JP2018516092A5 - - Google Patents
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- JP2018516092A5 JP2018516092A5 JP2018503725A JP2018503725A JP2018516092A5 JP 2018516092 A5 JP2018516092 A5 JP 2018516092A5 JP 2018503725 A JP2018503725 A JP 2018503725A JP 2018503725 A JP2018503725 A JP 2018503725A JP 2018516092 A5 JP2018516092 A5 JP 2018516092A5
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 129
- 229920001184 polypeptide Polymers 0.000 claims description 123
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 123
- 230000027455 binding Effects 0.000 claims description 104
- 206010028980 Neoplasm Diseases 0.000 claims description 56
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 44
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- 238000000034 method Methods 0.000 claims description 33
- 238000006467 substitution reaction Methods 0.000 claims description 28
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 24
- 235000001014 amino acid Nutrition 0.000 claims description 24
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- 102000036639 antigens Human genes 0.000 claims description 17
- 108091007433 antigens Proteins 0.000 claims description 17
- 150000001413 amino acids Chemical class 0.000 claims description 16
- 108020001507 fusion proteins Proteins 0.000 claims description 16
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- 101000998120 Homo sapiens Interleukin-3 receptor subunit alpha Proteins 0.000 claims description 15
- 102100033493 Interleukin-3 receptor subunit alpha Human genes 0.000 claims description 15
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 12
- 235000018417 cysteine Nutrition 0.000 claims description 12
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 12
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- 229930186217 Glycolipid Natural products 0.000 claims description 3
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims description 3
- 101000834898 Homo sapiens Alpha-synuclein Proteins 0.000 claims description 3
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- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims description 3
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims description 3
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 claims description 3
- 101001103039 Homo sapiens Inactive tyrosine-protein kinase transmembrane receptor ROR1 Proteins 0.000 claims description 3
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 claims description 3
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims description 3
- 101001103036 Homo sapiens Nuclear receptor ROR-alpha Proteins 0.000 claims description 3
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 claims description 3
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- 101000610604 Homo sapiens Tumor necrosis factor receptor superfamily member 10B Proteins 0.000 claims description 3
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- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims description 3
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- 102000003735 Mesothelin Human genes 0.000 claims description 3
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- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims description 3
- 102100040112 Tumor necrosis factor receptor superfamily member 10B Human genes 0.000 claims description 3
- 108010087914 epidermal growth factor receptor VIII Proteins 0.000 claims description 3
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims description 3
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- 238000012737 microarray-based gene expression Methods 0.000 claims description 3
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- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims description 3
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- 102100023990 60S ribosomal protein L17 Human genes 0.000 claims description 2
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims description 2
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- 208000002250 Hematologic Neoplasms Diseases 0.000 claims description 2
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims description 2
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims description 2
- 101000946856 Homo sapiens CD83 antigen Proteins 0.000 claims description 2
- 101001109503 Homo sapiens NKG2-C type II integral membrane protein Proteins 0.000 claims description 2
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims description 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims description 2
- 102100022683 NKG2-C type II integral membrane protein Human genes 0.000 claims description 2
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims description 2
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 2
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims description 2
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- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims description 2
- 230000005809 anti-tumor immunity Effects 0.000 claims description 2
- 229960002685 biotin Drugs 0.000 claims description 2
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- 229940127089 cytotoxic agent Drugs 0.000 claims description 2
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- 230000001086 cytosolic effect Effects 0.000 description 3
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- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 description 2
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Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021068754A JP7244567B2 (ja) | 2015-04-06 | 2021-04-15 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
| JP2023007753A JP2023052563A (ja) | 2015-04-06 | 2023-01-23 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
| JP2024049923A JP2024075751A (ja) | 2015-04-06 | 2024-03-26 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562143772P | 2015-04-06 | 2015-04-06 | |
| US62/143,772 | 2015-04-06 | ||
| PCT/US2016/025868 WO2016164305A1 (en) | 2015-04-06 | 2016-04-04 | De novo binding domain containing polypeptides and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021068754A Division JP7244567B2 (ja) | 2015-04-06 | 2021-04-15 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018516092A JP2018516092A (ja) | 2018-06-21 |
| JP2018516092A5 true JP2018516092A5 (enExample) | 2019-05-09 |
| JP6871232B2 JP6871232B2 (ja) | 2021-05-12 |
Family
ID=57072017
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018503726A Active JP6873101B2 (ja) | 2015-04-06 | 2016-04-04 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
| JP2018503725A Active JP6871232B2 (ja) | 2015-04-06 | 2016-04-04 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
| JP2021068754A Active JP7244567B2 (ja) | 2015-04-06 | 2021-04-15 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
| JP2023007753A Withdrawn JP2023052563A (ja) | 2015-04-06 | 2023-01-23 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
| JP2024049923A Pending JP2024075751A (ja) | 2015-04-06 | 2024-03-26 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018503726A Active JP6873101B2 (ja) | 2015-04-06 | 2016-04-04 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021068754A Active JP7244567B2 (ja) | 2015-04-06 | 2021-04-15 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
| JP2023007753A Withdrawn JP2023052563A (ja) | 2015-04-06 | 2023-01-23 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
| JP2024049923A Pending JP2024075751A (ja) | 2015-04-06 | 2024-03-26 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
Country Status (26)
| Country | Link |
|---|---|
| US (8) | US10647775B2 (enExample) |
| EP (3) | EP3280432B8 (enExample) |
| JP (5) | JP6873101B2 (enExample) |
| KR (2) | KR20250048140A (enExample) |
| CN (4) | CN115160438A (enExample) |
| AU (4) | AU2016246426B2 (enExample) |
| BR (1) | BR112017021308A2 (enExample) |
| CA (2) | CA2981616C (enExample) |
| CY (1) | CY1124453T1 (enExample) |
| DK (2) | DK3280432T3 (enExample) |
| EA (1) | EA201792226A1 (enExample) |
| ES (2) | ES2901273T3 (enExample) |
| HR (1) | HRP20210498T1 (enExample) |
| HU (1) | HUE054435T2 (enExample) |
| IL (2) | IL254907B (enExample) |
| LT (1) | LT3280432T (enExample) |
| MX (2) | MX387517B (enExample) |
| PH (1) | PH12017501834B1 (enExample) |
| PL (1) | PL3280432T3 (enExample) |
| PT (1) | PT3280432T (enExample) |
| RS (1) | RS61907B1 (enExample) |
| SG (2) | SG10202007987QA (enExample) |
| SI (1) | SI3280432T1 (enExample) |
| SM (1) | SMT202100285T1 (enExample) |
| WO (3) | WO2016164305A1 (enExample) |
| ZA (1) | ZA201706875B (enExample) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9340800B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | Extended DNA-sensing GRNAS |
| CA2981616C (en) * | 2015-04-06 | 2025-06-17 | Arcellx, Inc. | De novo binding domain polypeptides and their uses |
| WO2018075586A1 (en) * | 2016-10-18 | 2018-04-26 | Memorial Sloan-Kettering Cancer Center | Antigen-binding proteins targeting melanoma differentiation antigens and uses thereof |
| CA3053010A1 (en) | 2017-02-08 | 2018-08-16 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
| JP2020507577A (ja) * | 2017-02-10 | 2020-03-12 | ドラゴンフライ セラピューティクス， インコーポレイテッド | Ｐｓｍａ、ｎｋｇ２ｄおよびｃｄ１６に結合するタンパク質 |
| CA3054642A1 (en) * | 2017-02-10 | 2018-08-16 | Dragonfly Therapeutics, Inc. | Proteins binding bcma, nkg2d and cd16 |
| CA3054079A1 (en) | 2017-02-20 | 2018-08-23 | Dragonfly Therapeutics, Inc. | Proteins binding her2, nkg2d and cd16 |
| WO2018165631A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Cancer vaccine |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| WO2018165629A1 (en) | 2017-03-10 | 2018-09-13 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| WO2018209052A1 (en) | 2017-05-10 | 2018-11-15 | Wellstat Immuno Therapeutics, Llc | Enveloped virus resistant to complement inactivation for the treatment of cancer |
| CN107216395B (zh) * | 2017-07-03 | 2018-07-20 | 上海科医联创生物科技有限公司 | 一种tm4sf1特异性嵌合抗原受体及其应用 |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| JP7303802B2 (ja) * | 2017-09-23 | 2023-07-05 | メモリアル スローン ケタリング キャンサー センター | Ａ３３抗体組成物および放射性免疫療法におけるその使用方法 |
| EP3706801B1 (en) | 2017-11-08 | 2026-01-14 | L.E.A.F Holdings Group LLC | Platinum complexes and uses thereof |
| TWI701259B (zh) * | 2017-11-09 | 2020-08-11 | 大陸商上海懷越生物科技有限公司 | ４﹘１ｂｂ抗體及其製備方法和應用 |
| BR112020009136A2 (pt) * | 2017-11-14 | 2020-10-13 | Arcellx, Inc. | polipeptídeos que contêm domínio d e usos dos mesmos |
| IL274677B2 (en) * | 2017-11-14 | 2025-01-01 | Arcellx Inc | Therapies with multifunctional immune system cells |
| US11464803B2 (en) | 2017-11-14 | 2022-10-11 | Arcellx, Inc. | D-domain containing polypeptides and uses thereof |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| JP2021512914A (ja) | 2018-02-08 | 2021-05-20 | ドラゴンフライ セラピューティクス， インコーポレイテッド | ナチュラルキラー細胞を活性化する多特異的結合タンパク質を伴うがんの併用療法 |
| DK3749346T3 (da) | 2018-02-08 | 2024-09-09 | Dragonfly Therapeutics Inc | Antistof variable domænekombinationer rettet mod nkg2d-receptoren |
| SG11202007945UA (en) | 2018-02-20 | 2020-09-29 | Dragonfly Therapeutics Inc | Multi-specific binding proteins that bind cd33, nkg2d, and cd16, and methods of use |
| WO2019178518A1 (en) * | 2018-03-16 | 2019-09-19 | The Regents Of The University Of California | Cellular signaling domain engineering in chimeric antigen receptor-modified regulatory t cells |
| MA52571A (fr) | 2018-05-08 | 2021-03-17 | Amgen Inc | Anticorps bispécifiques ayant des étiquettes appairées à des charges c-terminales clivables |
| WO2020014261A1 (en) | 2018-07-09 | 2020-01-16 | The Broad Institute, Inc. | Rna programmable epigenetic rna modifiers and uses thereof |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| KR20250112921A (ko) * | 2018-08-08 | 2025-07-24 | 드래곤플라이 쎄라퓨틱스, 인크. | Nkg2d, cd16 및 종양 관련 항원에 결합하는 단백질 |
| WO2020033630A1 (en) | 2018-08-08 | 2020-02-13 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind bcma, nkg2d and cd16, and methods of use |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| WO2020154500A1 (en) | 2019-01-23 | 2020-07-30 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| GB201903479D0 (en) * | 2019-03-14 | 2019-05-01 | Univ Oxford Innovation Ltd | Polypeptide with enchanced rate of spontaneous isopeptide bond formation with it's peptide tag partner and uses thereof |
| BR112021018607A2 (pt) | 2019-03-19 | 2021-11-23 | Massachusetts Inst Technology | Métodos e composições para editar sequências de nucleotídeos |
| JP2022527351A (ja) * | 2019-04-02 | 2022-06-01 | イーライ リリー アンド カンパニー | 結合ペプチドを選択し検出するための方法 |
| EP3956349A1 (en) | 2019-04-17 | 2022-02-23 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| CN111848733B (zh) * | 2019-04-30 | 2024-03-12 | 上海细胞治疗集团有限公司 | 一种多肽组合物及疫苗 |
| MX2021014334A (es) * | 2019-05-24 | 2022-02-21 | Avitide LLC | Agentes afines a aav9. |
| JP2022535511A (ja) * | 2019-05-31 | 2022-08-09 | ルーブリック・セラピューティクス・インコーポレイテッド | メソスケール操作されたペプチドおよび選択方法 |
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