BR112022021884A2 - Proteínas que se ligam a nkg2d, cd16 e clec12a - Google Patents
Proteínas que se ligam a nkg2d, cd16 e clec12aInfo
- Publication number
- BR112022021884A2 BR112022021884A2 BR112022021884A BR112022021884A BR112022021884A2 BR 112022021884 A2 BR112022021884 A2 BR 112022021884A2 BR 112022021884 A BR112022021884 A BR 112022021884A BR 112022021884 A BR112022021884 A BR 112022021884A BR 112022021884 A2 BR112022021884 A2 BR 112022021884A2
- Authority
- BR
- Brazil
- Prior art keywords
- clec12a
- bind
- nkg2d
- proteins
- multispecific binding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
PROTEÍNAS QUE SE LIGAM A NKG2D, CD16 E CLEC12A. A presente invenção refere-se a proteínas de ligação multiespecíficas que se ligam a receptor de NKG2D, CD16 e CLEC12A, composições farmacêuticas que compreendem as proteínas de ligação multiespecíficas e métodos terapêuticos úteis para o tratamento de câncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063020798P | 2020-05-06 | 2020-05-06 | |
PCT/US2021/030821 WO2021226193A1 (en) | 2020-05-06 | 2021-05-05 | Proteins binding nkg2d, cd16 and clec12a |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022021884A2 true BR112022021884A2 (pt) | 2022-12-20 |
Family
ID=78468474
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022021884A BR112022021884A2 (pt) | 2020-05-06 | 2021-05-05 | Proteínas que se ligam a nkg2d, cd16 e clec12a |
Country Status (15)
Country | Link |
---|---|
US (1) | US20220119534A1 (pt) |
EP (1) | EP4146271A1 (pt) |
JP (1) | JP2023508942A (pt) |
KR (1) | KR20230008181A (pt) |
CN (1) | CN115836088A (pt) |
AR (1) | AR122018A1 (pt) |
AU (1) | AU2021268340A1 (pt) |
BR (1) | BR112022021884A2 (pt) |
CA (1) | CA3177024A1 (pt) |
CL (1) | CL2022003077A1 (pt) |
CO (1) | CO2022015929A2 (pt) |
IL (1) | IL297922A (pt) |
MX (1) | MX2022013944A (pt) |
TW (1) | TW202208428A (pt) |
WO (1) | WO2021226193A1 (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4050026A1 (en) * | 2014-04-01 | 2022-08-31 | Adimab, LLC | Method of obtaining or identifying one or more common light chains for use in preparing a multispecific antibody |
AU2018219887A1 (en) | 2017-02-08 | 2019-08-22 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
ES2955074T3 (es) | 2017-02-20 | 2023-11-28 | Dragonfly Therapeutics Inc | Proteínas que se unen a HER2, NKG2D Y CD16 |
BR112020016190A2 (pt) | 2018-02-08 | 2020-12-15 | Dragonfly Therapeutics, Inc. | Domínios variáveis de anticorpos direcionando o receptor nkg2d |
BR112020016939A2 (pt) * | 2018-02-20 | 2020-12-15 | Dragonfly Therapeutics, Inc. | Proteínas de ligação multiespecíficas que se ligam a cd33, nkg2d, e cd16 e métodos de uso |
WO2023107956A1 (en) * | 2021-12-08 | 2023-06-15 | Dragonfly Therapeutics, Inc. | Proteins binding nkg2d, cd16 and 5t4 |
WO2023201238A1 (en) * | 2022-04-11 | 2023-10-19 | Vor Biopharma Inc. | Binding agents and methods of use thereof |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9163090B2 (en) * | 2012-05-07 | 2015-10-20 | Cellerant Therapeutics, Inc. | Antibodies specific for CLL-1 |
US20180326027A1 (en) * | 2015-11-09 | 2018-11-15 | The University Of British Columbia | Epitopes in amyloid beta and conformationally-selective antibodies thereto |
EP3851457A1 (en) * | 2016-01-21 | 2021-07-21 | Novartis AG | Multispecific molecules targeting cll-1 |
JP2019535250A (ja) * | 2016-10-29 | 2019-12-12 | ジェネンテック, インコーポレイテッド | 抗mic抗体及び使用方法 |
CA3112990A1 (en) * | 2017-08-16 | 2019-02-21 | Dragonfly Therapeutics, Inc. | Proteins binding nkg2d, cd16, and egfr, ccr4, or pd-l1 |
AU2018322178A1 (en) * | 2017-08-23 | 2020-02-20 | Dragonfly Therapeutics, Inc. | Proteins binding NKG2D, CD16 and a tumor-associated antigen |
KR20200051789A (ko) * | 2017-09-14 | 2020-05-13 | 드래곤플라이 쎄라퓨틱스, 인크. | Nkg2d, cd16, 및 c-유형 렉틴-유사 분자-1 (cll-1)에 결합하는 단백질 |
WO2019164929A1 (en) * | 2018-02-20 | 2019-08-29 | Dragonfly Therapeutics, Inc. | Antibody variable domains targeting cd33, and use thereof |
CA3113539A1 (en) * | 2018-10-10 | 2020-04-16 | Zymeworks Inc. | Antibody constructs binding 4-1bb and tumor-associated antigens and uses thereof |
CN114929745A (zh) * | 2019-10-17 | 2022-08-19 | 明尼苏达大学董事会 | Clec12a抗体片段序列和方法 |
-
2021
- 2021-05-05 AU AU2021268340A patent/AU2021268340A1/en active Pending
- 2021-05-05 IL IL297922A patent/IL297922A/en unknown
- 2021-05-05 JP JP2022538765A patent/JP2023508942A/ja active Pending
- 2021-05-05 CA CA3177024A patent/CA3177024A1/en active Pending
- 2021-05-05 KR KR1020227042774A patent/KR20230008181A/ko active Search and Examination
- 2021-05-05 BR BR112022021884A patent/BR112022021884A2/pt unknown
- 2021-05-05 US US17/308,691 patent/US20220119534A1/en active Pending
- 2021-05-05 WO PCT/US2021/030821 patent/WO2021226193A1/en active Application Filing
- 2021-05-05 AR ARP210101229A patent/AR122018A1/es unknown
- 2021-05-05 EP EP21800226.9A patent/EP4146271A1/en active Pending
- 2021-05-05 CN CN202180047702.3A patent/CN115836088A/zh active Pending
- 2021-05-05 TW TW110116242A patent/TW202208428A/zh unknown
- 2021-05-05 MX MX2022013944A patent/MX2022013944A/es unknown
-
2022
- 2022-11-04 CO CONC2022/0015929A patent/CO2022015929A2/es unknown
- 2022-11-04 CL CL2022003077A patent/CL2022003077A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
JP2023508942A (ja) | 2023-03-06 |
KR20230008181A (ko) | 2023-01-13 |
CN115836088A (zh) | 2023-03-21 |
WO2021226193A1 (en) | 2021-11-11 |
CL2022003077A1 (es) | 2023-07-21 |
IL297922A (en) | 2023-01-01 |
US20220119534A1 (en) | 2022-04-21 |
CA3177024A1 (en) | 2021-11-11 |
MX2022013944A (es) | 2022-11-30 |
AR122018A1 (es) | 2022-08-03 |
EP4146271A1 (en) | 2023-03-15 |
AU2021268340A1 (en) | 2022-12-08 |
CO2022015929A2 (es) | 2023-02-16 |
TW202208428A (zh) | 2022-03-01 |
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