JP2016502512A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016502512A5 JP2016502512A5 JP2015539602A JP2015539602A JP2016502512A5 JP 2016502512 A5 JP2016502512 A5 JP 2016502512A5 JP 2015539602 A JP2015539602 A JP 2015539602A JP 2015539602 A JP2015539602 A JP 2015539602A JP 2016502512 A5 JP2016502512 A5 JP 2016502512A5
- Authority
- JP
- Japan
- Prior art keywords
- car
- seq
- intracellular
- cell
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261717960P | 2012-10-24 | 2012-10-24 | |
| US61/717,960 | 2012-10-24 | ||
| PCT/US2013/060332 WO2014065961A1 (en) | 2012-10-24 | 2013-09-18 | M971 chimeric antigen receptors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018088908A Division JP6643394B2 (ja) | 2012-10-24 | 2018-05-02 | Ｍ９７１キメラ抗原受容体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016502512A JP2016502512A (ja) | 2016-01-28 |
| JP2016502512A5 true JP2016502512A5 (enExample) | 2016-11-10 |
| JP6338252B2 JP6338252B2 (ja) | 2018-06-06 |
Family
ID=49304331
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015539602A Active JP6338252B2 (ja) | 2012-10-24 | 2013-09-18 | Ｍ９７１キメラ抗原受容体 |
| JP2018088908A Active JP6643394B2 (ja) | 2012-10-24 | 2018-05-02 | Ｍ９７１キメラ抗原受容体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018088908A Active JP6643394B2 (ja) | 2012-10-24 | 2018-05-02 | Ｍ９７１キメラ抗原受容体 |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US10072078B2 (enExample) |
| EP (1) | EP2912061B1 (enExample) |
| JP (2) | JP6338252B2 (enExample) |
| CN (2) | CN110229834B (enExample) |
| AU (2) | AU2013335180B2 (enExample) |
| BR (1) | BR112015009003B1 (enExample) |
| CA (1) | CA2889055C (enExample) |
| ES (1) | ES2718903T3 (enExample) |
| RU (2) | RU2658485C2 (enExample) |
| WO (1) | WO2014065961A1 (enExample) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3608022A1 (en) | 2013-03-15 | 2020-02-12 | The Trustees of Princeton University | Methods and devices for high throughput purification |
| US20150064153A1 (en) | 2013-03-15 | 2015-03-05 | The Trustees Of Princeton University | High efficiency microfluidic purification of stem cells to improve transplants |
| EP2971287B1 (en) | 2013-03-15 | 2019-08-14 | GPB Scientific, LLC | On-chip microfluidic processing of particles |
| US12590955B2 (en) | 2013-03-15 | 2026-03-31 | Zeon Corporation | Methods and systems for processing particles |
| JP2017522884A (ja) * | 2014-07-29 | 2017-08-17 | ファイザー・インク | がん免疫療法のためのＥＧＦＲｖＩＩＩ特異的キメラ抗原受容体 |
| WO2016090190A1 (en) | 2014-12-03 | 2016-06-09 | Juno Therapeutics, Inc. | Methods and compositions for adoptive cell therapy |
| IL301458A (en) | 2014-12-24 | 2023-05-01 | Autolus Ltd | A cell that simultaneously expresses a chimeric antigen receptor (CAR) of 19CD and 22CD |
| US10738116B2 (en) * | 2015-03-19 | 2020-08-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Dual specific anti-CD22-anti-CD19 chimeric antigen receptors |
| MX2017012939A (es) | 2015-04-08 | 2018-05-22 | Novartis Ag | Terapias cd20, terapias cd22 y terapias de combinacion con una celula que expresa un receptor quimerico de antigeno (car) de cd19. |
| CN104829733B (zh) * | 2015-05-25 | 2018-06-05 | 广州百暨基因科技有限公司 | 抗原结合单元稳定的嵌合抗原受体及制备方法与应用 |
| US10976232B2 (en) | 2015-08-24 | 2021-04-13 | Gpb Scientific, Inc. | Methods and devices for multi-step cell purification and concentration |
| US10562952B2 (en) | 2015-09-10 | 2020-02-18 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-CD276 chimeric antigen receptors |
| WO2017139199A1 (en) | 2016-02-10 | 2017-08-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Inducible arginase |
| AU2017306557B2 (en) | 2016-08-03 | 2023-08-03 | Washington University | Gene editing of CAR-T cells for the treatment of T cell malignancies with chimeric antigen receptors |
| CA3035615A1 (en) * | 2016-09-02 | 2018-03-08 | Lentigen Technology, Inc. | Compositions and methods for treating cancer with duocars |
| CN107964549B (zh) * | 2016-10-20 | 2020-12-08 | 上海恒润达生生物科技有限公司 | 靶向cd22的嵌合抗原受体及其用途 |
| MA46995A (fr) | 2016-12-03 | 2019-10-09 | Acerta Pharma Bv | Méthodes et compositions pour l'utilisation de lymphocytes t thérapeutiques en association avec des inhibiteurs de kinase |
| CN110913954A (zh) | 2017-03-03 | 2020-03-24 | 黑曜石疗法公司 | 免疫疗法的组合物和方法 |
| CN112695050B (zh) * | 2017-03-24 | 2025-08-08 | 莱蒂恩技术公司 | 用于用抗cd33免疫疗法治疗癌症的组合物和方法 |
| AU2018246378A1 (en) * | 2017-03-31 | 2019-10-17 | Cellectis Sa | New universal chimeric antigen receptor T cells specific for CD22 |
| US11344578B2 (en) | 2017-04-19 | 2022-05-31 | Board Of Regents, The University Of Texas System | Immune cells expressing engineered antigen receptors |
| CA3062433A1 (en) * | 2017-05-15 | 2018-11-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Bicistronic chimeric antigen receptors and their uses |
| CN111225675B (zh) | 2017-06-02 | 2024-05-03 | 朱诺治疗学股份有限公司 | 使用过继细胞疗法治疗的制品和方法 |
| CN109385402A (zh) * | 2017-08-11 | 2019-02-26 | 上海恒润达生生物科技有限公司 | 一种等比例混合两种靶点cart细胞的制备方法及应用 |
| EP3675876A4 (en) | 2017-09-01 | 2021-06-02 | GPB Scientific, Inc. | METHOD FOR PRODUCING THERAPEUTICALLY ACTIVE CELLS USING MICROFLUIDICS |
| KR102521245B1 (ko) * | 2017-09-15 | 2023-04-17 | 카이트 파마 인코포레이티드 | 관리 연속성 및 신원 연속성 생물학적 샘플 추적으로 환자-특이적 면역요법 절차를 수행하기 위한 방법 및 시스템 |
| CN107759700A (zh) * | 2017-10-18 | 2018-03-06 | 银丰生物工程集团有限公司 | 靶向cd19抗原的转基因t细胞及其制备方法与应用 |
| CN109836495A (zh) * | 2017-11-25 | 2019-06-04 | 深圳宾德生物技术有限公司 | 一种靶向cd22的单链抗体、嵌合抗原受体t细胞及其制备方法和应用 |
| CN109837305A (zh) * | 2017-11-25 | 2019-06-04 | 深圳宾德生物技术有限公司 | 一种敲除pd1的靶向cd22的嵌合抗原受体t细胞及其制备方法和应用 |
| CN109988242A (zh) * | 2018-01-02 | 2019-07-09 | 武汉波睿达生物科技有限公司 | 联合嵌合抗原受体、表达载体、慢病毒及t细胞 |
| WO2019165121A1 (en) | 2018-02-21 | 2019-08-29 | Board Of Regents, The University Of Texas System | Methods for activation and expansion of natural killer cells and uses therof |
| CN112262212B (zh) | 2018-04-24 | 2024-07-12 | 美国卫生和人力服务部 | 使用羟基柠檬酸和/或其盐产生t细胞群体的方法 |
| CN108715859B (zh) * | 2018-05-31 | 2021-08-03 | 中国医学科学院血液病医院(中国医学科学院血液学研究所) | 靶向cd22的嵌合抗原受体及其应用 |
| WO2020014482A1 (en) * | 2018-07-12 | 2020-01-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Affinity matured cd22-specific monoclonal antibody and uses thereof |
| AU2020275049A1 (en) * | 2019-05-16 | 2022-01-06 | Nanjing Legend Biotech Co., Ltd. | Engineered immune cells comprsing a recognition molecule |
| EP3999081A1 (en) | 2019-07-18 | 2022-05-25 | GPB Scientific, Inc. | Ordered processing of blood products to produce therapeutically active cells |
| US20230028754A1 (en) | 2019-12-28 | 2023-01-26 | Gpb Scientific, Inc. | Microfluidic cartridges for processing particles and cells |
| JP7614659B2 (ja) * | 2019-12-30 | 2025-01-16 | ブリスター イムノテック リミテッド | 強化されたｔ細胞受容体ｓｔａｒ及びその用途 |
| IL295421A (en) * | 2020-02-14 | 2022-10-01 | Univ Leland Stanford Junior | Chimeric antigen receptors with cd2 activation |
| CN116157510A (zh) | 2020-06-17 | 2023-05-23 | 詹森生物科技公司 | 用于制造多能干细胞的材料和方法 |
| WO2022012680A1 (en) | 2020-07-16 | 2022-01-20 | Nanjing Legend Biotech Co., Ltd. | Cd20 binding molecules and uses thereof |
| AU2021341969A1 (en) | 2020-09-08 | 2023-03-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | T cell phenotypes associated with response to adoptive cell therapy |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| TW202237827A (zh) | 2020-12-03 | 2022-10-01 | 美商世紀治療股份有限公司 | 經基因工程改造之細胞及其用途 |
| JP2024500847A (ja) | 2020-12-18 | 2024-01-10 | センチュリー セラピューティクス，インコーポレイテッド | 適合可能な受容体特異性を有するキメラ抗原受容体システム |
| WO2022251070A1 (en) * | 2021-05-27 | 2022-12-01 | Innovative Cellular Therapeutics Holdings, Ltd. | Modified chimeric antigen receptor and use thereof |
| WO2022269473A1 (en) | 2021-06-23 | 2022-12-29 | Janssen Biotech, Inc. | Materials and methods for hinge regions in functional exogenous receptors |
| AU2022310862A1 (en) | 2021-07-14 | 2024-02-01 | Regeneron Pharmaceuticals, Inc. | Engineered t cell receptors fused to binding domains from antibodies |
| IL316032A (en) | 2022-04-08 | 2024-11-01 | Regeneron Pharma | Multicomponent receptor and signaling complexes |
| US20250188492A1 (en) | 2022-07-22 | 2025-06-12 | Janssen Biotech, Inc. | Enhanced Transfer of Genetic Instructions to Effector Immune Cells |
| WO2025049972A1 (en) * | 2023-09-01 | 2025-03-06 | Cargo Therapeutics, Inc. | Compositions and methods for immunotherapies |
| WO2025171388A1 (en) | 2024-02-09 | 2025-08-14 | Dispatch Biotherapeutics, Inc. | Engineered cancer antigens with modified domains and related methods and uses |
| WO2025171383A2 (en) | 2024-02-09 | 2025-08-14 | Dispatch Biotherapeutics, Inc. | Engineered cancer antigens and related methods and uses |
| WO2025231185A1 (en) | 2024-05-01 | 2025-11-06 | Legend Biotech Ireland Limited | Viral glycoprotein variants and uses thereof |
| CN121896173A (zh) | 2024-10-21 | 2026-04-21 | 深圳市湾岛细胞科技有限公司 | 表达外源肌苷单磷酸脱氢酶的真核细胞 |
| WO2026096515A1 (en) | 2024-10-28 | 2026-05-07 | Legend Biotech Ireland Limited | Viral glycoprotein variants and uses thereof |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3854480A (en) | 1969-04-01 | 1974-12-17 | Alza Corp | Drug-delivery system |
| US3832253A (en) | 1973-03-21 | 1974-08-27 | Baxter Laboratories Inc | Method of making an inflatable balloon catheter |
| US4450150A (en) | 1973-05-17 | 1984-05-22 | Arthur D. Little, Inc. | Biodegradable, implantable drug delivery depots, and method for preparing and using the same |
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4667014A (en) | 1983-03-07 | 1987-05-19 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists |
| US4452775A (en) | 1982-12-03 | 1984-06-05 | Syntex (U.S.A.) Inc. | Cholesterol matrix delivery system for sustained release of macromolecules |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| CA1200416A (en) | 1983-05-13 | 1986-02-11 | Societe Des Produits Nestle S.A. | Food process |
| US5019369A (en) | 1984-10-22 | 1991-05-28 | Vestar, Inc. | Method of targeting tumors in humans |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| IN165717B (enExample) | 1986-08-07 | 1989-12-23 | Battelle Memorial Institute | |
| US5075109A (en) | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| AU8507191A (en) | 1990-08-29 | 1992-03-30 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| JPH04167172A (ja) | 1990-10-31 | 1992-06-15 | Nec Corp | ベクトルプロセッサ |
| JP3266311B2 (ja) | 1991-05-02 | 2002-03-18 | 生化学工業株式会社 | 新規ポリペプチドおよびこれを用いる抗ｈｉｖ剤 |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| US6265150B1 (en) | 1995-06-07 | 2001-07-24 | Becton Dickinson & Company | Phage antibodies |
| US5714352A (en) | 1996-03-20 | 1998-02-03 | Xenotech Incorporated | Directed switch-mediated DNA recombination |
| EP1257289A1 (en) | 2000-02-08 | 2002-11-20 | The Penn State Research Foundation | Immunotherapy using interleukin 13 receptor subunit alpha 2 |
| GB0210121D0 (en) | 2002-05-02 | 2002-06-12 | Celltech R&D Ltd | Biological products |
| CN1279056C (zh) * | 2003-06-06 | 2006-10-11 | 马菁 | 肿瘤相关抗原sm5－1的特异性抗体及其应用 |
| CN100374464C (zh) * | 2003-07-10 | 2008-03-12 | 上海单抗制药技术有限公司 | 抗sars病毒的单克隆抗体、其编码序列及应用 |
| WO2007134272A2 (en) * | 2006-05-12 | 2007-11-22 | Janssen Pharmaceutica N.V. | Humanized models via targeted mtagenesis with zinc finger nuclease |
| WO2008045437A2 (en) | 2006-10-09 | 2008-04-17 | The General Hospital Corporation | Chimeric t-cell receptors and t-cells targeting egfrviii on tumors |
| WO2009091826A2 (en) * | 2008-01-14 | 2009-07-23 | The Board Of Regents Of The University Of Texas System | Compositions and methods related to a human cd19-specific chimeric antigen receptor (h-car) |
| US8591889B2 (en) | 2008-04-04 | 2013-11-26 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Human monoclonal antibodies specific for CD22 |
| US8465743B2 (en) | 2009-10-01 | 2013-06-18 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-vascular endothelial growth factor receptor-2 chimeric antigen receptors and use of same for the treatment of cancer |
| KR101688522B1 (ko) * | 2009-12-15 | 2016-12-21 | 삼성전자주식회사 | 안지오포이에틴-2에 특이적으로 결합하는 항체 및 그의 용도 |
| PH12013501201A1 (en) * | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| IN2014CN02906A (enExample) | 2011-10-20 | 2015-07-03 | Us Health |
-
2013
- 2013-09-18 RU RU2015117237A patent/RU2658485C2/ru active
- 2013-09-18 EP EP13773468.7A patent/EP2912061B1/en active Active
- 2013-09-18 WO PCT/US2013/060332 patent/WO2014065961A1/en not_active Ceased
- 2013-09-18 CN CN201910500128.7A patent/CN110229834B/zh active Active
- 2013-09-18 US US14/437,889 patent/US10072078B2/en active Active
- 2013-09-18 AU AU2013335180A patent/AU2013335180B2/en active Active
- 2013-09-18 CN CN201380061387.5A patent/CN104822705B/zh active Active
- 2013-09-18 CA CA2889055A patent/CA2889055C/en active Active
- 2013-09-18 BR BR112015009003-6A patent/BR112015009003B1/pt active IP Right Grant
- 2013-09-18 ES ES13773468T patent/ES2718903T3/es active Active
- 2013-09-18 JP JP2015539602A patent/JP6338252B2/ja active Active
-
2018
- 2018-05-02 JP JP2018088908A patent/JP6643394B2/ja active Active
- 2018-05-04 RU RU2018116582A patent/RU2770411C1/ru active
- 2018-06-14 AU AU2018204257A patent/AU2018204257B2/en active Active
- 2018-08-21 US US16/107,271 patent/US10703816B2/en active Active
-
2020
- 2020-05-08 US US16/869,792 patent/US11807682B2/en active Active
-
2023
- 2023-11-06 US US18/503,107 patent/US20240084008A1/en active Pending
- 2023-11-06 US US18/502,993 patent/US20240084007A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014534207A5 (enExample) | ||
| JP2018505139A5 (enExample) | ||
| RU2015117237A (ru) | Химерные антигенные рецепторы м971 | |
| JP2020529841A5 (enExample) | ||
| JP2018529380A5 (enExample) | ||
| JP2017537622A5 (enExample) | ||
| JP2019528769A5 (enExample) | ||
| JP2018531014A5 (enExample) | ||
| BR112014008849A2 (pt) | receptores quiméricos de antígeno anti-cd22 | |
| JP2020519298A5 (enExample) | ||
| IL292650B2 (en) | COSTIMULATORY CHIMERIC ANTIGEN RECEPTOR T CELLS TARGETING IL13Ra2 | |
| JP2017513478A5 (enExample) | ||
| JP2017538401A5 (enExample) | ||
| JP2018064568A5 (enExample) | ||
| JP2010273685A5 (enExample) | ||
| JP2017535284A5 (enExample) | ||
| FI3642344T3 (fi) | Menetelmiä ja koostumuksia syöpäsoluihin kohdentuvaa kimeeristä antigeenireseptoria varten | |
| IL275497B (en) | Serum proteins with type iii fibronectin binding domains | |
| CA2868121C (en) | Anti-mesothelin chimeric antigen receptors | |
| JP2019519529A5 (enExample) | ||
| JP2017537627A5 (enExample) | ||
| JP2016516735A5 (enExample) | ||
| JP2015509717A5 (enExample) | ||
| JP2016532693A5 (enExample) | ||
| JP2016534717A5 (enExample) |