DE60141518D1 - Pleiotrophin wachstumfaktor rezeptor alk zur behandlung von proliferativen, gefässer- und neurologischen erkrankungen - Google Patents
Pleiotrophin wachstumfaktor rezeptor alk zur behandlung von proliferativen, gefässer- und neurologischen erkrankungenInfo
- Publication number
- DE60141518D1 DE60141518D1 DE60141518T DE60141518T DE60141518D1 DE 60141518 D1 DE60141518 D1 DE 60141518D1 DE 60141518 T DE60141518 T DE 60141518T DE 60141518 T DE60141518 T DE 60141518T DE 60141518 D1 DE60141518 D1 DE 60141518D1
- Authority
- DE
- Germany
- Prior art keywords
- pleiotrophin
- pleiotrophine
- proliferative
- vascular
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000011282 treatment Methods 0.000 title abstract 2
- 102000009465 Growth Factor Receptors Human genes 0.000 title 1
- 108010009202 Growth Factor Receptors Proteins 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000000926 neurological effect Effects 0.000 title 1
- 230000002062 proliferating effect Effects 0.000 title 1
- 230000002792 vascular Effects 0.000 title 1
- 108090000368 Fibroblast growth factor 8 Proteins 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 3
- 102000005162 pleiotrophin Human genes 0.000 abstract 3
- 208000005623 Carcinogenesis Diseases 0.000 abstract 1
- 208000012239 Developmental disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000036952 cancer formation Effects 0.000 abstract 1
- 231100000504 carcinogenesis Toxicity 0.000 abstract 1
- 230000004709 cell invasion Effects 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037824 growth disorder Diseases 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 230000002452 interceptive effect Effects 0.000 abstract 1
- 239000002547 new drug Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21149100P | 2000-06-14 | 2000-06-14 | |
| PCT/US2001/018938 WO2001096394A2 (en) | 2000-06-14 | 2001-06-14 | Pleiotrophin growth factor receptor for the treatment of proliferative, vascular and neurological disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60141518D1 true DE60141518D1 (de) | 2010-04-22 |
Family
ID=22787128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60141518T Expired - Lifetime DE60141518D1 (de) | 2000-06-14 | 2001-06-14 | Pleiotrophin wachstumfaktor rezeptor alk zur behandlung von proliferativen, gefässer- und neurologischen erkrankungen |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US7528109B2 (de) |
| EP (1) | EP1305337B1 (de) |
| AT (1) | ATE460427T1 (de) |
| AU (3) | AU6687601A (de) |
| CA (2) | CA2412650C (de) |
| DE (1) | DE60141518D1 (de) |
| WO (1) | WO2001096394A2 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2401633A1 (en) * | 2000-02-29 | 2001-09-07 | Barnes-Jewish Hospital | Modulation of pleiotrophin signaling by receptor-type protein tyrosine phosphatase .beta./.zeta. |
| EP1305337B1 (de) * | 2000-06-14 | 2010-03-10 | Georgetown University | Pleiotrophin wachstumfaktor rezeptor alk zur behandlung von proliferativen, gefässer- und neurologischen erkrankungen |
| US7888485B2 (en) * | 2003-03-26 | 2011-02-15 | Georgetown University | Anti-pleiotrophin antibodies and methods of use thereof |
| WO2005014022A1 (en) * | 2003-07-16 | 2005-02-17 | Develogen Aktiengesellschaft | Use of pleitrophin for preventing and treating pancreatic diseases and/or obesity and/or metabolic syndrome |
| US7951532B2 (en) | 2003-11-12 | 2011-05-31 | Children's Hospital Medical Center | Method of screening a midkine modulating agent |
| WO2007002543A2 (en) | 2005-06-23 | 2007-01-04 | Medimmune, Inc. | Antibody formulations having optimized aggregation and fragmentation profiles |
| WO2007059300A2 (en) * | 2005-11-15 | 2007-05-24 | Medimmune, Inc. | Anti-alk antagonist and agonist antibodies and uses thereof |
| AU2012244351B2 (en) * | 2006-04-28 | 2014-05-15 | Delenex Therapeutics Ag | Antibodies binding to the extracellular domain of the Receptor Tyrosine Kinase ALK |
| PL2013236T3 (pl) | 2006-04-28 | 2015-12-31 | Delenex Therapeutics Ag | Przeciwciała łączące się z zewnątrzkomórkową domeną receptora kinazy tyrozynowej ALK |
| KR101582852B1 (ko) * | 2012-05-24 | 2016-01-07 | 서울대학교 산학협력단 | 타우 단백질 매개 신경 퇴행성 질환 치료제 |
| US11091559B2 (en) | 2015-08-27 | 2021-08-17 | Celldex Therapeutics, Inc. | Anti-ALK antibodies and methods for use thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5529925A (en) | 1993-12-03 | 1996-06-25 | St. Jude Children's Research Hospital | Nucleic acid sequences and fusion proteins present in human t(2;5) lymphoma |
| US6696548B2 (en) | 1993-12-03 | 2004-02-24 | St. Jude Children's Research Hospital | Antibodies for recognition of alk protein tyrosine/kinase receptor |
| US5675063A (en) * | 1995-02-28 | 1997-10-07 | Loyola University Of Chicago | Immortalized rabbit hybridoma fusion partner |
| US20020173629A1 (en) * | 1997-05-05 | 2002-11-21 | Aya Jakobovits | Human monoclonal antibodies to epidermal growth factor receptor |
| EP1071445A2 (de) * | 1998-04-17 | 2001-01-31 | Angiogenix, Incorporated | Therapeutische angiogene faktoren und methoden zu deren verwendung |
| EP1121598A4 (de) | 1998-10-06 | 2002-01-30 | Univ Georgetown | Nachweis von pleiotrophin |
| AU1236801A (en) * | 1999-10-27 | 2001-05-08 | Chiron Corporation | Activation of hcv-specific t cells |
| EP1305337B1 (de) * | 2000-06-14 | 2010-03-10 | Georgetown University | Pleiotrophin wachstumfaktor rezeptor alk zur behandlung von proliferativen, gefässer- und neurologischen erkrankungen |
| US6569431B2 (en) * | 2000-10-17 | 2003-05-27 | The Regents Of The University Of California | Recombinant antibody fragments as autoantibody antagonists |
| US20030073623A1 (en) * | 2001-07-30 | 2003-04-17 | Drmanac Radoje T. | Novel nucleic acid sequences obtained from various cDNA libraries |
| US20030158132A1 (en) * | 2002-01-22 | 2003-08-21 | Genvec, Inc. | Method for enhancing bone density or formation |
| US7888485B2 (en) * | 2003-03-26 | 2011-02-15 | Georgetown University | Anti-pleiotrophin antibodies and methods of use thereof |
-
2001
- 2001-06-14 EP EP01944466A patent/EP1305337B1/de not_active Expired - Lifetime
- 2001-06-14 CA CA2412650A patent/CA2412650C/en not_active Expired - Fee Related
- 2001-06-14 US US09/880,097 patent/US7528109B2/en not_active Expired - Fee Related
- 2001-06-14 AT AT01944466T patent/ATE460427T1/de not_active IP Right Cessation
- 2001-06-14 AU AU6687601A patent/AU6687601A/xx active Pending
- 2001-06-14 DE DE60141518T patent/DE60141518D1/de not_active Expired - Lifetime
- 2001-06-14 AU AU2001266876A patent/AU2001266876B2/en not_active Ceased
- 2001-06-14 WO PCT/US2001/018938 patent/WO2001096394A2/en active Application Filing
- 2001-06-14 CA CA2736957A patent/CA2736957A1/en not_active Abandoned
-
2006
- 2006-05-18 US US11/436,244 patent/US7608264B2/en not_active Expired - Fee Related
- 2006-11-23 AU AU2006241331A patent/AU2006241331B2/en not_active Ceased
-
2009
- 2009-09-11 US US12/557,559 patent/US20100111964A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1305337B1 (de) | 2010-03-10 |
| AU2006241331B2 (en) | 2010-02-11 |
| US7528109B2 (en) | 2009-05-05 |
| US20090232815A1 (en) | 2009-09-17 |
| AU2006241331A1 (en) | 2006-12-14 |
| CA2412650A1 (en) | 2001-12-20 |
| EP1305337A2 (de) | 2003-05-02 |
| AU6687601A (en) | 2001-12-24 |
| CA2412650C (en) | 2011-08-02 |
| WO2001096394A3 (en) | 2003-03-06 |
| US7608264B2 (en) | 2009-10-27 |
| US20020034768A1 (en) | 2002-03-21 |
| WO2001096394A2 (en) | 2001-12-20 |
| US20100111964A1 (en) | 2010-05-06 |
| CA2736957A1 (en) | 2001-12-20 |
| AU2001266876B2 (en) | 2006-08-31 |
| ATE460427T1 (de) | 2010-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |