EA200800011A1 - Тиенопиримидиновые и тиенопиридиновые модуляторы киназы - Google Patents

Тиенопиримидиновые и тиенопиридиновые модуляторы киназы

Info

Publication number
EA200800011A1
EA200800011A1 EA200800011A EA200800011A EA200800011A1 EA 200800011 A1 EA200800011 A1 EA 200800011A1 EA 200800011 A EA200800011 A EA 200800011A EA 200800011 A EA200800011 A EA 200800011A EA 200800011 A1 EA200800011 A1 EA 200800011A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
flt3
thyenopyrimidine
thyenopyridine
kinase modulators
Prior art date
Application number
EA200800011A
Other languages
English (en)
Inventor
Майкл Дэвид Гаул
Кевин Дуглас Кройттер
Кристиан Эндрю Бауманн
Original Assignee
Янссен Фармацевтика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Н.В. filed Critical Янссен Фармацевтика Н.В.
Publication of EA200800011A1 publication Critical patent/EA200800011A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Изобретение относится к тиенопиримидиновым и тиенопиридиновым соединениям формулы I и формулы II,где R, R, В, Z, Q, р, q и Х определены в настоящем описании, применению таких соединений в качестве модуляторов тирозиновых протеинкиназ, в частности ингибиторов FLT3, применению таких соединений для снижения или ингибирования киназной активности FLT3 в клетке или у пациента и применению таких соединений для профилактики или лечения у пациента клеточного пролиферативного расстройства и/или расстройств, связанных с FLT3. Настоящее изобретение, кроме того, относится к фармацевтическим композициям, включающим соединения по настоящему изобретению, и к способам лечения таких состояний, как раковые заболевания и другие клеточные пролиферативные расстройства.
EA200800011A 2005-06-10 2006-06-07 Тиенопиримидиновые и тиенопиридиновые модуляторы киназы EA200800011A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68971005P 2005-06-10 2005-06-10
US74694106P 2006-05-10 2006-05-10
PCT/US2006/022151 WO2006135639A1 (en) 2005-06-10 2006-06-07 Thiξnopyrimidine and thienopyridine derivatives as flt-3 kinase inhibitors

Publications (1)

Publication Number Publication Date
EA200800011A1 true EA200800011A1 (ru) 2008-06-30

Family

ID=37074647

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200800011A EA200800011A1 (ru) 2005-06-10 2006-06-07 Тиенопиримидиновые и тиенопиридиновые модуляторы киназы

Country Status (19)

Country Link
US (3) US20060281768A1 (ru)
EP (1) EP1899355A1 (ru)
JP (1) JP2008543759A (ru)
KR (1) KR20080021126A (ru)
AR (1) AR057063A1 (ru)
AU (1) AU2006258049A1 (ru)
BR (1) BRPI0613644A2 (ru)
CA (1) CA2611587A1 (ru)
CR (1) CR9650A (ru)
EA (1) EA200800011A1 (ru)
EC (1) ECSP077992A (ru)
IL (1) IL187689A0 (ru)
MX (1) MX2007015741A (ru)
NI (1) NI200700311A (ru)
NO (1) NO20080162L (ru)
PE (1) PE20070070A1 (ru)
TW (1) TW200716651A (ru)
UY (1) UY29590A1 (ru)
WO (1) WO2006135639A1 (ru)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY179032A (en) 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
JP5606734B2 (ja) 2006-04-25 2014-10-15 アステックス、セラピューティックス、リミテッド 医薬化合物
US20090124610A1 (en) * 2006-04-25 2009-05-14 Gordon Saxty Pharmaceutical compounds
WO2008039794A1 (en) * 2006-09-25 2008-04-03 Arete Therapeutics, Inc. Soluble epoxide hydrolase inhibitors
US8193178B2 (en) 2007-09-14 2012-06-05 Janssen Pharmaceutica Nv Thieno- and furo-pyrimidine modulators of the histamine H4 receptor
CN101861321B (zh) 2007-10-11 2013-02-06 阿斯利康(瑞典)有限公司 作为蛋白激酶b抑制剂的吡咯并[2,3-d]嘧啶衍生物
US9402847B2 (en) 2011-04-01 2016-08-02 Astrazeneca Ab Combinations comprising (S)-4-amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide
JP5933902B2 (ja) 2011-05-13 2016-06-15 アレイ バイオファーマ、インコーポレイテッド Ｔｒｋａキナーゼ阻害剤としてのピロリジニル尿素およびピロリジニルチオ尿素化合物
AR090037A1 (es) * 2011-11-15 2014-10-15 Xention Ltd Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio
CA2856646C (en) 2011-11-30 2020-01-14 Astrazeneca Ab Combination treatment of cancer
AU2013204533B2 (en) 2012-04-17 2017-02-02 Astrazeneca Ab Crystalline forms
RS59286B1 (sr) 2014-05-15 2019-10-31 Array Biopharma Inc 1-((3s,4r)-4-(3-fluorofenil)-1-(2-metoksietil)pirolidin-3-il)-3-(4-metil-3-(2-metilpirimidin-5-il)-1-fenil-1h-pirazol-5-il)urea kao inhibitor trka kinaze
EP3559006A4 (en) * 2016-12-23 2021-03-03 Arvinas Operations, Inc. COMPOUNDS AND METHODS FOR TARGETED DEGRADATION OF FETAL LIVER KINASE POLYPEPTIDES
CN113874015A (zh) 2018-12-21 2021-12-31 细胞基因公司 Ripk2的噻吩并吡啶抑制剂

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0627940B1 (en) * 1992-03-05 2003-05-07 Board of Regents, The University of Texas System Use of immunoconjugates for the diagnosis and/or therapy of vascularized tumors
US5474765A (en) * 1992-03-23 1995-12-12 Ut Sw Medical Ctr At Dallas Preparation and use of steroid-polyanionic polymer-based conjugates targeted to vascular endothelial cells
US5932765A (en) * 1997-05-23 1999-08-03 Merck Patent Gesellschaft Mit Nitromethyl ketones, process for preparing them and compositions containing them
CN1280580A (zh) * 1997-11-11 2001-01-17 辉瑞产品公司 用作抗癌药的噻吩并嘧啶和噻吩并吡啶衍生物
ZA99607B (en) * 1998-01-27 1999-07-27 Rhone Poulenc Rorer Pharma Substituted oxoazaheterocyclyl factor xa inhibitors.
WO2000064946A2 (en) * 1999-04-28 2000-11-02 Board Of Regents, The University Of Texas System Compositions and methods for cancer treatment by selectively inhibiting vegf
US6776796B2 (en) * 2000-05-12 2004-08-17 Cordis Corportation Antiinflammatory drug and delivery device
DE10110750A1 (de) * 2001-03-07 2002-09-12 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
AR035885A1 (es) * 2001-05-14 2004-07-21 Novartis Ag Derivados de 4-amino-5-fenil-7-ciclobutilpirrolo (2,3-d)pirimidina, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos derivados para la preparacion de una composicion farmaceutica
US7105505B2 (en) * 2002-04-18 2006-09-12 Schering Corporation Benzimidazole derivatives useful as histamine H3 antagonists
MY141867A (en) * 2002-06-20 2010-07-16 Vertex Pharma Substituted pyrimidines useful as protein kinase inhibitors
MXPA05001631A (es) * 2002-08-12 2005-08-19 Takeda Pharmaceutical Derivado de benceno fusionado y su uso.
JPWO2004039782A1 (ja) * 2002-10-29 2006-03-02 麒麟麦酒株式会社 Ｆｌｔ３自己リン酸化を阻害するキノリン誘導体およびキナゾリン誘導体並びにそれらを含有する医薬組成物
US20050026944A1 (en) * 2003-07-24 2005-02-03 Patrick Betschmann Thienopyridine and furopyridine kinase inhibitors
US20060281769A1 (en) * 2005-06-10 2006-12-14 Baumann Christian A Synergistic modulation of flt3 kinase using thienopyrimidine and thienopyridine kinase modulators

Also Published As

Publication number Publication date
NI200700311A (es) 2009-03-03
KR20080021126A (ko) 2008-03-06
AU2006258049A1 (en) 2006-12-21
JP2008543759A (ja) 2008-12-04
TW200716651A (en) 2007-05-01
CA2611587A1 (en) 2006-12-21
WO2006135639A1 (en) 2006-12-21
UY29590A1 (es) 2006-10-02
NO20080162L (no) 2008-03-07
ECSP077992A (es) 2008-01-23
MX2007015741A (es) 2008-04-29
US20060281768A1 (en) 2006-12-14
PE20070070A1 (es) 2007-03-08
CR9650A (es) 2008-09-09
BRPI0613644A2 (pt) 2011-01-25
EP1899355A1 (en) 2008-03-19
US20090163710A1 (en) 2009-06-25
US20090143378A1 (en) 2009-06-04
AU2006258049A8 (en) 2006-12-21
IL187689A0 (en) 2008-08-07
AR057063A1 (es) 2007-11-14

Similar Documents

Publication Publication Date Title
EA200800011A1 (ru) Тиенопиримидиновые и тиенопиридиновые модуляторы киназы
TW200716598A (en) Aminoquinoline and aminoquinazoline kinase modulators
TW200801007A (en) Triazolopyridazines as kinase modulators
EA200800017A1 (ru) Алкилхинолиновые и алкилхиназолиновые модуляторы киназы
EA200602100A1 (ru) Соединения и способы для ингибирования митотической прогрессии
EA200800018A1 (ru) Аминопиримидины в качестве модуляторов киназы
NO20061194L (no) Mitotiske kinesininbibitorer
EA200870373A1 (ru) Пиридил- и пиримидинилзамещённые производные пиррола, тиофена и фурана в качестве ингибиторов киназ
DE602004014117D1 (de) Thiazole zur verwendung als inhibitoren von protein-kinasen
GEP20094845B (en) Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors
BR0316350A (pt) Diaminotriazóis úteis como inibidores de proteìna cinases
ATE450530T1 (de) Zusammensetzungen zur verwendung als protein- kinase-inhibitoren
EA200800015A1 (ru) Аминопиримидины в качестве модуляторов киназы
HK1096673A1 (en) Compositions useful as inhibitors of protein kinases
IL173348A (en) Thienopyridine compounds, pharmaceuticals containing them and their use in the preparation of drugs
TW200634012A (en) 3-amino-pyrazolo[3,4b]pyridines as inhibitors of protein tyrosine kinases, their production and use as pharmaceutical agents
ATE435858T1 (de) Prodrugs von als erk-proteinkinase-inhibitoren wirkenden pyrrolylpyrimidinen
ATE419249T1 (de) Inhibitoren von mitotischem kinesin
TW200740808A (en) Inhibiteurs de proteines kinases
MX2010003563A (es) Inhibidores de proteina cinasa de c-met.
MX2008013017A (es) Tratamiento de malignidades hematologicas con fts y un inhibidor de tirosina cinasa de bcr-abl.
BRPI0411864A (pt) combinação de inibidores de src quinase e agentes quimioterápicos para o tratamento de doenças proliferativas
ATE465165T1 (de) Pyrimidothienindazole als tyrosinkinasehemmer des epidermalen wachstumsfaktors
TW200503722A (en) Substituted 7-aza-quinazoline compounds
MX2007013306A (es) Nuevas tiazolidinonas sin nitrogeno basico, su produccion y su uso como agentes farmaceuticos.