargas c-terminales escindibles. |
| CA3108427A1 (en) * | 2018-08-08 | 2020-02-13 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind bcma, nkg2d and cd16, and methods of use |
| MX2021001527A (es) * | 2018-08-08 | 2021-06-15 | Dragonfly Therapeutics Inc | Proteínas de unión a nkg2d, cd16 y a un antígeno asociado a tumor. |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| GB201903479D0 (en) | 2019-03-14 | 2019-05-01 | Univ Oxford Innovation Ltd | Polypeptide with enchanced rate of spontaneous isopeptide bond formation with it's peptide tag partner and uses thereof |
| CN113661240B (zh) * | 2019-04-02 | 2024-11-05 | 伊莱利利公司 | 选择和检测结合肽的方法 |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| CN111848733B (zh) * | 2019-04-30 | 2024-03-12 | 上海细胞治疗集团有限公司 | 一种多肽组合物及疫苗 |
| MX2021014334A (es) * | 2019-05-24 | 2022-02-21 | Avitide LLC | Agentes afines a aav9. |
| EP3977117A4 (en) | 2019-05-31 | 2023-08-16 | iBio, Inc. | Meso-scale engineered peptides and methods of selecting |
| CN114555127A (zh) | 2019-08-06 | 2022-05-27 | L.E.A.F.控股集团公司 | 制备聚谷氨酸化抗叶酸剂的方法以及它们的组合物的用途 |
| WO2021100585A1 (ja) * | 2019-11-20 | 2021-05-27 | 国立大学法人東海国立大学機構 | キメラ抗原受容体遺伝子改変リンパ球の調製方法 |
| WO2021115333A1 (zh) * | 2019-12-10 | 2021-06-17 | 苏州克睿基因生物科技有限公司 | 一种融合蛋白及表达此蛋白的工程化免疫细胞及其应用 |
| EP4146271A4 (en) | 2020-05-06 | 2024-09-04 | Dragonfly Therapeutics, Inc. | PROTEINS THAT BIND NKG2D, CD16 AND CLEC12A |
| CN111560391B (zh) * | 2020-05-21 | 2022-02-11 | 北京大学 | 一种蛋白质异质索烃的生物合成方法 |
| CN111732635B (zh) * | 2020-06-22 | 2022-03-22 | 中国医学科学院基础医学研究所 | 与cd123蛋白特异性结合的多肽、多肽复合物、共递送系统及其制备方法与应用 |
| US20230391866A1 (en) * | 2020-07-03 | 2023-12-07 | The Trustees Of Columbia University In The City Of New York | Polyfunctional orthogonal protein chimeras |
| CN114380907B (zh) * | 2020-10-16 | 2024-06-18 | 中国科学院上海药物研究所 | 靶向cmtm6的纳米抗体及其制备方法和应用 |
| CA3208273A1 (en) * | 2021-01-20 | 2022-07-28 | Coding Bio Limited | Methods for high throughput screening of chimeric antigen receptors |
| EP4301774A4 (en) | 2021-03-03 | 2025-08-13 | Dragonfly Therapeutics Inc | METHODS OF TREATING CANCER USING MULTI-SPECIFIC BINDING PROTEINS THAT BIND TO NKG2D, CD16, AND A TUMOR-ASSOCIATED ANTIGEN |
| JP2024512590A (ja) | 2021-03-26 | 2024-03-19 | アーセルクス インコーポレイテッド | 多機能免疫細胞療法 |
| JP2024544559A (ja) | 2021-11-15 | 2024-12-03 | アーセルクス インコーポレイテッド | Ｄドメイン含有ポリペプチドおよびその使用法 |
| CN119095953A (zh) * | 2022-02-18 | 2024-12-06 | 丹娜-法伯癌症研究院 | 细胞表面受体的表位工程 |
| JP2025509573A (ja) | 2022-03-17 | 2025-04-11 | シンギュラー イミューン インコーポレイテッド | 組換え融合タンパク質の組成物及びｃａｒ免疫細胞を作製するためのその使用方法 |
| WO2023212602A2 (en) * | 2022-04-27 | 2023-11-02 | Board Of Regents, The University Of Texas System | Cd30 hinge and/or transmembrane domain-based chimeric antigen receptors |
| CN115028689B (zh) * | 2022-06-15 | 2023-05-30 | 浙江东方基因生物制品股份有限公司 | 特异性检测hpv6和hpv11的双特异性检测试剂盒 |
| CN116380854B (zh) * | 2023-03-06 | 2025-05-30 | 上海电力大学 | 一种基于荧光光谱快速检测水中微塑料污染的方法 |
| WO2024254346A1 (en) * | 2023-06-07 | 2024-12-12 | The Broad Institute, Inc. | Engineered viral like particles (evlps) for the selective transduction of target cells |
| WO2025122460A1 (en) * | 2023-12-04 | 2025-06-12 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
Family Cites Families (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| EP0216846B2 (en) | 1985-04-01 | 1995-04-26 | Celltech Limited | Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same |
| US5374548A (en) | 1986-05-02 | 1994-12-20 | Genentech, Inc. | Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor |
| MX9203291A (es) | 1985-06-26 | 1992-08-01 | Liposome Co Inc | Metodo para acoplamiento de liposomas. |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US5723286A (en) | 1990-06-20 | 1998-03-03 | Affymax Technologies N.V. | Peptide library and screening systems |
| JP4124480B2 (ja) | 1991-06-14 | 2008-07-23 | ジェネンテック・インコーポレーテッド | 免疫グロブリン変異体 |
| US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| US5733731A (en) | 1991-10-16 | 1998-03-31 | Affymax Technologies N.V. | Peptide library and screening method |
| DK0617706T3 (da) | 1991-11-25 | 2001-11-12 | Enzon Inc | Multivalente antigenbindende proteiner |
| US5350674A (en) | 1992-09-04 | 1994-09-27 | Becton, Dickinson And Company | Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof |
| US5922545A (en) | 1993-10-29 | 1999-07-13 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
| SE9400088D0 (sv) | 1994-01-14 | 1994-01-14 | Kabi Pharmacia Ab | Bacterial receptor structures |
| US5541087A (en) | 1994-09-14 | 1996-07-30 | Fuji Immunopharmaceuticals Corporation | Expression and export technology of proteins as immunofusins |
| AU7378096A (en) | 1995-09-28 | 1997-04-17 | Alexion Pharmaceuticals, Inc. | Porcine cell interaction proteins |
| ES2190543T3 (es) | 1996-10-08 | 2003-08-01 | Bisys B V U | Procedimientos y sistemas que permiten seleccionar peptidos y proteinas que tienen una afinidad especifica respecto a un blanco. |
| US7763258B2 (en) | 1997-05-20 | 2010-07-27 | The Trustees Of The University Of Pennsylvania | Virus-like particles (VLPs) comprising heterologous multiple membrane spanning proteins |
| DE19802708A1 (de) | 1998-01-24 | 1999-07-29 | Hoechst Marion Roussel De Gmbh | Verwendung von hydroxypyridon-haltigen Puderzubereitungen zur Behandlung von Unterschenkel- und Druckgeschwüren |
| US20020155604A1 (en) | 1998-02-19 | 2002-10-24 | Jeffrey A. Ledbetter | Compositions and methods for regulating lymphocyte activation |
| US7425541B2 (en) | 1998-12-11 | 2008-09-16 | Medarex, Inc. | Enzyme-cleavable prodrug compounds |
| PT2067788E (pt) | 1999-05-18 | 2015-10-29 | Dyax Corp | Bibliotecas de fragmentos fab e métodos para a sua utilização |
| AU1086501A (en) | 1999-10-15 | 2001-04-30 | Carnegie Institution Of Washington | Rna interference pathway genes as tools for targeted genetic interference |
| US6326193B1 (en) | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
| AU784285B2 (en) | 1999-12-24 | 2006-03-02 | Genentech Inc. | Methods and compositions for prolonging elimination half-times of bioactive compounds |
| AU2001275474A1 (en) | 2000-06-12 | 2001-12-24 | Akkadix Corporation | Materials and methods for the control of nematodes |
| NZ523912A (en) | 2000-07-31 | 2005-03-24 | Biolex Inc | Expression of biologically active polypeptides in duckweed |
| US7829084B2 (en) | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
| EP2359685B1 (en) | 2001-12-27 | 2013-12-04 | GlycoFi, Inc. | Methods to engineer mammalian-type carbohydrate structures |
| EP1474161A4 (en) | 2002-01-16 | 2005-06-29 | Zyomyx Inc | TRANSGENIC BINDING PROTEINS |
| US20040002587A1 (en) | 2002-02-20 | 2004-01-01 | Watkins Jeffry D. | Fc region variants |
| US7314974B2 (en) * | 2002-02-21 | 2008-01-01 | Monsanto Technology, Llc | Expression of microbial proteins in plants for production of plants with improved properties |
| AU2003219402B2 (en) | 2002-03-19 | 2008-05-08 | Stichting Dienst Landbouwkundig Onderzoek | GnTIII (UDP-n-acethylglucosamine:beta-D mannoside beta (1,4)-N-acethylglucosaminy ltransferase III) expression in plants |
| DE60335000D1 (de) | 2002-09-06 | 2010-12-30 | Isogenica Ltd | In vitro peptid-expressionsbank |
| ATE472604T1 (de) | 2002-09-12 | 2010-07-15 | Greenovation Biotech Gmbh | Verfahren zur herstellung von proteinen |
| JP4559358B2 (ja) | 2002-12-20 | 2010-10-06 | グリーンオベーション バイオテク ゲーエムベーハー | コケ細胞における異種グリコシル化タンパク質の産生 |
| GB0230203D0 (en) | 2002-12-27 | 2003-02-05 | Domantis Ltd | Fc fusion |
| EP1452868A2 (en) | 2003-02-27 | 2004-09-01 | Pepscan Systems B.V. | Method for selecting a candidate drug compound |
| US8377447B2 (en) | 2003-09-05 | 2013-02-19 | Oregon Health & Science University | Monomeric recombinant MHC molecules useful for manipulation of antigen-specific T cells |
| CN1871252A (zh) | 2003-09-05 | 2006-11-29 | Gtc生物治疗学公司 | 在转基因哺乳动物奶中生产融合蛋白的方法 |
| NZ548828A (en) * | 2004-01-20 | 2009-07-31 | Merus B V | Mixtures of binding proteins |
| EP1776384B1 (en) | 2004-08-04 | 2013-06-05 | Mentrik Biotech, LLC | Variant fc regions |
| US7700099B2 (en) | 2005-02-14 | 2010-04-20 | Merck & Co., Inc. | Non-immunostimulatory antibody and compositions containing the same |
| WO2006130834A2 (en) | 2005-05-31 | 2006-12-07 | Board Of Regents, The University Of Texas System | IGGl ANTIBODIES WITH MUTATED FC PORTION FOR INCREASED BINDING TO FCRN RECEPTOR AND USES THEREOF |
| US20100015044A1 (en) * | 2005-08-03 | 2010-01-21 | Robert Qiu | Methods and compositions for diagnosis of iga-and igm-mediated kidney diseases |
| BR122017024057B8 (pt) | 2006-03-15 | 2021-05-25 | Alexion Pharma Inc | anticorpo que se liga à c5 e composição farmacêutica compreendendo dito anticorpo e um veículo farmaceuticamente aceitável |
| WO2008052043A2 (en) | 2006-10-24 | 2008-05-02 | Cogenesys, Inc. | Opioid receptor agonist fusion proteins |
| GB0907251D0 (en) | 2009-04-28 | 2009-06-10 | Univ Leiden | Coplymers |
| US20120172419A1 (en) | 2009-09-15 | 2012-07-05 | Medical College Of Wisconsin Research Foundation Inc. | Reagents and methods for modulating cone photoreceptor activity |
| WO2012044999A2 (en) * | 2010-10-01 | 2012-04-05 | Ludwig Institute For Cancer Research Ltd. | Reversible protein multimers, methods for their production and use |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| WO2012167109A2 (en) | 2011-06-03 | 2012-12-06 | Massachusetts Eye & Ear Infirmary | Rpgrip1 gene therapy for leber congenital amaurosis |
| WO2014028776A1 (en) | 2012-08-15 | 2014-02-20 | Zyngenia, Inc. | Monovalent and multivalent multispecific complexes and uses thereof |
| AU2013318928A1 (en) * | 2012-09-21 | 2015-04-09 | Kaneka Corporation | Protein ligand for affinity isolation matrix |
| US20160031996A1 (en) | 2013-03-14 | 2016-02-04 | Csl Limited | Anti il-3r alpha agents and uses thereof |
| US9840539B2 (en) * | 2013-03-14 | 2017-12-12 | University Of Washington Through Its Center For Commercialization | High affinity digoxigenin binding proteins |
| US9657105B2 (en) * | 2013-03-15 | 2017-05-23 | City Of Hope | CD123-specific chimeric antigen receptor redirected T cells and methods of their use |
| GB201306634D0 (en) | 2013-04-11 | 2013-05-29 | Univ Bristol | Cage-like particles |
| US9045545B1 (en) | 2014-07-15 | 2015-06-02 | Kymab Limited | Precision medicine by targeting PD-L1 variants for treatment of cancer |
| PT3137497T (pt) | 2014-05-02 | 2021-07-12 | Genzyme Corp | Vetores de aav para terapia genética na retina e snc |
| EP3025719B1 (en) | 2014-11-26 | 2018-09-26 | Miltenyi Biotec GmbH | Combination immunotherapy of antigen-recognizing receptors and hematopoietic cells for the treatment of diseases |
| WO2016154621A1 (en) | 2015-03-26 | 2016-09-29 | The California Institute For Biomedical Research | SWITCHABLE NON-scFv CHIMERIC RECEPTORS, SWITCHES, AND USES THEREOF |
| DK3280432T3 (da) | 2015-04-06 | 2021-04-26 | Subdomain Llc | Polypeptider indeholdende de novo-bindingsdomæner og anvendelser deraf |
| KR20160126340A (ko) | 2015-04-23 | 2016-11-02 | 삼성전자주식회사 | 3중-나선 다발 단백질 및 이의 용도 |
| WO2017083511A1 (en) | 2015-11-13 | 2017-05-18 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-bcma polypeptides and proteins |
| SG11201903454VA (en) | 2016-11-02 | 2019-05-30 | Univ Basel | Immunologically discernible cell surface variants for use in cell therapy |
| CN107254447B (zh) | 2017-06-01 | 2020-10-16 | 刘未斌 | Anti AFP CAR-T细胞及其制备方法和应用 |
| US11464803B2 (en) | 2017-11-14 | 2022-10-11 | Arcellx, Inc. | D-domain containing polypeptides and uses thereof |
| US11377482B2 (en) | 2017-11-14 | 2022-07-05 | Arcellx, Inc. | D-domain containing polypeptides and uses thereof |
| IL274677B2 (en) | 2017-11-14 | 2025-01-01 | Arcellx Inc | Therapies with multifunctional immune system cells |
| JP2024512590A (ja) | 2021-03-26 | 2024-03-19 | アーセルクス インコーポレイテッド | 多機能免疫細胞療法 |
| JP2024544559A (ja) | 2021-11-15 | 2024-12-03 | アーセルクス インコーポレイテッド | Ｄドメイン含有ポリペプチドおよびその使用法 |
| EP4626912A2 (en) | 2022-11-29 | 2025-10-08 | Arcellx, Inc. | D-domain containing polypeptides and uses thereof |
-
2016
- 2016-04-04 DK DK16777107.0T patent/DK3280432T3/da active
- 2016-04-04 BR BR112017021308-7A patent/BR112017021308A2/pt not_active Application Discontinuation
- 2016-04-04 CA CA2981616A patent/CA2981616C/en active Active
- 2016-04-04 HU HUE16777107A patent/HUE054435T2/hu unknown
- 2016-04-04 ES ES16777109T patent/ES2901273T3/es active Active
- 2016-04-04 PT PT167771070T patent/PT3280432T/pt unknown
- 2016-04-04 CN CN201680032016.8A patent/CN107708720A/zh active Pending
- 2016-04-04 SM SM20210285T patent/SMT202100285T1/it unknown
- 2016-04-04 CN CN201680032015.3A patent/CN107921090A/zh active Pending
- 2016-04-04 CA CA2981711A patent/CA2981711A1/en active Pending
- 2016-04-04 DK DK16777109.6T patent/DK3280433T3/da active
- 2016-04-04 KR KR1020177031697A patent/KR102788389B1/ko active Active
- 2016-04-04 US US15/564,319 patent/US10647775B2/en active Active
- 2016-04-04 US US15/564,325 patent/US10662248B2/en active Active
- 2016-04-04 JP JP2018503725A patent/JP6871232B2/ja active Active
- 2016-04-04 WO PCT/US2016/025868 patent/WO2016164305A1/en not_active Ceased
- 2016-04-04 PH PH1/2017/501834A patent/PH12017501834B1/en unknown
- 2016-04-04 CN CN202510559733.7A patent/CN120424177A/zh active Pending
- 2016-04-04 ES ES16777107T patent/ES2866202T3/es active Active
- 2016-04-04 MX MX2017012679A patent/MX387517B/es unknown
- 2016-04-04 EP EP16777109.6A patent/EP3280433B1/en active Active
- 2016-04-04 SG SG11201708257UA patent/SG11201708257UA/en unknown
- 2016-04-04 AU AU2016246426A patent/AU2016246426B2/en active Active
- 2016-04-04 KR KR1020257009799A patent/KR20250048140A/ko active Pending
- 2016-04-04 EP EP16777107.0A patent/EP3280432B8/en active Active
- 2016-04-04 SI SI201631199T patent/SI3280432T1/sl unknown
- 2016-04-04 EA EA201792226A patent/EA201792226A1/ru unknown
- 2016-04-04 LT LTEP16777107.0T patent/LT3280432T/lt unknown
- 2016-04-04 CN CN202210256708.8A patent/CN115160438A/zh active Pending
- 2016-04-04 JP JP2018503726A patent/JP6873101B2/ja active Active
- 2016-04-04 RS RS20210529A patent/RS61907B1/sr unknown
- 2016-04-04 EP EP21155053.8A patent/EP3903804A1/en active Pending
- 2016-04-04 HR HRP20210498TT patent/HRP20210498T1/hr unknown
- 2016-04-04 SG SG10202007987QA patent/SG10202007987QA/en unknown
- 2016-04-04 PL PL16777107T patent/PL3280432T3/pl unknown
- 2016-04-04 WO PCT/US2016/025880 patent/WO2016164308A1/en not_active Ceased
- 2016-04-05 US US15/564,430 patent/US20180209983A1/en not_active Abandoned
- 2016-04-05 WO PCT/US2016/026054 patent/WO2016164369A2/en not_active Ceased
-
2017
- 2017-10-02 MX MX2021013161A patent/MX2021013161A/es unknown
- 2017-10-06 IL IL254907A patent/IL254907B/en active IP Right Grant
- 2017-10-11 ZA ZA2017/06875A patent/ZA201706875B/en unknown
-
2020
- 2020-01-24 US US16/751,730 patent/US20200362046A1/en not_active Abandoned
- 2020-03-13 US US16/817,755 patent/US11008397B2/en active Active
- 2020-03-20 US US16/824,809 patent/US20210002381A1/en active Pending
-
2021
- 2021-02-09 AU AU2021200810A patent/AU2021200810B2/en active Active
- 2021-04-13 US US17/228,817 patent/US12358995B2/en active Active
- 2021-04-15 JP JP2021068754A patent/JP7244567B2/ja active Active
- 2021-04-27 IL IL282704A patent/IL282704A/en unknown
- 2021-06-03 CY CY20211100483T patent/CY1124453T1/el unknown
-
2022
- 2022-12-22 US US18/145,169 patent/US20240043550A1/en active Pending
-
2023
- 2023-01-23 JP JP2023007753A patent/JP2023052563A/ja not_active Withdrawn
- 2023-08-22 AU AU2023219820A patent/AU2023219820B2/en active Active
-
2024
- 2024-03-26 JP JP2024049923A patent/JP2024075751A/ja active Pending
-
2025
- 2025-04-23 AU AU2025202871A patent/AU2025202871A1/en active Pending
- 2025-06-06 US US19/231,210 patent/US20250353920A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018516092A5 (enExample) | ||
| US11008376B2 (en) | Trifunctional T cell-antigen coupler and methods and uses thereof | |
| JP7068459B2 (ja) | Ｎｙｅｓｏ ｔｃｒ | |
| JP7487112B2 (ja) | Ｃｄ１９指向性キメラ抗原受容体および免疫療法におけるその使用 | |
| HRP20210498T1 (hr) | De novo vezujuća domena koja sadrži polipeptide i njihova upotreba | |
| CN113082201B (zh) | 刺激t细胞介导的对表达抗原的细胞群的免疫应答的方法 | |
| EP3472205B1 (en) | Chimeric antigen receptor | |
| JP7227630B2 (ja) | Ｙ１８２ｔ突然変異を有するｔ細胞－抗原カプラおよびその方法ならびに使用 | |
| US11878035B2 (en) | T cell-antigen coupler with various construct optimizations | |
| JP2020530989A5 (enExample) | ||
| JP7404279B2 (ja) | 様々な構築物最適化を備えたｔ細胞抗原カプラ | |
| JP2019534246A5 (enExample) | ||
| JP2017537622A5 (enExample) | ||
| JP2023512452A (ja) | Ｂｃｍａ指向性細胞免疫療法組成物および方法 | |
| JP7174144B2 (ja) | Ｈａ－１特異的ｔ細胞受容体およびその使用 | |
| JP2025527657A (ja) | Ｎｙ－ｅｓｏ－１特異的ｔ細胞受容体とキメラ共刺激受容体との組み合わせ物 | |
| JP2023542208A (ja) | Ｍａｇｅ－ａ３特異的ｔ細胞受容体およびその使用 | |
| CN115873801A (zh) | 工程化免疫细胞及其用途 | |
| JPWO2023086983A5 (enExample) | ||
| NZ736022B2 (en) | De novo binding domain containing polypeptides and uses thereof | |
| HK40054580A (en) | Trifunctional t cell-antigen coupler and methods and uses thereof | |
| NZ805407A (en) | D-domain containing polypeptides and uses thereof | |
| HK1234091A1 (en) | Trifunctional t cell-antigen coupler and methods and uses thereof |