EA201792226A1 - Полипептиды, содержащие de novo связывающий домен, и их применение - Google Patents

Полипептиды, содержащие de novo связывающий домен, и их применение

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Publication number
EA201792226A1
EA201792226A1 EA201792226A EA201792226A EA201792226A1 EA 201792226 A1 EA201792226 A1 EA 201792226A1 EA 201792226 A EA201792226 A EA 201792226A EA 201792226 A EA201792226 A EA 201792226A EA 201792226 A1 EA201792226 A1 EA 201792226A1
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EA
Eurasian Patent Office
Prior art keywords
dbdpp
binding domain
libraries
polypeptides containing
application
Prior art date
Application number
EA201792226A
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English (en)
Inventor
Дэвид Уилльям Лафлер
Дэвид М. Хилберт
Original Assignee
САБДОМЭН, ЭлЭлСи
Арселлкс, Инк
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Application filed by САБДОМЭН, ЭлЭлСи, Арселлкс, Инк filed Critical САБДОМЭН, ЭлЭлСи
Publication of EA201792226A1 publication Critical patent/EA201792226A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
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    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001103—Receptors for growth factors
    • A61K39/001104—Epidermal growth factor receptors [EGFR]
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    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
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    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
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Abstract

В настоящей заявке предложены полипептиды, содержащие de novo связывающий домен (DBDpp), которые специфично связывают представляющую интерес мишень. Также предложены нуклеиновые кислоты, кодирующие DBDpp, векторы и клетки-хозяева, содержащие нуклеиновые кислоты. Также включены библиотеки DBDpp, способы получения и скрининга таких библиотек и DBDpp, идентифицированные в таких библиотеках и скринингах. Дополнительно предложены способы получения и применения DBDpp. Такое применение включает, без ограничения, аффинную очистку и диагностические и терапевтические применения.
EA201792226A 2015-04-06 2016-04-04 Полипептиды, содержащие de novo связывающий домен, и их применение EA201792226A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562143772P 2015-04-06 2015-04-06
PCT/US2016/025868 WO2016164305A1 (en) 2015-04-06 2016-04-04 De novo binding domain containing polypeptides and uses thereof

Publications (1)

Publication Number Publication Date
EA201792226A1 true EA201792226A1 (ru) 2018-08-31

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EA201792226A EA201792226A1 (ru) 2015-04-06 2016-04-04 Полипептиды, содержащие de novo связывающий домен, и их применение

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