|
US8236A
(en)
|
|
1851-07-22 |
|
Hanging cakriage-body |
|
US319A
(en)
|
|
1837-07-31 |
|
Improvement in machines for breaking and dressing hemp and flax |
|
FR901464A
(fr)
|
1943-01-23 |
1945-07-27 |
Boehringer & Soehne Gmbh |
Procédé d'obtention de vanilline
|
|
US4434150A
(en)
|
1981-10-19 |
1984-02-28 |
Ortho Diagnostic Systems, Inc. |
Immunological reagents employing polymeric backbone possessing reactive functional groups
|
|
DE3307869A1
(de)
|
1983-03-05 |
1984-09-06 |
Dragoco Gerberding & Co Gmbh, 3450 Holzminden |
Methylsubstituierte 1-((3-methylthio)-1-oxo-butyl)-cyclohex-2-ene, verfahren zu deren herstellung und deren verwendung als riech- und aromastoffe
|
|
US4486414A
(en)
|
1983-03-21 |
1984-12-04 |
Arizona Board Of Reagents |
Dolastatins A and B cell growth inhibitory substances
|
|
US4545985A
(en)
|
1984-01-26 |
1985-10-08 |
The United States Of America As Represented By The Secretary, Dept. Of Health And Human Services |
Pseudomonas exotoxin conjugate immunotoxins
|
|
EP0335476A3
(en)
|
1984-02-08 |
1989-12-13 |
Cetus Corporation |
Recombinant methods for the production of ricin a, ricin b, ricin or diphtheria toxin (dt)a or ab' fragment, suitable hosts and vectors therefor, and conjugates comprising ricin toxin a chain or diphtheria toxin
|
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
US4880935A
(en)
|
1986-07-11 |
1989-11-14 |
Icrf (Patents) Limited |
Heterobifunctional linking agents derived from N-succinimido-dithio-alpha methyl-methylene-benzoates
|
|
US4892827A
(en)
|
1986-09-24 |
1990-01-09 |
The United States Of America As Represented By The Department Of Health And Human Services |
Recombinant pseudomonas exotoxins: construction of an active immunotoxin with low side effects
|
|
AU600575B2
(en)
|
1987-03-18 |
1990-08-16 |
Sb2, Inc. |
Altered antibodies
|
|
US4880078A
(en)
|
1987-06-29 |
1989-11-14 |
Honda Giken Kogyo Kabushiki Kaisha |
Exhaust muffler
|
|
US4816444A
(en)
|
1987-07-10 |
1989-03-28 |
Arizona Board Of Regents, Arizona State University |
Cell growth inhibitory substance
|
|
IL106992A
(en)
|
1988-02-11 |
1994-06-24 |
Bristol Myers Squibb Co |
Acylhydrazone derivatives of anthracycline and methods for their preparation
|
|
US5076973A
(en)
|
1988-10-24 |
1991-12-31 |
Arizona Board Of Regents |
Synthesis of dolastatin 3
|
|
FI903489A0
(fi)
|
1988-11-11 |
1990-07-10 |
Medical Res Council |
Ligander med en enda sektion, receptorer innehaollande naemnda ligander, foerfaranden foer deras framstaellning samt anvaendning av liganderna och receptorerna.
|
|
US4978744A
(en)
|
1989-01-27 |
1990-12-18 |
Arizona Board Of Regents |
Synthesis of dolastatin 10
|
|
US4879278A
(en)
|
1989-05-16 |
1989-11-07 |
Arizona Board Of Regents |
Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
|
|
US4986988A
(en)
|
1989-05-18 |
1991-01-22 |
Arizona Board Of Regents |
Isolation and structural elucidation of the cytostatic linear depsipeptides dolastatin 13 and dehydrodolastatin 13
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
US5138036A
(en)
|
1989-11-13 |
1992-08-11 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Isolation and structural elucidation of the cytostatic cyclodepsipeptide dolastatin 14
|
|
US5458878A
(en)
|
1990-01-02 |
1995-10-17 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
P. exotoxin fusio proteins have COOHG220101al alterations which increase cytotoxicity
|
|
US5124471A
(en)
|
1990-03-26 |
1992-06-23 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Bifunctional dtpa-type ligand
|
|
CA2109528A1
(en)
|
1991-05-01 |
1992-11-02 |
Gregory A. Prince |
A method for treating infectious respiratory diseases
|
|
US6287792B1
(en)
|
1991-06-17 |
2001-09-11 |
The Regents Of The University Of California |
Drug delivery of antisense oligonucleotides and peptides to tissues in vivo and to cells using avidin-biotin technology
|
|
US5622929A
(en)
|
1992-01-23 |
1997-04-22 |
Bristol-Myers Squibb Company |
Thioether conjugates
|
|
US5714350A
(en)
|
1992-03-09 |
1998-02-03 |
Protein Design Labs, Inc. |
Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
|
|
DK0563475T3
(da)
|
1992-03-25 |
2000-09-18 |
Immunogen Inc |
Konjugater af cellebindende midler og derivater af CC-1065
|
|
ZA932522B
(en)
|
1992-04-10 |
1993-12-20 |
Res Dev Foundation |
Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens
|
|
ES2130265T3
(es)
|
1992-05-06 |
1999-07-01 |
Harvard College |
Region de union al receptor de la toxina difterica.
|
|
US6034065A
(en)
|
1992-12-03 |
2000-03-07 |
Arizona Board Of Regents |
Elucidation and synthesis of antineoplastic tetrapeptide phenethylamides of dolastatin 10
|
|
US5635483A
(en)
|
1992-12-03 |
1997-06-03 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Tumor inhibiting tetrapeptide bearing modified phenethyl amides
|
|
US5410024A
(en)
|
1993-01-21 |
1995-04-25 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide amides
|
|
US5780588A
(en)
|
1993-01-26 |
1998-07-14 |
Arizona Board Of Regents |
Elucidation and synthesis of selected pentapeptides
|
|
WO1994016729A1
(en)
|
1993-01-28 |
1994-08-04 |
Neorx Corporation |
Targeted nitric oxide pathway or nitric oxide synthase modulation
|
|
US5934272A
(en)
|
1993-01-29 |
1999-08-10 |
Aradigm Corporation |
Device and method of creating aerosolized mist of respiratory drug
|
|
US6214345B1
(en)
|
1993-05-14 |
2001-04-10 |
Bristol-Myers Squibb Co. |
Lysosomal enzyme-cleavable antitumor drug conjugates
|
|
WO1995015770A1
(en)
|
1993-12-09 |
1995-06-15 |
Neorx Corporation |
Pretargeting methods and compounds
|
|
US5504191A
(en)
|
1994-08-01 |
1996-04-02 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide methyl esters
|
|
US5530097A
(en)
|
1994-08-01 |
1996-06-25 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory peptide amides
|
|
US5521284A
(en)
|
1994-08-01 |
1996-05-28 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide amides and esters
|
|
US5554725A
(en)
|
1994-09-14 |
1996-09-10 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Synthesis of dolastatin 15
|
|
US5599902A
(en)
|
1994-11-10 |
1997-02-04 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Cancer inhibitory peptides
|
|
US5663149A
(en)
|
1994-12-13 |
1997-09-02 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
|
|
US6019968A
(en)
|
1995-04-14 |
2000-02-01 |
Inhale Therapeutic Systems, Inc. |
Dispersible antibody compositions and methods for their preparation and use
|
|
US7696338B2
(en)
|
1995-10-30 |
2010-04-13 |
The United States Of America As Represented By The Department Of Health And Human Services |
Immunotoxin fusion proteins and means for expression thereof
|
|
ATE234635T1
(de)
|
1995-12-22 |
2003-04-15 |
Bristol Myers Squibb Co |
Verzweigte hydrazongruppen enthaltende kuppler
|
|
DE122004000004I1
(de)
*
|
1996-02-09 |
2004-08-12 |
Abott Biotechnology Ltd |
Humane Antikörper welche an Humanen TNFalpha binden.
|
|
IT1282692B1
(it)
|
1996-02-27 |
1998-03-31 |
San Raffaele Centro Fond |
Citochine modificate per l'uso in terapia
|
|
DK0885002T3
(da)
|
1996-03-04 |
2011-08-22 |
Penn State Res Found |
Materialer og fremgangsmåder til forøgelse af cellulær internalisering
|
|
US5985309A
(en)
|
1996-05-24 |
1999-11-16 |
Massachusetts Institute Of Technology |
Preparation of particles for inhalation
|
|
US5855913A
(en)
|
1997-01-16 |
1999-01-05 |
Massachusetts Instite Of Technology |
Particles incorporating surfactants for pulmonary drug delivery
|
|
US5874064A
(en)
|
1996-05-24 |
1999-02-23 |
Massachusetts Institute Of Technology |
Aerodynamically light particles for pulmonary drug delivery
|
|
EP0934612B1
(en)
|
1996-10-28 |
2001-11-07 |
Abb Power Systems Ab |
Land electrode for a high voltage direct current transmission system
|
|
CA2277801C
(en)
|
1997-01-16 |
2002-10-15 |
Massachusetts Institute Of Technology |
Preparation of particles for inhalation
|
|
CA2279590A1
(en)
|
1997-02-13 |
1998-08-20 |
Bone Care International, Inc. |
Targeted therapeutic delivery of vitamin d compounds
|
|
EP0973540B1
(en)
|
1997-02-25 |
2005-11-02 |
Arizona Board Of Regents |
Isolation and structural elucidation of the cytostatic linear and cyclo-depsipeptides dolastatin 16, dolastatin 17, and dolastatin 18
|
|
US7314632B1
(en)
|
1997-07-11 |
2008-01-01 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Pseudomonas exotoxin A-like chimeric immunogens
|
|
WO1999019500A1
(en)
|
1997-10-10 |
1999-04-22 |
The Government Of The United States Of America, Represented By The Secretary, Department Of Healt H And Human Services |
Complex of biotinylated viral vector and ligand for targeted gene delivery
|
|
WO1999066027A1
(en)
|
1998-06-15 |
1999-12-23 |
The Research Foundation Of State University Of New York |
Monoclonal antibodies that recognize antigens associated with tumor metastasis
|
|
CA2336139C
(en)
|
1998-06-24 |
2008-10-14 |
Advanced Inhalation Research, Inc. |
Large porous particles emitted from an inhaler
|
|
EP1176195B1
(en)
|
1999-04-09 |
2013-05-22 |
Kyowa Hakko Kirin Co., Ltd. |
Method for controlling the activity of immunologically functional molecule
|
|
CN1269087C
(zh)
|
1999-07-31 |
2006-08-09 |
朴奎珍 |
使用数字音频和字幕数据的学习方法和装置
|
|
US6323315B1
(en)
|
1999-09-10 |
2001-11-27 |
Basf Aktiengesellschaft |
Dolastatin peptides
|
|
HK1049787B
(en)
|
1999-10-01 |
2014-07-25 |
Immunogen, Inc. |
Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
|
|
WO2001090198A1
(en)
|
2000-05-24 |
2001-11-29 |
Ludwig Institute For Cancer Research |
Multicomponent conjugates which bind to target molecules and stimulate cell lysis
|
|
US7449308B2
(en)
|
2000-06-28 |
2008-11-11 |
Glycofi, Inc. |
Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
|
|
AU2001276842B2
(en)
|
2000-06-28 |
2007-04-26 |
Glycofi, Inc. |
Methods for producing modified glycoproteins
|
|
US6884869B2
(en)
|
2001-04-30 |
2005-04-26 |
Seattle Genetics, Inc. |
Pentapeptide compounds and uses related thereto
|
|
US20030083263A1
(en)
|
2001-04-30 |
2003-05-01 |
Svetlana Doronina |
Pentapeptide compounds and uses related thereto
|
|
US6441163B1
(en)
|
2001-05-31 |
2002-08-27 |
Immunogen, Inc. |
Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
|
|
WO2003016466A2
(en)
|
2001-08-17 |
2003-02-27 |
Eli Lilly And Company |
ANTI-Aβ ANTIBODIES
|
|
US7091186B2
(en)
|
2001-09-24 |
2006-08-15 |
Seattle Genetics, Inc. |
p-Amidobenzylethers in drug delivery agents
|
|
WO2003026577A2
(en)
|
2001-09-24 |
2003-04-03 |
Seattle Genetics, Inc. |
P-amidobenzylethers in drug delivery agents
|
|
US20030157108A1
(en)
|
2001-10-25 |
2003-08-21 |
Genentech, Inc. |
Glycoprotein compositions
|
|
JP2005538049A
(ja)
|
2002-05-01 |
2005-12-15 |
トレリス バイオサイエンス、インク． |
２元的ないし多元的ターゲティング及びその使用
|
|
US20050276812A1
(en)
|
2004-06-01 |
2005-12-15 |
Genentech, Inc. |
Antibody-drug conjugates and methods
|
|
DK1545613T3
(da)
|
2002-07-31 |
2011-11-14 |
Seattle Genetics Inc |
Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom
|
|
JP2005539009A
(ja)
|
2002-08-02 |
2005-12-22 |
イミュノジェン・インコーポレーテッド |
新規の効力のあるタキサンを含む細胞毒性物質、および、それらの治療用途
|
|
DE60336149D1
(de)
|
2002-08-16 |
2011-04-07 |
Immunogen Inc |
Vernetzer mit hoher reaktivität und löslichkeit und ihre verwendung bei der herstellung von konjugaten für die gezielte abgabe von kleinmolekularen arzneimitteln
|
|
DE10242146A1
(de)
|
2002-09-04 |
2004-03-18 |
Eberhard-Karls-Universität Tübingen Universitätsklinikum |
Antikörper zur Identifizierung und/oder Isolierung von hämatopoetischen Stammzellen
|
|
US7388079B2
(en)
|
2002-11-27 |
2008-06-17 |
The Regents Of The University Of California |
Delivery of pharmaceutical agents via the human insulin receptor
|
|
DE602004027992D1
(de)
|
2003-02-19 |
2010-08-19 |
Novartis Ag |
In metastatischen menschlichen tumorzellen exprimiertes glycoproteinantigen sima135
|
|
ATE472338T1
(de)
|
2003-02-20 |
2010-07-15 |
Seattle Genetics Inc |
Anti-cd70 antikörper-arzneimittelkonjugate und ihre verwendung zur behandlung von krebs
|
|
WO2004099254A2
(en)
|
2003-05-06 |
2004-11-18 |
The Government Of The United States, As Represented By The Secretary Of Health And Human Services |
Activation of recombinant diphtheria toxin fusion proteins by specific proteases highly expressed on the surface of tumor cells
|
|
US7432088B2
(en)
|
2003-05-08 |
2008-10-07 |
Immunogen Inc. |
Methods for the production of ansamitocins
|
|
WO2005020883A2
(en)
|
2003-05-08 |
2005-03-10 |
Immunogen, Inc. |
Methods for the production of ansamitocins
|
|
US8088387B2
(en)
|
2003-10-10 |
2012-01-03 |
Immunogen Inc. |
Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
|
|
JP4703566B2
(ja)
|
2003-05-14 |
2011-06-15 |
イムノゲン インコーポレーティッド |
薬剤複合体組成物
|
|
US7276497B2
(en)
|
2003-05-20 |
2007-10-02 |
Immunogen Inc. |
Cytotoxic agents comprising new maytansinoids
|
|
CR20170291A
(es)
|
2003-05-20 |
2017-07-27 |
Immunogen Inc |
Agentes citotoxicos mejorados que comprenden nuevos maitansinóides
|
|
GB0324656D0
(en)
|
2003-10-22 |
2003-11-26 |
Celltech R&D Ltd |
A protein involved in ovarian cancer
|
|
CN107213469A
(zh)
|
2003-11-06 |
2017-09-29 |
西雅图基因公司 |
能够与配体偶联的单甲基缬氨酸化合物
|
|
EP1687016A4
(en)
|
2003-11-25 |
2009-07-29 |
Anjin Corp |
GENETIC VARIANT OF DIPHTHERIC TOXIN
|
|
US20050214310A1
(en)
|
2004-01-23 |
2005-09-29 |
Seattle Genetics, Inc. |
Melphalan prodrugs
|
|
US20050175619A1
(en)
|
2004-02-05 |
2005-08-11 |
Robert Duffy |
Methods of producing antibody conjugates
|
|
EP2392586A1
(en)
|
2004-02-20 |
2011-12-07 |
The Trustees of The University of Pennsylvania |
Binding peptidomimetics and uses of the same
|
|
EP1718667B1
(en)
|
2004-02-23 |
2013-01-09 |
Genentech, Inc. |
Heterocyclic self-immolative linkers and conjugates
|
|
JP4942643B2
(ja)
|
2004-03-02 |
2012-05-30 |
シアトル ジェネティックス， インコーポレイテッド |
部分的に付加された抗体およびそれらの結合体化方法
|
|
US20050226882A1
(en)
|
2004-04-08 |
2005-10-13 |
Awdalla Essam T |
Method and multicomponent conjugates for treating cancer
|
|
JP2007535317A
(ja)
|
2004-04-15 |
2007-12-06 |
グライコフィ， インコーポレイテッド |
下等真核生物におけるガラクトシル化された糖タンパク質の産生
|
|
RU2402548C2
(ru)
|
2004-05-19 |
2010-10-27 |
Медарекс, Инк. |
Химические линкеры и их конъюгаты
|
|
US20080008719A1
(en)
*
|
2004-07-10 |
2008-01-10 |
Bowdish Katherine S |
Methods and compositions for the treatment of prostate cancer
|
|
JP4193771B2
(ja)
|
2004-07-27 |
2008-12-10 |
セイコーエプソン株式会社 |
階調電圧発生回路及び駆動回路
|
|
EP3505191A1
(en)
|
2004-11-12 |
2019-07-03 |
Seattle Genetics, Inc. |
Auristatins having an aminobenzoic acid unit at the n terminus
|
|
WO2006065533A2
(en)
|
2004-11-29 |
2006-06-22 |
Seattle Genetics, Inc. |
Engineered antibodies and immunoconjugates
|
|
US7301019B2
(en)
|
2005-01-21 |
2007-11-27 |
Immunogen, Inc. |
Method for the preparation of maytansinoid esters
|
|
ES2503719T3
(es)
|
2005-02-11 |
2014-10-07 |
Immunogen, Inc. |
Procedimiento para preparar conjugados de anticuerpos y de maitansinoides
|
|
EP1695717A1
(en)
|
2005-02-23 |
2006-08-30 |
Ludwig-Maximilians-Universität |
Transport of nano-and macromolecular structures into cytoplasm and nucleus of cells
|
|
CN101203241B
(zh)
|
2005-04-19 |
2012-02-22 |
西雅图基因公司 |
人源化抗-cd70结合物和其应用
|
|
US8871720B2
(en)
|
2005-07-07 |
2014-10-28 |
Seattle Genetics, Inc. |
Monomethylvaline compounds having phenylalanine carboxy modifications at the C-terminus
|
|
WO2007008603A1
(en)
|
2005-07-07 |
2007-01-18 |
Seattle Genetics, Inc. |
Monomethylvaline compounds having phenylalanine side-chain modifications at the c-terminus
|
|
DK1912671T3
(da)
|
2005-07-18 |
2017-11-27 |
Seattle Genetics Inc |
Beta-glucuronid-linker-lægemiddelkonjugater
|
|
AU2006283726C1
(en)
|
2005-08-24 |
2015-05-07 |
Immunogen, Inc. |
Process for preparing maytansinoid antibody conjugates
|
|
JP2007112734A
(ja)
|
2005-10-19 |
2007-05-10 |
Chugai Pharmaceut Co Ltd |
抗ｃｄｃｐ１抗体を含有する癌細胞増殖抑制剤
|
|
JP5117390B2
(ja)
|
2005-11-08 |
2013-01-16 |
イミュノジェン・インコーポレーテッド |
メイタンシノールの調製法
|
|
WO2007103288A2
(en)
|
2006-03-02 |
2007-09-13 |
Seattle Genetics, Inc. |
Engineered antibody drug conjugates
|
|
CA2690973A1
(en)
|
2006-06-23 |
2007-12-27 |
Paul M. Simon |
Targeted immune conjugates
|
|
US7825267B2
(en)
|
2006-09-08 |
2010-11-02 |
University Of Pittsburgh-Of The Commonwealth System Of Higher Education |
Synthesis of FR901464 and analogs with antitumor activity
|
|
WO2008054606A2
(en)
|
2006-10-02 |
2008-05-08 |
Regeneron Pharmaceuticals, Inc. |
High affinity human antibodies to human il-4 receptor
|
|
US7598028B2
(en)
|
2006-11-28 |
2009-10-06 |
The Regents Of The University Of Michigan |
Compositions and methods for detecting and treating prostate disorders
|
|
DK2099823T4
(da)
|
2006-12-01 |
2022-05-09 |
Seagen Inc |
Målbindingsmiddelvarianter og anvendelser deraf
|
|
TWI422594B
(zh)
|
2007-02-02 |
2014-01-11 |
Baylor Res Inst |
經由樹狀細胞去唾液酸糖蛋白受體（ｄｃ-ａｓｇｐｒ）接合抗原呈現細胞之藥劑
|
|
CN101679508B
(zh)
|
2007-02-02 |
2014-11-05 |
贝勒研究院 |
基于靶向抗原至抗原呈递细胞上表达的dcir的疫苗
|
|
PL2129396T3
(pl)
|
2007-02-16 |
2014-02-28 |
Merrimack Pharmaceuticals Inc |
Przeciwciała przeciw ERBB3 i ich zastosowania
|
|
US8481314B2
(en)
|
2007-02-23 |
2013-07-09 |
Baylor Research Institute |
Activation of human antigen-presenting cells through dendritic cell lectin-like oxidized LDL receptor-1 (LOX-1)
|
|
JP2010519313A
(ja)
|
2007-02-23 |
2010-06-03 |
ベイラー リサーチ インスティテュート |
Ｃｌｅｃ−６を介したヒト抗原提示細胞の活性化
|
|
EP2121745A2
(en)
|
2007-02-26 |
2009-11-25 |
Oxford Genome Sciences (UK) Limited |
Proteins
|
|
DK2208737T3
(en)
|
2007-05-03 |
2017-09-18 |
Lysomab Gmbh |
Complement factor H-derived short-consensus repeat antibody constructs
|
|
WO2009014835A2
(en)
|
2007-06-21 |
2009-01-29 |
Angelica Therapeutics, Inc. |
Modified toxins
|
|
WO2009080831A1
(en)
|
2007-12-26 |
2009-07-02 |
Biotest Ag |
Method of decreasing cytotoxic side-effects and improving efficacy of immunoconjugates
|
|
DK2265283T3
(da)
|
2008-03-18 |
2014-10-20 |
Seattle Genetics Inc |
Auristatin-lægemiddel-linker-konjugater
|
|
CN102083461B
(zh)
|
2008-04-30 |
2014-09-17 |
伊缪诺金公司 |
有效的偶联物和亲水性连接体
|
|
WO2009134870A1
(en)
|
2008-04-30 |
2009-11-05 |
Immunogen, Inc. |
Potent cell-binding agent drug conjugates
|
|
HUE034763T2
(en)
|
2008-04-30 |
2018-02-28 |
Immunogen Inc |
Crosslinkers and their use
|
|
US20100233154A1
(en)
|
2008-10-08 |
2010-09-16 |
Medimmune Limited |
Targeted binding agents directed to heparanase and uses thereof 463
|
|
US8394818B2
(en)
|
2008-10-17 |
2013-03-12 |
Dana-Farber Cancer Institute, Inc. |
Soluble mTOR complexes and modulators thereof
|
|
SG173152A1
(en)
|
2009-02-05 |
2011-08-29 |
Immunogen Inc |
Novel benzodiazepine derivatives
|
|
US8444983B2
(en)
|
2009-03-23 |
2013-05-21 |
Quark Pharmaceuticals, Inc. |
Composition of anti-ENDO180 antibodies and methods of use for the treatment of cancer and fibrotic diseases
|
|
WO2010126552A1
(en)
|
2009-04-30 |
2010-11-04 |
Immunogen, Inc. |
Potent cell-binding agent drug conjugates
|
|
SG10201401976YA
(en)
|
2009-05-06 |
2014-10-30 |
Biotest Ag |
Uses of immunoconjugates targeting cd138
|
|
MX2011012794A
(es)
|
2009-06-03 |
2012-05-08 |
Immunogen Inc |
Metodos de conjugacion.
|
|
DE102009026075A1
(de)
|
2009-06-30 |
2011-01-05 |
Röhm Gmbh |
Bohrvorrichtung
|
|
TW201113037A
(en)
*
|
2009-08-28 |
2011-04-16 |
Hoffmann La Roche |
Antibodies against CDCP1 for the treatment of cancer
|
|
TWI412375B
(zh)
|
2009-08-28 |
2013-10-21 |
Roche Glycart Ag |
人類化抗ｃｄｃｐ１抗體
|
|
US20110076232A1
(en)
|
2009-09-29 |
2011-03-31 |
Ludwig Institute For Cancer Research |
Specific binding proteins and uses thereof
|
|
KR20120080611A
(ko)
|
2009-10-06 |
2012-07-17 |
이뮤노젠 아이엔씨 |
효능 있는 접합체 및 친수성 링커
|
|
US9149544B2
(en)
|
2009-11-06 |
2015-10-06 |
The Penn State Research Foundation |
Bioconjugation of calcium phosphosilicate nanoparticles for selective targeting of cells in vivo
|
|
GB0919751D0
(en)
|
2009-11-11 |
2009-12-30 |
King S College Hospital Nhs Fo |
Conjugate molecule
|
|
GB201001791D0
(en)
|
2010-02-03 |
2010-03-24 |
Ucb Pharma Sa |
Process for obtaining antibodies
|
|
TWI672318B
(zh)
|
2010-02-24 |
2019-09-21 |
美商免疫遺傳股份有限公司 |
葉酸受體１抗體類和免疫共軛物類及彼等之用途
|
|
US20110214205A1
(en)
*
|
2010-02-26 |
2011-09-01 |
Monsanto Technology Llc. |
Isolated Novel Nucleic Acid and Protein Molecules from Foxtail Millet and Methods of Using Those Molecules to Generate Transgenic Plants with Enhanced Agronomic Traits
|
|
KR101772354B1
(ko)
|
2010-04-15 |
2017-08-28 |
시애틀 지네틱스, 인크. |
표적화된 피롤로벤조디아제핀 접합체
|
|
ES2623057T3
(es)
|
2010-04-15 |
2017-07-10 |
Medimmune Limited |
Pirrolobenzodiazepinas usadas para tratar enfermedades proliferativas
|
|
WO2012027494A1
(en)
|
2010-08-24 |
2012-03-01 |
Regents Of The University Of Minnesota |
Bispecific targeting reagents
|
|
MX347954B
(es)
|
2010-09-29 |
2017-05-19 |
Agensys Inc |
Conjugados de anticuerpo farmaco (adc) que enlazan a proteinas 191p4d12.
|
|
ES2553874T3
(es)
|
2010-09-29 |
2015-12-14 |
Seattle Genetics, Inc. |
N-Carboxialquil-auristatinas y su uso
|
|
CA2815363C
(en)
|
2010-10-22 |
2020-07-14 |
Seattle Genetics, Inc. |
Synergistic effects between auristatin-based antibody drug conjugates and inhibitors of the pi3k-akt mtor pathway
|
|
US8790649B2
(en)
|
2010-10-29 |
2014-07-29 |
Immunogen, Inc. |
EGFR-binding molecules and immunoconjugates thereof
|
|
CA2816681A1
(en)
|
2010-11-03 |
2012-05-10 |
Immunogen, Inc. |
Cytotoxic agents comprising new ansamitocin derivatives
|
|
PL3153504T3
(pl)
|
2010-12-09 |
2019-04-30 |
Immunogen Inc |
Sposoby otrzymywania naładowanych środków sieciujących
|
|
KR20190089048A
(ko)
|
2011-02-15 |
2019-07-29 |
이뮤노젠 아이엔씨 |
컨쥬게이트의 제조방법
|
|
JP6023097B2
(ja)
|
2011-03-16 |
2016-11-09 |
シアトル ジェネティックス， インコーポレイテッド |
Ｎカルボキシアルキルオーリスタチンおよびその使用
|
|
WO2012135517A2
(en)
|
2011-03-29 |
2012-10-04 |
Immunogen, Inc. |
Preparation of maytansinoid antibody conjugates by a one-step process
|
|
WO2012138749A1
(en)
|
2011-04-04 |
2012-10-11 |
Immunogen, Inc. |
Methods for decreasing ocular toxicity of antibody drug conjugates
|
|
AU2012244673A1
(en)
|
2011-04-21 |
2013-11-28 |
Seattle Genetics, Inc. |
Novel binder-drug conjugates (ADCs) and their use
|
|
US9574002B2
(en)
|
2011-06-06 |
2017-02-21 |
Amgen Inc. |
Human antigen binding proteins that bind to a complex comprising β-Klotho and an FGF receptor
|
|
CA2837892A1
(en)
*
|
2011-06-14 |
2012-12-20 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Tem8 antibodies, conjugates thereof, and their use
|
|
SG10201605041VA
(en)
|
2011-06-21 |
2016-08-30 |
Immunogen Inc |
Novel maytansinoid derivatives with peptide linker and conjugates thereof
|
|
US9526798B2
(en)
|
2011-10-14 |
2016-12-27 |
Seattle Genetics, Inc. |
Pyrrolobenzodiazepines and targeted conjugates
|
|
MX358757B
(es)
|
2011-10-14 |
2018-09-03 |
Seattle Genetics Inc |
Pirrolobenzodiazepinas y conjugados dirigidos.
|
|
EP2794658B1
(en)
|
2011-12-19 |
2017-03-15 |
Synimmune GmbH |
Bispecific antibody molecule
|
|
EP2800583A1
(en)
|
2012-01-02 |
2014-11-12 |
Novartis AG |
Cdcp1 and breast cancer
|
|
CN104583194A
(zh)
|
2012-05-11 |
2015-04-29 |
艾伯维公司 |
作为nampt抑制剂的哒嗪和吡啶衍生物
|
|
US9504756B2
(en)
|
2012-05-15 |
2016-11-29 |
Seattle Genetics, Inc. |
Self-stabilizing linker conjugates
|
|
HUE055443T2
(hu)
|
2012-09-26 |
2021-11-29 |
Immunogen Inc |
Javított eljárások maytansinol acilezéséhez
|
|
CN105189548A
(zh)
|
2013-03-14 |
2015-12-23 |
瑞泽恩制药公司 |
Grem1的人抗体
|
|
WO2015082446A1
(en)
|
2013-12-02 |
2015-06-11 |
F. Hoffmann-La Roche Ag |
Treatment of cancer using an anti-cdcp1 antibody and a taxane
|
|
TWI541022B
(zh)
|
2013-12-18 |
2016-07-11 |
應克隆公司 |
針對纖維母細胞生長因子受體－３（ｆｇｆｒ３）之化合物及治療方法
|
|
US10815469B2
(en)
|
2014-06-11 |
2020-10-27 |
Molecular Templates, Inc. |
Cell-targeting molecules comprising protease-cleavage resistant, Shiga toxin A subunit effector polypeptides and carboxy-terminal moieties
|
|
JP6805137B2
(ja)
|
2014-07-11 |
2020-12-23 |
アンセルム（アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル） |
血液学的癌を診断するための方法
|
|
US10988531B2
(en)
|
2014-09-03 |
2021-04-27 |
Immunogen, Inc. |
Conjugates comprising cell-binding agents and cytotoxic agents
|
|
EP3029067A1
(en)
|
2014-12-01 |
2016-06-08 |
Deutsches Krebsforschungszentrum |
Use of blocking-reagents for reducing unspecific T cell-activation
|
|
JP6921001B2
(ja)
*
|
2015-04-13 |
2021-08-18 |
ファイザー・インク |
Ｂ細胞成熟抗原を標的にするキメラ抗原受容体
|
|
JP7350313B2
(ja)
|
2016-12-16 |
2023-09-26 |
ブルーフィン バイオメディシン， インコーポレイテッド |
抗ｃｕｂドメイン含有タンパク質１（ｃｄｃｐ１）抗体、抗体薬物コンジュゲート、およびその使用方法
|