MX2023003125A - Proteinas multiespecificas de union al antigeno. - Google Patents
Proteinas multiespecificas de union al antigeno.Info
- Publication number
- MX2023003125A MX2023003125A MX2023003125A MX2023003125A MX2023003125A MX 2023003125 A MX2023003125 A MX 2023003125A MX 2023003125 A MX2023003125 A MX 2023003125A MX 2023003125 A MX2023003125 A MX 2023003125A MX 2023003125 A MX2023003125 A MX 2023003125A
- Authority
- MX
- Mexico
- Prior art keywords
- binding proteins
- multispecific antigen
- antigen binding
- domains
- same
- Prior art date
Links
- 102000025171 antigen binding proteins Human genes 0.000 title abstract 4
- 108091000831 antigen binding proteins Proteins 0.000 title abstract 4
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/44—Antibodies bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39566—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against immunoglobulins, e.g. anti-idiotypic antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/30—Detection of binding sites or motifs
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/50—Mutagenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Evolutionary Biology (AREA)
- Oncology (AREA)
- Analytical Chemistry (AREA)
- Theoretical Computer Science (AREA)
- Medical Informatics (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Transplantation (AREA)
Abstract
Se proveen, entre otras cosas, proteínas multiespecíficas de unión al antígeno, o sus fragmentos de unión al antígeno, que comprenden una o más mutaciones en los dominios VH/VL y/o en los dominios CH1/CL, composiciones farmacéuticas que las comprenden, ácidos nucleicos aislados, vectores, y células huésped que las codifican/expresan, un método para preparar las proteínas multiespecíficas de unión al antígeno, un medio legible por ordenador para evaluar proteínas multiespecíficas de unión al antígeno, y genotecas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562152735P | 2015-04-24 | 2015-04-24 | |
US201562264291P | 2015-12-07 | 2015-12-07 | |
US201662310555P | 2016-03-18 | 2016-03-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2023003125A true MX2023003125A (es) | 2023-03-23 |
Family
ID=55911088
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017013482A MX2017013482A (es) | 2015-04-24 | 2016-04-22 | Proteinas multiespecificas de union al antigeno. |
MX2023003125A MX2023003125A (es) | 2015-04-24 | 2017-10-19 | Proteinas multiespecificas de union al antigeno. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017013482A MX2017013482A (es) | 2015-04-24 | 2016-04-22 | Proteinas multiespecificas de union al antigeno. |
Country Status (11)
Country | Link |
---|---|
US (2) | US11116840B2 (es) |
EP (1) | EP3286227A2 (es) |
JP (3) | JP6952605B2 (es) |
KR (2) | KR20240093813A (es) |
CN (2) | CN107787332B (es) |
AU (2) | AU2016252773B2 (es) |
CA (1) | CA2980189A1 (es) |
HK (1) | HK1250722A1 (es) |
IL (2) | IL254738B (es) |
MX (2) | MX2017013482A (es) |
WO (1) | WO2016172485A2 (es) |
Families Citing this family (93)
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US9914785B2 (en) | 2012-11-28 | 2018-03-13 | Zymeworks Inc. | Engineered immunoglobulin heavy chain-light chain pairs and uses thereof |
WO2015154052A1 (en) | 2014-04-04 | 2015-10-08 | Mayo Foundation For Medical Education And Research | Isotyping immunoglobulins using accurate molecular mass |
BR112016027888A2 (pt) | 2014-05-28 | 2017-10-24 | Zymeworks Inc | construto de polipeptídeo de ligação ao antígeno isolado, polinucleotídeo isolado ou um conjunto de polinucleotídeos isolados, vetor ou conjunto de vetores, célula isolada, composição farmacêutica, uso do construto, método para tratar um sujeito com uma doença ou distúrbio, método para obter um construto, método para preparar um construto, meio de armazenamento legível por computador, método para produzir um construto de polipeptídeo de ligação com antígeno bi-específico e método para preparar um construto de polipeptídeo de ligação com antígeno isolado |
EP3286227A2 (en) | 2015-04-24 | 2018-02-28 | F. Hoffmann-La Roche AG | Multispecific antigen-binding proteins |
AU2016326757B2 (en) | 2015-09-24 | 2022-09-01 | Mayo Foundation For Medical Education And Research | Identification of immunoglobulin free light chains by mass spectrometry |
AU2016334063B2 (en) | 2015-10-08 | 2023-05-25 | Zymeworks Bc Inc. | Antigen-binding polypeptide constructs comprising kappa and lambda light chains and uses thereof |
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US10047167B2 (en) * | 2013-03-15 | 2018-08-14 | Eli Lilly And Company | Methods for producing fabs and bi-specific antibodies |
CA2905223A1 (en) | 2013-04-05 | 2014-10-09 | Genentech, Inc. | Anti-il-4 antibodies and bispecific antibodies and uses thereof |
WO2015173756A2 (en) | 2014-05-16 | 2015-11-19 | Pfizer Inc. | Bispecific antibodies |
BR112016027888A2 (pt) | 2014-05-28 | 2017-10-24 | Zymeworks Inc | construto de polipeptídeo de ligação ao antígeno isolado, polinucleotídeo isolado ou um conjunto de polinucleotídeos isolados, vetor ou conjunto de vetores, célula isolada, composição farmacêutica, uso do construto, método para tratar um sujeito com uma doença ou distúrbio, método para obter um construto, método para preparar um construto, meio de armazenamento legível por computador, método para produzir um construto de polipeptídeo de ligação com antígeno bi-específico e método para preparar um construto de polipeptídeo de ligação com antígeno isolado |
EP3286227A2 (en) | 2015-04-24 | 2018-02-28 | F. Hoffmann-La Roche AG | Multispecific antigen-binding proteins |
-
2016
- 2016-04-22 EP EP16720641.6A patent/EP3286227A2/en active Pending
- 2016-04-22 JP JP2017555244A patent/JP6952605B2/ja active Active
- 2016-04-22 MX MX2017013482A patent/MX2017013482A/es unknown
- 2016-04-22 WO PCT/US2016/028850 patent/WO2016172485A2/en active Application Filing
- 2016-04-22 CN CN201680037013.3A patent/CN107787332B/zh active Active
- 2016-04-22 CN CN202211044002.1A patent/CN116063543A/zh active Pending
- 2016-04-22 KR KR1020247016700A patent/KR20240093813A/ko unknown
- 2016-04-22 AU AU2016252773A patent/AU2016252773B2/en active Active
- 2016-04-22 KR KR1020177034034A patent/KR102668727B1/ko active IP Right Grant
- 2016-04-22 CA CA2980189A patent/CA2980189A1/en active Pending
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2017
- 2017-09-27 IL IL254738A patent/IL254738B/en unknown
- 2017-10-19 MX MX2023003125A patent/MX2023003125A/es unknown
- 2017-10-20 US US15/789,670 patent/US11116840B2/en active Active
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2018
- 2018-08-02 HK HK18109985.8A patent/HK1250722A1/zh unknown
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2020
- 2020-06-30 JP JP2020112362A patent/JP7228545B2/ja active Active
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2021
- 2021-08-04 IL IL285366A patent/IL285366A/en unknown
- 2021-08-05 US US17/395,400 patent/US12053525B2/en active Active
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2022
- 2022-09-02 AU AU2022224860A patent/AU2022224860A1/en active Pending
- 2022-09-26 JP JP2022152359A patent/JP2023002538A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
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JP2018516546A (ja) | 2018-06-28 |
US20180177873A1 (en) | 2018-06-28 |
WO2016172485A2 (en) | 2016-10-27 |
JP6952605B2 (ja) | 2021-10-20 |
JP7228545B2 (ja) | 2023-02-24 |
MX2017013482A (es) | 2018-03-01 |
EP3286227A2 (en) | 2018-02-28 |
AU2016252773B2 (en) | 2022-06-02 |
WO2016172485A3 (en) | 2016-12-15 |
IL285366A (en) | 2021-09-30 |
CN107787332B (zh) | 2022-09-09 |
KR20240093813A (ko) | 2024-06-24 |
AU2022224860A1 (en) | 2022-09-29 |
JP2020184996A (ja) | 2020-11-19 |
HK1250722A1 (zh) | 2019-01-11 |
IL254738B (en) | 2021-09-30 |
JP2023002538A (ja) | 2023-01-10 |
CA2980189A1 (en) | 2016-10-27 |
CN116063543A (zh) | 2023-05-05 |
CN107787332A (zh) | 2018-03-09 |
US20220409725A1 (en) | 2022-12-29 |
IL254738A0 (en) | 2017-11-30 |
AU2016252773A1 (en) | 2017-10-12 |
KR102668727B1 (ko) | 2024-05-28 |
US11116840B2 (en) | 2021-09-14 |
KR20170140331A (ko) | 2017-12-20 |
US12053525B2 (en) | 2024-08-06 |
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