JP7161940B2 - がんの治療のための、補体不活性化に耐性のエンベロープウイルス - Google Patents
がんの治療のための、補体不活性化に耐性のエンベロープウイルス Download PDFInfo
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- JP7161940B2 JP7161940B2 JP2018564966A JP2018564966A JP7161940B2 JP 7161940 B2 JP7161940 B2 JP 7161940B2 JP 2018564966 A JP2018564966 A JP 2018564966A JP 2018564966 A JP2018564966 A JP 2018564966A JP 7161940 B2 JP7161940 B2 JP 7161940B2
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Description
Annex C/ST.25テキストファイルの形式で電子出願された配列表及び関連ファイル参照21003-PCTは、本開示の一部である。
[実施例]
Carroll, M. C., E. M. Alicot, P. J. Katzman, L. B. Klickstein, J. A. Smith, and D. T. Fearon. 1988. Organization of the genes encoding complement receptors type 1 and 2, decay-accelerating factor, and C4-binding protein in the RCA locus on human chromosome 1. J. Exp. Med. 167:1271
Rey-Campos, J., P. Rubinstein, and S. Rodriguez de Cordoba. 1988. A physical map of the human regulator of complement activation gene cluster linking the complement genes CR1, CR2, DAF, and C4BP. J. Exp. Med. 167:664
Lublin, D. M., and J. P. Atkinson. 1989. Decay-accelerating factor: biochemistry, molecular biology, and function. Annu. Rev. Immunol. 7:35. 5. Nakano, Y., K. Sumida, N. Kikuta, N. H. Miura, T. Tobe, and M. Tomita. 1992. Complete determination of disulfide bonds localized within the short consensus repeat units of decay accelerating factor (CD55 antigen). Biochim. Biophys. Acta 1116:235
Censullo, P., and M.A. Davitz. 1994a. How GPI-anchored proteins turnover: or where do they go after arrival at the plasma membrane. Semin Immunol. 6:81
Censullo, P., and M.A. Davitz. 1994b. The fate of GPI-anchored molecules. Braz J. Med. Biol. Res. 27:289
Morgan, B. P., and S. Meri. 1994. Membrane proteins that protect against complement lysis. Springer Semin. Immunopathol. 15:369
Turner A.J. 1994. PIG-tailed membrane proteins. Essays Biochem. 28:113
Kim D.D., and W.C. Song. 2006. Membrane complement regulatory proteins. Clin. Immunol. 118:127
Pecora, A.L., Rizvi, N., Cohen, G.I., Meropol, N.J., Sterman, D., Marshall, J.L., Goldberg, S., Gross, P., O’Neil, J.D., Groene, W.S., Roberts, M.S., Rabin, H., Bamat, M.K., and R.M. Lorence. 2002. Phase I trial of intravenous administration of PV701, an oncolytic virus, in patients with advanced solid cancers. J. Clin. Oncol. 20:2251
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Claims (19)
- 腫瘍溶解性エンベロープウイルスに組み込むための融合タンパク質であって、(a)CD55の4個のショートコンセンサスリピート(SCR)を含む、CD55ペプチド配列、(b)前記CD55ペプチド配列のC末端側にリンカー配列、(c)前記リンカー配列のC末端側にCD8膜貫通ドメイン、及び(d)前記膜貫通ドメインのC末端側に、トランケートしたCD8細胞内ドメインを含み、GPIアンカーを含有せず、配列番号2又は配列番号3の配列を有する、前記融合タンパク質。
- 配列番号2の配列を有する、請求項1に記載の融合タンパク質。
- 配列番号3の配列を有する、請求項1に記載の融合タンパク質。
- 請求項1~3のいずれかに記載の融合タンパク質をコードする核酸。
- DNAである、請求項4に記載の核酸。
- 1又は2以上のイントロンをさらに含む、請求項4又は5に記載の核酸。
- 配列番号2の配列を有するタンパク質をコードする、請求項4~6のいずれかに記載の核酸。
- 配列番号1の配列を有する、請求項7に記載の核酸。
- 制御配列に作動可能に連結された、請求項4~8のいずれかに記載の核酸を含む発現ベクター。
- 請求項1~3のいずれかに記載の融合タンパク質を細胞表面に安定に発現する細胞株。
- 哺乳動物細胞株である、請求項10に記載の細胞株。
- DF-1ニワトリ胚線維芽細胞株である、請求項10に記載の細胞株。
- 請求項1~3のいずれかに記載の融合タンパク質をウイルス膜上に組み込んでいるエンベロープウイルス。
- 腫瘍溶解性ウイルスである、請求項13に記載のウイルス。
- 腫瘍溶解性ウイルスがニューカッスル病ウイルスである、請求項14に記載のウイルス。
- 請求項13~15のいずれかに記載のウイルスと、薬学的に許容される担体とを含む医薬組成物。
- 請求項13~15のいずれかに記載のウイルスを含む、哺乳動物対象における新生物状態の治療剤。
- ウイルスが腫瘍内投与用に製剤化された、請求項17に記載の治療剤。
- ウイルスが静脈内投与用に製剤化された、請求項17に記載の治療剤。
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AU2018234810B2 (en) | 2017-03-15 | 2023-05-11 | Pandion Operations, Inc. | Targeted immunotolerance |
WO2018217989A1 (en) | 2017-05-24 | 2018-11-29 | Pandion Therapeutics, Inc. | Targeted immunotolerance |
US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
US10174092B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
US11981715B2 (en) | 2020-02-21 | 2024-05-14 | Pandion Operations, Inc. | Tissue targeted immunotolerance with a CD39 effector |
JP2024509796A (ja) * | 2021-02-26 | 2024-03-05 | シルラジェン,インコーポレイテッド | 抗がんウイルス及びその用途(Oncolytic Virus and Uses Thereof) |
CN113736810B (zh) * | 2021-09-08 | 2024-05-24 | 苏州因特药物研发有限公司 | 构建体、载体、蛋白、细胞、制备方法、产品及应用 |
KR20240003051A (ko) * | 2022-06-29 | 2024-01-08 | 신라젠(주) | Cd55 및 cd59를 동시 발현하는 항암 바이러스 |
KR20240035360A (ko) * | 2022-09-07 | 2024-03-15 | 신라젠(주) | 항암 바이러스의 신규 용도 |
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