JP2017537622A5 - - Google Patents

Info

Publication number

JP2017537622A5

JP2017537622A5 JP2017529284A JP2017529284A JP2017537622A5 JP 2017537622 A5 JP2017537622 A5 JP 2017537622A5 JP 2017529284 A JP2017529284 A JP 2017529284A JP 2017529284 A JP2017529284 A JP 2017529284A JP 2017537622 A5 JP2017537622 A5 JP 2017537622A5

Authority

JP

Japan

Prior art keywords

nucleic acid

seq

acid sequence

domain

vector

Prior art date

2015-12-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 150000007523 nucleic acids Chemical group 0.000 claims 51
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 34
• 108020004707 nucleic acids Proteins 0.000 claims 16
• 102000039446 nucleic acids Human genes 0.000 claims 16
• 210000004027 cell Anatomy 0.000 claims 11
• 108090000765 processed proteins & peptides Proteins 0.000 claims 11
• 239000013598 vector Substances 0.000 claims 10
• 102100025825 Methylated-DNA-protein-cysteine methyltransferase Human genes 0.000 claims 9
• 108040008770 methylated-DNA-[protein]-cysteine S-methyltransferase activity proteins Proteins 0.000 claims 9
• 230000011664 signaling Effects 0.000 claims 9
• 102000003816 Interleukin-13 Human genes 0.000 claims 8
• 108090000176 Interleukin-13 Proteins 0.000 claims 8
• 210000004962 mammalian cell Anatomy 0.000 claims 6
• 229920001184 polypeptide Polymers 0.000 claims 6
• 102000004196 processed proteins & peptides Human genes 0.000 claims 6
• 230000001086 cytosolic effect Effects 0.000 claims 5
• 239000003446 ligand Substances 0.000 claims 5
• 239000013603 viral vector Substances 0.000 claims 5
• 125000003275 alpha amino acid group Chemical group 0.000 claims 4
• 239000002246 antineoplastic agent Substances 0.000 claims 4
• 229940127089 cytotoxic agent Drugs 0.000 claims 4
• 108090000623 proteins and genes Proteins 0.000 claims 4
• 102000004169 proteins and genes Human genes 0.000 claims 4
• 208000003174 Brain Neoplasms Diseases 0.000 claims 3
• 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 3
• 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 3
• 239000002773 nucleotide Substances 0.000 claims 3
• 125000003729 nucleotide group Chemical group 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 108020004414 DNA Proteins 0.000 claims 2
• 230000000139 costimulatory effect Effects 0.000 claims 2
• 230000001177 retroviral effect Effects 0.000 claims 2
• 108010016626 Dipeptides Proteins 0.000 claims 1
• 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
• 210000001744 T-lymphocyte Anatomy 0.000 claims 1
• 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 1
• 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• 239000000427 antigen Substances 0.000 claims 1
• 102000036639 antigens Human genes 0.000 claims 1
• 108091007433 antigens Proteins 0.000 claims 1
• 208000029824 high grade glioma Diseases 0.000 claims 1
• 210000002865 immune cell Anatomy 0.000 claims 1
• 210000000265 leukocyte Anatomy 0.000 claims 1
• 201000011614 malignant glioma Diseases 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 108010091748 peptide A Proteins 0.000 claims 1
• 102200146131 rs1131692037 Human genes 0.000 claims 1