EA200800017A1 - Алкилхинолиновые и алкилхиназолиновые модуляторы киназы - Google Patents
Алкилхинолиновые и алкилхиназолиновые модуляторы киназыInfo
- Publication number
- EA200800017A1 EA200800017A1 EA200800017A EA200800017A EA200800017A1 EA 200800017 A1 EA200800017 A1 EA 200800017A1 EA 200800017 A EA200800017 A EA 200800017A EA 200800017 A EA200800017 A EA 200800017A EA 200800017 A1 EA200800017 A1 EA 200800017A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compounds
- trkb
- kit
- flt3
- present
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Настоящее изобретение относится к алкилхинолиновым и алкилхиназолиновым соединениям формулы I, где R, R, R, В, Z, G, Q и Х такие, как определены в данном описании, к применению указанных соединений как модуляторов протеинтирозинкиназ, в частности как ингибиторов FLT3, и/или с-kit, и/или TrkB, к применению указанных соединений для снижения или ингибирования киназной активности FLT3, и/или c-kit, и/или TrkB в клетках или у субъекта и к применению указанных соединений для профилактики или лечения у субъекта клеточного пролиферативного расстройства и/или расстройств, связанных с FLT3, и/или c-kit, и/или TrkB. Настоящее изобретение относится также к фармацевтическим композициям, содержащим соединения по настоящему изобретению, и к способам лечения состояний, таких как раки и другие клеточные пролиферативные расстройства.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68938405P | 2005-06-10 | 2005-06-10 | |
US73091905P | 2005-10-27 | 2005-10-27 | |
PCT/US2006/022414 WO2006135721A1 (en) | 2005-06-10 | 2006-06-07 | Alkylquinoline and alkylquinazoline kinase modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200800017A1 true EA200800017A1 (ru) | 2008-08-29 |
Family
ID=37038081
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200800017A EA200800017A1 (ru) | 2005-06-10 | 2006-06-07 | Алкилхинолиновые и алкилхиназолиновые модуляторы киназы |
Country Status (18)
Country | Link |
---|---|
US (1) | US8071768B2 (ru) |
EP (1) | EP1893598A1 (ru) |
JP (1) | JP2009501135A (ru) |
KR (1) | KR20080028912A (ru) |
AR (1) | AR054386A1 (ru) |
AU (1) | AU2006257945A1 (ru) |
BR (1) | BRPI0611964A2 (ru) |
CA (1) | CA2611242A1 (ru) |
CR (1) | CR9652A (ru) |
EA (1) | EA200800017A1 (ru) |
EC (1) | ECSP077997A (ru) |
GT (1) | GT200600251A (ru) |
IL (1) | IL187692A0 (ru) |
NO (1) | NO20080174L (ru) |
PE (1) | PE20070014A1 (ru) |
TW (1) | TW200716599A (ru) |
UY (1) | UY29588A1 (ru) |
WO (1) | WO2006135721A1 (ru) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2641106C2 (ru) * | 2013-10-16 | 2018-01-16 | Фуджифилм Корпорэйшн | Соль азотсодержащего гетероциклического соединения или ее кристаллическая форма, фармацевтическая композиция и ингибитор flt3 |
RU2717830C2 (ru) * | 2015-07-15 | 2020-03-26 | Фуджифилм Корпорэйшн | Способ получения азотсодержащего гетероциклического соединения и его промежуточного соединения |
Families Citing this family (12)
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US7825244B2 (en) * | 2005-06-10 | 2010-11-02 | Janssen Pharmaceutica Nv | Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis |
US8071768B2 (en) | 2005-06-10 | 2011-12-06 | Janssen Pharmaceutica, N.V. | Alkylquinoline and alkylquinazoline kinase modulators |
US8760507B2 (en) * | 2008-08-05 | 2014-06-24 | Inspectron, Inc. | Light pipe for imaging head of video inspection device |
CA2785284A1 (en) * | 2009-12-25 | 2011-06-30 | Tomoyuki Kamino | Novel aryl urea derivative |
EP2621923B1 (en) | 2010-09-29 | 2017-03-29 | Intervet International B.V. | N-heteroaryl compounds with cyclic bridging unit for the treatment of parasitic diseases |
WO2013014170A1 (en) | 2011-07-27 | 2013-01-31 | Ab Science | Oxazole and thiazole derivatives as selective protein kinase inhibitors (c-kit) |
LT2922845T (lt) * | 2012-11-20 | 2018-09-10 | Merial, Inc. | Antihelmintiniai junginiai ir kompozicijos ir jų naudojimo būdai |
CA2934010A1 (en) * | 2013-12-20 | 2015-06-25 | Pfizer Limited | N-acylpiperidine ether tropomyosin-related kinase inhibitors |
UY36390A (es) * | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen |
CA2964276A1 (en) | 2014-11-05 | 2016-05-12 | Flexus Biosciences, Inc. | Immunoregulatory agents |
TWI731420B (zh) * | 2018-09-27 | 2021-06-21 | 大陸商深圳微芯生物科技股份有限公司 | 具有吲哚胺-2,3-雙加氧酶抑制活性的喹啉衍生物及其製備方法、藥物組合物、聯合用藥物與用途 |
US20220154220A1 (en) * | 2018-12-21 | 2022-05-19 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Small molecules for increasing precise genome editing efficiency |
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-
2006
- 2006-06-06 US US11/422,349 patent/US8071768B2/en active Active
- 2006-06-07 BR BRPI0611964-6A patent/BRPI0611964A2/pt not_active Application Discontinuation
- 2006-06-07 AU AU2006257945A patent/AU2006257945A1/en not_active Abandoned
- 2006-06-07 JP JP2008515954A patent/JP2009501135A/ja not_active Withdrawn
- 2006-06-07 EA EA200800017A patent/EA200800017A1/ru unknown
- 2006-06-07 PE PE2006000627A patent/PE20070014A1/es not_active Application Discontinuation
- 2006-06-07 CA CA002611242A patent/CA2611242A1/en not_active Abandoned
- 2006-06-07 WO PCT/US2006/022414 patent/WO2006135721A1/en active Application Filing
- 2006-06-07 KR KR1020087000405A patent/KR20080028912A/ko not_active Application Discontinuation
- 2006-06-07 EP EP06772652A patent/EP1893598A1/en not_active Withdrawn
- 2006-06-08 GT GT200600251A patent/GT200600251A/es unknown
- 2006-06-08 UY UY29588A patent/UY29588A1/es unknown
- 2006-06-09 AR ARP060102422A patent/AR054386A1/es not_active Application Discontinuation
- 2006-06-09 TW TW095120477A patent/TW200716599A/zh unknown
-
2007
- 2007-11-27 IL IL187692A patent/IL187692A0/en unknown
- 2007-12-10 EC EC2007007997A patent/ECSP077997A/es unknown
-
2008
- 2008-01-09 CR CR9652A patent/CR9652A/es not_active Application Discontinuation
- 2008-01-10 NO NO20080174A patent/NO20080174L/no not_active Application Discontinuation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2641106C2 (ru) * | 2013-10-16 | 2018-01-16 | Фуджифилм Корпорэйшн | Соль азотсодержащего гетероциклического соединения или ее кристаллическая форма, фармацевтическая композиция и ингибитор flt3 |
RU2717830C2 (ru) * | 2015-07-15 | 2020-03-26 | Фуджифилм Корпорэйшн | Способ получения азотсодержащего гетероциклического соединения и его промежуточного соединения |
Also Published As
Publication number | Publication date |
---|---|
WO2006135721A1 (en) | 2006-12-21 |
NO20080174L (no) | 2008-02-19 |
US8071768B2 (en) | 2011-12-06 |
GT200600251A (es) | 2007-01-12 |
UY29588A1 (es) | 2006-10-02 |
IL187692A0 (en) | 2008-08-07 |
JP2009501135A (ja) | 2009-01-15 |
BRPI0611964A2 (pt) | 2009-01-27 |
TW200716599A (en) | 2007-05-01 |
US20060281772A1 (en) | 2006-12-14 |
AR054386A1 (es) | 2007-06-20 |
EP1893598A1 (en) | 2008-03-05 |
KR20080028912A (ko) | 2008-04-02 |
AU2006257945A1 (en) | 2006-12-21 |
CR9652A (es) | 2008-09-09 |
ECSP077997A (es) | 2008-01-23 |
CA2611242A1 (en) | 2006-12-21 |
PE20070014A1 (es) | 2007-03-08 |
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