JP2018531014A5 - - Google Patents
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- JP2018531014A5 JP2018531014A5 JP2018518999A JP2018518999A JP2018531014A5 JP 2018531014 A5 JP2018531014 A5 JP 2018531014A5 JP 2018518999 A JP2018518999 A JP 2018518999A JP 2018518999 A JP2018518999 A JP 2018518999A JP 2018531014 A5 JP2018531014 A5 JP 2018531014A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- domain
- car
- intracellular
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 17
- 210000001744 T-lymphocyte Anatomy 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 11
- 230000003834 intracellular effect Effects 0.000 claims 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 230000005754 cellular signaling Effects 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 101100166600 Homo sapiens CD28 gene Proteins 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 239000013604 expression vector Substances 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 3
- 238000003259 recombinant expression Methods 0.000 claims 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 101000746783 Homo sapiens Cytochrome b-c1 complex subunit 6, mitochondrial Proteins 0.000 claims 1
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 230000000139 costimulatory effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 102000048638 human UQCRH Human genes 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000006798 recombination Effects 0.000 claims 1
- 238000005215 recombination Methods 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562241896P | 2015-10-15 | 2015-10-15 | |
| US62/241,896 | 2015-10-15 | ||
| PCT/US2016/056262 WO2017066122A1 (en) | 2015-10-15 | 2016-10-10 | Anti-cd30 chimeric antigen receptors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018531014A JP2018531014A (ja) | 2018-10-25 |
| JP2018531014A6 JP2018531014A6 (ja) | 2018-12-13 |
| JP2018531014A5 true JP2018531014A5 (enExample) | 2019-11-21 |
Family
ID=57178532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018518999A Pending JP2018531014A (ja) | 2015-10-15 | 2016-10-10 | 抗ｃｄ３０キメラ抗原受容体 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10815301B2 (enExample) |
| EP (1) | EP3362476B1 (enExample) |
| JP (1) | JP2018531014A (enExample) |
| KR (1) | KR20180057723A (enExample) |
| CN (1) | CN108137703A (enExample) |
| AU (1) | AU2016338747B2 (enExample) |
| BR (1) | BR112018006995A2 (enExample) |
| CA (1) | CA3002000A1 (enExample) |
| IL (1) | IL258527A (enExample) |
| MX (1) | MX2018004503A (enExample) |
| WO (1) | WO2017066122A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20240093757A (ko) * | 2014-06-02 | 2024-06-24 | 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 | Cd19를 표적화하는 키메라 항원 수용체 |
| EP3674327A4 (en) * | 2018-02-01 | 2021-05-05 | Nanjing Iaso Biotherapeutics Co., Ltd. | CHEMICAL ANTIGENIC RECEPTOR (CAR) BINDING TO BCMA AND ITS APPLICATIONS |
| IT201800003464A1 (it) * | 2018-03-13 | 2019-09-13 | Ospedale Pediatrico Bambino Gesu | Cellule T CAR-CD30 per il trattamento di tumori CD30+ |
| WO2020009868A1 (en) | 2018-07-03 | 2020-01-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-slamf7 chimeric antigen receptors |
| EP3852788A1 (en) * | 2018-09-17 | 2021-07-28 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Bicistronic chimeric antigen receptors targeting cd19 and cd20 and their uses |
| US11667721B2 (en) | 2018-09-24 | 2023-06-06 | Medical College Of Wisconsin, Inc. | CD30 bispecific antibodies and method of immunotherapy of CD30+ malignancies |
| WO2020068764A1 (en) * | 2018-09-24 | 2020-04-02 | The Medical College Of Wisconsin, Inc. | Anti-cd30 antibodies and methods of use |
| TW202031679A (zh) * | 2018-10-26 | 2020-09-01 | 日商橘生藥品工業股份有限公司 | 高效率之基因改造細胞之製作方法 |
| WO2021019706A1 (ja) * | 2019-07-31 | 2021-02-04 | 国立大学法人信州大学 | Ｃａｒ発現免疫細胞を含む細胞集団の製造方法 |
| CN110628823B (zh) * | 2019-10-21 | 2022-12-27 | 江苏省肿瘤医院 | 一种cd30 car慢病毒表达载体及其制备方法和应用 |
| CN110559430B (zh) * | 2019-10-21 | 2023-07-11 | 江苏省肿瘤医院 | 一种抗淋巴瘤的car-t药物及其应用 |
| CN113527507A (zh) * | 2020-04-16 | 2021-10-22 | 上海赛比曼生物科技有限公司 | 靶向cd22的嵌合抗原受体及其制法和应用 |
| WO2021221927A1 (en) * | 2020-04-27 | 2021-11-04 | Parsons Corporation | Narrowband iq signal obfuscation |
| EP4251741A1 (en) | 2020-11-30 | 2023-10-04 | CRISPR Therapeutics AG | Gene-edited natural killer cells |
| US12404315B2 (en) | 2020-12-21 | 2025-09-02 | Allogene Therapeutics, Inc. | Protease-activating CD45-gate CAR |
| US11473060B2 (en) | 2020-12-30 | 2022-10-18 | Crispr Therapeutics Ag | Compositions and methods for differentiating stem cells into NK cells |
| JP2024505075A (ja) | 2021-01-29 | 2024-02-02 | アロジーン セラピューティクス，インコーポレイテッド | 同種細胞産物のＴ細胞認識を軽減するための、ＴＡＰ２、ＮＬＲＣ５、β２ｍ、ＴＲＡＣ、ＲＦＸ５、ＲＦＸＡＰ及びＲＦＸＡＮＫのうち１つ以上のノックダウン又はノックアウト |
| CA3211463A1 (en) * | 2021-03-01 | 2022-09-09 | Nantbio, Inc. | Anti-cd30 monoclonal antibodies and chimeric antigen receptors |
| KR102671409B1 (ko) | 2021-03-02 | 2024-05-31 | 진화섭 | Cd30을 발현하는 세포에 독성을 나타내는 재조합 단백질 및 이를 유효성분으로 포함하는 암의 치료용 약학적 조성물 |
| KR20230012129A (ko) | 2021-07-14 | 2023-01-26 | 주식회사 이뮤노로지컬디자이닝랩 | Cd30에 특이적으로 결합하는 키메릭 항원 수용체 및 이의 용도 |
| WO2023205148A1 (en) | 2022-04-19 | 2023-10-26 | Intellia Therapeutics, Inc. | Chimeric antigen receptor compositions and uses |
| JP2025525779A (ja) | 2022-07-29 | 2025-08-07 | アロジーン セラピューティクス，インコーポレイテッド | 免疫細胞の認識を低減させるために遺伝子発現が低下した、操作された細胞 |
| WO2024160845A1 (en) | 2023-01-30 | 2024-08-08 | Ludwig-Maximilians-Universität München | Anti-cd86 car expressing lymphocytes for targeted tumor therapy |
| WO2025059162A1 (en) | 2023-09-11 | 2025-03-20 | Dana-Farber Cancer Institute, Inc. | Car-engager containing il-2 variants to enhance the functionality of car t cells |
| WO2025096560A1 (en) | 2023-10-30 | 2025-05-08 | Allogene Therapeutics, Inc. | Engineered cells |
| EP4674430A1 (en) | 2024-07-01 | 2026-01-07 | Universität zu Köln | Edited cytotoxic cells with chimeric antigen receptors targeting cd30 for the treatment of infections |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1482972A4 (en) | 2001-11-20 | 2005-11-23 | Seattle Genetics Inc | TREATMENT OF IMMUNOLOGICAL DISORDERS USING ANTI-CD30 ANTIBODIES |
| KR100668538B1 (ko) * | 2002-01-09 | 2007-01-16 | 메다렉스, 인코포레이티드 | Ｃｄ３０에 대한 인간 모노클로날 항체 |
| DK1545204T3 (en) | 2002-09-06 | 2016-11-14 | The Government Of The Us Secretary Dept Of Health And Human Services | Immunotherapy with in vitro selected antigen-specific lymphocytes following non-myeloablative lymphodepletive chemotherapy |
| CA2625998C (en) | 2005-10-06 | 2015-12-01 | Xencor, Inc. | Optimized anti-cd30 antibodies |
| US8383099B2 (en) | 2009-08-28 | 2013-02-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adoptive cell therapy with young T cells |
| US8465743B2 (en) * | 2009-10-01 | 2013-06-18 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-vascular endothelial growth factor receptor-2 chimeric antigen receptors and use of same for the treatment of cancer |
| US20120244133A1 (en) | 2011-03-22 | 2012-09-27 | The United States of America, as represented by the Secretary, Department of Health and | Methods of growing tumor infiltrating lymphocytes in gas-permeable containers |
| US9598489B2 (en) * | 2012-10-05 | 2017-03-21 | The Trustees Of The Univeristy Of Pennsylvania | Human alpha-folate receptor chimeric antigen receptor |
| EP3039040B1 (en) | 2013-08-26 | 2021-12-22 | Hinrich Abken | Anti cd30 chimeric antigen receptor and its use |
| CN105859890A (zh) | 2015-01-19 | 2016-08-17 | 西比曼生物科技（上海）有限公司 | 嵌合抗原受体及其基因和重组表达载体、工程化cd30靶向性的nkt细胞及其应用 |
| US11248058B2 (en) * | 2015-02-19 | 2022-02-15 | University Of Florida Research Foundation, Inc. | Chimeric antigen receptors and uses thereof |
-
2016
- 2016-10-10 EP EP16784695.5A patent/EP3362476B1/en active Active
- 2016-10-10 KR KR1020187013573A patent/KR20180057723A/ko not_active Withdrawn
- 2016-10-10 WO PCT/US2016/056262 patent/WO2017066122A1/en not_active Ceased
- 2016-10-10 US US15/766,948 patent/US10815301B2/en active Active
- 2016-10-10 BR BR112018006995A patent/BR112018006995A2/pt not_active Application Discontinuation
- 2016-10-10 AU AU2016338747A patent/AU2016338747B2/en not_active Expired - Fee Related
- 2016-10-10 MX MX2018004503A patent/MX2018004503A/es unknown
- 2016-10-10 CN CN201680059341.3A patent/CN108137703A/zh active Pending
- 2016-10-10 JP JP2018518999A patent/JP2018531014A/ja active Pending
- 2016-10-10 CA CA3002000A patent/CA3002000A1/en active Pending
-
2018
- 2018-04-08 IL IL258527A patent/IL258527A/en unknown
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