JP2018532407A5 - - Google Patents
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- Publication number
- JP2018532407A5 JP2018532407A5 JP2018520157A JP2018520157A JP2018532407A5 JP 2018532407 A5 JP2018532407 A5 JP 2018532407A5 JP 2018520157 A JP2018520157 A JP 2018520157A JP 2018520157 A JP2018520157 A JP 2018520157A JP 2018532407 A5 JP2018532407 A5 JP 2018532407A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- chimeric receptor
- endodomain
- receptor
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108700010039 chimeric receptor Proteins 0.000 claims description 163
- 150000007523 nucleic acids Chemical group 0.000 claims description 122
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 88
- 102000003675 cytokine receptors Human genes 0.000 claims description 52
- 108010057085 cytokine receptors Proteins 0.000 claims description 52
- 230000003834 intracellular effect Effects 0.000 claims description 34
- 108020004707 nucleic acids Proteins 0.000 claims description 34
- 102000039446 nucleic acids Human genes 0.000 claims description 34
- 210000004027 cell Anatomy 0.000 claims description 25
- 108020001507 fusion proteins Proteins 0.000 claims description 22
- 102000037865 fusion proteins Human genes 0.000 claims description 22
- 102000042286 type I cytokine receptor family Human genes 0.000 claims description 20
- 108091052247 type I cytokine receptor family Proteins 0.000 claims description 20
- 102000035160 transmembrane proteins Human genes 0.000 claims description 18
- 108091005703 transmembrane proteins Proteins 0.000 claims description 18
- 125000006850 spacer group Chemical group 0.000 claims description 16
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 14
- 239000000427 antigen Substances 0.000 claims description 14
- 102000036639 antigens Human genes 0.000 claims description 14
- 108091007433 antigens Proteins 0.000 claims description 14
- 230000005754 cellular signaling Effects 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 12
- 239000008194 pharmaceutical composition Substances 0.000 claims description 11
- 230000000295 complement effect Effects 0.000 claims description 8
- 239000003446 ligand Substances 0.000 claims description 8
- 201000010099 disease Diseases 0.000 claims description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
- 230000004186 co-expression Effects 0.000 claims description 6
- 108020001756 ligand binding domains Proteins 0.000 claims description 6
- 108090000695 Cytokines Proteins 0.000 claims description 4
- 102000004127 Cytokines Human genes 0.000 claims description 4
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 4
- 101000818543 Homo sapiens Tyrosine-protein kinase ZAP-70 Proteins 0.000 claims description 4
- 102000018682 Interleukin Receptor Common gamma Subunit Human genes 0.000 claims description 4
- 108010066719 Interleukin Receptor Common gamma Subunit Proteins 0.000 claims description 4
- 102000010789 Interleukin-2 Receptors Human genes 0.000 claims description 4
- 108010038453 Interleukin-2 Receptors Proteins 0.000 claims description 4
- 102000010782 Interleukin-7 Receptors Human genes 0.000 claims description 4
- 108010038498 Interleukin-7 Receptors Proteins 0.000 claims description 4
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 4
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 4
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims description 4
- 102100021125 Tyrosine-protein kinase ZAP-70 Human genes 0.000 claims description 4
- 230000004068 intracellular signaling Effects 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 239000012528 membrane Substances 0.000 claims description 4
- 102100027207 CD27 antigen Human genes 0.000 claims description 2
- 101150013553 CD40 gene Proteins 0.000 claims description 2
- 108020004705 Codon Proteins 0.000 claims description 2
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 230000000139 costimulatory effect Effects 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 230000006801 homologous recombination Effects 0.000 claims description 2
- 238000002744 homologous recombination Methods 0.000 claims description 2
- 238000002955 isolation Methods 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 102000005962 receptors Human genes 0.000 claims description 2
- 108020003175 receptors Proteins 0.000 claims description 2
- 230000001177 retroviral effect Effects 0.000 claims description 2
- 230000011664 signaling Effects 0.000 claims description 2
- 238000010361 transduction Methods 0.000 claims description 2
- 230000026683 transduction Effects 0.000 claims description 2
- 238000001890 transfection Methods 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 238000010276 construction Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022007006A JP2022058681A (ja) | 2015-10-23 | 2022-01-20 | 受容体 |
| JP2023222448A JP2024024014A (ja) | 2015-10-23 | 2023-12-28 | 受容体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1518816.2 | 2015-10-23 | ||
| GBGB1518816.2A GB201518816D0 (en) | 2015-10-23 | 2015-10-23 | Receptor |
| PCT/GB2016/053290 WO2017068360A1 (en) | 2015-10-23 | 2016-10-21 | Receptor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022007006A Division JP2022058681A (ja) | 2015-10-23 | 2022-01-20 | 受容体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018532407A JP2018532407A (ja) | 2018-11-08 |
| JP2018532407A5 true JP2018532407A5 (enExample) | 2019-10-03 |
| JP7082046B2 JP7082046B2 (ja) | 2022-06-07 |
Family
ID=55130152
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018520157A Active JP7082046B2 (ja) | 2015-10-23 | 2016-10-21 | 受容体 |
| JP2022007006A Withdrawn JP2022058681A (ja) | 2015-10-23 | 2022-01-20 | 受容体 |
| JP2023222448A Pending JP2024024014A (ja) | 2015-10-23 | 2023-12-28 | 受容体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022007006A Withdrawn JP2022058681A (ja) | 2015-10-23 | 2022-01-20 | 受容体 |
| JP2023222448A Pending JP2024024014A (ja) | 2015-10-23 | 2023-12-28 | 受容体 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11242377B2 (enExample) |
| EP (1) | EP3364998A1 (enExample) |
| JP (3) | JP7082046B2 (enExample) |
| CN (1) | CN108135988A (enExample) |
| AU (1) | AU2016342560B2 (enExample) |
| CA (1) | CA3001792A1 (enExample) |
| GB (1) | GB201518816D0 (enExample) |
| HK (1) | HK1252163A1 (enExample) |
| WO (1) | WO2017068360A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2949648T3 (es) | 2012-12-20 | 2023-10-02 | Purdue Research Foundation | Células T que expresan un receptor antigénico quimérico como terapia contra el cáncer |
| IL301458A (en) * | 2014-12-24 | 2023-05-01 | Autolus Ltd | A cell that simultaneously expresses a chimeric antigen receptor (CAR) of 19CD and 22CD |
| GB201514875D0 (en) | 2015-08-20 | 2015-10-07 | Autolus Ltd | Receptor |
| GB201518816D0 (en) * | 2015-10-23 | 2015-12-09 | Autolus Ltd | Receptor |
| WO2017177149A2 (en) | 2016-04-08 | 2017-10-12 | Purdue Research Foundation | Methods and compositions for car t cell therapy |
| CN118546256A (zh) | 2016-12-13 | 2024-08-27 | 西雅图儿童医院（Dba西雅图儿童研究所） | 在体外和体内对工程化的细胞中表达的化学物质诱导的信号传导复合物进行外源性药物激活的方法 |
| EP3579870A4 (en) | 2017-02-07 | 2020-12-30 | Seattle Children's Hospital (DBA Seattle Children's Research Institute) | PHOSPHOLIPID ETHER (PLE) T CAR-LYMPHOCYTE TUMOR (CTCT) TARGETING AGENTS |
| ES3010559T3 (en) | 2017-02-28 | 2025-04-03 | Endocyte Inc | Compositions and methods for car t cell therapy |
| TW201940182A (zh) | 2018-01-22 | 2019-10-16 | 美商安德賽特公司 | Car t 細胞之使用方法 |
| CA3090089A1 (en) | 2018-02-06 | 2019-08-15 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Fluorescein-specific cars exhibiting optimal t cell function against fl-ple labelled tumors |
| JP7568224B2 (ja) | 2018-02-23 | 2024-10-16 | エンドサイト・インコーポレイテッド | Ｃａｒ ｔ細胞療法のための配列決定法 |
| AR114273A1 (es) | 2018-03-02 | 2020-08-12 | Allogene Therapeutics Inc | Receptores inducibles de citoquina quimérica |
| US11987804B2 (en) | 2018-04-27 | 2024-05-21 | Seattle Children's Hospital | Rapamycin resistant cells |
| CN110615843B (zh) * | 2018-06-20 | 2023-05-09 | 上海隆耀生物科技有限公司 | 一种包含第三信号受体的嵌合抗原受体及其应用 |
| GB201814203D0 (en) * | 2018-08-31 | 2018-10-17 | King S College London | Engineered regulatory t cell |
| CN111378046B (zh) * | 2018-12-27 | 2024-03-15 | 上海细胞治疗集团有限公司 | 一种免疫效应细胞转换受体 |
| WO2020172641A1 (en) * | 2019-02-21 | 2020-08-27 | Arbele Limited | Artificial immunosurveillance chimeric antigen receptor and cells expressing the same |
| EP3931208A1 (en) | 2019-03-01 | 2022-01-05 | Allogene Therapeutics, Inc. | Chimeric cytokine receptors bearing a pd-1 ectodomain |
| PH12021551861A1 (en) | 2019-03-01 | 2022-05-30 | Allogene Therapeutics Inc | Constitutively active chimeric cytokine receptors |
| BR112022003553A2 (pt) | 2019-08-30 | 2022-05-24 | Allogene Therapeutics Inc | Receptores de citocina quiméricos compreendendo domínios de ligação a tgf beta |
| US20220401537A1 (en) * | 2019-09-16 | 2022-12-22 | Fred Hutchinson Cancer Research Center | Chimeric receptor proteins and uses thereof |
| CN115175929A (zh) | 2020-02-24 | 2022-10-11 | 艾洛基治疗公司 | 活性增强的bcma car-t细胞 |
| CN111269326A (zh) * | 2020-02-28 | 2020-06-12 | 南京北恒生物科技有限公司 | 新型嵌合抗原受体及其用途 |
| EP4403580A1 (en) | 2023-01-23 | 2024-07-24 | Medizinische Hochschule Hannover | Anti-entpd3 chimeric antigen receptor |
| KR20250169635A (ko) | 2023-01-23 | 2025-12-03 | 메디치니쉐 호흐슐레 하노버 | 항-entpd3 키메라 항원 수용체 |
| CN120787258A (zh) | 2023-02-07 | 2025-10-14 | 圭尔医疗有限公司 | Treg细胞培养方法 |
| EP4669343A1 (en) | 2023-02-24 | 2025-12-31 | Medizinische Hochschule Hannover | CHIMERIC ANTIGEN RECIPIENT |
| EP4420676A1 (en) | 2023-02-24 | 2024-08-28 | Medizinische Hochschule Hannover | Chimeric antigen receptor |
| EP4434539A1 (en) | 2023-03-20 | 2024-09-25 | Medizinische Hochschule Hannover | Chimeric antigen receptor |
| EP4683660A1 (en) | 2023-03-20 | 2026-01-28 | Medizinische Hochschule Hannover | Chimeric antigen receptor |
| CN117903311B (zh) * | 2024-03-20 | 2024-10-25 | 湖南卓润生物科技有限公司 | sST2特异性结合蛋白及其制备方法和应用 |
| WO2026008994A1 (en) | 2024-07-04 | 2026-01-08 | Quell Therapeutics Limited | Expression construct |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9809658D0 (en) | 1998-05-06 | 1998-07-01 | Celltech Therapeutics Ltd | Biological products |
| PL2126054T3 (pl) | 2007-01-31 | 2017-01-31 | Yeda Research And Development Company Limited | Przekierowane, genetycznie modyfikowane regulatorowe komórki T i ich zastosowanie w hamowaniu choroby autoimmunologicznej i zapalnej |
| US9493740B2 (en) * | 2010-09-08 | 2016-11-15 | Baylor College Of Medicine | Immunotherapy of cancer using genetically engineered GD2-specific T cells |
| MX347656B (es) * | 2011-04-08 | 2017-05-08 | Baylor College Medicine | Inversion de los efectos del micro-ambiente de tumor utilizando receptores de citocina quimericos. |
| US10391126B2 (en) | 2011-11-18 | 2019-08-27 | Board Of Regents, The University Of Texas System | CAR+ T cells genetically modified to eliminate expression of T-cell receptor and/or HLA |
| AU2013204922B2 (en) | 2012-12-20 | 2015-05-14 | Celgene Corporation | Chimeric antigen receptors |
| CN105101803A (zh) | 2013-02-06 | 2015-11-25 | 人类起源公司 | 具有改进特异性的修饰的t淋巴细胞 |
| CA2907397C (en) | 2013-03-15 | 2022-11-22 | Anthrogenesis Corporation | Modified t lymphocytes |
| US9777061B2 (en) | 2014-07-21 | 2017-10-03 | Novartis Ag | Treatment of cancer using a CD33 chimeric antigen receptor |
| KR102612313B1 (ko) | 2014-07-21 | 2023-12-12 | 노파르티스 아게 | 인간화 항-bcma 키메라 항원 수용체를 사용한 암의 치료 |
| KR102607152B1 (ko) | 2015-02-12 | 2023-11-27 | 유니버시티 헬스 네트워크 | 키메라 항원 수용체 |
| WO2016134284A1 (en) | 2015-02-19 | 2016-08-25 | University Of Florida Research Foundation, Inc. | Chimeric antigen receptors and uses thereof |
| US10786549B2 (en) | 2015-04-23 | 2020-09-29 | Baylor College Of Medicine | CD5 chimeric antigen receptor for adoptive T cell therapy |
| WO2016197108A1 (en) | 2015-06-05 | 2016-12-08 | Board Of Regents, The University Of Texas System | Methods of treatment with natural killer cells matched for killer immunoglobulin receptor type |
| GB201514875D0 (en) | 2015-08-20 | 2015-10-07 | Autolus Ltd | Receptor |
| GB201518816D0 (en) * | 2015-10-23 | 2015-12-09 | Autolus Ltd | Receptor |
-
2015
- 2015-10-23 GB GBGB1518816.2A patent/GB201518816D0/en not_active Ceased
-
2016
- 2016-10-21 HK HK18111556.3A patent/HK1252163A1/zh unknown
- 2016-10-21 JP JP2018520157A patent/JP7082046B2/ja active Active
- 2016-10-21 CN CN201680061278.7A patent/CN108135988A/zh active Pending
- 2016-10-21 WO PCT/GB2016/053290 patent/WO2017068360A1/en not_active Ceased
- 2016-10-21 AU AU2016342560A patent/AU2016342560B2/en not_active Expired - Fee Related
- 2016-10-21 CA CA3001792A patent/CA3001792A1/en not_active Abandoned
- 2016-10-21 EP EP16787536.8A patent/EP3364998A1/en not_active Withdrawn
- 2016-10-21 US US15/770,110 patent/US11242377B2/en active Active
-
2021
- 2021-12-22 US US17/560,022 patent/US20220275052A1/en active Pending
-
2022
- 2022-01-20 JP JP2022007006A patent/JP2022058681A/ja not_active Withdrawn
-
2023
- 2023-12-28 JP JP2023222448A patent/JP2024024014A/ja active Pending
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