UY29590A1 - Moduladores de tienopirimidina y tienopiridina quinasa - Google Patents

Moduladores de tienopirimidina y tienopiridina quinasa

Info

Publication number
UY29590A1
UY29590A1 UY29590A UY29590A UY29590A1 UY 29590 A1 UY29590 A1 UY 29590A1 UY 29590 A UY29590 A UY 29590A UY 29590 A UY29590 A UY 29590A UY 29590 A1 UY29590 A1 UY 29590A1
Authority
UY
Uruguay
Prior art keywords
compounds
modulators
flt3
tienopirimidine
tienopiridine
Prior art date
Application number
UY29590A
Other languages
English (en)
Inventor
Michael David Gaul
Christian Andrew Baumann
Kevinn Douglas Kreutter
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of UY29590A1 publication Critical patent/UY29590A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Materials For Medical Uses (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invención está dirigida a compuestos tienopirimidinas y tienopiridinas de Fórmula I y Fórmula II: donde R1, R3, B,Z,Q, ,q y X son tal como se han definido aquí, al uso de dichos compuestos como moduladores de la proteína tirosinquinasa, particularmente inhibidores de FLT3, al uso de dichos compuestos para reducir o inhibir la actividad quinasa de FLT3 en una célula o en un sujeto, y al uso de dichos compuestos para prevenir o tratar en un sujeto, un desorden proliferativo de células y/o desordenes relacionados con FLT3. La presente invención está además dirigida a las composiciones farmacéuticas que comprenden los compuestos de la presente invención y a los métodos para tratar trastornos tales como cánceres y otros desórdenes proliferativos de células.
UY29590A 2005-06-10 2006-06-08 Moduladores de tienopirimidina y tienopiridina quinasa UY29590A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68971005P 2005-06-10 2005-06-10
US74694106P 2006-05-10 2006-05-10

Publications (1)

Publication Number Publication Date
UY29590A1 true UY29590A1 (es) 2006-10-02

Family

ID=37074647

Family Applications (1)

Application Number Title Priority Date Filing Date
UY29590A UY29590A1 (es) 2005-06-10 2006-06-08 Moduladores de tienopirimidina y tienopiridina quinasa

Country Status (19)

Country Link
US (3) US20060281768A1 (es)
EP (1) EP1899355A1 (es)
JP (1) JP2008543759A (es)
KR (1) KR20080021126A (es)
AR (1) AR057063A1 (es)
AU (1) AU2006258049A1 (es)
BR (1) BRPI0613644A2 (es)
CA (1) CA2611587A1 (es)
CR (1) CR9650A (es)
EA (1) EA200800011A1 (es)
EC (1) ECSP077992A (es)
IL (1) IL187689A0 (es)
MX (1) MX2007015741A (es)
NI (1) NI200700311A (es)
NO (1) NO20080162L (es)
PE (1) PE20070070A1 (es)
TW (1) TW200716651A (es)
UY (1) UY29590A1 (es)
WO (1) WO2006135639A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY179032A (en) 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
DK3421471T3 (da) 2006-04-25 2021-06-14 Astex Therapeutics Ltd Purin- og deazapurinderivater som farmaceutiske forbindelser
JP2009534454A (ja) * 2006-04-25 2009-09-24 アステックス、セラピューティックス、リミテッド 医薬化合物
US20080076770A1 (en) * 2006-09-25 2008-03-27 Arete Therapeutics, Inc. Soluble epoxide hydrolase inhibitors
KR101470933B1 (ko) 2007-09-14 2014-12-09 얀센 파마슈티카 엔.브이. 히스타민 ｈ4 수용체의 티에노- 및 푸로-피리미딘 조절제
MY150059A (en) 2007-10-11 2013-11-29 Astrazeneca Ab Pyrrolo [2,3-d] pyrimidin derivatives as protein kinase b inhibitors
EP2694056B1 (en) 2011-04-01 2019-10-16 AstraZeneca AB Therapeutic treatment
KR101960555B1 (ko) 2011-05-13 2019-03-20 어레이 바이오파마 인크. Trka 키나제 저해제로서의 피롤리디닐 유레아 및 피롤리디닐 티오유레아 화합물
AR090037A1 (es) * 2011-11-15 2014-10-15 Xention Ltd Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio
WO2013079964A1 (en) 2011-11-30 2013-06-06 Astrazeneca Ab Combination treatment of cancer
AU2013204533B2 (en) 2012-04-17 2017-02-02 Astrazeneca Ab Crystalline forms
MA40434B1 (fr) 2014-05-15 2019-09-30 Array Biopharma Inc 1-((3s,4r)-4-(3-fluorophényl)-1-(2-méthoxyéthyl)pyrrolidin-3-yl)-3-(4-méthyl-3-(2-méthylpyrimidin-5-yl)-1-phényl-1h-pyrazol-5-yl)urée comme inhibiteur de la kinase trka
EP3559006A4 (en) * 2016-12-23 2021-03-03 Arvinas Operations, Inc. COMPOUNDS AND METHODS FOR TARGETED DEGRADATION OF FETAL LIVER KINASE POLYPEPTIDES
TW202039481A (zh) 2018-12-21 2020-11-01 美商西建公司 Ripk2之噻吩并吡啶抑制劑

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE239506T1 (de) * 1992-03-05 2003-05-15 Univ Texas Verwendung von immunokonjugate zur diagnose und/oder therapie der vaskularisierten tumoren
US5474765A (en) * 1992-03-23 1995-12-12 Ut Sw Medical Ctr At Dallas Preparation and use of steroid-polyanionic polymer-based conjugates targeted to vascular endothelial cells
US5932765A (en) * 1997-05-23 1999-08-03 Merck Patent Gesellschaft Mit Nitromethyl ketones, process for preparing them and compositions containing them
CN101328186A (zh) * 1997-11-11 2008-12-24 辉瑞产品公司 用作抗癌药的噻吩并嘧啶和噻吩并吡啶衍生物
CN1291892A (zh) * 1998-01-27 2001-04-18 阿温蒂斯药物制品公司 取代的氧代氮杂杂环基因子Xa抑制剂
CA2372053C (en) * 1999-04-28 2008-09-02 Board Of Regents, The University Of Texas System Compositions and methods for cancer treatment by selectively inhibiting vegf
US6776796B2 (en) * 2000-05-12 2004-08-17 Cordis Corportation Antiinflammatory drug and delivery device
DE10110750A1 (de) * 2001-03-07 2002-09-12 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
TWI238824B (en) * 2001-05-14 2005-09-01 Novartis Ag 4-amino-5-phenyl-7-cyclobutyl-pyrrolo[2,3-d]pyrimidine derivatives
US7105505B2 (en) * 2002-04-18 2006-09-12 Schering Corporation Benzimidazole derivatives useful as histamine H3 antagonists
MY141867A (en) * 2002-06-20 2010-07-16 Vertex Pharma Substituted pyrimidines useful as protein kinase inhibitors
CA2495383A1 (en) * 2002-08-12 2004-02-26 Takeda Pharmaceutical Company Limited Fused benzene derivative and use
AU2003280599A1 (en) * 2002-10-29 2004-05-25 Kirin Beer Kabushiki Kaisha QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF Flt3 AND MEDICINAL COMPOSITIONS CONTAINING THE SAME
US20050026944A1 (en) * 2003-07-24 2005-02-03 Patrick Betschmann Thienopyridine and furopyridine kinase inhibitors
US20060281769A1 (en) * 2005-06-10 2006-12-14 Baumann Christian A Synergistic modulation of flt3 kinase using thienopyrimidine and thienopyridine kinase modulators

Also Published As

Publication number Publication date
KR20080021126A (ko) 2008-03-06
EP1899355A1 (en) 2008-03-19
JP2008543759A (ja) 2008-12-04
AU2006258049A8 (en) 2006-12-21
IL187689A0 (en) 2008-08-07
AR057063A1 (es) 2007-11-14
MX2007015741A (es) 2008-04-29
WO2006135639A1 (en) 2006-12-21
EA200800011A1 (ru) 2008-06-30
NI200700311A (es) 2009-03-03
US20090143378A1 (en) 2009-06-04
TW200716651A (en) 2007-05-01
US20090163710A1 (en) 2009-06-25
BRPI0613644A2 (pt) 2011-01-25
NO20080162L (no) 2008-03-07
CA2611587A1 (en) 2006-12-21
US20060281768A1 (en) 2006-12-14
CR9650A (es) 2008-09-09
ECSP077992A (es) 2008-01-23
PE20070070A1 (es) 2007-03-08
AU2006258049A1 (en) 2006-12-21

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