NI200700311A - Derivados de tienopirimidina y tienopiridina como inhibidores de la cinasa de flt-3 - Google Patents
Derivados de tienopirimidina y tienopiridina como inhibidores de la cinasa de flt-3Info
- Publication number
- NI200700311A NI200700311A NI200700311A NI200700311A NI200700311A NI 200700311 A NI200700311 A NI 200700311A NI 200700311 A NI200700311 A NI 200700311A NI 200700311 A NI200700311 A NI 200700311A NI 200700311 A NI200700311 A NI 200700311A
- Authority
- NI
- Nicaragua
- Prior art keywords
- compounds
- kinase
- inhibitors
- tienopirimidine
- tienopiridine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
La invención se refiere a compuestos de tienopirimidinas y tienopiridinas de Fórmula I y Fórmula II: donde R1, R3, B, Z, Q, p, q, y X son como se definen en presente documento, el uso de tales compuestos como moduladores de la proteína de tirosina cinasa, en particular inhibidores de FLT3, el uso de tales compuestos para reducir o inhibir la actividad de la cinasa de FLT3 en una célula o en un sujeto, y el uso de tales compuestos para prevenir o tratar en un sujeto un trastorno prolífero de célua y/o trastornos relacionados a FLT3. La presente invención también se refiere a composiciones farmacéuticas que comprenden los compuestos de la presente invención y a métodos para tratar condiciones tales como canceres y otros trastornos prolíferos de células.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68971005P | 2005-06-10 | 2005-06-10 | |
US74694106P | 2006-05-10 | 2006-05-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
NI200700311A true NI200700311A (es) | 2009-03-03 |
Family
ID=37074647
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NI200700311A NI200700311A (es) | 2005-06-10 | 2006-06-07 | Derivados de tienopirimidina y tienopiridina como inhibidores de la cinasa de flt-3 |
Country Status (19)
Country | Link |
---|---|
US (3) | US20060281768A1 (es) |
EP (1) | EP1899355A1 (es) |
JP (1) | JP2008543759A (es) |
KR (1) | KR20080021126A (es) |
AR (1) | AR057063A1 (es) |
AU (1) | AU2006258049A1 (es) |
BR (1) | BRPI0613644A2 (es) |
CA (1) | CA2611587A1 (es) |
CR (1) | CR9650A (es) |
EA (1) | EA200800011A1 (es) |
EC (1) | ECSP077992A (es) |
IL (1) | IL187689A0 (es) |
MX (1) | MX2007015741A (es) |
NI (1) | NI200700311A (es) |
NO (1) | NO20080162L (es) |
PE (1) | PE20070070A1 (es) |
TW (1) | TW200716651A (es) |
UY (1) | UY29590A1 (es) |
WO (1) | WO2006135639A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
EP2013206A1 (en) * | 2006-04-25 | 2009-01-14 | Astex Therapeutics Limited | Pharmaceutical compounds |
EP2043655A2 (en) | 2006-04-25 | 2009-04-08 | Astex Therapeutics Limited | Purine and deazapurine derivatives as pharmaceutical compounds |
JP2010504362A (ja) * | 2006-09-25 | 2010-02-12 | アレテ セラピューティクス, インコーポレイテッド | 可溶性エポキシドヒドロラーゼ阻害剤 |
AU2008301897B2 (en) * | 2007-09-14 | 2013-08-01 | Janssen Pharmaceutica N.V. | Thieno-and furo-pyrimidine modulators of the histamine H4 receptor |
RS53552B1 (en) | 2007-10-11 | 2015-02-27 | Astrazeneca Ab | DERIVATI PIROLO [2,3-D] PIRIMIDINA KAO INHIBITORI PROTEIN KINAZE B |
WO2012131399A1 (en) | 2011-04-01 | 2012-10-04 | Astrazeneca Ab | Therapeutic treatment |
CN105130967B (zh) | 2011-05-13 | 2018-04-17 | 阵列生物制药公司 | 作为trka激酶抑制剂的吡咯烷基脲和吡咯烷基硫脲化合物 |
AR090037A1 (es) * | 2011-11-15 | 2014-10-15 | Xention Ltd | Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio |
PT2785349T (pt) | 2011-11-30 | 2019-12-11 | Astrazeneca Ab | Tratamento combinado de cancro |
AU2013204533B2 (en) | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
LT3154959T (lt) | 2014-05-15 | 2019-09-25 | Array Biopharma, Inc. | 1-((3s,4r)-4-(3-fluorfenil)-1-(2-metoksietil)pirolidin-3-il)-3-(4-metil-3-(2-metilpirimidin-5-il)-1-fenil-1h-pirazol-5-il)karbamidas kaip trka kinazės inhibitorius |
WO2018118598A1 (en) * | 2016-12-23 | 2018-06-28 | Arvinas, Inc. | Compounds and methods for the targeted degradation of fetal liver kinase polypeptides |
WO2020132384A1 (en) | 2018-12-21 | 2020-06-25 | Celgene Corporation | Thienopyridine inhibitors of ripk2 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69332948T2 (de) * | 1992-03-05 | 2003-11-27 | Univ Texas | Verwendung von Immunokonjugate zur Diagnose und/oder Therapie der vaskularisierten Tumoren |
US5474765A (en) * | 1992-03-23 | 1995-12-12 | Ut Sw Medical Ctr At Dallas | Preparation and use of steroid-polyanionic polymer-based conjugates targeted to vascular endothelial cells |
US5932765A (en) * | 1997-05-23 | 1999-08-03 | Merck Patent Gesellschaft Mit | Nitromethyl ketones, process for preparing them and compositions containing them |
CN101328186A (zh) * | 1997-11-11 | 2008-12-24 | 辉瑞产品公司 | 用作抗癌药的噻吩并嘧啶和噻吩并吡啶衍生物 |
EA200000768A1 (ru) * | 1998-01-27 | 2001-06-25 | Эвентис Фармасьютикалз Продактс Инк. | ЗАМЕЩЕННЫЕ ОКСОАЗАГЕТЕРОЦИКЛИЧЕСКИЕ ИНГИБИТОРЫ ФАКТОРА Ха |
ES2223705T3 (es) * | 1999-04-28 | 2005-03-01 | Board Of Regents, The University Of Texas System | Composiciones y metodos para el tratamiento de cancer mediante inhibi cion selectiva del vegf. |
US6776796B2 (en) * | 2000-05-12 | 2004-08-17 | Cordis Corportation | Antiinflammatory drug and delivery device |
DE10110750A1 (de) * | 2001-03-07 | 2002-09-12 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
AR035885A1 (es) * | 2001-05-14 | 2004-07-21 | Novartis Ag | Derivados de 4-amino-5-fenil-7-ciclobutilpirrolo (2,3-d)pirimidina, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos derivados para la preparacion de una composicion farmaceutica |
US7105505B2 (en) * | 2002-04-18 | 2006-09-12 | Schering Corporation | Benzimidazole derivatives useful as histamine H3 antagonists |
MY141867A (en) * | 2002-06-20 | 2010-07-16 | Vertex Pharma | Substituted pyrimidines useful as protein kinase inhibitors |
MXPA05001631A (es) * | 2002-08-12 | 2005-08-19 | Takeda Pharmaceutical | Derivado de benceno fusionado y su uso. |
WO2004039782A1 (ja) * | 2002-10-29 | 2004-05-13 | Kirin Beer Kabushiki Kaisha | Flt3自己リン酸化を阻害するキノリン誘導体およびキナゾリン誘導体並びにそれらを含有する医薬組成物 |
US20050026944A1 (en) * | 2003-07-24 | 2005-02-03 | Patrick Betschmann | Thienopyridine and furopyridine kinase inhibitors |
US20060281769A1 (en) * | 2005-06-10 | 2006-12-14 | Baumann Christian A | Synergistic modulation of flt3 kinase using thienopyrimidine and thienopyridine kinase modulators |
-
2006
- 2006-06-06 US US11/422,359 patent/US20060281768A1/en not_active Abandoned
- 2006-06-07 JP JP2008515879A patent/JP2008543759A/ja not_active Withdrawn
- 2006-06-07 CA CA002611587A patent/CA2611587A1/en not_active Abandoned
- 2006-06-07 BR BRPI0613644-3A patent/BRPI0613644A2/pt not_active Application Discontinuation
- 2006-06-07 EA EA200800011A patent/EA200800011A1/ru unknown
- 2006-06-07 WO PCT/US2006/022151 patent/WO2006135639A1/en active Application Filing
- 2006-06-07 AU AU2006258049A patent/AU2006258049A1/en not_active Abandoned
- 2006-06-07 EP EP06772445A patent/EP1899355A1/en not_active Withdrawn
- 2006-06-07 MX MX2007015741A patent/MX2007015741A/es unknown
- 2006-06-07 KR KR1020087000618A patent/KR20080021126A/ko not_active Application Discontinuation
- 2006-06-07 NI NI200700311A patent/NI200700311A/es unknown
- 2006-06-08 UY UY29590A patent/UY29590A1/es unknown
- 2006-06-08 PE PE2006000640A patent/PE20070070A1/es not_active Application Discontinuation
- 2006-06-09 TW TW095120482A patent/TW200716651A/zh unknown
- 2006-06-09 AR ARP060102425A patent/AR057063A1/es not_active Application Discontinuation
-
2007
- 2007-11-27 IL IL187689A patent/IL187689A0/en unknown
- 2007-12-10 EC EC2007007992A patent/ECSP077992A/es unknown
-
2008
- 2008-01-09 NO NO20080162A patent/NO20080162L/no not_active Application Discontinuation
- 2008-01-09 CR CR9650A patent/CR9650A/es not_active Application Discontinuation
-
2009
- 2009-01-30 US US12/363,043 patent/US20090163710A1/en not_active Abandoned
- 2009-01-30 US US12/362,933 patent/US20090143378A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
TW200716651A (en) | 2007-05-01 |
EP1899355A1 (en) | 2008-03-19 |
MX2007015741A (es) | 2008-04-29 |
CA2611587A1 (en) | 2006-12-21 |
AU2006258049A8 (en) | 2006-12-21 |
US20090143378A1 (en) | 2009-06-04 |
BRPI0613644A2 (pt) | 2011-01-25 |
WO2006135639A1 (en) | 2006-12-21 |
KR20080021126A (ko) | 2008-03-06 |
CR9650A (es) | 2008-09-09 |
EA200800011A1 (ru) | 2008-06-30 |
JP2008543759A (ja) | 2008-12-04 |
AU2006258049A1 (en) | 2006-12-21 |
NO20080162L (no) | 2008-03-07 |
UY29590A1 (es) | 2006-10-02 |
ECSP077992A (es) | 2008-01-23 |
US20060281768A1 (en) | 2006-12-14 |
IL187689A0 (en) | 2008-08-07 |
AR057063A1 (es) | 2007-11-14 |
PE20070070A1 (es) | 2007-03-08 |
US20090163710A1 (en) | 2009-06-25 |
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