JP2009535021A5 - - Google Patents

Info

Publication number

JP2009535021A5

JP2009535021A5 JP2009506889A JP2009506889A JP2009535021A5 JP 2009535021 A5 JP2009535021 A5 JP 2009535021A5 JP 2009506889 A JP2009506889 A JP 2009506889A JP 2009506889 A JP2009506889 A JP 2009506889A JP 2009535021 A5 JP2009535021 A5 JP 2009535021A5

Authority

JP

Japan

Prior art keywords

sequence

antibody

seq

identity

heavy chain

Prior art date

2007-04-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 101000779641 Homo sapiens ALK tyrosine kinase receptor Proteins 0.000 claims 10
• 102100033793 ALK tyrosine kinase receptor Human genes 0.000 claims 8
• 108090000765 processed proteins & peptides Proteins 0.000 claims 5
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
• 150000001413 amino acids Chemical class 0.000 claims 4
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• 229940079593 drug Drugs 0.000 claims 3
• 230000035772 mutation Effects 0.000 claims 3
• 206010028980 Neoplasm Diseases 0.000 claims 2
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• 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
• 125000000539 amino acid group Chemical group 0.000 claims 2
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
• 239000013604 expression vector Substances 0.000 claims 2
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• 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
• 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
• FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
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