JP2016502512A5 - - Google Patents
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- JP2016502512A5 JP2016502512A5 JP2015539602A JP2015539602A JP2016502512A5 JP 2016502512 A5 JP2016502512 A5 JP 2016502512A5 JP 2015539602 A JP2015539602 A JP 2015539602A JP 2015539602 A JP2015539602 A JP 2015539602A JP 2016502512 A5 JP2016502512 A5 JP 2016502512A5
- Authority
- JP
- Japan
- Prior art keywords
- car
- seq
- intracellular
- cell
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261717960P | 2012-10-24 | 2012-10-24 | |
| US61/717,960 | 2012-10-24 | ||
| PCT/US2013/060332 WO2014065961A1 (en) | 2012-10-24 | 2013-09-18 | M971 chimeric antigen receptors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018088908A Division JP6643394B2 (ja) | 2012-10-24 | 2018-05-02 | Ｍ９７１キメラ抗原受容体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016502512A JP2016502512A (ja) | 2016-01-28 |
| JP2016502512A5 true JP2016502512A5 (enExample) | 2016-11-10 |
| JP6338252B2 JP6338252B2 (ja) | 2018-06-06 |
Family
ID=49304331
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015539602A Active JP6338252B2 (ja) | 2012-10-24 | 2013-09-18 | Ｍ９７１キメラ抗原受容体 |
| JP2018088908A Active JP6643394B2 (ja) | 2012-10-24 | 2018-05-02 | Ｍ９７１キメラ抗原受容体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018088908A Active JP6643394B2 (ja) | 2012-10-24 | 2018-05-02 | Ｍ９７１キメラ抗原受容体 |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US10072078B2 (enExample) |
| EP (1) | EP2912061B1 (enExample) |
| JP (2) | JP6338252B2 (enExample) |
| CN (2) | CN110229834B (enExample) |
| AU (2) | AU2013335180B2 (enExample) |
| BR (1) | BR112015009003B1 (enExample) |
| CA (1) | CA2889055C (enExample) |
| ES (1) | ES2718903T3 (enExample) |
| RU (2) | RU2658485C2 (enExample) |
| WO (1) | WO2014065961A1 (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150064153A1 (en) | 2013-03-15 | 2015-03-05 | The Trustees Of Princeton University | High efficiency microfluidic purification of stem cells to improve transplants |
| CN105264127B (zh) | 2013-03-15 | 2019-04-09 | Gpb科学有限责任公司 | 颗粒的片上微流体处理 |
| EP3608022A1 (en) | 2013-03-15 | 2020-02-12 | The Trustees of Princeton University | Methods and devices for high throughput purification |
| BR112017001818A2 (pt) * | 2014-07-29 | 2017-11-21 | Pfizer | receptores antigênicos quiméricos específicos para egfrviii para imunoterapia de câncer |
| CN107206025A (zh) | 2014-12-03 | 2017-09-26 | 朱诺治疗学股份有限公司 | 用于过继细胞治疗的方法和组合物 |
| IL301458A (en) * | 2014-12-24 | 2023-05-01 | Autolus Ltd | A cell that simultaneously expresses a chimeric antigen receptor (CAR) of 19CD and 22CD |
| US10738116B2 (en) * | 2015-03-19 | 2020-08-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Dual specific anti-CD22-anti-CD19 chimeric antigen receptors |
| CN119925616A (zh) | 2015-04-08 | 2025-05-06 | 诺华股份有限公司 | Cd20疗法、cd22疗法和与cd19嵌合抗原受体（car）表达细胞的联合疗法 |
| CN104829733B (zh) * | 2015-05-25 | 2018-06-05 | 广州百暨基因科技有限公司 | 抗原结合单元稳定的嵌合抗原受体及制备方法与应用 |
| US10976232B2 (en) | 2015-08-24 | 2021-04-13 | Gpb Scientific, Inc. | Methods and devices for multi-step cell purification and concentration |
| WO2017044699A1 (en) | 2015-09-10 | 2017-03-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-cd276 chimeric antigen receptors |
| WO2017139199A1 (en) | 2016-02-10 | 2017-08-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Inducible arginase |
| US12350349B2 (en) | 2016-08-03 | 2025-07-08 | Washington University | Gene editing of CAR-T cells for the treatment of T cell malignancies with chimeric antigen receptors |
| US11453712B2 (en) | 2016-09-02 | 2022-09-27 | Lentigen Technology Inc. | Compositions and methods for treating cancer with DuoCARs |
| CN107964549B (zh) * | 2016-10-20 | 2020-12-08 | 上海恒润达生生物科技有限公司 | 靶向cd22的嵌合抗原受体及其用途 |
| JP2020511462A (ja) | 2016-12-03 | 2020-04-16 | ジュノー セラピューティクス インコーポレイテッド | キナーゼ阻害剤との組み合わせで治療用ｔ細胞を使用するための方法および組成物 |
| CN112695050B (zh) * | 2017-03-24 | 2025-08-08 | 莱蒂恩技术公司 | 用于用抗cd33免疫疗法治疗癌症的组合物和方法 |
| AU2018246378A1 (en) * | 2017-03-31 | 2019-10-17 | Cellectis Sa | New universal chimeric antigen receptor T cells specific for CD22 |
| JP2020517259A (ja) | 2017-04-19 | 2020-06-18 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | 操作された抗原受容体を発現する免疫細胞 |
| WO2018213337A1 (en) * | 2017-05-15 | 2018-11-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Bicistronic chimeric antigen receptors and their uses |
| CN111225675B (zh) | 2017-06-02 | 2024-05-03 | 朱诺治疗学股份有限公司 | 使用过继细胞疗法治疗的制品和方法 |
| CN109385402A (zh) * | 2017-08-11 | 2019-02-26 | 上海恒润达生生物科技有限公司 | 一种等比例混合两种靶点cart细胞的制备方法及应用 |
| AU2018323875A1 (en) | 2017-09-01 | 2020-04-23 | Gpb Scientific, Inc. | Methods for preparing therapeutically active cells using microfluidics |
| CN114533863A (zh) * | 2017-09-15 | 2022-05-27 | 凯德药业股份有限公司 | 用于进行具有监管链和身份链生物样品跟踪的患者特异性免疫疗法规程的方法和系统 |
| CN107759700A (zh) * | 2017-10-18 | 2018-03-06 | 银丰生物工程集团有限公司 | 靶向cd19抗原的转基因t细胞及其制备方法与应用 |
| CN109836495A (zh) * | 2017-11-25 | 2019-06-04 | 深圳宾德生物技术有限公司 | 一种靶向cd22的单链抗体、嵌合抗原受体t细胞及其制备方法和应用 |
| CN109837305A (zh) * | 2017-11-25 | 2019-06-04 | 深圳宾德生物技术有限公司 | 一种敲除pd1的靶向cd22的嵌合抗原受体t细胞及其制备方法和应用 |
| CN109988242A (zh) * | 2018-01-02 | 2019-07-09 | 武汉波睿达生物科技有限公司 | 联合嵌合抗原受体、表达载体、慢病毒及t细胞 |
| US12473336B2 (en) | 2018-02-21 | 2025-11-18 | Board Of Regents, The University Of Texas System | Methods for activation and expansion of natural killer cells and uses thereof |
| CA3097858A1 (en) | 2018-04-24 | 2019-10-31 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of producing t cell populations using hydroxycitric acid and/or a salt thereof |
| CN108715859B (zh) * | 2018-05-31 | 2021-08-03 | 中国医学科学院血液病医院(中国医学科学院血液学研究所) | 靶向cd22的嵌合抗原受体及其应用 |
| AU2019301675B2 (en) * | 2018-07-12 | 2025-09-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Affinity matured CD22-specific monoclonal antibody and uses thereof |
| SG11202112554UA (en) * | 2019-05-16 | 2021-12-30 | Nanjing Legend Biotech Co Ltd | Immune cell receptors comprising cd4 binding moieties |
| WO2021011907A1 (en) | 2019-07-18 | 2021-01-21 | Gpb Scientific, Inc. | Ordered processing of blood products to produce therapeutically active cells |
| CN115209996B (zh) | 2019-12-28 | 2025-09-05 | 日本瑞翁株式会社 | 用于处理颗粒和细胞的微流体盒 |
| EP4086281A4 (en) * | 2019-12-30 | 2024-02-14 | China Immunotech (Beijing) Biotechnology Co., Ltd | IMPROVED STAR T CELL RECEPTOR AND ITS APPLICATION |
| IL295421A (en) * | 2020-02-14 | 2022-10-01 | Univ Leland Stanford Junior | Chimeric antigen receptors with cd2 activation |
| CN116157510A (zh) | 2020-06-17 | 2023-05-23 | 詹森生物科技公司 | 用于制造多能干细胞的材料和方法 |
| WO2022055946A1 (en) | 2020-09-08 | 2022-03-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | T cell phenotypes associated with response to adoptive cell therapy |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| KR20230118887A (ko) | 2020-12-03 | 2023-08-14 | 센츄리 쎄라퓨틱스 인코포레이티드 | 유전자 조작 세포 및 이의 용도 |
| JP2024500847A (ja) | 2020-12-18 | 2024-01-10 | センチュリー セラピューティクス，インコーポレイテッド | 適合可能な受容体特異性を有するキメラ抗原受容体システム |
| EP4352091A1 (en) * | 2021-05-27 | 2024-04-17 | Innovative Cellular Therapeutics Holdings, Ltd. | Modified chimeric antigen receptor and use thereof |
| WO2022269473A1 (en) | 2021-06-23 | 2022-12-29 | Janssen Biotech, Inc. | Materials and methods for hinge regions in functional exogenous receptors |
| IL309957A (en) | 2021-07-14 | 2024-03-01 | 2Seventy Bio Inc | Engineered t cell receptors fused to binding domains from antibodies |
| IL316137A (en) | 2022-04-08 | 2024-12-01 | Regeneron Pharma | Multipartite receptor and signaling complex |
| JP2025525612A (ja) | 2022-07-22 | 2025-08-05 | ヤンセン バイオテツク，インコーポレーテツド | エフェクター免疫細胞への遺伝的命令の増強された移入 |
| WO2025049972A1 (en) * | 2023-09-01 | 2025-03-06 | Cargo Therapeutics, Inc. | Compositions and methods for immunotherapies |
| WO2025171383A2 (en) | 2024-02-09 | 2025-08-14 | Dispatch Biotherapeutics, Inc. | Engineered cancer antigens and related methods and uses |
| WO2025171388A1 (en) | 2024-02-09 | 2025-08-14 | Dispatch Biotherapeutics, Inc. | Engineered cancer antigens with modified domains and related methods and uses |
| WO2025231185A1 (en) | 2024-05-01 | 2025-11-06 | Legend Biotech Ireland Limited | Viral glycoprotein variants and uses thereof |
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-
2013
- 2013-09-18 RU RU2015117237A patent/RU2658485C2/ru active
- 2013-09-18 CA CA2889055A patent/CA2889055C/en active Active
- 2013-09-18 AU AU2013335180A patent/AU2013335180B2/en active Active
- 2013-09-18 CN CN201910500128.7A patent/CN110229834B/zh active Active
- 2013-09-18 EP EP13773468.7A patent/EP2912061B1/en active Active
- 2013-09-18 US US14/437,889 patent/US10072078B2/en active Active
- 2013-09-18 JP JP2015539602A patent/JP6338252B2/ja active Active
- 2013-09-18 WO PCT/US2013/060332 patent/WO2014065961A1/en not_active Ceased
- 2013-09-18 CN CN201380061387.5A patent/CN104822705B/zh active Active
- 2013-09-18 BR BR112015009003-6A patent/BR112015009003B1/pt active IP Right Grant
- 2013-09-18 ES ES13773468T patent/ES2718903T3/es active Active
-
2018
- 2018-05-02 JP JP2018088908A patent/JP6643394B2/ja active Active
- 2018-05-04 RU RU2018116582A patent/RU2770411C1/ru active
- 2018-06-14 AU AU2018204257A patent/AU2018204257B2/en active Active
- 2018-08-21 US US16/107,271 patent/US10703816B2/en active Active
-
2020
- 2020-05-08 US US16/869,792 patent/US11807682B2/en active Active
-
2023
- 2023-11-06 US US18/502,993 patent/US20240084007A1/en active Pending
- 2023-11-06 US US18/503,107 patent/US20240084008A1/en active Pending
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