JP2016538830A5 - - Google Patents

Download PDF

Info

Publication number
JP2016538830A5
JP2016538830A5 JP2016521314A JP2016521314A JP2016538830A5 JP 2016538830 A5 JP2016538830 A5 JP 2016538830A5 JP 2016521314 A JP2016521314 A JP 2016521314A JP 2016521314 A JP2016521314 A JP 2016521314A JP 2016538830 A5 JP2016538830 A5 JP 2016538830A5
Authority
JP
Japan
Prior art keywords
cell
car
item
bcma
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016521314A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016538830A (ja
JP6632073B2 (ja
Filing date
Publication date
Priority claimed from GBGB1317929.6A external-priority patent/GB201317929D0/en
Application filed filed Critical
Publication of JP2016538830A publication Critical patent/JP2016538830A/ja
Publication of JP2016538830A5 publication Critical patent/JP2016538830A5/ja
Application granted granted Critical
Publication of JP6632073B2 publication Critical patent/JP6632073B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016521314A 2013-10-10 2014-10-10 キメラ抗原受容体 Active JP6632073B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1317929.6 2013-10-10
GBGB1317929.6A GB201317929D0 (en) 2013-10-10 2013-10-10 Chimeric antigen receptor
PCT/GB2014/053058 WO2015052538A1 (en) 2013-10-10 2014-10-10 Chimeric antigen receptor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019002499A Division JP2019052190A (ja) 2013-10-10 2019-01-10 キメラ抗原受容体

Publications (3)

Publication Number Publication Date
JP2016538830A JP2016538830A (ja) 2016-12-15
JP2016538830A5 true JP2016538830A5 (enExample) 2017-09-21
JP6632073B2 JP6632073B2 (ja) 2020-01-15

Family

ID=49679854

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016521314A Active JP6632073B2 (ja) 2013-10-10 2014-10-10 キメラ抗原受容体
JP2019002499A Withdrawn JP2019052190A (ja) 2013-10-10 2019-01-10 キメラ抗原受容体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2019002499A Withdrawn JP2019052190A (ja) 2013-10-10 2019-01-10 キメラ抗原受容体

Country Status (16)

Country Link
US (5) US10160794B2 (enExample)
EP (1) EP3055326B1 (enExample)
JP (2) JP6632073B2 (enExample)
KR (1) KR20160067177A (enExample)
CN (1) CN105658671B (enExample)
AU (1) AU2014333564B2 (enExample)
BR (1) BR112016007805A2 (enExample)
CA (1) CA2926560A1 (enExample)
CL (1) CL2016000734A1 (enExample)
ES (1) ES2918626T3 (enExample)
GB (1) GB201317929D0 (enExample)
IL (1) IL244784A0 (enExample)
MX (1) MX2016004362A (enExample)
RU (2) RU2684713C2 (enExample)
SG (1) SG11201602414SA (enExample)
WO (1) WO2015052538A1 (enExample)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201317928D0 (en) * 2013-10-10 2013-11-27 Ucl Business Plc Molecule
GB201317929D0 (en) * 2013-10-10 2013-11-27 Ucl Business Plc Chimeric antigen receptor
WO2015128653A2 (en) 2014-02-27 2015-09-03 Ucl Business Plc Ligand
US11385233B2 (en) 2015-03-05 2022-07-12 Autolus Limited Methods of depleting malignant T-cells
US20230027993A1 (en) 2014-03-05 2023-01-26 Autolus Limited Methods
GB201403972D0 (en) 2014-03-06 2014-04-23 Ucl Business Plc Chimeric antigen receptor
AU2015248956B2 (en) 2014-04-14 2020-06-25 Cellectis BCMA (CD269) specific chimeric antigen receptors for cancer immunotherapy
US20180002435A1 (en) 2015-01-26 2018-01-04 Cellectis mAb-DRIVEN CHIMERIC ANTIGEN RECEPTOR SYSTEMS FOR SORTING/DEPLETING ENGINEERED IMMUNE CELLS
JP6921001B2 (ja) 2015-04-13 2021-08-18 ファイザー・インク B細胞成熟抗原を標的にするキメラ抗原受容体
GB201507111D0 (en) * 2015-04-27 2015-06-10 Ucl Business Plc Nucleic acid construct
GB201507108D0 (en) * 2015-04-27 2015-06-10 Ucl Business Plc Nucleic acid construct
GB201507115D0 (en) * 2015-04-27 2015-06-10 Ucl Business Plc Nucleic Acid Construct
MX2017014822A (es) 2015-05-18 2018-04-30 Tcr2 Therapeutics Inc Composiciones y métodos para la reprogramación del tcr con proteínas de fusión.
JP7245647B2 (ja) * 2015-07-15 2023-03-24 ジュノー セラピューティクス インコーポレイテッド 養子細胞療法用の操作された細胞
EP3670535A1 (en) 2015-08-03 2020-06-24 EngMab Sàrl Monoclonal antibodies against bcma
CN105384825B (zh) * 2015-08-11 2018-06-01 南京传奇生物科技有限公司 一种基于单域抗体的双特异性嵌合抗原受体及其应用
WO2017130223A2 (en) 2016-01-29 2017-08-03 Virocan Therapeutics Pvt. Ltd. A chimeric antigen receptor specific to b-cell maturation antigen, a recombinant expression vector and a method thereof
US10688104B2 (en) 2016-05-20 2020-06-23 Eli Lilly And Company Combination therapy with Notch and PD-1 or PD-L1 inhibitors
SG10202012157QA (en) * 2016-06-07 2021-01-28 Max Delbrueck Centrum Fuer Molekulare Medizin Helmholtz Gemeinschaft Chimeric antigen receptor and car-t cells that bind bcma
CA3032498A1 (en) 2016-08-02 2018-02-08 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
MX2019003899A (es) 2016-10-07 2019-08-14 Tcr2 Therapeutics Inc Composiciones y metodos para reprogramacion de receptores de linfocitos t mediante el uso de proteinas de fusion.
US11124577B2 (en) 2016-11-02 2021-09-21 Engmab Sàrl Bispecific antibody against BCMA and CD3 and an immunological drug for combined use in treating multiple myeloma
CN110114371A (zh) * 2016-11-11 2019-08-09 奥托路斯有限公司 嵌合抗原受体
EP3544996A2 (en) 2016-11-22 2019-10-02 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
WO2018102795A2 (en) 2016-12-02 2018-06-07 University Of Southern California Synthetic immune receptors and methods of use thereof
CA3048648A1 (en) * 2017-01-10 2018-07-19 The General Hospital Corporation T cells expressing a chimeric antigen receptor
CN110461335A (zh) 2017-02-17 2019-11-15 弗雷德哈钦森癌症研究中心 用于治疗bcma相关癌症和自身免疫性失调的联合疗法
GB201709508D0 (en) * 2017-06-15 2017-08-02 Autolus Ltd Chimeric antigen receptor
WO2019025800A1 (en) * 2017-08-02 2019-02-07 Autolus Limited CELLS EXPRESSING A CHIMERIC ANTIGENIC RECEPTOR OR A MANIPULATED TCR AND COMPRISING A SELECTIVELY EXPRESSED SELECTIVE NUCLEOTIDE SEQUENCE
GB201716728D0 (en) 2017-10-12 2017-11-29 Autolus Ltd Cell
KR102845789B1 (ko) 2017-11-01 2025-08-14 주노 쎄러퓨티크스 인코퍼레이티드 B 세포 성숙 항원에 특이적인 키메라 항원 수용체 및 암호화 폴리뉴클레오타이드
US11851679B2 (en) 2017-11-01 2023-12-26 Juno Therapeutics, Inc. Method of assessing activity of recombinant antigen receptors
US12193994B2 (en) 2017-11-06 2025-01-14 Juno Therapeutics, Inc. Combination of a cell therapy and a gamma secretase inhibitor
WO2019113557A1 (en) 2017-12-08 2019-06-13 Juno Therapeutics, Inc. Process for producing a composition of engineered t cells
CN109971715A (zh) * 2017-12-28 2019-07-05 深圳华大生命科学研究院 一种扩增特异性car-t细胞的培养方法
US20210054086A1 (en) * 2018-01-10 2021-02-25 The General Hospital Corporation Immune cells expressing a chimeric antigen receptor
AU2019214163B2 (en) * 2018-02-01 2021-06-24 Innovent Biologics (Suzhou) Co., Ltd. Chimeric antigen receptor (CAR) binding to BCMA, and uses thereof
JP7404331B2 (ja) * 2018-03-23 2023-12-25 ガビッシュ-ガリラヤ バイオ アプリケーションズ リミテッド 膜結合型IL-10をコードする核酸分子及びそれを発現する遺伝子的にリプログラミングされたTreg
GB201807693D0 (en) 2018-05-11 2018-06-27 Autolus Ltd Cell
KR20250151605A (ko) 2018-06-01 2025-10-21 노파르티스 아게 Bcma에 대한 결합 분자 및 이의 용도
CA3103610A1 (en) 2018-06-12 2019-12-19 The Regents Of The University Of California Single-chain bispecific chimeric antigen receptors for the treatment of cancer
TWI838389B (zh) 2018-07-19 2024-04-11 美商再生元醫藥公司 雙特異性抗-BCMAx抗-CD3抗體及其用途
PL3856775T3 (pl) 2018-09-27 2025-06-09 Autolus Limited Chimeryczny receptor antygenowy
CA3116413A1 (en) 2018-11-01 2020-05-07 Juno Therapeutics, Inc. Chimeric antigen receptors specific for g protein-coupled receptor class c group 5 member d (gprc5d)
MX2021005024A (es) 2018-11-01 2021-07-21 Juno Therapeutics Inc Metodos de tratamiento que utilizan receptores de antigenos quimericos especificos para antigeno de maduracion de celulas b.
EP3893923A2 (en) 2018-12-14 2021-10-20 Autolus Limited Cell
GB201904160D0 (en) 2019-03-26 2019-05-08 Autolus Ltd Cell
CN113891718B (zh) * 2019-02-21 2025-01-28 杭州天康麦生物技术有限公司 人工免疫监视嵌合抗原受体(ai-car)及其表达细胞
US20220145325A1 (en) 2019-03-08 2022-05-12 Autolus Limited Compositions and methods comprising engineered chimeric antigen receptor and modulator of car
GB201903237D0 (en) 2019-03-08 2019-04-24 Autolus Ltd Method
MA55372A (fr) 2019-03-21 2022-01-26 Regeneron Pharma Combinaison d'inhibiteurs de la voie il-4/il-13 et d'ablation de plasmocytes pour traiter une allergie
AU2020245329A1 (en) * 2019-03-26 2021-10-28 Gavish-Galilee Bio Applications Ltd. Genetically reprogrammed Tregs expressing CARs
GB201904971D0 (en) 2019-04-08 2019-05-22 Autolus Ltd Cell
GB201906202D0 (en) 2019-05-02 2019-06-19 Autolus Ltd Cell
CN113784732B (zh) 2019-05-07 2024-03-22 亘喜生物科技(上海)有限公司 靶向bcma的工程化免疫细胞及其用途
US12570743B2 (en) 2019-05-07 2026-03-10 Gracell Bioscience (Shanghai) Co., Ltd. BCMA-targeting engineered immune cell and use thereof
TWI905099B (zh) 2019-05-21 2025-11-21 瑞士商諾華公司 Cd19 結合分子及其用途
CN110592015A (zh) * 2019-09-27 2019-12-20 中国科学院西双版纳热带植物园 一种诱导增强cik细胞的滇重楼多糖组合物及其应用
CN116635064A (zh) 2020-12-18 2023-08-22 世纪治疗股份有限公司 具有适应性受体特异性的嵌合抗原受体系统
KR20250047766A (ko) 2022-08-05 2025-04-04 주노 쎄러퓨티크스 인코퍼레이티드 Gprc5d 및 bcma에 특이적인 키메라 항원 수용체
WO2025076113A1 (en) 2023-10-05 2025-04-10 Capstan Therapeutics, Inc. Ionizable cationic lipids with conserved spacing and lipid nanoparticles
WO2025076127A1 (en) 2023-10-05 2025-04-10 Capstan Therapeutics, Inc. Constrained ionizable cationic lipids and lipid nanoparticles
US20250242018A1 (en) 2024-01-26 2025-07-31 Regeneron Pharmaceuticals, Inc. Combination immunosuppression for inhibiting an immune response and enabling immunogen administration and re-administration
TW202540428A (zh) 2024-01-26 2025-10-16 美商雷傑納榮製藥公司 使用漿細胞耗乏劑及/或b細胞耗乏劑遏制宿主抗aav抗體反應且實現aav轉導及重複給藥的方法及組成物
US20250276092A1 (en) 2024-03-01 2025-09-04 Regeneron Pharmaceuticals, Inc. Methods and compositions for re-dosing aav using anti-cd40 antagonistic antibody to suppress host anti-aav antibody response
GB202403564D0 (en) 2024-03-12 2024-04-24 Autolus Ltd Method
WO2025217452A1 (en) 2024-04-11 2025-10-16 Capstan Therapeutics, Inc. Constrained ionizable cationic lipids and lipid nanoparticles
WO2025217454A2 (en) 2024-04-11 2025-10-16 Capstan Therapeutics, Inc. Ionizable cationic lipids and lipid nanoparticles

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ294615B6 (cs) * 1997-09-12 2005-02-16 Apotech R & D Sa Léčivo obsahující protilátky reaktivní s polypeptidovým ligandem APRIL pro léčení rakoviny
UA74798C2 (uk) * 1999-10-06 2006-02-15 Байоджен Айдек Ма Інк. Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами
SI1297013T1 (sl) * 2000-04-27 2007-06-30 Biogen Idec Inc Uporaba TACI kot protitumorskega sredstva
AU2001288260A1 (en) * 2000-08-15 2002-03-13 Human Genome Sciences, Inc. Neutrokine-alpha and neutrokine-alpha splice variant
WO2002066516A2 (en) * 2001-02-20 2002-08-29 Zymogenetics, Inc. Antibodies that bind both bcma and taci
CA2887716C (en) * 2002-04-09 2017-01-24 Biogen Idec Ma Inc. Methods for treating tweak-related conditions
AU2003270715A1 (en) * 2002-09-19 2004-04-08 Biogen Idec Ma Inc. Improved methods for preparing highly active april ligand polypeptides
WO2006067210A1 (en) * 2004-12-23 2006-06-29 Laboratoires Serono S.A. Bcma polypeptides and uses thereof
AT503861B1 (de) * 2006-07-05 2008-06-15 F Star Biotech Forsch & Entw Verfahren zur manipulation von t-zell-rezeptoren
WO2008045437A2 (en) 2006-10-09 2008-04-17 The General Hospital Corporation Chimeric t-cell receptors and t-cells targeting egfrviii on tumors
TWI679212B (zh) 2011-11-15 2019-12-11 美商安進股份有限公司 針對bcma之e3以及cd3的結合分子
EA201990959A1 (ru) * 2012-04-11 2020-02-10 Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез Химерные антигенные рецепторы, нацеленные на антиген созревания b-клеток
CN103145849B (zh) * 2013-02-18 2014-06-11 冯振卿 嵌合抗原受体及其用途
GB201317929D0 (en) * 2013-10-10 2013-11-27 Ucl Business Plc Chimeric antigen receptor
WO2015128653A2 (en) 2014-02-27 2015-09-03 Ucl Business Plc Ligand
CN110114371A (zh) 2016-11-11 2019-08-09 奥托路斯有限公司 嵌合抗原受体
GB201709508D0 (en) 2017-06-15 2017-08-02 Autolus Ltd Chimeric antigen receptor
US20210054086A1 (en) * 2018-01-10 2021-02-25 The General Hospital Corporation Immune cells expressing a chimeric antigen receptor

Similar Documents

Publication Publication Date Title
JP2016538830A5 (enExample)
JP2016537966A5 (enExample)
JP2017508466A5 (enExample)
RU2019102382A (ru) Химерный антигенный рецептор
JP2017500869A5 (enExample)
JP2018531014A5 (enExample)
JP2018500014A5 (enExample)
EP4282877A3 (en) Chimeric antigen receptors targeting bcma and methods of use thereof
JP2010511388A5 (enExample)
JP2017514787A5 (enExample)
JP2014534242A5 (enExample)
JP2017506217A5 (enExample)
JP2016196468A5 (enExample)
JP2019511222A5 (enExample)
JP2017501129A5 (enExample)
JP2013538057A5 (enExample)
JP2016520074A5 (enExample)
JP2020511152A5 (enExample)
JP2017501130A5 (enExample)
HRP20161656T4 (hr) Sredstva za vezanje na cd33
RU2018121619A (ru) Pd1/ctla4-связывающие вещества
HRP20241228T1 (hr) T stanični receptori i imunološka terapija uporabom istih protiv pram pozitivnih karcinoma
JP2016505635A5 (enExample)
JP2009535021A5 (enExample)
FI4050034T3 (fi) Cd3:een sitoutuvia vasta-aineita